ライフサイエンスコーパス: functional significance

1 ing firmer inferences to be made about their functional significance.

2 n wing discs reduced wing size demonstrating functional significance.

3 e to demonstrate that this capacity has some functional significance.

4 ic compartment or cellular structure and its functional significance.

5 Regions retaining nucleosomes may be of functional significance.

6 oligomers of poorly understood structure and functional significance.

7 nome-wide, unbiased manner and elucidate its functional significance.

8 raising intriguing questions regarding their functional significance.

9 haracterize alternative exons with potential functional significance.

10 D156E) variants of CrChR2, strengthening its functional significance.

11 the hypothesis that the Phe zipper motif has functional significance.

12 re therefore important for understanding its functional significance.

13 ticality, and give a brief discussion of its functional significance.

14 l present in truncated genes to assess their functional significance.

15 is single nucleotide polymorphism might have functional significance.

16 that phosphorylated phaseolin isoforms have functional significance.

17 um differentially expressed genes and are of functional significance.

18 mplex containing beta-catenin and HMGA1 have functional significance.

19 ndicating that ExoU oligomerization may have functional significance.

20 drive, mood, and sexual aversion, providing functional significance.

21 Med-PIC structure reveals two components of functional significance, absent from previous structures

22 s a variety of animal and human studies, its functional significance and behavioral relevance have be

23 However, the functional significance and behavioral relevance of vari

24 underlying social behavior - including their functional significance and evolution - can only be full

25 Here, we explore the functional significance and evolutionary history of a T/

26 The results are discussed in light of the functional significance and evolutionary success of the

27 s, but more work is needed to understand the functional significance and fitness consequences for the

28 However, the functional significance and mechanisms of other classes

29 of cerebral small vessel disease, but their functional significance and mechanisms remain uncertain.

30 The strength, functional significance and origins of direct parasympat

31 The strength, functional significance and origins of parasympathetic i

32 The functional significance and signaling capabilities of th

33 However, the prevalence, functional significance and targets of lncRNA-mediated s

34 l characterized, the role of adaptation, its functional significance and the ecological conditions wh

35 We describe the allele frequency, functional significance, and chromosomal distribution of

36 hese results suggest that species origin has functional significance, and that eutrophication will le

37 These regimes may have a profound functional significance as stationary patterns may play

38 We demonstrated that SLPI expression has functional significance, as it promotes CRPC cell surviv

39 epression susceptibility and confirmed their functional significance at the levels of gene transcript

40 Here, we show that the T/F motif has broader functional significance beyond neutralization sensitivit

41 We thus aimed to identify GRK5 variants of functional significance by analysing 187 individuals wit

42 tions/case (median 79 mutations of potential functional significance/case).

43 Consistent with its functional significance, CCR2 antibody staining revealed

44 e vestibular nuclei, consistent with a broad functional significance contributing to vestibulo-ocular

45 f DNA are crucial toward understanding their functional significance due to their significant role in

46 methyl-CpG-binding protein 2 (MeCP2) and its functional significance during cardiac pressure overload

47 These results identify functional significance for neuronal MT stability and su

48 These results provide a possible functional significance for the distinct AOB physiology

49 RP1 under steady-state conditions could have functional significance for these proteins.

50 in AC-type SAMs, an anatomical anomaly whose functional significance has been debated in the botanica

51 n also strongly binds PtdIns(4,5)P2, but the functional significance has been unclear.

52 ed in sporadic cases of MPGN, although their functional significance has not been assessed.

53 mbrane-compartmentalized organelles, but the functional significance has remained elusive.

54 ly transcriptional response, and their wider functional significance, has remained unclear.

55 molecular basis of this interaction, and its functional significance, have not been elucidated.

56 NAs is the initial step in determining their functional significance in ageing and osteoarthritis, an

57 ocated in excitatory neurons, suggesting its functional significance in epileptogenesis.

58 genetic association study and to assess its functional significance in in vitro cell studies and on

59 identify mechanisms involved, and determine functional significance in myocytes of small cerebral ar

60 m of miR-506 regulation and investigated its functional significance in pancreatic cancer.

