ライフサイエンスコーパス: functional redundancy

1 wn whether this diversity reflects extensive functional redundancy.

2 statistical power) raise the possibility of functional redundancy.

3 exhibited synergistic phenotypes, indicating functional redundancy.

4 sSPTa promoter, indicating ssSPTa and ssSPTb functional redundancy.

5 l through the same proteins, and can exhibit functional redundancy.

6 defects, presumably due to their significant functional redundancy.

7 roteins whose structural similarity suggests functional redundancy.

8 jor impact on pancreas formation, indicating functional redundancy.

9 utM share several overlapping activities and functional redundancy.

10 y overlapping manner, indicating a degree of functional redundancy.

11 malian actin isoforms that appear to exhibit functional redundancy.

12 al expression largely supports the notion of functional redundancy.

13 ing due to overlapping tissue expression and functional redundancy.

14 its transfection into HEK293 cells suggests functional redundancy.

15 for postnatal glucose homeostasis, with some functional redundancy.

16 required for reactivation, indicating little functional redundancy.

17 ression of either RPN5a or RPN5b, indicating functional redundancy.

18 be maintained in sponge microbiomes through functional redundancy.

19 uld substitute for each other, indicative of functional redundancy.

20 nce identity as a means to identify possible functional redundancy.

21 xpress Nkx6.1, suggesting the possibility of functional redundancy.

22 is-regulatory network seems to exhibit great functional redundancy.

23 wed no obvious phenotype, further suggesting functional redundancy.

24 apping waves of expression, and they display functional redundancy.

25 ns remains poorly defined in part because of functional redundancy.

26 king EHDs 1, 2, and 4 confirms this apparent functional redundancy.

27 a reproducible severe phenotype, suggesting functional redundancy.

28 derstanding gene duplication and identifying functional redundancy.

29 endocochlear potential are poorly secured by functional redundancy.

30 hat the low levels of other isoforms provide functional redundancy.

31 ed by a combination of embryonic defects and functional redundancy.

32 ct with the same set of GPCRs, which implies functional redundancy.

33 oviding a molecular basis for their observed functional redundancy.

34 ome cases, be at the basis of their apparent functional redundancy.

35 of the polymers with a remarkable degree of functional redundancy.

36 curately predict current densities and chart functional redundancy.

37 compensatory mechanism and suggests partial functional redundancy.

38 ore, our results challenge the generality of functional redundancy.

39 ifferent developmental stages, indicative of functional redundancy.

40 onnections, and an apparently high degree of functional redundancy.

41 1(-/-) and Tll1(-/-) lethality and issues of functional redundancy.

42 tion (i.e., Aegyptin, apyrase, D7) represent functional redundancy.

43 hese roles have been masked by unanticipated functional redundancies.

44 dered to increase genetic robustness through functional redundancy, accelerating the evolution of nov

45 loor, and determined to what extent there is functional redundancy across ants, other invertebrate an

46 Functionally, GeoChip analyses showed a functional redundancy across the toposequence, with gene

47 This functional redundancy allows limited fatty acid biosynth

48 To circumvent the functional redundancies among the Type I BMP receptors,

49 We conclude that there is significant functional redundancy among activators and that the spec

50 While there is likely to be some functional redundancy among C. elegans tubulin genes, ou

51 s and 53BP1 at DSBs, suggesting considerable functional redundancy among cellular DUBs that restrict

52 gR3 as CSPG receptors, suggest that there is functional redundancy among CSPG receptors, and provide

53 XE receptors indicates that there is limited functional redundancy among Dictyostelium P2X receptors.

54 This discrepancy is possibly due to the functional redundancy among different Wnts.

55 Functional redundancy among factors and pathways underli

56 ontinental scales indicates a high degree of functional redundancy among fungal communities in global

57 The lack of functional redundancy among GmRIN4a and GmRIN4b and thei

58 ypic variation that was previously hidden by functional redundancy among homoeologs.

59 These findings identify functional redundancy among Kit-dependent hematopoietic

60 However, functional redundancy among localization elements has ma

61 results indicate that although there is some functional redundancy among mitophagy receptors, efficie

62 hile the complexity of glycosylation and the functional redundancy among sialyltransferases provide o

63 mains incompletely defined, and the level of functional redundancy among subsets of these proteins re

64 al change, which is often taken to infer low functional redundancy among such species, but such relat

65 We also acquired evidence for functional redundancy among tetraspanins in both C. eleg

66 Until now, functional redundancy among the actin-bundling proteins

67 static stability and that there is a lack of functional redundancy among the different KChIPs in hipp

68 elieved to be maintained by a combination of functional redundancy among the four ubiquitin genes, st

69 infection model, suggesting at least partial functional redundancy among the homologues.

