ライフサイエンスコーパス: functional similarity

1 on structural characteristics rather than on functional similarity.

2 ng closely related species by means of their functional similarity.

3 g functions of unknown proteins based on the functional similarity.

4 I) reduction and OmcB expression, suggesting functional similarity.

5 ation to aid interpretation of structure and functional similarity.

6 ed p40 subunit, this does not translate into functional similarity.

7 rol of acpA and acpB, two genes with partial functional similarity.

8 ance is how structural similarity relates to functional similarity.

9 w extensive sequence homology, indicative of functional similarity.

10 charge distribution, which may explain their functional similarity.

11 nts and animals as the cause of sequence and functional similarity.

12 deed have genetic alterations of significant functional similarity.

13 ns and protein-protein interactions based on functional similarity.

14 inR can complement a luxN mutant, suggesting functional similarity.

15 ation typically uses structural, sequence or functional similarity.

16 e study, causing an underestimation in their functional similarity.

17 inding proteins with striking structural and functional similarities.

18 hen run on gene sets with varying degrees of functional similarities.

19 ture strongly suggests that the enzymes have functional similarities.

20 ished six groups of potential structural and functional similarities.

21 family of proteins that share structural and functional similarities.

22 brane mucins with a number of structural and functional similarities.

23 origins of replication, predicting important functional similarities.

24 I together with TFIIB highlights significant functional similarities.

25 ale gene expression dataset and predict gene functional similarities.

26 and BCR signal transduction pathways exhibit functional similarities, additional studies were conduct

27 e another according to different measures of functional similarity, after which belief propagation is

28 utational methods for automated inference of functional similarities among genes and their products.

29 f the most ancient of cellular processes and functional similarities among its molecular machinery ar

30 However, because many functional similarities among these organisms have arise

31 inner ear, these experiments suggest a deep functional similarity among primary somatosensory neuron

32 e no reliable means to predict the extent of functional similarity among proteins.

33 ubstrate space provide a distance measure of functional similarity among the MMPs.

34 tructures, implying structural, and possibly functional, similarity among existing RNAs.

35 s of human EB1 family proteins and to reveal functional similarities and differences among these prot

36 PC1 other than inhibition, and to establish functional similarities and differences between 7B2 and

37 t a physical-chemical basis for the observed functional similarities and differences between these tw

38 CYP1A1 possesses functional similarities and differences with human CYP1A

39 is study addresses whether OSC and VTC share functional similarities and extends this hypothesis to t

40 oring scheme which measures enzyme-to-enzyme functional similarity and a fast algorithm which efficie

41 d duplicates still maintain a high degree of functional similarity and are synthetically lethal or si

42 visualization, retrieval, and computation of functional similarity and associations of GO terms and g

43 eloped NaviGO, which visualizes and analyses functional similarity and associations of GO terms and g

44 ic data to accurately evaluate the extent of functional similarity and divergence between paralogs on

45 The relationships between the gene functional similarity and gene expression profile, and b

46 oach, we quantified the relationship between functional similarity and high-throughput data, and code

47 isms show that: (i) the relationship between functional similarity and network proximity is captured

48 Despite functional similarity and structural homology, they exhi

49 ork similarity measure, sequence similarity, functional similarity and structural similarity.

50 similarity of capistruin and MccJ25 reflects functional similarity and suggest that the functional ta

51 nd evaluation of evolutionary divergence and functional similarity, and discuss future applications o

52 t rely on genetic homology or structural and functional similarity, and it significantly outperforms

53 urrent theories of rodent/primate prefrontal functional similarity, and provide insight into the role

54 oposed metric should not be interpreted as a functional similarity, and therefore cannot be used to s

55 ng similarities of gene expression maps, the functional similarities are increased too.

56 These functional similarities are reflected at the anatomical,

57 ed with PIWI and TDRD5/7 revealed that these functional similarities are reflected in remarkable stru

58 underlying neuronal mechanisms allowing the functional similarity are incompletely understood.

