ライフサイエンスコーパス: functional interaction

1 ptin localization and function, suggesting a functional interaction.

2 and gH/gL exhibit an essential type-specific functional interaction.

3 n binding (a 'transport metabolon') or local functional interaction.

4 n speckles, suggesting a direct physical and functional interaction.

5 agement, along with theories regarding their functional interaction.

6 concurrently overexpressed, confirming their functional interaction.

7 TRPV1 contributes to the complexity of their functional interaction.

8 es and this allows MDM4 to promote p53/HIPK2 functional interaction.

9 ged as the predominant motif associated with functional interactions.

10 involved in Ca(2+)-dependent exocytosis into functional interactions.

11 mechanistic links to prefrontal-hippocampal functional interactions.

12 cts in an allele-specific manner, signifying functional interactions.

13 ndence between DHPR positioning and DHPR/RyR functional interactions.

14 mulation in the OFC, is required for OFC-BLA functional interactions.

15 providing specificity for NEIL1's multiple, functional interactions.

16 ule relations combine mutual exclusivity and functional interactions.

17 ein interactions as well as suggesting novel functional interactions.

18 providing a molecular explanation for their functional interactions.

19 72 EBV-human protein pairs, we obtain 51,485 functional interactions (7.94%), 869 stringent physical

20 ions are associated with highly coherent and functional interactions across several millimeters of th

21 ational modelling to characterize changes in functional interactions across widespread neural network

22 reatment decisions may also be influenced by functional interactions among different MDRO species, wi

23 n OFC and MFC.SIGNIFICANCE STATEMENT Altered functional interactions among orbital frontal cortex (OF

24 ately 50 kb-10 Mb is crucial for identifying functional interactions among regulatory elements and th

25 everal recent studies have helped define the functional interactions among the different cellular sub

26 heir diversification is likely shaped by the functional interactions among these biotic stresses.

27 nance of glucose homeostasis is achieved via functional interactions among various organs: liver, ske

28 To identify functional interactions among yeast chronological ageing

29 growth upon co-manipulation suggest complex functional interaction and cross-regulation between thes

30 ing analysis can accelerate the discovery of functional interactions and 3D structures involving RNA.

31 s complementarity must be optimized both for functional interactions and against mis-interactions, an

32 e findings together demonstrated synergistic functional interactions and clinical relevance of concur

33 risk through altered prefrontal-hippocampal functional interactions and suggest a link to both ongoi

34 tabilities of folding and strengths of their functional interactions are exactly evaluated from their

35 -driven genes and associated networks, whose functional interactions are likely to be actively modula

36 mechanisms by which they evolve to maintain functional interactions are poorly understood.

37 physical) interactions, as well as indirect (functional) interactions, as long as both are specific a

38 lar loop (ECL2) with radioligand binding and functional interaction assays to quantify effects on all

39 mic AMPAR plasticity, our results identify a functional interaction between acidotoxicity and excitot

40 The functional interaction between actin oligomers and PMCA

41 rtially attenuates FRAP recovery, indicating functional interaction between actin subunit turnover at

42 n vitro and murine data that suggest a close functional interaction between ADAMTS3 and CCBE1 in trig

43 The functional interaction between basic amino acids and STM

44 Here we characterize a functional interaction between BBS4 and the secreted pro

45 Here we interrogate functional interaction between BRCA1 and COBRA1 during m

46 phospho-NKCC2 in SORLA-deficient mice, and a functional interaction between calcineurin Abeta and SOR

47 esults are the first to demonstrate a direct functional interaction between CaMKII and NL-1, two prim

48 of focal adhesion tension and suggests that functional interaction between Cav1 Y14 phosphorylation

49 a reveal a novel molecular mechanism for the functional interaction between CB1R and 5-HT2AR mediatin

50 In support of the functional interaction between CD24 and p53, in silico a

51 iates fear inhibition, we hypothesize that a functional interaction between Cnr1 and CCKB receptor (C

52 Here, we investigate the functional interaction between D1 dopamine receptors (D1

53 egulatory phosphorylation site of KCC2 and a functional interaction between different conformation-ch

54 Here, we describe a physical and functional interaction between EBOV VP40 (eVP40) and WWP

55 d the phenotype caused by C2879U, suggesting functional interaction between eIF5B and the A loop.

56 displaced [(3)H]SR141716A, but there was no functional interaction between either of these ligands a

57 FGF19 increases functional interaction between endogenous SHP and SREBP-

58 We have identified a functional interaction between FcepsilonRI and CD13 in m

59 These data are indicative of a functional interaction between FcepsilonRI and CD13 on M

60 rat model of PD, partial elimination of the functional interaction between FKBP12 and calcineurin, w

61 The functional interaction between FLCN and Rab7A appears co

62 eins between HSV-1 and SaHV-1, we revealed a functional interaction between gD and gH/gL.