70 nts in these neurons, that there may be some functional redundancy among the kinesin-1 isoforms with

71 rs have been difficult to discern because of functional redundancy among these factors, as well as po

72 time frame for hepatopancreas specification, functional redundancy among Wnt ligands, and pleiotropic

73 actors, AP-2alpha and AP-2gamma, we unmasked functional redundancies and discovered an essential role

74 The newfound multiplicity, functional redundancy and conservation of cis-acting con

75 d TAGL1 genes and to better understand their functional redundancy and diversification, we characteri

76 These cells lack significant PARP-1 functional redundancy and efficiently support the posten

77 The importance of these genes in confirming functional redundancy and enhancing the value of single

78 uggest that UPEC iron receptors provide both functional redundancy and niche specificity for this pat

79 d LPS synthesis in a wbpW mutant, indicating functional redundancy and overlapping roles for these tw

80 The functional redundancy and overlapping target specificiti

81 To investigate functional redundancy and plasticity in S. oneidensis MR

82 Genetic background, functional redundancy, and perhaps other factors may pro

83 sly marginal species can achieve a degree of functional redundancy, and that their compensatory herbi

84 te genes in mouse are widely thought to have functional redundancy, and to be less essential than sin

85 Since c-Myc and N-myc share substantial functional redundancy, another factor that could influen

86 subset of the bacteria exhibit low levels of functional redundancy as documented for many plant and a

87 osely related proteins exhibited substantial functional redundancy, as ectopic expression of either p

88 GO4/6/9, based on their sequence similarity, functional redundancy, as well as species and features o

89 cteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift.

90 Several levels of functional redundancy at different scales of the bacteri

91 These results underscore functional redundancy at the TopIB-DNA interface.

92 tion is advised in drawing conclusions about functional redundancy based on a single environmental si

93 modulation of stress-induced anxiety and the functional redundancy between AEA and 2-AG signaling in

94 High functional redundancy between APP and APLP2 suggests tha

95 a in the mesenchymal component and a limited functional redundancy between BmprIa and BmprIb in a tis

96 To overcome functional redundancy between different NF-kappaB subuni

97 In this study, we tested the functional redundancy between different SAMPs and how th

98 n give rise to stronger phenotypes, implying functional redundancy between distinct residues on histo

99 In the nucleus, there is significant functional redundancy between DNA ligase IIIalpha and DN

100 ishment and plant growth, suggesting partial functional redundancy between DRP3A and DRP3B.

101 We propose that functional redundancy between duplicated paralogous gene

102 elastic fiber formation and suggest possible functional redundancy between fibulin-1 and fibulin-2.

103 These results demonstrate functional redundancy between Gata4 and Gata5 during car

104 Functional redundancy between gene family members is one

105 Taken together, our findings reveal a functional redundancy between GL2 and HDG11, two homeodo

106 Our results demonstrate a functional redundancy between human SHOX and mouse Shox2

107 Finally, we demonstrate functional redundancy between Ldb1 and Ldb2.

108 aling pathway in mammals, and to investigate functional redundancy between Mek1 and Mek2, we disrupte

109 al role for these factors and the absence of functional redundancy between members of this family.

110 This may be due, in part, to functional redundancy between miRNAs.

111 NMDA receptor-mediated currents, suggesting functional redundancy between NLs and LRRTMs during earl

112 The functional redundancy between PLCs in the virulence of B

113 UVR8-mediated responses in plants, although functional redundancy between proteins could influence t

114 onferred H(2)O(2)-sensitivity, demonstrating functional redundancy between Rad18 and non-homologous e

115 These results support a model in which the functional redundancy between roX1 and roX2 RNAs is base

116 e SLK genes and to investigate the degree of functional redundancy between SEU and SLK genes, we char

117 n this study, we set to investigate possible functional redundancy between SHOX and SHOX2 in vitro an

118 These data reveal functional redundancy between specific assembly factors

119 tudies for Stx1 have been elusive due to the functional redundancy between Stx1 isoforms Stx1A and St

120 In this work, we seek to determine the functional redundancy between the kinase domains of the

121 uld control HIF timing and we probed for the functional redundancy between the three main PHD protein

122 These findings show that there is a level of functional redundancy between the two ATG4s, and that AT

123 perties tested here, indicating considerable functional redundancy between the two proteins.

124 Our findings support the existence of functional redundancy between the Y chromosome genes and

125 expression and extinction but that there is functional redundancy between them.