59 ting measures and (ii) network proximity and functional similarity are significantly more correlated

60 nd XIAP demonstrate no obvious structural or functional similarity, are not coordinately regulated wi

61 in nonlymphoid tissues share phenotypic and functional similarities, as well as a unique shared deve

62 To test whether the contact metric detects functional similarity, as defined by Gene Ontology (GO)

63 e H2B deubiquitination complexes show strong functional similarity, as do suppressors in the silencin

64 We determined the extent of functional similarity at different levels of sequence id

65 Moreover, the results from functional similarity-based network alignment display li

66 the concanavalin A-type lectins, highlights functional similarities between agrin and laminin G doma

67 nto TFIIIB complexes, reveals structural and functional similarities between Bdp1 and Pol II factors

68 . cerevisiae CTD kinase and provide striking functional similarities between Bur1 and metazoan P-TEFb

69 Because of structural and functional similarities between C1q and members of the c

70 The remarkable functional similarities between CFIm and SR proteins sug

71 The biochemical and functional similarities between DAR1 and other animal se

72 These data provide evidence of further functional similarities between DCs and H/RS cells.

73 ght several developmental, morphological and functional similarities between Drosophila and vertebrat

74 The structural and functional similarities between dynamin and Drp1 suggest

75 of maps: chroGPS(factors), which visualizes functional similarities between epigenetic factors, and

76 -catenin signaling pathway and highlight the functional similarities between gal-3 and beta-catenin.

77 The model predicts the functional similarities between genes to a certain degre

78 Thus, our results indicate functional similarities between immune T cells residing

79 These studies highlight the structural and functional similarities between kindlins and the talin h

80 Although unrelated by sequence, there are functional similarities between LANA and the EBNA-1 prot

81 sponding M. marinum mutants, emphasizing the functional similarities between M. tuberculosis and M. m

82 Based on the homology and functional similarities between Met and Ron it was hypot

83 ion about miRNAs and diseases, including the functional similarities between miRNAs, the similarities

84 es and vertebrates have revealed a number of functional similarities between motion-processing pathwa

85 re prediction of the MUN domain and suggests functional similarities between MUN domain-containing pr

86 es have highlighted extensive phenotypic and functional similarities between normal stem cells and ca

87 Our results also indicate significant functional similarities between POT1 and Cdc13 from budd

88 stigations of individual subunits, including functional similarities between Ppc89 and the budding ye

89 Structural and functional similarities between RbfA, NusA, and other ba

90 The sequence and functional similarities between RTA and IRFs suggest tha

91 the Mediator complex and further extend the functional similarities between Saccharomyces cerevisiae

92 In light of the functional similarities between SPC proteins, we develop

93 tage of the repair process and extending the functional similarities between TCR in bacteria and euka

94 lators, TF co-occurrence, open chromatin and functional similarities between TFs and genes are better

95 I highlight functional similarities between the activation mechanism

96 een the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 doma

97 In more general terms, we suggest functional similarities between the HIRAN, the OB, the H

98 and MoaD-adenylate forms, and highlight the functional similarities between the MoeB- and E1-substra

99 Functional similarities between the partition system of

100 Here, we demonstrate functional similarities between the replication and chec

101 Nopp140 reinforces previous observations of functional similarities between these nucleolar proteins

102 is only 18%, these results suggest that the functional similarities between these proteins containin

103 ese studies reveal that, despite the overall functional similarities between these proteins, monomers

104 The anatomical overlap and functional similarities between these two neurotransmitt

105 scussed in light of the known structural and functional similarities between troponin I and the gamma

106 rminants for oligomer assembly and to assess functional similarities between Yta10 and Yta12.

107 ed to influence feeding owing in part to the functional similarity between acetylcholine and nicotine

108 nge edges is best explained by the degree of functional similarity between current and novel competit

109 e been recently proposed for quantifying the functional similarity between gene products according to

110 To explore possible functional similarity between HTT and Atg11, we investig

111 Here we show that GO-based functional similarity between human and mouse orthologs,

112 We apply similarity measures to assess the functional similarity between interacting proteins.

113 y to each gene utilizing a known property of functional similarity between neighboring genes in bacte

114 Our data, showing the structural and functional similarity between PaNth and EcNth, suggests

115 first postnatal week greatly diminished the functional similarity between sister neurons, suggesting

116 Given the sequence and functional similarity between spastin and katanin, we hy

117 eIF4G and eIFiso4G were distinct despite the functional similarity between the eIF4G proteins.

118 The structural and functional similarity between the ligand-binding region

119 The functional similarity between the NS2B/NS3 proteases fro

120 these findings highlighted a high degree of functional similarity between the RSV antigenomic and ge

121 These observations reveal a functional similarity between the tryptophan-based endoc

122 mf1 and emf2 mutants was consistent with the functional similarity between the two genes.

123 f the WT enzyme, suggesting a structural and functional similarity between the two positively charged

124 This may imply a hitherto unrecognized functional similarity between these three protein classe

125 other proteins as an approach to investigate functional similarity between these two proteins.