61 We aimed to explore its functional significance in prostate tumor initiation and

62 ular damage, extracellular vesicles may have functional significance in renal health and disease by f

63 c studies suggest that KIR3DL1 variation has functional significance in several disease states, inclu

64 including melanoma, and have examined their functional significance in these settings.

65 rtant tertiary interactions elucidates their functional significance in transcription regulation.

66 Our work opens avenues to exploring the functional significance, informational content, and temp

67 ent has been observed in many organisms, its functional significance is not clear.

68 the C terminus of all Coa molecules, but its functional significance is not known.

69 avage under inflammatory conditions, but the functional significance is not known.

70 For many base modifications in tRNAs, the functional significance is not well understood, and the

71 Their functional significance is often unclear.

72 horylation sites for single kinases, but the functional significance is poorly understood.

73 s is pervasive in most genomes; however, its functional significance is still unclear.

74 ilar pharmacological mechanism, although the functional significance is still unclear.

75 cyl-PTMs) have been discovered, of which the functional significance is still under intense study.

76 spacers between 1 and 18 bp; however, their functional significance is unclear at present.

77 fish, yet despite its ubiquitous nature, the functional significance is unclear.

78 s in specific anatomical subfields and their functional significance is unclear.

79 vegetative diploid budding yeast, but their functional significance is unknown.

80 Genotypes were classified on functional significance (LL, LS, SS).

81 Practical interpretation of their functional significance must rely on computational infer

82 taneous wave-free ratio (iFR) are indices of functional significance of a coronary stenosis measured

83 y provides the first in vivo evidence of the functional significance of a minor transcript of BRCA2 t

84 biological evidence indicating the potential functional significance of ABCB1 and ABCB4, underlines t

85 Moreover, the functional significance of acetylation or how specific a

86 t, the biochemical regulation as well as the functional significance of actin catch bonds has not bee

87 To examine the functional significance of ADAR2 and GluA2 Q/R site edit

88 The functional significance of ADARs is much more diverse th

89 f a virus-antibody arms race, illustrate the functional significance of affinity maturation by mutati

90 tion, an important step in understanding the functional significance of all TLDc domain-containing pr

91 However, the in vivo functional significance of allosteric regulation in euka

92 ur study highlights the need to consider the functional significance of alterations to community attr

93 To investigate the functional significance of altered endothelial cell beha

94 -model system to experimentally validate the functional significance of an especially novel genetic a

95 We currently evaluated the functional significance of an LncRNA called Fos downstre

96 To understand the functional significance of annexin A5 in renal cell deat

97 ed numerous opportunities to interrogate the functional significance of any given genomic site, there

98 r example, the fact that we address both the functional significance of attractiveness-related biases

99 dge gaps and challenges in understanding the functional significance of bacterial communities and bac

100 To understand the functional significance of Bcr knockdown in the context

101 Collectively, our results demonstrate the functional significance of BMP signaling in regulating M

102 To study the functional significance of c-Met-induced PD-L1 expressio

103 ntly, our findings allow us to interpret the functional significance of cancer associated ZRANB3 muta

104 The functional significance of catalytic-domain pairing is n

105 These data identify the functional significance of CCK(NTS) neurons and reveal a

106 we used CCR9 knockout mice to determine the functional significance of CCR9 in regulating post-MI ca

107 The functional significance of chromatin in the cytoplasm is

108 nandez-Alvarez et al. (2016) reveal that the functional significance of clustering is to promote spin

109 )Gal linked to hydroxylysine in animals, the functional significance of collagen glycosylation remain

110 low reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is m

111 during coronary angiography to determine the functional significance of coronary stenoses.

112 feasible and accurate for assessment of the functional significance of coronary stenosis.

113 iagnostic accuracy than DSQCA to predict the functional significance of coronary stenosis.

114 ve site and c-di-GMP binding, as well as the functional significance of crystallographic interprotome

115 The clinical and functional significance of CTCs is still under investiga

116 To explore the functional significance of cytokinin signaling for cambi

117 mprinting and X-chromosome inactivation, the functional significance of cytosine methylation and deme

118 any individual organism, the prevalence and functional significance of differentially present genes

119 Here, we test the functional significance of dimeric organization of the s

120 However, the functional significance of Dlx5 in patterning the oropha

121 We then quantified the functional significance of each O2 pathway defect by cal

122 To understand the functional significance of each of these NH2-terminal do

123 en the extensive data on frequency-dependent functional significance of EEG oscillations, a frequency

124 Here, the functional significance of eL4 and the outer region of T

125 Recent efforts to probe the occurrence and functional significance of EMT in clinical samples and a

126 gene regulation and disease, and discuss the functional significance of enhancer clustering.

