ライフサイエンスコーパス: functionalization

1 the sensor chip surface from fouling during functionalization.

2 anotubes (CNTs) including size, capping, and functionalization.

3 2 pg/mL for 24-48 hours post-antibody sensor functionalization.

4 continuous energy input or special particle functionalization.

5 and MFM-132a, with different linker backbone functionalization.

6 stituted by an allyl chain ready for further functionalization.

7 f nano- and microparticles require molecular functionalization.

8 heteroatom bonds without requiring any prior functionalization.

9 oading and the method used for their surface functionalization.

10 to their low cytotoxicity and facile surface functionalization.

11 s a unique control element for selective C-H functionalization.

12 or a period of 10 hours post-antibody sensor functionalization.

13 efins could open almost unlimited avenues to functionalization.

14 ll as a vinyl halide allowing for additional functionalization.

15 as intrinsic directing groups for C(sp(2))-H functionalization.

16 tion of target analytes post-antibody sensor functionalization.

17 ratrole motifs were competent substrates for functionalization.

18 e regioselectivity, from the 1,5- to the 1,3-functionalization.

19 hly effective reagent for promoting C-H bond functionalization.

20 effective and versatile strategy for surface functionalization.

21 degree of versatility for postisomerization functionalization.

22 oligopeptide-pharmacophore conjugates by C-H functionalization.

23 ferent metal ions with no need to ligand and functionalization.

24 rst release of the drug, and limited surface functionalization.

25 hat were sputtered on the BP through surface functionalization.

26 cal device fabrication, miniaturization, and functionalization.

27 er, as well as a click-handle for subsequent functionalization.

28 oss-talk for 0-48 hours post-antibody sensor functionalization.

29 ements for 2D assemblies with face-selective functionalization.

30 ng complementary selectivity to directed C-H functionalization.

31 nanoparticle building blocks and mode of DNA functionalization.

32 articles also enables site-selective surface functionalization.

33 ntal, of the extensive literature on methane functionalization.

34 at ring B by using stage dependent selective functionalizations.

35 acylations and can be applied to late-stage functionalizations.

36 legant solution to the question of selective functionalization, achieving homogeneity using native am

37 Robust membrane functionalization across epithelial, mesenchymal, and no

38 Elaboration of this simple functionalization allows preparation of conjugates with

39 he chemical treatment steps required for the functionalization and activation of the QCM surface, pri

40 ribute further to the areas of catalytic C-H functionalization and applied computational chemistry ar

41 hthylamines with azoles is developed via C-H functionalization and C-N bond formation.

42 approaches for the covalent and non-covalent functionalization and characterization of GBMs.

43 dition increase with greater levels of prior functionalization and decreasing temperature.

44 a novel approach for the selective chemical functionalization and localized assembly of one-dimensio

45 cation is a key step in facilitating protein functionalization and manipulation.

46 (AFM) confirmed the efficiency of electrode functionalization and on-electrode hybridization.

47 starting from graphene synthetic strategies, functionalization and processibility protocols up to the

48 tallic, depending on the substrate, chemical functionalization and strain.

49 ly fabricated without any additional surface functionalization and successfully applied to the separa

50 lasses for Cp*Co(III) -catalyzed C(sp(3) )-H functionalization and the first to exploit thioamides.

51 n of viral immuno-specificity due to surface functionalization and the physical size measurements ena

52 we demonstrate with extensive small molecule functionalization and the production and initial charact

53 rse aminoarenes, with a focus on aryne amino functionalization and transition-metal-catalyzed arene C

54 d indazole group offers a handle for further functionalization and tuning of its properties, as it is

55 ng of basic principles of reductive graphene functionalization and will serve as a guide in the desig

56 Several examples of site-selective olefin functionalizations and C-C bond formations are also incl

57 s of programming their shapes, site-specific functionalizations and responsive behaviours.

58 ), based upon the systematic activation (DNA functionalization) and passivation (self-assembled monol

59 Nanoparticles (NPs) size, surface functionalization, and concentration were claimed to con

60 -glycine equivalent, chemoselective nitrogen functionalization, and ring closure.