63 of trophoblast invasion through physical and functional interaction between HtrA family members.

64 In support of a functional interaction between Ihog and members of the S

65 n of Aire mRNA in keratinocytes depends on a functional interaction between K17 and the heterogeneous

66 We explored the functional interaction between Kv1.3 and NavBeta1 throug

67 These findings reflect a functional interaction between Lto1 and the Rli1/ABCE1 [

68 le of LUBAC in TLR3 signaling and discover a functional interaction between LUBAC components and TLR3

69 In this study, we report a functional interaction between macroautophagy and Cortic

70 We further demonstrate that functional interaction between MCT4 and CAII requires di

71 pharmacophores for use as tools to study the functional interaction between MOP and CB1 receptors in

72 objects across sensory modalities relied on functional interaction between multiple cortical regions

73 Together, the data reveal a functional interaction between neprilysin 1 and amyloid

74 re, these data indicate for the first time a functional interaction between Orai1, TRPC1, and CaV1.2

75 The present study explored the functional interaction between p38 MAPK-mediated NET reg

76 lectively, our data suggest a biological and functional interaction between PD-L1 and chemoresistance

77 with Abcc4 deficiency, illustrated a crucial functional interaction between phosphodiesterases and AB

78 ated by a range of acidic membrane lipids, a functional interaction between PI(4,5)P2 and HIV-Tat was

79 Arp2/3 complex and confirmed a physical and functional interaction between Plk4 and Arp2 in mediatin

80 inase phosphorylating Ser-268 and describe a functional interaction between residues Ser-268 and Ser-

81 cell-like ionic conditions, consistent with functional interaction between RNAP and the 30S subunit.

82 with photoreceptor ciliary rootlets and the functional interaction between rootletin and Nesprin1 in

83 Here, we report a functional interaction between Rx1 and NbGlk1, a Golden2

84 ced by oenocytes in spin mutants allude to a functional interaction between Spin and Lpp, underscorin

85 However, nothing is known about a potential functional interaction between STEP and PSD-95.

86 We also measured a functional interaction between the alpha6beta4 nAChRs an

87 The functional interaction between the brain's two hemispher

88 eview clinical evidence in light of this new functional interaction between the cerebellum and basal

89 The functional interaction between the coupled pairs correla

90 Collectively, these results implicate a functional interaction between the Fanconi anemia DNA re

91 retrieval are accommodated by shifts in the functional interaction between the hippocampal CA1 subre

92 The functional interaction between the microtubule asters an

93 These data demonstrate a functional interaction between the N-terminal and linker

94 veal that ATP hydrolysis by UPF1 modulates a functional interaction between the NMD machinery and ter

95 We elucidated a genetic and functional interaction between the respective KS-associa

96 al cytoplasmic segment are necessary for the functional interaction between the STT3A and Sec61 compl

97 This suggests that a negative functional interaction between the TIR and NB domains ho

98 ypothesized these glands were the sites of a functional interaction between these 2 hormones.

99 Despite the physical and functional interaction between these factors, mutations

100 that this physical association underlies the functional interaction between these molecules.

101 A functional interaction between these regions during acti

102 Furthermore, we demonstrate a functional interaction between these two determinants in

103 A direct functional interaction between TLR4 and TRPV1 is shown i

104 The functional interaction between topoisomerase I and RNA p

105 This study initially shows both physical and functional interaction between VCL and cardiac sodium ch

106 Together, the physical and functional interaction between WTX and TRIM28 suggests t

107 Taken together, these results suggest a functional interaction between Ypk1 and Plb1 in which al

108 on in the Drosophila embryo is controlled by functional interactions between a large network of prote

109 Furthermore, affect modulated functional interactions between affective and perceptual

110 emonstrate, for the first time, physical and functional interactions between beta4 integrin and FAK t

111 Functional interactions between brain regions were inves

112 es in network science to analyze patterns of functional interactions between brain regions.