126 A previously suggested general functional redundancy between these and other lipoprotei

127 t physiological roles, a pharmacological and functional redundancy between these canonical eCB signal

128 promote Type 2 responses, but the extent of functional redundancy between these cytokines is unclear

129 nd vertebrates were excluded, indicating low functional redundancy between these groups.

130 Although this similarity suggests some functional redundancy between these proteins, an increas

131 ap in their endodermal expression domains, a functional redundancy between these signals might mask a

132 ole-plant phenotype, suggesting considerable functional redundancy between these two genes.

133 strong ern1-1 ern2-1 phenotype demonstrates functional redundancy between these two transcriptional

134 We now report evidence of functional redundancy between transporters CO3H5.2 and S

135 This is the first evidence of functional redundancy between Wnt ligands in posterior p

136 al of WOX2, providing an explanation for the functional redundancy between WOX2 and STPL.

137 We also provide new information on functional redundancy between WRN and BLM.

138 This study demonstrates functional redundancy between YidC orthologs in gram-neg

139 d physiological assays revealed that despite functional redundancy, BIN2 plays a dominant role among

140 ctive Zn-SodCII and while CopA and GolT show functional redundancy, both require CueP to activate Sod

141 volve neutrally after duplication because of functional redundancy but a fraction of these genes were

142 between distinct combinations are not due to functional redundancy but indicate specific interactions

143 LC and dermal DC subsets often show functional redundancy, but LCs are required for specific

144 scued by both RPT2a and RPT2b, indicative of functional redundancy, but not by RPT2a mutants altered

145 the purine pathway unexpectedly bypasses its functional redundancy by exploiting both the nature of p

146 ved in ephrin-B3 null mutant mice because of functional redundancy by virtue of other B-ephrins.

147 This result suggests that functional redundancy can further decrease when spatial

148 sponsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic func

149 ection of posttranslational modifications or functional redundancy conferred by protein families, whi

150 nclear why three proteins with such apparent functional redundancy exist in mammals.

151 ary tumor model highlights the importance of functional redundancies existing between the Apc protein

152 null mutants, suggest that a high degree of functional redundancy exists among CLE gene family membe

153 rvations suggest that although some level of functional redundancy exists between Pak1 and Pak6 in pr

154 However, no such functional redundancy exists for the 3'-phosphatase acti

155 t in any phenotypic changes, suggesting that functional redundancy exists in proteins containing simi

156 tion, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C.

157 their physiological roles and the extent of functional redundancy following embryo implantation.

158 In addition, the absence of functional redundancy for Drpr in Drosophila may help el

159 s, previous studies identify a high level of functional redundancy for PKD1 and PKD2 in various cellu

160 We also uncover functional redundancy for somatic embryogenesis among ot

161 n loss of mycobacterial LM/LAM, indicating a functional redundancy for this enzyme in mycobacteria.

162 four SOD alleles within the genome provides functional redundancy for this key enzyme.

163 Lack of functional redundancy for this species highlights the im

164 t are incompletely described possibly due to functional redundancy, gene family proliferation, and/or

165 N/Eph system concerns their large number and functional redundancy given the promiscuous cross-activa

166 raits in polyploid wheat; we also argue that functional redundancy has 'locked up' a wide range of ph

167 In contrast, extreme functional redundancy has evolved among expanded gene fa

168 kt isoforms in the retina is suggestive of a functional redundancy; however, our studies clearly demo

169 ty of the species-rich biota to display high functional redundancy: i.e., a high number of species pe

170 the pocket protein family provides for some functional redundancy, important differences have been o

171 Maps of genetic interactions can dissect functional redundancies in cellular networks.

172 regarding the role of paralogs and potential functional redundancies in large-genome microbes.

173 out strong phenotypes, presumably because of functional redundancies in this gene family.

174 Functional redundancy in Ag presentation by these class

175 skin, where H3K27me3 is abolished, revealing functional redundancy in EZH1/2 proteins.

176 Additionally, there appears to be functional redundancy in genera of CCRA providing cues t

177 with multiple members in each class suggests functional redundancy in growth inhibition.

178 Shapes suggesting functional redundancy in one environment can change, sug

179 This functional redundancy in RasGEFs during negative selecti

180 in unrestored networks, indicating a higher functional redundancy in restored communities.

181 DCL2, DCL3 and DCL4 showed functional redundancy in siRNA and tasiRNA production an

182 th the notion that there is a high degree of functional redundancy in target gene regulation by ETS-d

183 distinct BBSome components, show unexpected functional redundancy in the context of cilia in C. eleg

184 Our results support the concept of functional redundancy in the E2F family and suggest that

185 Our data clearly establish a functional redundancy in the essential C(26)-monooxygena

186 mutant provided some evidence for a lack of functional redundancy in the gene family.