61 m disulfide (MoS2) through covalent chemical functionalization, and thereby directly influence the ki

62 ed metal complexes and cage-compounds, oxime functionalizations, and the preparation of new classes o

63 , 48, 96, and 168 hours post-antibody sensor functionalization; and (b) continuous detection of targe

64 g1 protein are ancestral and predate the sub-functionalization apparent in S. cerevisiae after the ge

65 functional units into account, the reported functionalization approach opens great flexibility for t

66 ems that do not specifically involve methane functionalization are excluded.

67 les bearing moieties suitable for subsequent functionalization are prepared.

68 However, compounds containing multiple functionalizations are rare, with scarcity increasing wi

69 al C(sp(3))-H and C(sp(2))-H silylations and functionalizations, as well as diastereoselective C-H si

70 n organic molecules and its availability for functionalization at almost any stage in a synthetic seq

71 ing pyrazole scaffolds that allow orthogonal functionalization at C5 and C4.

72 s on carboxylate-assisted C-H activation and functionalization at group 8-10 transition metal centers

73 stability and affinity, facile site-directed functionalization at introduced unique lysines or cystei

74 Selective functionalization at the meta position of arenes remains

75 mistry to our understanding of catalytic C-H functionalization based on carboxylate-assisted C-H acti

76 ide enables efficient site-specific antibody functionalization, based on molecular recognition of the

77 catalysts, such that catalyst-controlled C-H functionalization becomes a broadly applied strategy for

78 he Hex nanocarrier is modular, which enables functionalization beyond Fc-binding.

79 cent developments in C-H bond activation and functionalization by Pt complexes are surveyed.

80 Alkene functionalization by Sharpless dihydroxylation affords t

81 d pave the way toward rational design of C-H functionalization catalysts.

82 ment, the degree of spin-orbit coupling, the functionalization chemistry or the substrate, making the

83 el for site selectivity and extend this aryl functionalization chemistry to a selected set of heteroa

84 tion products, would allow diverse substrate functionalization chemistry to be coupled to O2 reductio

85 ications in de novo synthesis and late-stage functionalization chemistry.

86 the thin film sensing area through chemical functionalization [(CHO-(CH2)3-CHO) and APTES; NH2-(CH2)

87 s and fundamental establishment of the novel functionalization concept; and second, its subsequent us

88 rve as a guide in the design of new graphene functionalization concepts.

89 such operation is a tailored late-stage C-H functionalization converting a carboxylic acid into a la

90 While the first C-H functionalization could involve Ru-N covalent bond, the

91 ions to produce soluble graphenes with high functionalization densities of one pendant aromatic ring

92 Critical to achieving high functionalization density is the Hyperstage-1 GIC state,

93 This intermolecular C-H bond functionalization does not requires any exogenous ligand

94 scend the normal regioselectivity of the C-F functionalization event.

95 thus advancing our understanding of how neo-functionalization events have shaped the array of differ

96 an be exploited towards obtaining C-terminal functionalization exclusively.

97 en described as a quintessential "late-stage functionalization" exercise wherein natural products ser

98 development of advanced molecular solids and functionalization for applications.

99 xploited as a directing group for C(sp(3))-H functionalization for the first time.

100 rivatives that are poised to undergo further functionalization for the preparation of a diverse array

101 demonstrated by iterative application of C-H functionalization for the rapid synthesis of a patented

102 The apparent neo-functionalization from F3'H is associated with a Thr498

103 ral strategy for aliphatic gamma-C(sp(3) )-H functionalization guided by a masked alcohol.

104 A mechanism that enables direct aldehyde C-H functionalization has been achieved via the synergistic

105 Transition-metal mediated C-H functionalization has emerged as a powerful method in th

106 this work, several synthetic protocols for N-functionalization have been developed, and a variety of

107 he development of new reactions based on C-H functionalization have led to its wider adoption across

108 t optical gap tuning can be achieved through functionalization have, up until now, found only systems

109 ation of the degree of addition and the bulk functionalization homogeneity (Hbulk).