126 etabolism and proliferation, thus suggesting functional similarity between this immunoreceptor and tu

127 recent paper has proposed a metric for the "functional similarity" between two genes that uses only

128 a4 cytoplasmic domains, despite sequence and functional similarities, enhance cell migration by diffe

129 arning methodology to predict pair-wise gene functional similarity from multiplex gene expression map

130 arning methodology to predict pair-wise gene functional similarity from multiplex gene expression map

131 ared several methods for detecting gene-gene functional similarity from phenotypic knock-down profile

132 Structural and functional similarities, genomic context in operons cont

133 This expectation of functional similarity has not been tested experimentally

134 New measures of functional similarity have been integrated, including fo

135 ocations of these two genes as well as their functional similarity have hindered efforts to define wh

136 les of these proteins and exposing potential functional similarities hidden by their rapid evolution,

137 that share very little sequence or seemingly functional similarities; however, their translocations i

138 Despite high overall structural and functional similarity, human (h) and murine (m) MD-2 exh

139 not only on sequence similarity, but also on functional similarity, i.e. sequences in each family mus

140 -43 and FUS/TLS have striking structural and functional similarities, implicating alterations in RNA

141 In this review, we describe functional similarities in eyes and gaze stabilization r

142 roseate terns by characterizing genetic and functional similarities in species aryl hydrocarbon rece

143 Despite the structural and in vivo functional similarities in the compounds, only (R)-18 wa

144 megalovirus proteins IE1 and pp71 share some functional similarities in their abilities to counteract

145 al attributes across entity groups to assess functional similarity in a statistically meaningful and

146 results indicate that ABF1 and RAP1 achieve functional similarity in part via mechanistically distin

147 Results show high functional similarity in resulting gene sets, increasing

148 ever, genes associated with each trait share functional similarities, including genes involved in apo

149 We demonstrate that, despite the functional similarity, IRF-5 possesses unique characteri

150 Based on sequence and functional similarity, it was believed that their three-

151 Despite high sequence and functional similarities, KorB (pSB24.2) was found to exi

152 We propose a statistically motivated functional similarity measure that takes into account fu

153 carry out network alignment using a protein functional similarity measure.

154 formally compare it with other quantitative functional similarity measures (such as, shortest path w

155 Despite these functional similarities, MERS-CoV nsp1 used a strikingly

156 network, by means of combining a fused gene functional similarity network, gene-disease associations

157 cing clusters of genes with great amounts of functional similarity, new data-mining algorithms are re

158 despite their high degree of structural and functional similarities, normal levels of both p300 and

159 e structurally related pseudoknot pairs have functional similarities not previously known: one pair i

160 this study was to elucidate the mechanism of functional similarities observed in the two pathways.

161 larities of Gene Ontology (GO) terms and the functional similarities of gene products, and for furthe

162 s still no effective method to determine the functional similarities of genes based on gene annotatio

163 esults of using our algorithm to measure the functional similarities of genes in pathways retrieved f

164 Therefore, functional similarities of GO terms that are not explici

165 The structural and functional similarities of gp10, gp11, and gp12 and thei

166 However, despite the functional similarities of HDAC4 and HDAC5, their intrac

167 The sequence and functional similarities of P4H1 to animal HIFalpha-type

168 om expression maps and the labels denote the functional similarities of pairs of genes.

169 ventral stream and a dorsal stream, and the functional similarities of the areas in humans and macaq

170 Given structural and functional similarities of the GP1 receptor binding site

171 ntified in this study closely paralleled the functional similarities of the mutant gene products, the

172 n those already described and to investigate functional similarities of the regulators.

173 The structural and functional similarities of the Ustilago replication-coup

174 tively, our data provide strong evidence for functional similarities of Type 1 CRYs across insect spe

175 hich the genes act, explaining why a greater functional similarity of (within-species) paralogs than

176 We present biochemical evidence for the functional similarity of Escherichia coli RecO protein a

177 One class of such methods measures the functional similarity of genes based on their distance i

178 , we designed a new algorithm to measure the functional similarity of genes.

179 It instead proposed that the functional similarity of homologous genes is primarily d

180 The strong functional similarity of human ADAR2 and Drosophila Adar

181 To examine the functional similarity of mammalian homologs of SID-1 (SI

182 Given the functional similarity of mammalian vitamin K-dependent c

183 Furthermore, we demonstrate that the functional similarity of proteins within known regulator

184 is that weak binding sites contribute to the functional similarity of sequences.