187 e explored the hypothesis that an underlying functional redundancy in the homologous elements hs3a an

188 are more stringently required, likely due to functional redundancy in the latter.

189 etion of either isoform alone, demonstrating functional redundancy in the maintenance of sensory neur

190 Second, there may be high functional redundancy in the methanogens with regard to

191 at determine life support functions, but the functional redundancy in the microbiota of most soils ha

192 entified, nor has the mechanism behind their functional redundancy in the thymus.

193 d not show any altered phenotype, indicating functional redundancy in these genes.

194 pathogenic Pseudomonas syringae, indicating functional redundancy in this large gene family.

195 Consistent with this functional redundancy in vitro, T.k. strains have been c

196 rnible phenotype in Tmprss2-/- mice suggests functional redundancy involving one or more of the type

197 Whether these predictions reflect actual functional redundancies is unclear.

198 embers exist in distinct NuRD complexes, and functional redundancy is lacking among MTA family member

199 We found that the highest functional redundancy is located in the Central Indo-Pac

200 re dependent on Cdk/cyclin complexes and the functional redundancy is more limited.

201 any developing organs but whether they share functional redundancy is not known.

202 However, this functional redundancy is not normally evidenced because

203 t TFI gene expression cannot be explained by functional redundancy, is supported by active transcript

204 ecombination in normal cells, but because of functional redundancy, it is absolutely required for thi

205 nces of type-III effectors, as well as their functional redundancy, make studying type-III effectors

206 n in this organism, the absence of extensive functional redundancy makes C. elegans an ideal model fo

207 dly, given the multigenic nature and partial functional redundancy observed in the PYR/PYL family, th

208 To uncover functional redundancies of these genes during growth and

209 comes intrinsic drug resistance ensuing from functional redundancy of Bcl-2 proteins, but also abroga

210 t display any cognitive phenotype supporting functional redundancy of both factors.

211 ts closely related homolog bt1, indicating a functional redundancy of BT1 and BT2 for NUE.

212 Such functional redundancy of class IA PI3K isoforms upon sus

213 s, duplicated genes are widely observed, and functional redundancy of closely related duplicates has

214 s of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes.

215 results provide the basis to understand the functional redundancy of CPPs and CAPs.

216 ed in the mir-58.1 single mutant, indicating functional redundancy of distinct members of this miRNA

217 ts in DVL1-mediated Robinow syndrome and the functional redundancy of DVL1, DVL2, and DVL3, we electe

218 These AlaXps are thought to provide functional redundancy of editing.

219 This dissociation between the functional redundancy of either the mouse or the fly tra

220 dependence on PRC2 activity and the partial functional redundancy of enhancer of zeste homolog 1 (Ez

221 us work from our laboratory suggested either functional redundancy of ERK isoforms or a predominant r

222 verexpression in RWPE cells, emphasizing the functional redundancy of ETS rearrangements.

223 of IL-36alpha in the lung, demonstrates the functional redundancy of IL-36alpha with other agonist c

224 Although we have not observed a functional redundancy of kif3b and kif17, kif17 is able

225 e priming step and further insights into the functional redundancy of lipoteichoic acid biosynthesis

226 eting cancer drugs is thought to result from functional redundancy of mitotic kinesins.

227 Reverse genetics showed functional redundancy of NHX1 and NHX2 genes.

228 vice versa, providing an explanation for the functional redundancy of nuclear galectins in splicing.

229 ot affect fruit development, which suggested functional redundancy of PIN proteins, but did lead to a

230 Gene disruption studies revealed the functional redundancy of scyl and chrb, as well as their

231 The results demonstrate the functional redundancy of Sia and Twn and their essential

232 its target, but also the innate or adaptive functional redundancy of that target and its attendant p

233 However, functional identity and functional redundancy of the community as a whole remain

234 similarity, close location and the potential functional redundancy of the gene family members.

235 ration is controversial, probably due to the functional redundancy of the PARP family in mammalian ce

236 Functional redundancy of the Pf-5 Fpvs was also apparent

237 expressed under 35S promoter, indicating the functional redundancy of the RWA proteins.