110 titution (SNAr) is a direct method for arene functionalization; however, it can be hampered by low re

111 o predict the site selectivity of direct C-H functionalization in a number of heterocycles and identi

112 the simultaneous nanoparticle formation and functionalization in an aqueous medium.

113 for stereoselective stilbene epoxidation and functionalization in an invertebrate animal infection mo

114 struct triaryl(heteroaryl)methanes via a C-H functionalization in good to excellent yield, and repres

115 has largely hindered the application of C-H functionalization in late-stage heterocycle drug discove

116 atalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2-

117 Functionalization in the presence of HO(*) results in th

118 Further, functionalization increased MSC adhesion to the surfaces

119 This formal C-H bond functionalization is a direct and efficient means of sel

120 n multiple types of C-H bonds, selective C-H functionalization is a major ongoing challenge.

121 the determining regioselectivity in fluorine functionalization is fluoride fragmentation from the rad

122 Importantly, this functionalization is generally electronically orthogonal

123 a colloidal sample in terms of its molecular functionalization is highly desirable but not accessible

124 arker applications, electrophilic N-terminus functionalization is likely to impair GSH homeostasis su

125 One long-standing issue in directed C-H functionalization is that either nitrogen or sulfur atom

126 eatures related to the synthesis and surface functionalization may play a crucial role in determining

127 The C-H functionalization method is effective with methylarenes

128 Many site-selective palladium-catalyzed C-H functionalization methods require directing groups.

129 alogues that are not accessible by other C-H functionalization methods.

130 surrounding the core and hydrophilic surface functionalization minimize the luminescence quenching ef

131 To achieve functionalization, monolayers are often patterned using

132 d involve Ru-N covalent bond, the second C-H functionalization most likely involves Ru-O coordinate b

133 chlorides that proceeds through selective 2-functionalization of 1,3-dioxolane through nickel and ph

134 e, the target capturing step was designed by functionalization of 3-aminopropyltrimethoxysilane coate

135 d hydrogenation-dehydrogenation process, the functionalization of a C-H group by direct attack onto a

136 The functionalization of a CD hydrophobic cavity with an ino

137 e capsule is compatible with enzyme mediated functionalization of a therapeutic mRNA-cleaving DNAzyme

138 ibe an electrochemical immunosensor based on functionalization of a working electrode by electrograft

139 romatic substrates and we demonstrate direct functionalization of advanced synthetic intermediates, d

140 The selective C-H functionalization of aliphatic molecules remains a chall

141 pargylamines, such as A(3) couplings and C-H functionalization of alkynes, have been described and or

142 been successfully applied to the late-stage functionalization of amide- and lactam-containing drugs,

143 ent and general one-pot trifluoromethylative functionalization of amides has been accomplished for th

144 n of 3D-printing for the miniaturization and functionalization of an ion source for (portable) mass s

145 perties of Aop, studies on the stability and functionalization of Aop-containing collagen triple heli

146 Methods for the direct C-H functionalization of aromatic compounds are in demand fo

147 Direct C-H functionalization of aromatic compounds is a useful synt

148 the work is the highly selective C(sp(2))-H functionalization of benzyl nitriles in the presence of

149 Meta-C-H functionalization of benzylamines has been developed usi

150 Edge functionalization of bottom-up synthesized graphene nano

151 The functionalization of C(sp(3) )-H bonds streamlines chemi

152 gen atoms, by transition metal catalyzed C-H functionalization of C-alkenyl azoles is disclosed.

153 n particular, the catalytic enantioselective functionalization of C-H bonds represents a highly atom-

154 Following our work on the C-H functionalization of carbohydrates by the 1,5 insertion

155 mportant advantages of defect/edge-selective functionalization of carbon materials (CNTs/graphene/gra

156 The functionalization of carbon-hydrogen (C-H) bonds is one

157 In the case of elaborating benzothiophenes, functionalization of carbon-hydrogen bonds at carbon-num

158 The functionalization of carbon-hydrogen bonds in non-nucleo

159 heterojunctions prepared through late-stage functionalization of chevron GNRs obtained from a single

160 molecules by catalyst-controlled, selective functionalization of complex molecules is an emerging ca

161 f this method of synthesis to the late-stage functionalization of complex molecules.