113 y these results identify strong physical and functional interactions between C9orf72 and SMCR8 and su

114 It can also be used to predict new functional interactions between cancer driving genes and

115 We use hot-wired endocytosis to describe the functional interactions between clathrin and AP2.

116 al. (2013) provide mechanistic insights into functional interactions between commensal microbes and i

117 Furthermore, the functional interactions between cortical neurons are wel

118 ral nucleus of the amygdala (CeA) to explore functional interactions between CRF and N/OFQ systems in

119 d implications for understanding the complex functional interactions between diet, gut microbiota, an

120 uenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut m

121 directed to understanding the complexity of functional interactions between different brain regions

122 These findings suggest that enhanced functional interactions between distributed brain region

123 Our findings suggest that functional interactions between dlPFC and vmPFC are a ke

124 This study examines the functional interactions between Down syndrome critical r

125 Taken together, functional interactions between ELS, methamphetamine SA,

126 sease (PD), it is important to determine the functional interactions between factors linked to the di

127 common genetic cause of ALS, suggesting that functional interactions between G4 RNAs may contribute t

128 tween co-occurrence, mutual exclusivity, and functional interactions between genes will further impro

129 We assessed functional interactions between key frontal and subcorti

130 Taken together, our data suggest that functional interactions between KIR and HLA modify risks

131 The data suggest that previous reports of functional interactions between KIR2DL4 and HLA-G may ha

132 Our understanding of the physical and functional interactions between meiotic proteins is also

133 Finally, potential functional interactions between metabolic disorders and

134 aracterize how ketamine impacts on bipartite functional interactions between neural subsystems.

135 The functional interactions between neurons and glial cells

136 mented in the brain, less is known about the functional interactions between neurons that maintain ga

137 Functional interactions between neurons, vasculature, an

138 computational analyses, we show physical and functional interactions between NF-kappaB and the E2 Fac

139 umatic brain injury result from breakdown of functional interactions between nodes within the fronto-

140 Thus, physical and functional interactions between NPHP and Bardet-Biedl sy

141 The emergence of functional interactions between nucleic acids and polype

142 The functional interactions between Pax9 and Dkk1 are shown

143 In the current study, we review the known functional interactions between PDZ domain-containing pr

144 s receptor desensitization, we also examined functional interactions between PKC and DGKeta.

145 Our results reveal functional interactions between protein and RNA componen

146 Functional interactions between proteins result in coevo

147 est stages of ICL repair and define specific functional interactions between RAP80 complex-dependent

148 s in establishing the pluripotent state, and functional interactions between reprogramming factors an

149 mutagenesis demonstrate that ET-MIp predicts functional interactions between residue pairs, particula

150 se findings characterize, in space and time, functional interactions between scene- and object-proces

151 pportunities for gaining novel insights into functional interactions between sexual and clonal reprod

152 Here we report that physical and functional interactions between SIK2 and p97/VCP underli

153 Emerging evidence suggests that functional interactions between small molecules and the

154 Functional interactions between some PD genes, like PINK

155 We identify physical and functional interactions between specific domains of DLX3

156 There is good evidence for functional interactions between splicing and transcripti

157 Facilitatory and inhibitory functional interactions between striatal A2AR and CB1R h

158 omponents that enable us to suggest possible functional interactions between the chromophores of the

159 mbrane synthesis may not require physical or functional interactions between the divisome and phospho

160 Functional interactions between the dorsolateral prefron

161 There are also known functional interactions between the eCB and serotonin sy

162 ur knowledge-the existence and mechanisms of functional interactions between the endogenous mammalian

163 a suppressor of the p53 response, suggested functional interactions between the exocyst and the DDR.

164 cellular function requires knowledge of all functional interactions between the expressed proteins.

165 Downstream analyses of the functional interactions between the host and its microbi

166 There is increasing evidence for important functional interactions between the miRNA and nuclear re

167 e, we use mutant cycle analysis to probe for functional interactions between the N-Cap/PAS domains an

168 We investigated whether physical and functional interactions between the Na(+),HCO3(-) cotran

169 n, its structural similarity with TFIID, and functional interactions between the SAGA modules.

170 during fMRI provides a detailed view of the functional interactions between the two visual processin

171 ory enhancement, depends on the integrity of functional interactions between these different brain re

172 ut wall provides the microanatomic basis for functional interactions between these elements, supporti

173 However, functional interactions between these proteins during as

174 Investigations of putative functional interactions between these regions are compli

175 Critically, the pattern of responses and functional interactions between these three sets of regi

176 Furthermore, functional interactions between this network and hippoca

177 treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathwa

178 Our studies reveal unexpected genetic and functional interactions between two seemingly unrelated

179 cular Cell, document unexpected physical and functional interactions between two unrelated enzymes: O

180 The functional interactions between VDAC and alpha-syn, reve

181 Physical and functional interactions between VP40 and host proteins s

182 Physical and functional interactions between VP40 and host proteins s

183 d that the actin cytoskeleton regulates this functional interaction by influencing the organization o

184 he exact mode of action and the relevance of functional interactions differ, pointing to a surprising

185 al mechanism of genome folding that mediates functional interactions during interphase and compacts c

186 g that catecholamines reduce the strength of functional interactions during rest.