127 gulating CDK1 activity are well defined, the functional significance of epigenetic changes remains la

128 However, the functional significance of extracellular phosphorylation

129 romotes ventricular tachycardia, showing the functional significance of FXR1 upregulation observed in

130 We examined the functional significance of gene variants by using gene e

131 form of the Bronsted equation to assess the functional significance of general acid catalysis in the

132 logical tools are required to understand the functional significance of genetic events revealed by wh

133 To assess the functional significance of GILZ downregulation, we gener

134 To elucidate the functional significance of glycosylation in ZIKV pathoge

135 en discuss what is presently known about the functional significance of GPCR-G protein activation in

136 hy matched controls to better understand the functional significance of greater extracellular water.

137 sites targeted for H3NT proteolysis and the functional significance of H3NT cleavage remain largely

138 we address the current understanding of the functional significance of HO-1 against a variety of vir

139 structural stability, global centrality and functional significance of hotspot residues involved in

140 The functional significance of hyperphosphorylation remains

141 Here, we reported a novel functional significance of iASPP upregulation in cervica

142 However, the functional significance of INS-membrane interaction is n

143 In the present study, we address the functional significance of interfacial residues between

144 However, an understanding of the functional significance of intratumoral heterogeneity is

145 tails of SETDB1's enzymatic activity and the functional significance of its SET-Insertion.

146 These findings shed light on the functional significance of lateral inhibition between MS

147 expression in cyanobacterium, and reveal the functional significance of light-independent chlorophyll

148 To elucidate the functional significance of liver metabolic zonation in t

149 se populations is necessary to establish the functional significance of lobules implicated in cogniti

150 The functional significance of loss of babA expression is un

151 However, the functional significance of LPC activation during memory

152 S-OPA1 in normal conditions, suggesting the functional significance of maintaining both OPA1 forms,

153 on versus control subjects and to assess the functional significance of major differentially expresse

154 While the functional significance of many ISGs has yet to be deter

155 lly well-characterised but the existence and functional significance of many post-translational modif

156 As debates continue over the functional significance of many specific lncRNAs, suppor

157 terpretation at a time when the ontogeny and functional significance of microglia had not yet been ch

158 ns in cell invasion in vitro, indicating the functional significance of miR-375 regulation of specifi

159 exception of a few spinal circuits where the functional significance of motor neuron feedback is stil

160 to ROS-induced apoptosis, the expression and functional significance of MUC1 in CTCL have not been pr

161 re likely to be of value in interpreting the functional significance of mutations in the CTLA-4 pathw

162 Moreover, the in vivo functional significance of NO2-Tyr(166)-apoA-I, a specif

163 The review concludes by considering the functional significance of noisy activity for neural net

164 The functional significance of noncoding transcripts is curr

165 rnative model for studying the evolution and functional significance of nonvisual opsins.

166 Assessing the functional significance of novel putative oncogenes rema

167 To show the functional significance of nuclear localization, we demo

168 regulation of MBT timing, demonstrating the functional significance of nuclear size during developme

169 Clarifying the functional significance of nuclear size necessitates an

170 However, the functional significance of Nur77 in beta-AR signaling in

171 oss of specific neuron types, supporting the functional significance of parental biases.