162 s protocol is demonstrated on the late-stage functionalization of complex nitrogen-containing drugs.

163 protecting-group-free approach for the alpha-functionalization of cyclic secondary amines.

164 in body-centered cubic crystals, whereas DNA functionalization of cysteines results in AB2 packing.

165 e medicinal chemist's toolbox for late stage functionalization of drug-like molecules' by Tim Cernak

166 nal group tolerance, enabling the late-stage functionalization of drug-like molecules.

167 is new concept is demonstrated in the direct functionalization of enaminone precursors, such as alkyl

168 n to be primarily a function of differential functionalization of enantiotopic arenes, although addit

169 ields with excellent enantioselectivities by functionalization of enantiotopic methyl groups under mi

170 avenues for the processing, fabrication, and functionalization of fluorinated materials with easy rem

171 r-derived 1,2- or 1,3-diol motif, permitting functionalization of free OH groups.

172 A new method for the functionalization of fullerenes based on the reaction be

173 Carboxyl-functionalization of graphene carbon can modulate its vi

174 mples of these processes range from covalent functionalization of graphene to modify its properties a

175 Here, we describe the functionalization of HA either with adamantanes (guest m

176 The photocatalytic C-F functionalization of highly fluorinated arenes is a powe

177 Site-selective functionalization of hydroxy groups in sugar derivatives

178 Site-selective functionalization of hydroxyl groups in carbohydrates is

179 on metal-catalyzed enantioselective beta-C-H functionalization of isobutyric acid-derived substrates

180 he polymer backbone requires less than a 15% functionalization of its repeating units with beta-sheet

181 ient directing group approach for C(sp(3))-H functionalization of ketones.

182 effects the molecular mechanisms involved in functionalization of low-fouling carboxy-functional coat

183 ctive organic iodide molecular traps through functionalization of metal-organic framework materials w

184 tions that can be used for the synthesis and functionalization of multicomponent polymers and further

185 al photocatalysis ensuing two sp(3) C-H bond functionalization of N,N-dimethylanilines.

186 This work shows that surface functionalization of nanocapsules is an effective and in

187 In addition, functionalization of nanocapsules with multiple pyridine

188 ry few chemical strategies for the selective functionalization of nanostructures have been developed

189 pyl triethoxysilane (APTES) was used for the functionalization of nHfO2@RGO and electrophoretic depos

190 gineering of a new class of ECHs through the functionalization of non-conductive polymers with a cond

191 The surface functionalization of NPs with ascorbic acid significantl

192 hich serves as an activating group, enabling functionalization of one of the boron-bound oxygen atoms

193 ch, we achieve the site- and stereoselective functionalization of one subterminal dehydroalanine resi

194 ach, it is herein demonstrated that carboxyl functionalization of poly(lactic-co-glycolic acid) can a

195 It is applicable to the functionalization of primary amides, sulfonamides, and o

196 The catalytic asymmetric alpha-functionalization of prochiral barbituric acids, a subty

197 and application of a reagent for the direct functionalization of pyridines.

198 Chirality-selective functionalization of semiconducting single-walled carbon

199 The reactivity and the regioselective functionalization of silyl-diene enol ethers under a bif

200 In addition to the functionalization of small building blocks and late-stag

201 bstituted molecules, and enabling late stage functionalization of spiroligomer termini.

202 d introduce oxime ligation as a tool for the functionalization of synthetic collagen.