187 olutionary couplings help identify important functional interactions-e.g., at switch points in ribosw

188 ved in various neurological disorders, their functional interactions have not yet been studied.

189 r in contact with each other, many exhibited functional interactions, implying at-a-distance coupling

190 tion and excitation is well described, their functional interaction in signal processing remains elus

191 vin, indicating pathway cross-regulation and functional interaction in vitro.

192 expression and complex, but largely unknown, functional interactions in a sub-population of primary s

193 ata provide strong evidence that large-scale functional interactions in the brain dynamically reconfi

194 nstrate that although the LGN and V1 display functional interactions in the lower frequency bands, ga

195 tides add additional complexity to potential functional interactions influencing HSV-2 neurovirulence

196 of this critical cytokine and we reveal its functional interaction interface with high-affinity liga

197 r, our results suggest that evolution of the functional interactions involving the chimeric NS5 prote

198 Furthermore, we demonstrate that this functional interaction is important for GC1 targeting to

199 rategy of "second-site suppressors," where a functional interaction is inferred between two proteins

200 lls in experimental osteoarthritis and their functional interaction is promoted by the CXCL10/CXCR3 a

201 ed in vivo, but the structural basis of this functional interaction is still a matter of debate.

202 directly activated by cAMP (Epac), but their functional interaction is unclear.

203 it different brain networks, compared to the functional interactions it entertains during perception

204 which the F and attachment (G) glycoprotein functional interaction leads to enhanced fusion and F is

205 wn-regulation and indicate that PTF1a/TRIP12 functional interaction may regulate pancreatic epithelia

206 utionarily conserved in M proteins to enable functional interactions necessary for pathogenesis.

207 Functional interaction network analysis suggested enrich

208 atogenesis-related mRNAs involved in the p53 functional interaction network.

209 the GWAS results onto the amygdala-specific functional interaction network.

210 ng genetic studies using the tissue-specific functional interaction network.

211 Building on the importance of anatomical and functional interactions, network models have provided in

212 We present genome-wide functional interaction networks for 144 human tissues an

213 -based dual-luciferase reporter gene assays, functional interaction occurred between miR-18a-5p and t

214 Here, we set out to study the functional interaction of 18 related nanobodies with the

215 uggesting that this site is critical for the functional interaction of bile acids with the channel.

216 t with our observation that IGF-1 alters the functional interaction of CAL and CFTR in the Golgi.

217 -mediated degradation, without affecting the functional interaction of IgE-tp with important receptor

218 p70 solubility but also directly assists the functional interaction of mtHsp70 with substrate protein

219 ffects signal transduction and suggests that functional interaction of nNOS with NOS1AP might be targ

220 Functional interaction of Osx and Runx2 in the regulatio

221 Furthermore, functional interaction of RAS with p110alpha in host tis

222 e DNA helicase RECQ1, suggesting a conserved functional interaction of RPA-interacting helicases.

223 We further analyzed the functional interaction of Slx5 and Siz1 in vitro and in

224 Functional interaction of TCAF1/TRPM8 also leads to a re

225 se results, we propose (i) there is definite functional interaction of the linker both with the DNA b

226 cambium and wood, but how the expression and functional interaction of these genes determine the uniq

227 tion, we provide evidence for anatomical and functional interaction of this freezing pathway with lon

228 erase complementation assay, we identified a functional interaction of two RRs of the OmpR/PhoB subfa

229 Here we describe a functional interaction of VE-cadherin with the cell pola

230 NMDAR blockade during adolescence alters the functional interaction of vHipp-BLA inputs in regulating

231 The functional interaction of visual cortical neurons and hi

232 in developing approaches to investigate the functional interactions of bitopic membrane proteins emb

233 tion of the actin cytoskeleton in regulating functional interactions of FcepsilonRI.

234 d a novel role of FRbeta: that is, we report functional interactions of FRbeta with receptors mediati

235 constraints, we examined the mechanisms and functional interactions of RNase L and TTP to attenuate

236 Our findings provide novel insight into the functional interactions of soil bacteria active in proce

237 To delineate the architecture and functional interactions of the MBD2-NuRD complex, we pre

238 Second, dynamic functional interactions of the SN were among the most sp

239 r outpaces the research on the structure and functional interactions of these RNA gene sequences.