185 This indicates functional similarity of the human isoforms in yeast and

186 The functional similarity of the MARCH family and the K3 fam

187 The homology, expression profile, and functional similarity of the receptors in the dog, ferre

188 To test the functional similarity of their respective intracellular

189 the HCV E2 ectodomain shares structural and functional similarities only with domain III of class II

190 s of ancient origin, and examine some of the functional similarities polydnaviruses share with phage-

191 Plant parasites share functional similarities regarding feeding, but many simi

192 ation in global properties between networks, functional similarity remains high.

193 First, it computes our novel protein functional similarity scores by fusing information from

194 heir ability to produce good topological vs. functional similarity scores, whereas SANA usually outsc

195 RdRps have no sequence homology, they share functional similarities such as copying messenger RNA te

196 Nevertheless, these proteins show several functional similarities, such as their ability to bind t

197 The structural and functional similarities suggest that Bdf1 corresponds to

198 fusion proteins share several structural or functional similarities, suggesting that they may impart

199 Despite their structural and functional similarities, superantigens display subtle di

200 Depending on structural and functional similarities, the six members of PAK family a

201 The method integrated the miRNA functional similarity, the disease similarity, and the m

202 cationic and share this particular aspect of functional similarity, their protein sequence identity i

203 Based on sequence and functional similarities, this novel IL-17 receptor homol

204 K7 bears sequence and functional similarities to A52, which interacts with int

205 g and annealing activities and displays some functional similarities to bacterial RecG and RecQ helic

206 yte-like cells, which display structural and functional similarities to bile duct cells in normal liv

207 ural similarities to the lung collectins and functional similarities to C1q.

208 e early Cambrian of China and Greenland with functional similarities to certain modern crustaceans an

209 show that ABH2 and ABH3 have structural and functional similarities to E.coli AlkB.

210 , alias Krox20) protein shows structural and functional similarities to Egr-1, these two related earl

211 -proline-rich (H/P) domain with sequence and functional similarities to HKa-D5.

212 -B*06:03 variant has striking structural and functional similarities to HLA-B*57, the human allotype

213 obulin domains, but show strong sequence and functional similarities to human LILR.

214 ial heme peroxidase with high structural and functional similarities to LPO was described.

215 ch individual subject, three regions showing functional similarities to macaque core, belt, and parab

216 ubtype that shows striking morphological and functional similarities to mammalian astrocytes.

217 3 in the heavy chain and have structural and functional similarities to native ligands.

218 Taste receptor cells harbor functional similarities to neurons but, like epithelial

219 e T cells with distinct Ag specificities but functional similarities to NKT cells.

220 Despite the substantial structural and functional similarities to p53, accumulating evidence su

221 les were induced by expressing 1a, which has functional similarities to retrovirus virion protein Gag

222 in the lymph gland, a signaling center, with functional similarities to stromal signaling in mammalia

223 plants possess an NAE-signaling pathway with functional similarities to the "endocannabinoid" pathway

224 ve origin of mitochondria, and examine their functional similarities to the lambda bacteriophage (lam

225 ion regulation on cellular stress and reveal functional similarities to the mammalian system.

226 Because this protein displays functional similarities to the N-system amino acid trans

227 x)-deficient PLB-985 cells, indicating close functional similarities to the phagocyte oxidase (phox).

228 Since this protein has sequence and functional similarities to the previously identified sys

229 la nephrocyte has molecular, structural, and functional similarities to the renal proximal tubule cel

230 Structural and functional similarities to the Tet repressor and the Bmr

231 TBL1 displays structural and functional similarities to Tup1 and Groucho corepressors

232 ely 80-residue N-domain shows structural and functional similarity to 106-residue Escherichia coli Cl

233 ed within the beta-tubulin site and exhibits functional similarity to a portion of the B9-B10 loop in

234 allows position specific plots of potential functional similarity to be compared in a simple compact

235 to insulin(+) cells with close molecular and functional similarity to beta cells.

236 CRK4-regulated phosphoproteins with greatest functional similarity to CDK2 substrates, particularly p

237 expansion of an atypical NK cell subset with functional similarity to cells referred as IFN-producing

238 addition, exhibits extensive amino acid and functional similarity to E. coli CadC.

239 Because of functional similarity to Fen1, and because Exo1 is invol

240 of eIF3 subunit TIF32 that has sequence and functional similarity to HCR1.

241 We show that using functional similarity to map proteins across species imp

242 hares a high degree of sequence homology and functional similarity to mNAT, we named it mNAT2.

243 PV+ neurons showed functional similarity to neighboring neuronal population

244 ibitors is complicated by its structural and functional similarity to other protein prenyltransferase

245 and adherence, Als1p has both structural and functional similarity to S. cerevisiae Flo11p.