203 sultam ring and allows late stage sequential functionalization of the amine and amide nitrogens to ra

204 Surface functionalization of the AuNPs with custom-designed meso

205 id derived moiety (approach (b)) enables the functionalization of the BASHY platform for a broad spec

206 I)-catalyzed BDG-assisted C-H activation and functionalization of the beta-C(sp(3))-H bonds of carbox

207 ilings and rare earth deposits, we show that functionalization of the cell surface with LBT yielded s

208 f recovery periods, we achieved the enhanced functionalization of the CNT surface and the removal of

209 ion chemistry-based strategy for the surface functionalization of the external metal nodes of MOF nan

210 re available that deal with the BDG-directed functionalization of the gamma-C(sp(3))-H bonds.

211 omputational study of the effect of chemical functionalization of the imidazole linker on the framewo

212 By leveraging the functionalization of the inner surfaces of the MTs with

213 has been successfully applied for selective functionalization of the less activated benzylic C-H bon

214 ly-structured charge trap layers through the functionalization of the monolayer/dielectric interfaces

215 a dirhodium catalyst for the site-selective functionalization of the most accessible non-activated (

216 c frameworks (MOFs) can be tuned by chemical functionalization of the organic ligands that connect th

217 hods for radiolabeling nanoparticles involve functionalization of the particle surface, core, or coat

218 olecules or nanoclusters, as well as for the functionalization of the same substrate with two differe

219 iodine in a catalytic amount facilitates the functionalization of the sp(3) C-H bond of acetophenones

220 scribe a new catalytic approach to selective functionalization of the strong C-F bonds in trifluorome

221 e a new perspective for the modification and functionalization of the surface with any type of mMOF b

222 here the first example of single C(sp(3))-F functionalization of trifluoromethylarenes via visible-l

223 7-dihydroindolo[2,3-b]carbazoles through the functionalization of two indole C(sp(2))-H and one C(sp(

224 vEV) in vitro, which catalyze elongation and functionalization of two ketide units followed by cycliz

225 d carbene/nitrene transfer, for the directed functionalization of unactivated C(sp(3) )-H bonds.

226 he development of new methods for the direct functionalization of unactivated C-H bonds is ushering i

227 A dual catalysis approach enables selective functionalization of unconventional feedstocks composed

228 Processes for site-selective, sequential functionalizations of carbohydrate derivatives are descr

229 emonstrated by the late-stage site-selective functionalizations of complex molecules; a rapid modular

230 Other functionalizations of corroles include a large diversity

231 An unprecedented three consecutive C-H functionalizations of two styrenes are involved in this

232 romatic substitutions to stereoselective C-H functionalizations on remote carbon centers and can init

233 urface-to-volume ratio and adaptable surface functionalization, particles are widely used in bioanaly

234 A new C-F bond functionalization path that provides unprecedented possi

235 ectronic structure properties with degree of functionalization, photoelectron spectroscopy was used t

236 bioactive agents by eliminating any surface functionalization process for further mass-sensitive bio

237 c voltammetry (CV) was applied during the WE functionalization process to characterize the gold WE su

238 e isocyano group or can be exploited in post-functionalization processes.

239 ert, the recent emergence of methods for C-H functionalization promises to transform the way syntheti

240 f interest by simply adapting an appropriate functionalization protocol and thus is very generic in n

241 ive catalytic cross-dehydrogenative C-H bond functionalization protocol for the construction of C(sp)

242 We present a surface functionalization protocol that allows minimization of u

243 Allylic functionalization provides a direct path to chiral build

244 The carbon-fluorine bond functionalization reaction is highly selective for the f

245 ew is to provide guidance for the use of C-H functionalization reactions and inspire future research

246 Cp(X)Rh(III)-catalyzed C-H functionalization reactions are a proven method for the

247 Although many C-H functionalization reactions involve C(sp(3))-C(sp(2)) co

248 This review covers the functionalization reactions of meso-arylcorroles, both a

249 armaceuticals, agrochemicals, and late-stage functionalization reactions on complex molecules.

250 Key peripheral functionalization reactions such as halogenation, formyl

251 ariations in the reaction mechanisms for C-H functionalization reactions that may be extant for this

252 the design of other catalyst-controlled C-H functionalization reactions.

