ライフサイエンスコーパス: functional protein

1 balances adenine nucleotide pool, is a multi-functional protein.

2 ut we showed that this would not result in a functional protein.

3 ystrophin gene that result in the absence of functional protein.

4 site that restore splicing and production of functional protein.

5 rtion of transcribed DNA does not code for a functional protein.

6 nd cytoplasm until its final deployment as a functional protein.

7 f a length that may be suitable for coding a functional protein.

8 l SMA patients, which produces low levels of functional protein.

9 ey function-switching mutations yields a non-functional protein.

10 be a frameshift mutation and not to encode a functional protein.

11 majority of the NHS gene, all leading to no functional protein.

12 t contains only the GARS domain of GART as a functional protein.

13 d amino acids, indicates that matR encodes a functional protein.

14 y of alternatives that would correspond to a functional protein.

15 hypomorphic alleles that generate partially functional protein.

16 n packing forms the teritiary structure of a functional protein.

17 ovides a source of Zn2+ for regenerating the functional protein.

18 transcripts lack exon 7, resulting in a non-functional protein.

19 substitutions or whether the gene produces a functional protein.

20 statin A) leads to expression of ER mRNA and functional protein.

21 retained in the endoplasmic reticulum as non-functional protein.

22 eparation-of-function-mutation in this multi-functional protein.

23 e because the mutated gene still expresses a functional protein.

24 and plants is often limited by low titers of functional protein.

25 o its coding region is unlikely to produce a functional protein.

26 in cells expressing the fluorescently tagged functional protein.

27 rol inspection and export of the mutant, yet functional protein.

28 codon in intron 1 and a much truncated, non-functional protein.

29 e GroEL/ES to prevent misfolding and produce functional protein.

30 ms from the inability of obtaining purified, functional protein.

31 (HSP90) significantly increased the yield of functional protein.

32 ions and partially restore the expression of functional proteins.

33 ity, indicating that both NCED4 genes encode functional proteins.

34 e ribosome is essential for the synthesis of functional proteins.

35 y convert stable off-pathway conformers into functional proteins.

36 ions and partially restore the expression of functional proteins.

37 gen presentation than the turnover of mature functional proteins.

38 this approach has for the rational design of functional proteins.

39 and Asn-19 followed by genetic screening for functional proteins.

40 tides can be generated from fully folded and functional proteins.

41 onserved regions within HIV's structural and functional proteins.

42 ular biological components including diverse functional proteins.

43 ters (yaps), nine of which appear to produce functional proteins.

44 ypes) suggest that all 39 predictions encode functional proteins.

45 CERV1 and -2 proviruses are known to encode functional proteins.

46 cessing the viral precursor polyprotein into functional proteins.

47 es, including epitopes normally derived from functional proteins.

48 mall percentage become new genes that encode functional proteins.

49 structurally, it is more difficult to design functional proteins.

50 caffolding, can produce mg ml(-1) amounts of functional proteins.

51 eld, the P-gel produced up to 5 mg ml(-1) of functional proteins.

52 translation of evolutionarily conserved and functional proteins.

53 a small percentage of DNA actually codes for functional proteins.

54 s encoding a host of cellular structural and functional proteins.

55 polymers, polypeptides, polysaccharides, and functional proteins.

56 important step toward the creation of novel functional proteins.

57 that the novel SDF-1 splice variants encode functional proteins.

58 s in some or all genes that are expressed as functional proteins.

59 an retrovirus, HERV-K, can encode individual functional proteins.

60 rnavirus-derived elements (EBL) might encode functional proteins.

61 tations by preventing the expression of semi-functional proteins.

62 tionary time to be incorporated into stable, functional proteins.

63 synonymous codon usage on the production of functional proteins.

64 to TRAIL-induced apoptosis by inhibiting key functional proteins.

65 obodies that bind conformational epitopes of functional proteins.

66 an in-frame mRNA and a truncated, but still functional, protein.

67 ificially express pseudogenes into novel and functional proteins?

68 l of transported mRNAs to be translated into functional proteins after transport.

69 , E. coli ensures the presence of sufficient functional protein albeit at a considerable energetic co

70 trait analysis) indicate that the genotyped functional protein-altering variation yields a heritabil

71 compound that reactivates mutant p53 into a functional protein and blocks VEGF production.

72 P2C is the most likely duplicate to encode a functional protein and is among the most fixed human-spe

73 er EmrE in vitro from a denatured state to a functional protein and monitored the influence of lipids

74 that the nitrogen assimilation genes encode functional proteins and are expressed in the ocean.