246 We discuss a possible functional similarity to the better understood turnover

247 and structure we assigned various levels of functional similarity to the domain pairs, based on a si

248 This 5'-nuclease has strong structural and functional similarity to the FEN1 nuclease family.

249 yte has remarkable anatomical, molecular and functional similarity to the glomerular podocyte, a cell

250 These data reveal EpiSC/hESC functional similarity to the glycolytic phenotype in can

251 PTBA exhibits structural and functional similarity to the histone deacetylase (HDAC)

252 and characterize due to their phenotypic and functional similarity to the memory subset.

253 to members of the actin-fold family and the functional similarity to the nitrogenase Fe- protein.

254 of xisC showed that the XisC recombinase has functional similarity to the phage integrase family.

255 ation of TgVP1 in enriched fractions shows a functional similarity to the respective plant enzyme.

256 Based on its sequence and functional similarity to U2AF(35), U2AF(26) may play a r

257 sophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and

258 d type II enzymes show marked structural and functional similarities, topoisomerase V represents a di

259 The notion that sequence homology implies functional similarity underlies much of computational bi

260 Functional similarity was observed in regulation by huma

261 In contrast to their structural and functional similarity, we observe a remarkable differenc

262 ionally critical amino acids and may suggest functional similarity when geometrically matched to othe

263 The key structural and functional similarities, which we found between Rho-depe

264 Moreover, the structural and functional similarities with Basonuclin1 suggest that Ba

265 Because HPPL cysts display structural and functional similarities with bile ducts, the 3D culture

266 Transcriptional targets of Cn Sp1 shared functional similarities with Crz1 factors, such as cell

267 Platelets share structural and functional similarities with granulocytes known to parti

268 These proteins have some functional similarities with herpes simplex virus 1 (HSV

269 HPV E7 proteins share structural and functional similarities with oncoproteins encoded by oth

270 Although HDAC3 shares some structural and functional similarities with other class I HDACs, it exi

271 mily of transporters and shares sequence and functional similarities with P-glycoprotein of cancer ce

272 exchangeable apolipoprotein that shares many functional similarities with related apolipoproteins suc

273 We conclude that AAF shares structural and functional similarities with RPA-32 and regulates DNA re

274 However, based on its structural and functional similarities with soluble collectins, we hypo

275 CXCR5(+) CD4(+) T cells share phenotypic and functional similarities with T follicular helper cells.

276 dendritic process sharing organizational and functional similarities with the AIS.

277 e shares substantial amino acid sequence and functional similarities with the bacteriophage T7 primas

278 terium nucleatum, which share structural and functional similarities with the chlamydial major outer

279 e domain receptor that shares structural and functional similarities with the family of atypical chem

280 Despite striking structural and functional similarities with the lymphatic vascular syst

281 coded factor Mc, which shares structural and functional similarities with the male sex-determining fa

282 n vivo, and shares intriguing structural and functional similarities with the mammalian telomeric pro

283 ve these configurations, and they share some functional similarities with the plasminogen disulfides.

284 -sensing signal, AgrD, shares structural and functional similarities with the PSM family of toxins.

285 inal center formation, these results suggest functional similarities with the unrelated Bcl-6 oncopro

286 Cdc5 and Plo1, respectively) bear remarkable functional similarities with those in metazoan organisms

287 an invertebrate IgCAM, shares structural and functional similarities with vertebrate NCAM and therefo

288 effectiveness of this approach in detecting functional similarity with an average F-score: 0.85.

289 GTPases and shares significant sequence and functional similarity with Cdc42.

290 amily GTPase that shares strong sequence and functional similarity with Cdc42.

291 ed late in plant evolution and exhibits more functional similarity with eIF4G than with eIFiso4G1 dur

292 hese data suggest that the Map53 shares some functional similarity with human p53 as well as with oth

293 rucial role in RGC axon pathfinding, sharing functional similarity with its C. elegans homolog, UNC-1

294 ein, shares significant sequence homolog and functional similarity with p53.

295 and shares the highest sequence identity and functional similarity with PEPM.

296 MLN shares structural and functional similarity with phospholamban (PLN) and sarco

297 LmACR2 displays sequence and functional similarity with the arsenate reductase ScACR2

298 Wrch-1 shares significant sequence and functional similarity with the Cdc42 small GTPase.

299 ons expressing CaMKIIalpha displayed no such functional similarity with the neighboring population.

300 , members of this class share structural and functional similarities, with conserved features of the