ライフサイエンスコーパス: functional regulation

1 er known molecular chaperones by its mode of functional regulation.

2 roviding another potential mechanism for its functional regulation.

3 opments in the basic understanding of KCC2's functional regulation.

4 a non-conventional mechanism for T(reg)-cell functional regulation.

5 the NetProphet targets also show evidence of functional regulation.

6 ique TLR8 signaling pathway linking to their functional regulation.

7 s, which suggests novel mechanisms in T cell functional regulation.

8 K molecules did not appear to be involved in functional regulation.

9 DM2 interaction with KAP1 contributes to p53 functional regulation.

10 etc.), which provides a novel framework for functional regulation.

11 be one of their most important mechanisms of functional regulation.

12 fore be a useful tool in the study of IP(3)R functional regulation.

13 ing upon NOTCH1 inhibition shows broad-scale functional regulation across the entire range of predict

14 mmunoprecipitation proved less predictive of functional regulation and less amenable to systematic el

15 Further, our results imply a link between functional regulation and structural dynamics of SH3 and

16 and MMPs in myocardial matrix remodeling and functional regulation and support the hypothesis that bo

17 xhibited by chemokines, reveal a new mode of functional regulation, and may serve as the basis for th

18 s not only a biologically important site for functional regulation, but also an important target for

19 3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-subst

20 Functional regulation by cofactors is fundamentally impo

21 substrate of JNK, the role of Mcl-1 and its functional regulation by JNK in TNF-induced hepatocyte a

22 rmeation, pathological mutations, as well as functional regulation by orthosteric and allosteric effe

23 omain converts the selective association and functional regulation by SNX27.

24 cular structure-function relationships: that functional regulation can be achieved by alterations in

25 Thus, microarray studies of functional regulation could, in principle, be extended t

26 interacting proteins that participate in its functional regulation in rat cerebellum, where DAO expre

27 sequently, determination of the mechanism of functional regulation in such systems requires elucidati

28 understanding of its mechanism of action and functional regulation is essential.

29 n of the ENaC channel complex, (ii) that the functional regulation is isoform specific, and (iii) sug

30 ailability and Na(+) channel composition and functional regulation may differ in these subpopulations

31 We show here a novel functional regulation of a co-activator directly by G pr

32 core component Ring1b and Runx1/CBFbeta and functional regulation of a considerable fraction of comm

33 Here, we investigated the functional regulation of ACD11 and CPTP by anionic phosp

34 able of physiologic hemostatic responses and functional regulation of adhesive integrins in response

35 ads to structural changes in DACs, impairing functional regulation of AII amacrine cells.

36 ures and maintenance of T cell memory in the functional regulation of Aire-mediated promiscuous gene

37 Thus, functional regulation of alpha7 nAChRs could influence t

38 Functional regulation of alpha7beta1 by developmentally

39 1 phosphorylationby CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lo

40 or the PKA phosphorylation of an AKAP in the functional regulation of an ion channel protein and post

41 clear export pathway may be important in the functional regulation of autophagic growth control.

42 -subunits, the results reveal an all-or-none functional regulation of BK channels by gamma-subunits:

43 trate a critical role for acetylation in the functional regulation of C/EBPepsilon activity during te

44 prevents invasive DNA methylation and allows functional regulation of canyon-associated genes.

45 ntrolled in part by selective expression and functional regulation of cell adhesion molecules (CAMs)

46 important role in the degradation and other functional regulation of cellular proteins in organisms

47 n of three microRNA clusters and the similar functional regulation of clonal expansion by miR-200c pr

48 The functional regulation of CMV-specific MBCs may limit the

49 The functional regulation of Ets-1 activity by CCL2 was depe

50 nes/signal transduction cascades involved in functional regulation of fast excitatory transmission at

51 e map provides a basis for understanding the functional regulation of GAG-binding proteins in health

52 Thus, functional regulation of GAT1 in oocytes occurs via comp

53 are widely expressed [1], their role in the functional regulation of genes remains largely unknown.

54 e report 14-3-3 isoform-specific binding and functional regulation of GluN2C.

55 providing important evidence that the tight functional regulation of Hsp33 chaperone activity plays

56 roles of posttranslational modifications in functional regulation of IDPs, molecular mechanisms behi

57 s important questions about the differential functional regulation of individual-and perhaps sets of-

58 s shed light on the intricate structural and functional regulation of ISWI by the NTR and uncover sur

59 We now show that cAMP-mediated functional regulation of KCNQ1/KCNE1 channels, a consequ

60 ults demonstrate a critical role for Scd1 in functional regulation of LSCs, providing a new anti-LSC

61 and ESCs may have important implications for functional regulation of maintenance and induction of pl

62 ay be now considered to be essential for the functional regulation of many neocortex areas, perhaps a

63 uggested to be important with respect to the functional regulation of membrane proteins, including th

64 defined the protein domains required for the functional regulation of MHC class II genes.