75 C-terminus result in truncated but partially functional proteins and are often associated with leaky

76 le released from MSCs, were thought to carry functional proteins and RNAs to recipient cells and play

77 idence has indicated that EVs, which contain functional proteins and small RNAs, facilitate intercell

78 biology, amyloids are key structures in both functional proteins and the end product of pathologic pr

79 substitution results in poor secretion of a functional protein, and the domain-specific defect in fo

80 A) nanostructures to control the assembly of functional proteins, and facilitates further investigati

81 mation, by converting precursors into mature functional proteins, and in morphogenetic patterning, by

82 however, these mRNA are not translated into functional proteins, and these iPSC lines do not induce

83 number of experimental studies dominate the functional protein annotations collected in databases.

84 tructurally compact, units from which larger functional proteins are assembled; however, almost 4% of

85 Many functional proteins are at least partially disordered pr

86 principal players that assemble a complex of functional proteins around the ligand ER complex to init

87 cripts contain open reading frames for known functional proteins as well as numerous alternative read

88 orrection of BTK mRNA restored expression of functional protein, as shown both by enhanced lymphocyte

89 lar architectures, we measured the levels of functional proteins associated with EGF receptor (EGFR)

90 gical membrane coating consisting of diverse functional proteins associated with human platelets.

91 F), also known as mitosin, are large, multi-functional proteins associated with the outer kinetochor

92 Functional protein association networks, gene annotation

93 chanisms, both ultimately leading to loss of functional protein at the plasma membrane.

94 d to express, purify, and print thousands of functional proteins at high density on a microarray subs

95 However, quantitatively profiling of functional proteins at single CTC resolution has not yet

96 et decoding is crucial for the expression of functional protein because deviations either into the -1

97 way within Pex20p, leads to a stable but non-functional protein because it fails to recycle to the cy

98 ctions between individual interfaces used in functional protein binding and thereby contains the deta

99 The large number of these functional protein binding correlations point to a dynam

100 otein, is important for bacterial growth and functional protein biosynthesis under certain conditions

101 (3) is likely to be important for optimizing functional protein biosynthesis.

102 n produced a mutant mRNA that could encode a functional protein but was degraded by nonsense-mediated

103 genes are transcribed--and some may produce functional proteins--but are dispensable for infection o

104 that are subsequently used to produce fully functional protein by an in vitro refolding process.

105 system offers a novel approach to create new functional proteins by replacing a specific amino acid i

106 The multi-functional protein c-Cbl is an important modulator of ac

107 t undergo rearrangement and joining before a functional protein can be expressed.

108 e demonstrated that, alongside drug loading, functional proteins can be tethered to the surface utili

109 owing endocytosis, but also demonstrate that functional proteins can potentially regain their activit

110 n which splice together in cellula to form a functional protein capable of site-specific DNA cleavage

111 cal modifications, especially structural and functional protein changes.

112 Two gradients reflecting the abundance of functional protein classes along the longitudinal root a

113 1505 to 4082 amiRNAs, each targeting defined functional protein classes.

114 s in humans that fall into several different functional protein classes.

115 edicted to contain 137, 150, and 155 unique, functional protein-coding genes, respectively, of which

116 ts specified their degradation pathways, and functional protein-coding transcripts could be produced

117 ly interact with occludin and ZO-1 to form a functional protein complex at the BTB.

118 We here demonstrate the assembly of a novel functional protein complex at the TGN and its key member

119 l allosteric binding mechanism and that this functional protein complex mediated transport of the cor

120 These data suggest that MyRIP only forms a functional protein complex with BR-MyoVa on SGs when cAM

121 We have shown that gK forms a functional protein complex with UL20p, which is required

122 a novel mechanism in which the formation of functional protein complexes drives mitochondrial protei

123 ChaC may also be applicable to dissect other functional protein complexes in the context of phenotypi

124 iving cells achieve sufficient abundances of functional protein complexes while minimizing promiscuou

125 ate the physiology of the cell by generating functional protein complexes.

126 roteins to favor their correct assembly into functional protein complexes.

127 der long-term selective pressure to encode a functional protein; consequently, we hypothesized that t

128 Finally, we generated a functional protein consisting of an SpoVE-SpoVD fusion a

129 TRPM7 is an unusual bi-functional protein containing an ion channel covalently

130 demonstrates the feasibility of engineering functional proteins containing many copies of abiologica

131 protein transfection materials composed of a functional protein core chemically modified with a dense

132 nes A, B, and C and the sasA gene encode the functional protein core of the timing mechanism essentia

133 roteolysis was used to identify a stable and functional protein core, designated DdrA157, consisting

134 ifically collagen IV networks, contribute to functional protein damage in diabetes.

