ライフサイエンスコーパス: functionally

1 ferred to as 'orphan' and remained enigmatic functionally.

2 m and surgical education are often separated functionally.

3 tolerance, whereas AtPMT2 and AtPMT3 overlap functionally.

4 ly relevant neural circuits structurally and functionally.

5 il communities are diverse taxonomically and functionally.

6 otein level, and the accumulated protein was functionally active as shown by its ability to engage an

7 JFH-1 NS3 binds RNA with high affinity in a functionally active form that is capable of immediately

8 on sequence applicable to mass production of functionally active secretory proteins in a silkworm-bas

9 volved in carcinogenesis, including a novel, functionally active transcriptional variant of AKT3 Our

10 The HS oligosaccharide is functionally active, can restore protein binding, and al

11 ely requires approaching those HSCs that are functionally affected by age.

12 erasable and mobile, they could be useful in functionally agile devices: for example, creating and mo

13 of women undergoing spontaneous PTL harbored functionally altered B cell populations.

14 (ILCs) are rapidly-responding cells that are functionally analogous to diverse T cell subsets.

15 We functionally analyzed the KCNH2 (encoding for Kv11.1 or

16 oid genes highly correlate within and across functionally and anatomically different areas.

17 hat chromosomal contacts' maps could uncover functionally and clinically related genes.

18 are activated in each cell type to construct functionally and structurally distinct cells.

19 Therefore, inhibition is functionally and structurally more robust and diverse in

20 distinct demethylase, both structurally and functionally, and provides insight into demethylation an

21 h-throughput reverse genetic screens to help functionally annotate the Ae. aegypti genome.

22 e-associated alleles might be systematically functionally annotated using morphological profiling of

23 ncRNAs that have been identified are not yet functionally annotated.

24 to study early stages of NBL oncogenesis, to functionally assess NBL oncogenic drivers and to charact

25 4,055 unigenes were annotated and classified functionally based on protein databases.

26 of examples in which biological noise can be functionally beneficial.

27 Optimization, the ability to select the functionally best material and modify it appropriately f

28 in MOFs mimic homogeneous catalysts not just functionally, but also mechanistically.

29 We identified and functionally characterised a putative ferulate 5-hydroxy

30 We functionally characterize 14 DYNC1H1 mutations identifie

31 ar and physiological techniques were used to functionally characterize a newly identified branch of t

32 Here, we functionally characterize a novel ultraconserved lncRNA,

33 Here we describe and functionally characterize a previously unknown liver-spe

34 n mice with optogenetics to structurally and functionally characterize angiotensin type-1a receptor-c

35 This study, the first to functionally characterize NLS2, demonstrates NLS2 plays

36 Here, we identify and functionally characterize the regulatory regions of the

37 mechanisms of inhibition are thus needed to functionally characterize V-ATPase and to fully evaluate

38 tudy, two elongases, Elovl4 and Elovl5, were functionally characterized and their transcriptional reg

39 genes for the biofortification of wheat, we functionally characterized homologs of the VACUOLAR IRON

40 Thus, MoGSK1 is functionally characterized in this study.

41 Here, we structurally and functionally characterized one of these peptides named "

42 We functionally characterized the proteins encoded by these

43 pression, only a fraction of these have been functionally characterized, and the extent to which lncR

44 s polygalacturonases, few of which have been functionally characterized.

45 ectivity and temporal responses, and are not functionally clustered.

46 However, comprehensive discovery of functionally coherent biclusters from large datasets rem

47 In particular, BeME-WithFun helped identify functionally coherent modules that might be relevant for

48 All ILC subsets are functionally competent in vitro, and are sufficient to p

49 alled TbSTT3A, TbSTT3B, and TbSTT3C that can functionally complement the Saccharomyces cerevisiae OST

50 ge root and, of these, three were capable of functionally complementing Arabidopsis T-DNA insertion m

51 contribute to a better understanding of this functionally complex group of neurons.

52 Restoring P2Y14 R expression levels in functionally compromised hCPCs via lentiviral-mediated o

53 Therefore, empowering functionally compromised hCPCs with proregenerative mole

54 and thus expanded this protein family to 20 functionally confirmed members.