253 ding enantioselectivity) in Pd-catalyzed C-H functionalization reactions.

254 ss a variety of challenging anti-Markovnikov functionalization reactions.

255 The C-H bond functionalization reactivity is rationalized from a two-

256 creening, nonspecific binding, and stringent functionalization requirements.

257 An enantioselective C-H functionalization route to perfluoroalkyl-containing 3-a

258 potassium cation as a catalyst for C-H bond functionalization seems to be without precedent, and no

259 as an important contributor in governing the functionalization selectivity of monosubstituted cyclohe

260 ites provide perspectives for post-synthetic functionalizations, separations and catalysis.

261 arget, from introduction of a new or altered functionalization site, or from features as simple as im

262 tep and the oxidation state of Pd in the C-H functionalization step.

263 tion of large complex molecules will allow a functionalization strategy for the next generation of bi

264 le site in the molecule enlisting a powerful functionalization strategy.

265 design strategy is advantageous for surface functionalization, strong interface adhesion as well as

266 roups is evidenced by other delta-C(sp(2))-H functionalizations such as alkenylation, arylation, and

267 ked ultrathin Co3 O4 nanosheets with surface functionalization (SUCNs-SF) converted from layered hydr

268 response to the bare LSPR biosensor without functionalization, suggesting a different biophysical in

269 from previous azidoiodinane-initiated alkene functionalization, suggesting new reactivity of azidoiod

270 techniques and the various routes of surface functionalization that allow for precise control over th

271 ry, mainly due to the versatility of surface functionalization that can bestow a huge variety of chem

272 C-H bond functionalizations that lead to oxidations, aminations,

273 of transition metal substitution and organic functionalization, the electronic structure of these mat

274 asily be removed at any suitable stage after functionalization, the method provides a facile access t

275 Despite the advances in catalytic C-H functionalization, the use of aliphatic amine coupling p

276 ress recent progress on controlling covalent functionalization through chemical and physical methods,

277 ed in simultaneous chemical delamination and functionalization to targeted CONs.

278 0 molar) at 110 degrees C, pyridine-directed functionalization took place and 3-chloro- or 3-bromobip

279 study unambiguously shows that the graphene functionalization using alkyl iodides leads to the best

280 truction of aromatic nitriles via direct C-H functionalization using an acridinium photoredox catalys

281 ioselective Pd(0)-catalyzed cyclopropane C-H functionalization using trifluoroacetimidoyl chlorides a

282 less director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) a

283 ecies could be exploited to realize a double functionalization via an electrophilic amination followe

284 f pyridines and an example of the subsequent functionalization via C-C bond formation.

285 The robust electrochemical C-H functionalization was characterized by ample substrate s

286 Electrochemical cobalt-catalyzed C-H functionalizations were achieved in terms of C-H oxygena

287 e substrate-controlled mechanisms in the C-H functionalizations were employed to investigate a number

288 acycle is favored over gamma-C(sp(2))-H bond functionalization when both positions are accessible.

289 itecture, but necessitates a challenging C-H functionalization, which is ultimately accomplished by a

290 e electroaddressed onto the gold WEs through functionalization with 4-carboxymethyl aryl diazonium (C

291 N bonds, using primary amines, by direct C-H functionalization with an acridinium photoredox catalyst

292 o-noise, and even heightened selectivity via functionalization with an embedded receptor.

293 o palladium and accelerates non-directed C-H functionalization with arene as the limiting reagent.

294 ypes, but internalization can be enhanced by functionalization with bio-adhesive end-groups.

295 these probes is further enhanced by covalent functionalization with bisphosphonate.

296 otected amino acid ligands (Pd/MPAA) via C-H functionalization with molecular iodine provide mechanis

297 Directed chemical design via side-chain functionalization with polar groups allows manipulation

298 ring approaches such as nanoparticle surface functionalization with poly(ethylene glycol) and/or immu

299 After functionalization with the nucleants, we found that thes

300 - and Cp*Rh(III)-catalyzed directed C-H bond functionalizations with diazo-compound substrates.