135 examined the role of glucose autoxidation in functional protein damage using lysozyme and RGD-alpha3N

136 onstrate that these lipids are effective for functional protein delivery into mouse brain for gene re

137 e (TTQ) to yield the mature protein with the functional protein-derived TTQ cofactor.

138 dence is emerging on peptides derived from a functional protein, directly translated from small open

139 id side chains lead to higher structural and functional protein diversity and are, therefore, a leadi

140 anisms by which these proteins assemble into functional protein-DNA complexes are not fully understoo

141 at allows for the unbiased identification of functional protein domains expressed from nested-deletio

142 rresponding receptors and for fingerprinting functional protein domains in living cells.

143 exclusively in patients were found in likely functional protein domains.

144 trinsic structural price to be paid for some functional protein domains.

145 a transcription factor, WTX lacks conserved functional protein domains.

146 ciated into their constituent structural and functional protein domains.

147 ng CRISPR-Cas9 mutagenesis to exons encoding functional protein domains.

148 evel promises to impact our understanding of functional protein dynamics and energy landscapes.

149 n regulatory protein C (NtrC), by connecting functional protein dynamics of phosphorylation-dependent

150 ast genomes and the resulting high levels of functional protein expression can be achieved in approxi

151 se biological functions by means of inducing functional protein expression in a dose-dependent and ti

152 lations, and discuss how comparisons between functional protein filaments and structures that are ass

153 o bypass mutations and generate modified but functional proteins for an array of genetic disorders.

154 r corneal cells, we selected 9 structural or functional proteins for which 3D patterns were specific

155 teins (IDPs) are a newly recognized class of functional proteins for which a lack of stable tertiary

156 undation for engineering a new generation of functional proteins free from natural evolution.

157 nied by an enhanced capacity to synthesize a functional protein from a DDP-damaged gene and, most imp

158 tes with the cognate Hsp70 system to recover functional protein from aggregates.

159 ctive Hsp104 variant impairs the recovery of functional protein from aggregates.

160 significant hurdle is the extraction of the functional protein from its natural lipid membrane.

161 be due to persistent low-level expression of functional protein from their mutant allele.

162 linked to their encoding mRNA, to select for functional proteins from an in vitro translated protein

163 in vitro selection and directed evolution of functional proteins from libraries of more than 10(12) d

164 hat facilitates quantification of a panel of functional proteins from statistical numbers of single c

165 ins; it should now be possible to design new functional proteins from the ground up to tackle current

166 to a new mRNA (form) that encodes for a new functional protein (function) is likely to be retained,

167 In this work, we compiled the basic functional protein groups of the three main routes for h

168 c lesions in RIBA1 and FLU encoding the dual-functional protein GTP cyclohydrolase II/3,4-dihydroxy-2

169 A number of fully functional proteins have been identified to exist in a p

170 n mRNA and allow production of a full-length functional protein hold great therapeutic potential for

171 romatin domains, and reflect the assembly of functional protein hubs and DNA processing during the ra

172 nt protein expression and availability, (ii) functional protein immobilisation and purification in a

173 Functional protein immobilization on the surface was con

174 es integration into a microarray format with functional protein immunoassays, all of which are incorp

175 The amount of folded functional protein in a cell is controlled by a number o

176 ant DNA molecules can produce a biologically functional protein in a foreign host.

177 t TRAP1 mutation leading to complete loss of functional protein in a patient with late onset Parkinso

178 mutations and partially restore full-length, functional protein in a zebrafish model of choroideraemi

179 d from a proximal promoter and that produces functional protein in neurons.

180 ncreased in size, confirming the presence of functional protein in these cells.

181 rogenase 11 (RDH11) gene, resulting in a non-functional protein, in all affected children.

182 -Pol polyproteins into mature structural and functional proteins, including itself, and is therefore

183 The transition from soluble, functional protein into insoluble amyloid fibril occurs

184 rylate nanoparticles for delivery of intact, functional proteins into neurons and neuronal cell lines

185 nstration of a nonviral-mediated delivery of functional proteins into the spinal cord establishes the

186 nthetic processing of precursors into mature functional proteins involved in ECM assembly.