238 This yields insights on the functional redundancy of the system as well as its behav

239 the absence of any single ZDHHC, suggesting functional redundancy of these enzymes in the IFITM3-med

240 To address the potential for functional redundancy of these genes, homozygous double

241 in neurons to investigate the specificity or functional redundancy of these HDACs in learning and syn

242 As a result of the functional redundancy of these three cytokines on eosino

243 e than in Fli1(+/-) mice, indicating partial functional redundancy of these transcription factors dur

244 despite the strong structural similarity and functional redundancy of these two enzymes, the mechanis

245 Corresponding to this apparent functional redundancy of TLR signaling pathways, HRS imm

246 port that there is a previously unrecognized functional redundancy of Trx f1 and NTRC in regulating p

247 enesis appears normal, thereby demonstrating functional redundancy of type I BMP receptors during cer

248 The functional redundancy of Wnt genes and the many forms of

249 these studies reveal a surprising degree of functional redundancy operating both at the level of the

250 or morphology, indicating either a degree of functional redundancy or a function in an alternative st

251 However, the functional redundancy or differentiation of PACT and TRB

252 ecies and changes in species' relative local functional redundancy or distinctness.

253 Therefore, we did not find any functional redundancy or synergy during lymphocyte devel

254 L receptors, but little is known about their functional redundancy, or if their mutation can be physi

255 However, due to functional redundancy, other PSD-MAGUKs can presumably c

256 Given the functional redundancies present in human tumors and esca

257 The resulting genetic and functional redundancy prevents the analysis of their spe

258 unities, despite their extreme diversity and functional redundancy, respond to disturbances like many

259 Because of functional redundancies, single gene mutations in the pl

260 man colon is very high with apparently large functional redundancy such that within each bacterial fu

261 Together, these data emphasize the functional redundancy that leads to robustness in the ca

262 relaxed evolutionary constraint, with enough functional redundancy that variation in, or even loss of

263 While multiple LPA genes may have some functional redundancy, the combined expression of multip

264 However, due to functional redundancy, their contribution to osmotic str

265 The need for functional redundancy through biological diversity in wa

266 be indicative of unappreciated evolutionary functional redundancy to facilitate angiogenesis and ens

267 dual cells while also being flexible through functional redundancy to guarantee high fidelity of the

268 However, due to functional redundancy, typically the contribution of ind

269 icient for cell specificity, indicating that functional redundancy underlies this key aspect of C(4)

270 s overlapping subsets of tubulin genes whose functional redundancy varies between cell types and in v

271 Functional redundancy was confirmed through analysis of

272 Thus, in addition to revealing TLS and HR functional redundancy, we establish that UV-induced reco

273 To investigate whether there is functional redundancy, we have generated double knockout

274 erns throughout development, indicating high functional redundancy, which might be necessary for safe

275 ablished network of signalling cascades with functional redundancy, which provides them with robust c

276 ra copy of a gene is thought to provide some functional redundancy, which results in a higher rate of

277 rt, but consistent with a widespread loss of functional redundancy, while adaptive radiations of gene

278 dings underscore the importance of potential functional redundancy with additional Fgfs in the develo

279 omal signal joins or coding joins because of functional redundancy with ataxia telangiectasia mutated

280 issue-specific requirement of BmprIa and its functional redundancy with BmprIb during the development

281 In the nucleus, LigIII has functional redundancy with DNA ligase I whereas LigIII i

282 Here, we show that XLF has dramatic functional redundancy with DNA-PKcs in the V(D)J SJ join

283 cause an overt phenotype, likely because of functional redundancy with Ezh1.

284 ing domains, but to what extent they provide functional redundancy with FMRP is unclear.

285 critical for embryogenesis and shows partial functional redundancy with its homolog PCAF.

286 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C).

287 ono- and di-methyltransferase with a partial functional redundancy with MLL3 (KMT2C).

288 or enhancer H3K4me1/2 methyltransferase with functional redundancy with MLL3 (KMT2C).

289 To address potential functional redundancy with murin Dcx, we targeted one of

290 nt effect on meiotic cross-overs, suggesting functional redundancy with other RECQ family members.

291 e responsible for pilus assembly and exhibit functional redundancy with respect to backbone assembly

292 (-/-) homozygotes, apparently as a result of functional redundancy with the paralogous Alx4 gene.

293 There is extensive functional redundancy within and between these protease

294 robiota illustrates niche specialization and functional redundancy within members of its major bacter

295 ors on vertebrate cardiogenesis is masked by functional redundancy within multiple lineages.

296 ficantly affected due to potential bacterial functional redundancy within the compost samples.

297 Here we exploit functional redundancy within the keratin gene family as

298 median eminence suggested that rather than a functional redundancy within the TIDA population, the do

299 at these interactions also contribute to the functional redundancy within this gene family.

300 aptic targeting, and we uncover a remarkable functional redundancy within this protein family.