65 er the role of NHERF-1 in the expression and functional regulation of Mrp2 remains largely unknown.

66 hic factor (BDNF) has been implicated in the functional regulation of neural input to other targets o

67 Functional regulation of NHE by alpha 1-ARs was determin

68 activity demonstrating a role of PKA in the functional regulation of NHE-3 by cAMP.

69 edside-to-bench" approach to investigate the functional regulation of NMDA receptors (NMDARs).

70 tes training-dependent induction of tph-1 by functional regulation of olfactory sensory neurons, whic

71 tween the brain's innate immune response and functional regulation of P-glycoprotein.

72 ings may have important implications for the functional regulation of p75NTR.

73 Therefore, understanding the functional regulation of PC2 and its interaction with ot

74 ion of individual PKC sites demonstrates the functional regulation of PITX2 through phosphorylation.

75 of the two CNB domains is necessary for the functional regulation of PKA activity.

76 SNAP-23 is therefore important for the functional regulation of postsynaptic glutamate receptor

77 s the possibility that another mechanism for functional regulation of protein activity may be availab

78 Functional regulation of proteins is central to living o

79 these findings provide novel evidence of the functional regulation of reversible PKC membrane localiz

80 We report in this study the acute functional regulation of RGS10 thru the specific and ind

81 r findings may provide new insights into the functional regulation of RPTPalpha by oxidative stress i

82 are likely responsible for the differential functional regulation of RyR1 and RyR2 by CaM.

83 With respect to the functional regulation of RyR1 and RyR2, the FKBP12E31Q/D

84 These findings demonstrate functional regulation of RyR1 by a previously unreported

85 ylation sites of CDCP1 are important for the functional regulation of SFKs in several tumor types.

86 We have therefore examined the functional regulation of somatodendritic expression leve

87 Despite its importance, the functional regulation of SRC-3 remains poorly understood

88 We sought to determine whether there is functional regulation of Stat3 by wild-type (wt) p53.

89 We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53.

90 is localization of SHP-1 is required for its functional regulation of T cell activation events, how S

91 oarray analysis (ChIP-chip) and validate the functional regulation of targets in vitro.

92 le is known about the subunit composition or functional regulation of the channel itself.

93 In this study, we investigated the functional regulation of the cyclic adenosine monophosph

94 igomerization and suggest the existence of a functional regulation of the dimer-dodecamer equilibrium

95 The functional regulation of the endothelium by local hemody

96 lead to a comprehensive understanding of the functional regulation of the gamma-secretase complex, an

97 that Edn1-Ednra signalling is essential for functional regulation of the heart by sympathetic nerves

98 o the role of a conformational switch in the functional regulation of the intrinsically disordered tr

99 utral amino acid glutamine in structural and functional regulation of the kidney filtration barrier.

100 heless, it has been difficult to demonstrate functional regulation of the LC-noradrenergic system by

101 llar circuit is specifically involved in the functional regulation of the motor areas of the neocorte

102 rocerebellar circuit is also involved in the functional regulation of the nonmotor areas of the neoco

103 ide a biophysical rationale for the reported functional regulation of the p53 C-terminal region.

104 Thus, functional regulation of the purified soluble integrin a

105 switch" are believed to be essential to the functional regulation of the skeletal muscle ryanodine r

106 Molecular organization and functional regulation of this process are not well under

107 We investigated the functional regulation of three Akt isoforms, Akt1/PKBalp

108 domain shedding and has implications for the functional regulation of TRANCE by potentially more than

109 more complex role of prefrontal input in the functional regulation of TRN and gating of thalamic outp

110 The conformational and functional regulation of TSP1 activity by fibronectin re

111 ght into the role that IL-2 and CD25 play in functional regulation of two important immunoregulatory

112 mine the effect of CA and hypothermia on the functional regulation of two major drug metabolizing cyt

113 To investigate the temporal and functional regulation of Wip1, we identified a microRNA,

114 However, the suppressive mechanisms and functional regulations of this new subset of unconventio

115 t hemostasis and von Willebrand factor (vWF) functional regulation offer new insights into the pathog

116 doxin-glutamate synthase), likely reflecting functional regulation through their N termini.

117 afficked to the cell membrane and were fully functional; regulation was normal except when YFP was in

118 y we propose an alternative mechanism of p53 functional regulation, which involves a separate molecul