55 molecules that drive these processes and may functionally connect them to the transient calcium pulse

56 G and lateral occipital complex (LOC) became functionally connected and this interaction was benefici

57 ties in connecting white matter pathways and functionally connected more posterior cortical areas cou

58 ion itself, we also identified brain regions functionally connected to each lesion location.

59 k mapping was used to identify brain regions functionally connected to the lesion locations.

60 Similarly, 16 of 17 lesion locations were functionally connected to the right frontal cortex, the

61 Although RCrusI is functionally connected with ASD-implicated circuits, the

62 be and left cerebellar lobule VIIb, which is functionally connected with prefrontal regions supportin

63 FYCO1 functionally connects autophagic and endocytic pathways,

64 This functionally conserved epitope is a potential target for

65 We find that TOP2A cleavage has functionally conserved local sequence preferences, occur

66 Network alignments have been used to uncover functionally conserved network parts and to transfer ann

67 WT cells, suggesting that c-MYC upregulation functionally contributes to the proliferative phenotype

68 the OXPHOS machinery physically interact and functionally cooperate to enhance ANT transport capacity

69 At rest the lPAG was functionally correlated with cortical sensorimotor areas

70 tion and the channel pore (T288N), which are functionally coupled during receptor activation.

71 tion analysis indicated that both nodes were functionally coupled with the vmPFC in support of the hu

72 Conversely, PI3Kdelta was functionally critical in Treg, acting there to control T

73 This loop contains a functionally critical Tyr at position 71.

74 mbda4 activity, or between patients encoding functionally defective IFN-lambda4 (IFN-lambda4-Ser70) a

75 chronic neutrophilic leukemia (e.g., T618I), functionally defective mutations in the extracellular do

76 While MEC contains subsets of identifiable functionally defined cell types, recent work employing u

77 n cortical computations, but how synapses of functionally defined cortical networks are arranged with

78 in which both hIL-12 receptor subunits were functionally deleted.

79 ymethylcytosine in postmitotic neurons is to functionally demethylate expressed gene bodies while ret

80 able the late-stage hydroxylation of several functionally-dense drug-like aryl halides.

81 third of acute ischemic stroke patients were functionally dependent or dead 3 months postacute stroke

82 onths post-discharge, 36.5% of patients were functionally dependent or dead.

83 Functionally, depleting cellular Sal-1 strongly renders

84 The effect of HA-coatings on murine MSC was functionally determined both, in vitro and in vivo as a

85 ed and free-living bacterial assemblages are functionally different and that the interplay between pa

86 control cell death and are structurally and functionally different from normal cell mitochondria.

87 Functionally, disrupting DISC1/Ndel1 complex formation p

88 Our study provides insight into functionally disruptive, rare-variant mutations in human

89 n entorhinal cortex (ERC) is subdivided into functionally distinct anterolateral (alERC) and posterom

90 at miRNA profiles differ dramatically across functionally distinct cell types of the mouse jejunal in

91 verse HCV strains, assigning the NAbs to two functionally distinct clusters.

92 mTOR kinase acts in two functionally distinct complexes, mTOR complex 1 (mTORC1)

93 testinal tumors can contain dynamic pools of functionally distinct CSC populations, which seem to int

94 enable the derivation of cardiomyocytes and functionally distinct endothelial cell (EC) subtypes fro

95 Up to 53% of each mapped, functionally distinct forest presents an opportunity for

96 ialized vasculature that is structurally and functionally distinct from that of the periphery.

97 RTEs are functionally distinct from their more mature but still n

98 nd plasticity measures form structurally and functionally distinct groups.

99 that hair cells express two molecularly and functionally distinct mechanotransduction channels with

100 ytic subunit in two structurally related but functionally distinct multi-component kinase complexes,

101 nd structural modeling of ABHD5 and ABHD4, a functionally distinct paralog that diverged from ABHD5

102 -specific interventions in the GPe to target functionally distinct pathways, with the potential to in

103 In this study, we generated two functionally distinct sorafenib-resistant human Huh-7 HC

104 gh differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T hel

105 The metabolic programs of functionally distinct T cell subsets are tailored to the

106 e are widespread and comprise at least three functionally distinct types.