187 mation, by converting precursors into mature functional proteins involved in forming the extracellula

188 ial transcription factor A (TFAM) is a multi-functional protein, involved in different aspects of mai

189 Exocytosis of functional proteins is a prerequisite for the activity o

190 quiring A-to-I editing to encode full-length functional proteins is AMD1 that encodes a protein with

191 Translation of the genome into functional proteins is critical for cellular life.

192 The design of stable, functional proteins is difficult.

193 possibility that RE splicing might generate functional protein isoforms.

194 ne family of Arabidopsis thaliana encodes 11 functional protein isovariants in four ancient subclasse

195 as a structural component, and its role as a functional protein key for organizing membrane domains f

196 t requires intracellular calcium release and functional protein kinase C (PKC) and Src activities.

197 Our results support the role of TIO as a functional protein kinase that interacts with Kinesin-12

198 ur study identifies CIPK24 (SOS2) as a multi-functional protein kinase that regulates different aspec

199 carrying an inducible antibody that causes a functional protein "knock-down" and allows temporal cont

200 Taken together with data showing that functional protein knockout shifts splicing toward the f

201 LC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due

202 Mutations in TBX3 that result in reduced functional protein lead to ulnar-mammary syndrome, a dev

203 ne expression profiles of tumor cells at the functional/protein level than conventional mRNA microarr

204 The intimate relationship between functional protein levels and cellular architectures exp

205 showed that salt-stress-responsive GR3 is a functional protein localized in chloroplasts and mitocho

206 ls to combine the most important tenets of a functional protein microarray such as covalent attachmen

207 methods will be useful for a wide variety of functional protein microarray users.

208 Here we demonstrate that functional protein microarrays are particularly well-sui

209 Fully functional protein microarrays, with monolayer arrangeme

210 Structural and functional protein modeling indicate a biochemical effec

211 pathway and image analyses, define multiple functional protein modules enriched in a conformation-sp

212 terizing simulation data, particularly since functional protein motions and transitions are often rar

213 sible suggest a route to the construction of functional protein nanomaterials tailored to specific ap

214 To understand this functional protein network, we analyzed the quantitative

215 To identify functional protein networks and potential inhibitors, we

216 ted proteins in both tissues were members of functional protein networks associated brain changes in

217 The proteins and functional protein networks of the tight junction remain

218 During polyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited ont

219 n-regulation of caveolin-1, a structural and functional protein of caveolae that function as signalin

220 nts with unique properties to design new and functional proteins, offering both a possible pathway of

221 g permitted highly specific visualization of functional protein on the cell surface and its subsequen

222 costs of protein misfolding, such as loss of functional protein or attenuation of growth-limiting pro

223 le describes a novel technique whereby fully functional proteins or multiprotein complexes are effici

224 c AS events are likely to be translated into functional proteins or simply reflect noisy splicing, th

225 MN2 is present, which produces low levels of functional protein owing to an alternative splicing even

226 cient for CSR and identified PA1 as its main functional protein partner.

227 n part, by the misfolding and aggregation of functional protein precursors into fibrillar states.

228 Arabidopsis thaliana mutants lacking functional protein prenyltransferase genes have also rev

229 ture termination codons (PTCs) and restoring functional protein production from genes disrupted by no

230 Ataluren was developed to restore functional protein production in genetic disorders cause

231 raction of truncating mutations can generate functional protein products.

232 e-relevant sequences can be rescued to yield functional protein products.

233 uORFs (namely, in SLC35A4 and MIEF1) encode functional protein products.

234 three K-homologous (KH) domains, PCPB2 forms functional protein-protein and RNA-protein complexes wit

235 h-bond behavior in biologically relevant and functional protein-protein bonds.

236 ensitivity of SA11-tsC and shed new light on functional protein-protein interaction sites of VP1.

237 log knowledge transfer method to reconstruct functional protein-protein interactions (PPI) networks b

238 Phage display screening allows the study of functional protein-protein interactions at the cell surf

239 In living cells, functional protein-protein interactions compete with a m

240 ptides as therapeutics for the disruption of functional protein-protein interactions in membranes.

241 e conclude that FHL2 has both structural and functional protein-protein interactions with beta-cateni

242 lated through mechanisms of gene regulation, functional protein-protein interactions, transcription f

243 We infer that these lysine residues impede functional protein-protein interactions.

244 e adhesion molecules have been implicated in functional protein-protein interactions.