172 macromolecules that move in the phloem, the functional significance of phloem transport of these rem

173 Thus, understanding the functional significance of polymorphisms in MOLF STING c

174 Here, we examined the functional significance of Prdx4 on beta-cell function w

175 We propose a reinterpretation of the functional significance of preparatory inhibition, one b

176 r, although golgins bind to Rab GTPases, the functional significance of Rab binding has yet to be det

177 To further reveal the functional significance of RBPs during neural developmen

178 The functional significance of sensorimotor beta-band (15-25

179 We demonstrate novel functional significance of serum miR-29a by showing that

180 ficiency in mice leads to tumorigenesis, the functional significance of somatic SIRT2 mutations in hu

181 ecies dominate many communities; however the functional significance of species' biogeographic origin

182 However, determining the functional significance of specific alterations remains

183 this review, we focus on the regulation and functional significance of SR-B1 in mediating cholestero

184 These observations underscore the functional significance of structure-encoded dynamics, o

185 role in bird diversification [4-8], whereas functional significance of substantial morphological div

186 The functional significance of such paucity of LPFC afferent

187 To investigate the functional significance of supralinear Ca2+ signals, we

188 in Nps1 seedlings, thereby highlighting the functional significance of the A'alpha helix region in p

189 The functional significance of the alpha rhythm is widely de

190 current understanding of the structural and functional significance of the components of the rabies

191 However, the functional significance of the constricted conformation

192 udied extensively, little is known about the functional significance of the corresponding EF-hand dom

193 The direct functional significance of the DNA methylation state of

194 f later stages of dentinogenesis, we provide functional significance of the dynamic Trps1 expression

195 , few studies have directly demonstrated the functional significance of the elytra against diverse en

196 To explore the functional significance of the full range of signaling d

197 We report here the functional significance of the G1-like M gene in H9N2 vi

198 our data establish a molecular mechanism and functional significance of the HBP in directly linking e

199 The functional significance of the Hsc70-TH interaction was

200 tal in silico and in vitro studies confirmed functional significance of the identified AGXT2 variants

201 man cells have been utilized for testing the functional significance of the identified mutation.

202 required for these activities, we tested the functional significance of the interaction between the C

203 ir ability to bind Fucalpha(1-2)Gal, and the functional significance of the interaction was investiga

204 la biogenesis and furthermore, highlight the functional significance of the intramembrane domain and

205 An analysis of the functional significance of the LTB using proxies indicat

206 However, the functional significance of the maxillary palp remained u

207 In this report, we have identified the functional significance of the membrane-proximal stalk r

208 of this study was to determine the role and functional significance of the mitochondrial sirtuin 3 (

209 Here we report on the functional significance of the most recurrent PPP2R1A mu

210 The functional significance of the observed patch of carboxy

211 Our results provide an explanation of the functional significance of the pervasive variability obs

212 ose of this investigation was to explore the functional significance of the phosphorylation of Tmod1

213 In this study, we evaluate the functional significance of the rRNA interaction and show

214 However, the functional significance of the S6 cytoplasmic region in

215 Thus, the results illustrate the functional significance of the SPL-IKKepsilon-IFN axis d

216 of key residues in the interface support the functional significance of the structural model and indi

217 imula, and to provide an explanation for the functional significance of the two floral morphs.

218 However, the detailed functional significance of the vast majority of them rem

219 To confirm the functional significance of these ACAAs, we tested and co

220 he final section, we offer an account of the functional significance of these attributions.

221 A expression over cancer development but the functional significance of these changes often rests upo

222 We provide evidence of functional significance of these complexes in Mael129 kn

223 To test the functional significance of these distinct interactions o

224 Finally, we speculate on the functional significance of these diverse polymers.

225 LNCaP and LNCaP-LN3 cells, demonstrating the functional significance of these findings.

226 The functional significance of these frequency bands is supp

227 However, characterizing the functional significance of these loci has proven challen

228 ther chain lengths have been identified, the functional significance of these low-abundance sphingoli

229 ncodes 12 pre-miRNAs during latency, and the functional significance of these microRNAs during KSHV i

230 rstanding of the spatiotemporal dynamics and functional significance of these modifications is limite

231 haviours, although the causal mechanisms and functional significance of these oscillations remain unk

232 The functional significance of these projections is not full

233 However, the functional significance of these receptors in the intact

234 The functional significance of these sites was demonstrated

235 ammals, relatively little is known about the functional significance of these structures in plants.

236 by DNA polymerase, thereby demonstrating the functional significance of these structures.