240 However, the functional interactions of these two pathways in cancer

241 e have focused this study on identifying the functional interactions of three Nipah virus proteins du

242 findings offer new insights into the latent functional interactions, or lack thereof, between compon

243 Here we identify Nipbl as a functional interaction partner of the neural transcripti

244 However, their spatial organization and functional interactions relative to the host have been m

245 e findings indicate that InR pathway-Bam-Rbf functional interactions represent a newly identified mea

246 To investigate the complementary functional interaction site on protein S, we screened 44

247 This method enables functional interaction studies by the simultaneous injec

248 In functional interaction studies, we revealed that the miR

249 h Ebony strongly indicate a specific mode of functional interaction that, however, evades ERG detecti

250 es the analysis of gene networks and reveals functional interactions that are inaccessible to individ

251 hat the cortex provides a rich substrate for functional interactions that are not limited to the orie

252 raphs, we identify the presence of groups of functional interactions that fluctuate coherently in str

253 Here, we detail the functional interactions that make microRNA 155 (miR-155)

254 he recipient organism may acquire genes with functional interaction through two different HGT events

255 tergic and endocannabinoid systems exhibit a functional interaction to modulate several neural proces

256 The M-NA functional interaction we describe appears to underlie t

257 Several novel interaction hubs and functional interactions were discovered.

258 behaviors and induces specific new brainwide functional interactions, which predict the degree of anh

259 wall composition is further supported by its functional interaction with BasA (sphingolipid biosynthe

260 ilatation mediated by KCa channels and has a functional interaction with both NO and COX vasodilatato

261 ogether with fine-localization of d-LDH, the functional interaction with CYTc in vivo strongly sugges

262 evidence that Tim establishes a physical and functional interaction with DDX11, a super-family 2 iron

263 an upstream site in the Rnf43 gene, enabling functional interaction with distant TCF4/beta-catenin-bi

264 utant proteins are defective in physical and functional interaction with DnaK.

265 f TTC9A on anxiety-like behavior through its functional interaction with estrogen using the TTC9A(-/-

266 itin ligases, and the resultant physical and functional interaction with eVP40 facilitates VLP and vi

267 PTHrP and Col10a1, through its physical and functional interaction with Gli2.

268 The functional interaction with HSV-1 gD mapped to the N-ter

269 cal interaction by co-immunoprecipitaion and functional interaction with luciferase assays in human p

270 Hck binding may reorganize the Nef dimer for functional interaction with other signaling partners.

271 te-derived macrophages were investigated for functional interaction with patient-derived HBsAg.

272 protein sequence, phylogenetic history, and functional interaction with progressively increasing acc

273 d a stable Rca hexamer ring and analyzed its functional interaction with Rubisco.

274 However, it mediated the functional interaction with SAP102 of PSD-95 mutants to

275 P at Thr-55 is shown to be important for its functional interaction with SREBP-2 and reduction of liv

276 pressor in highly metastatic PCSCs by direct functional interaction with the 3'-untranslated regions

277 t PARK9 regulates exosome biogenesis through functional interaction with the endosomal sorting comple

278 e-dependent manner and displayed genetic and functional interaction with the Idd5 locus to potentiate

279 While each domain showed a close functional interaction with the respective histone mark

280 nd this was associated with increases in its functional interaction with transcription co-regulators

281 ch deposits H2A.Z, we uncovered evidence for functional interactions with components of the spliceoso

282 CYC4, CYC5 and CYC7, and their physical and functional interactions with CRK1.

283 ne escape of HIV-infected cells required for functional interactions with downstream binding partners

284 Interestingly, pericytes, in functional interactions with ECs, exhibited a proinflamm

285 ature Drp1 self-assembly in solution impairs functional interactions with membrane-anchored Mff.

286 However, their functional interactions with other fork recovery mechani

287 rmational dynamics of the FAT domain and its functional interactions with other parts of the molecule

288 structural framework necessary to understand functional interactions with over 60 other HDL-associate

289 terminal arms to expand outwards encouraging functional interactions with partner proteins.

290 densation establishment through differential functional interactions with Pds5p and Wpl1p.

291 direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2.

292 erpinned successful performance and involved functional interactions with the amygdala and hippocampu

293 t stress through cooperative physical and/or functional interactions with the Tail module.

294 d by NURF occurs partly through physical and functional interactions with the ubiquitous and multival

295 fects of the mutated proteins are due to non-functional interactions with the wild-type protein or PH

296 rtant regulator of these genes; however, its functional interactions with TR are not known.

297 oxygen sensing are increasingly dependent on functional interaction within this microenvironment.

298 regions, thalamic circuits shift and sustain functional interactions within and across cortical areas

299 l variation is a potent strategy for probing functional interactions within gene regulatory networks.

300 consequences that these lesions have on the functional interactions within the network.