245 ons for possible overlapping and distinctive functional protein-protein or protein-ligand interaction

246 The rugged folding landscapes of functional proteins puts them at risk of misfolding and

247 for the constructs we have analyzed, mature functional proteins, rather than defective ribosomal pro

248 red fluorescent protein (mRFP1) to produce a functional protein (RecA-RFP) that is suitable for in vi

249 Individual functional proteins recognize a set of multiple overlapp

250 MNDelta7 transgene to encode a modestly more functional protein referred to as SMN read-through (SMN(

251 Hsp104 is an active ATPase, the recovery of functional protein requires the species-specific coopera

252 orporation (exaptation) of TE fragments into functional proteins requires long evolutionary periods.

253 Production of functional proteins requires multiple steps, including g

254 e probability that frameshifts result in non-functional proteins, revealing that these species may ev

255 /or disordered regions, suggesting that many functional protein-RNA contacts remain unexplored.

256 munoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites.

257 rovides a robust, unbiased means to identify functional protein-RNA interactions in vivo.

258 on of ClC-7 have failed to yield evidence of functional protein, so it is unclear whether ClC-7 has a

259 on of astroglial processes and expression of functional proteins, such as GLT1, is significantly decr

260 ed morphology and the induction of important functional proteins, such as glutamate transporter GLT1.

261 hat provides a mechanism for optimization of functional protein synthesis.

262 binding of GDP to eIF2 and is therefore a bi-functional protein that acts as a GDP dissociation inhib

263 Iron regulatory protein 1 (IRP1) is a bi-functional protein that can act either as a post-transcr

264 beta-catenin is a multi-functional protein that has an important role in the mat

265 We found that recombinant RIG-I is a functional protein that interacts with double-stranded R

266 regulatory protein ICP27 is a multifunction functional protein that interacts with many cellular pro

267 on of NR1 splice variants may serve as a key functional protein that maintains hypersensitivity follo

268 ysis showed that region 1 and 3 genes encode functional proteins that are sufficient for the export o

269 PPS encoded in the A. thaliana genome 10 are functional proteins that can synthesize GGPP.

270 transcribed and translated and could encode functional proteins that contain important targets of an

271 Intrinsically disordered proteins (IDPs) are functional proteins that do not fold into well-defined t

272 h may offer general benefits for engineering functional proteins that have risky folding landscapes,

273 ple cleavage of long polyprotein chains into functional proteins that include the viral protease itse

274 Intrinsically disordered proteins (IDPs) are functional proteins that lack a well-defined three-dimen

275 Arrestins are multi-functional proteins that regulate signaling and traffick

276 ibraries of novel sequences and selected for functional proteins that rescue Escherichia coli cells i

277 BAG-1 is a multi-functional protein, the expression of which is up-regula

278 challenging problems, such as the design of functional proteins, this may not be acceptable.

279 he method can be generalized to design other functional proteins through backbone grafting.

280 GST protein anchor can be used to immobilize functional protein to PEGDA microspheres and the protein

281 mAb 3E10, has recently been used to deliver functional proteins to cells.

282 The delivery of fully functional proteins to infected cells upon virion envelo

283 The ability to direct functional proteins to specific DNA sequences is a long-

284 in most studies, the contribution of mature functional proteins to the class I peptide pool has not

285 nt conjugation, which allows the delivery of functional proteins to the hMSC membrane.

286 E-BP1 and S6K, which led to induction of the functional protein translational machinery.

287 ism to swiftly translate synaptic mRNAs into functional protein upon synaptic signaling using stalled

288 idence of transgene expression even when the functional protein was not visualized in skeletal muscle

289 ments in neurons are supplied with necessary functional proteins, we studied mechanisms of dendritic

290 Intrinsically disordered proteins (IDPs) are functional proteins where a lack of stable tertiary stru

291 patens expresses two UVR8 genes that encode functional proteins, whereas the single M. polymorpha UV

292 ds to dedifferentiation and loss of some key functional proteins, which may reflect an initial step i

293 Parkinson's disease when mutated, is a multi-functional protein with anti-oxidant and transcription r

294 with AGXT2L1 and AGXT2L2) forming bi- or tri-functional proteins with a putative kinase belonging to

295 i with a temperature-sensitive AK identified functional proteins with novel architectures, suggesting

296 sing evidence shows that cadherins are multi-functional proteins with novel, adhesion-independent sig

297 The expression system yielded high levels of functional protein, with the ligand-binding capacity (Bm

298 These vectors can produce functional proteins within defined regions of biomateria

299 In contrast, natural systems selected functional proteins without any design a priori.

300 el DNA hydrogel that is capable of producing functional proteins without any living cells.