237 To assess the functional significance of these variants, we took advan

238 lls in a wide variety of structures, but the functional significance of this architectural diversity

239 system of awake rabbits, we investigate the functional significance of this axonal diversity, and th

240 The functional significance of this change in insular micros

241 D and sought to understand the mechanism and functional significance of this entry.

242 ways and provide important insights into the functional significance of this evolutionarily conserved

243 promoters, and alternative splicing, but the functional significance of this evolutionary conserved d

244 d with distributed cortical regions, yet the functional significance of this extensive thalamocortica

245 We discuss the functional significance of this fine-structural organiza

246 We characterized the functional significance of this FP by using artificial m

247 ough odorant receptors in vitro However, the functional significance of this GEF in the olfactory neu

248 iate with chromatin, but the specificity and functional significance of this interaction are not clea

249 gulates the cortical actin cytoskeleton, the functional significance of this interaction is poorly un

250 Due to the central functional significance of this local connectivity in th

251 in calcium (Ca(2+)), but the mechanisms and functional significance of this localized signaling are

252 The functional significance of this MUC1-C-->BMI1 pathway is

253 GluN2A, and GluN2B subunits in vivo, but the functional significance of this multiplicity is unknown.

254 9L) missense variant in EHMT1 To examine the functional significance of this novel variant, we perfor

255 To test the functional significance of this observation, we combined

256 However, the functional significance of this phosphorylation is undef

257 We examined the functional significance of this phosphorylation mark by

258 To assess the functional significance of this post-translational modif

259 To test the functional significance of this predicted structure, we

260 Ts are highly static, yet the mechanisms and functional significance of this property are not well un

261 nown to be triggered by abiotic factors, the functional significance of this protein organization has

262 ism and other neuropsychiatric problems, the functional significance of this protein remains unclear.

263 Furthermore, we demonstrate the functional significance of this rapid transcriptional ch

264 nsible for pigment dephosphorylation and the functional significance of this reaction remain unknown.

265 overexpressing IL-6Ralpha, thus defining the functional significance of this receptor in GLI2-mediate

266 neutralizing antibody 5J7 and then test the functional significance of this region by transplanting

267 Our goal was to determine the functional significance of this region, which being inte

268 ion on genetic variation, but predicting the functional significance of this variation is a difficult

269 However, the functional significance of this variation remains largel

270 However, the precise functional significance of this well-established orderly

271 it methylation from the oocyte, although the functional significance of this, and the common features

272 The present results revealed the functional significance of TNFalpha/TNFRI-mtO2(.-)-pCREB

273 a quantitative assessment of the drivers and functional significance of tool shape variation in a non

274 man cell line model systems, we examined the functional significance of two evolutionarily conserved

275 by alternative splicing when evaluating the functional significance of variants such as nonsense and

276 gically divergent species can illuminate the functional significance of variation in brain structure.

277 The functional significance of VM in SCLC suggests VM regula

278 igands are expressed in the vasculature, the functional significance of which is poorly understood.

279 t time we unravel the expression pattern and functional significance of Wnt5a in cerebellar developme

280 The functional significance of YAP in prostate cancer has re

281 Despite their functional significance, phytochrome diversity and evolu

282 Despite their high resolution and functional significance, published CAGE data are still u

283 wever, their physiological basis and precise functional significance remain poorly understood.

284 NA localization, although the mechanisms and functional significance remain unclear.

285 e mechanisms promoting this activity and its functional significance remain unresolved.

286 0 Hz) and overall duration so short that its functional significance remains an enigma.

287 Although present, their functional significance remains uncertain with findings

288 ous cancers and proliferating cells, but the functional significance remains unknown.

289 s is observed in diverse cortical areas, its functional significance remains unknown: it is not clear

290 solution and uncover structural features of functional significance that extend recent x-ray crystal

291 Despite its functional significance, the molecular mechanism of GnIH

292 g, and singing, are cultural universals with functional significance: these activities increase group

293 Adding key functional significance to our biochemical findings, we

294 The work highlights the danger of assigning functional significance to small differences between str

295 within the NS5 dimer interface, providing a functional significance to the crystal structure NS5 dim

296 ted from the guts of numerous mammals, their functional significance to their hosts has never been ex

297 est the prevalence of phylosymbiosis and its functional significance under highly controlled conditio

298 eQTLs were screened for functional significance using a large database of shoot

299 To determine its functional significance, we deleted BRCA1 in the develop

300 In order to characterize the functional significance, we overexpressed miR-335 in hum