107 These data demonstrate functionally distinct, but cooperative, roles for each k

108 analysis can be used for fast phenotyping of functionally diverse cell populations with reasonable ac

109 CHEMA recombination to create a large set of functionally diverse chimeras from three sequence-divers

110 basis for evolutionary tuning of function in functionally diverse enzyme homologs.

111 ortance of inhibitory circuits in generating functionally diverse excitatory pathways and suggest tha

112 uctural, and functional relationships of the functionally diverse flavin mononucleotide-dependent nit

113 iative positive-feedback loop and connecting functionally diverse hippocampal areas.

114 n the brain, many types of interneurons make functionally diverse inhibitory synapses onto principal

115 nisms by which structurally, chemically, and functionally diverse ligands modulate GPCR function.

116 Cyanobacteria produce structurally and functionally diverse polyketides, nonribosomal peptides

117 ved rare codon clusters are structurally and functionally diverse, they are enriched in functions ass

118 l as RNA- and protein-modifying enzymes that functionally diversify mammalian ribosomes.

119 ikely related to their beta-cells being more functionally efficient.

120 ng a mouse model whose knock-in BCR does not functionally engage with immunizing antigen, we found th

121 indicates there may be one or two additional functionally equivalent binding sites for propofol, othe

122 ing these oxidants toward the synthesis of a functionally equivalent binuclear Mn(II) species.

123 vitro studies show that Tolypothrix OCP1 is functionally equivalent to Synechocystis OCP1, including

124 and pharmacological inhibition of Trx-1 was functionally equivalent to the signal triggered by mCD40

125 Here we present the crystal structure of the functionally essential ICP4 DNA binding domain in comple

126 Additional studies should be conducted to functionally evaluate these loci and to identify other c

127 Functionally, exogenous expression of JMJD2B enhanced su

128 rsatile, time- and labor-efficient method to functionally explore the Saccharomyces cerevisiae genome

129 an orthologue, OR10J5, have been found to be functionally expressed in several non-olfactory systems.

130 ecies that is still common but ecologically (functionally) extinct and in a trajectory of further dec

131 orked information exchange pathways that may functionally facilitate intra- and intersubunit coordina

132 Tumour derived fibroblasts (TDFs) differ functionally from normal fibroblasts (NDFs), and play a

133 Functionally, hair cells with enlarged ribbons had large

134 Eosinophils are phenotypically and functionally heterogeneous.

135 Functionally, HL-HDL showed lower antioxidant activity (

136 We further functionally identified EgWRI1-1, one of three EgWRI1 or

137 no sex determination-related genes have been functionally identified in reptiles.

138 FA complementation group D2 protein (FANCD2) functionally impacts mitochondrial ATP production throug

139 RORgammat(+) T cells are proinflammatory and functionally impaired and may contribute to the pathogen

140 olite profiling showed that both targets are functionally impaired by the beta-lactone.

141 Skeletal muscles were functionally impaired from 2 months of age and a moderat

142 Proliferation and migration of functionally impaired hCPCs are enhanced by P2Y2R-mediat

143 upon the reactivation of tumor-specific but functionally impaired PD-1(+) T cells present before the

144 ls critically delay disease onset but become functionally impaired upon disease progression.

145 eal the presence of T cells that are not yet functionally impaired.

146 ites within proteins were assumed to be more functionally important and thus subject to stronger sele

147 ntranodal CCL21 gradients, and that CCL19 is functionally important at the boundary between B cell fo

148 Thus, we identify Syt2 as a functionally important Ca(2+) sensor at fast-releasing i

149 THOR represents a novel class of functionally important cancer/testis lncRNAs whose struc

150 We set out to identify novel and functionally important endothelial lncRNAs.

151 We demonstrated that these pockets were functionally important for 5-LOX activity.

152 ization of the APC-dependent RNA subgroup is functionally important for cell migration.Adenomatous po

153 ranslation is through suppressing eIF4A, and functionally important for suppression of mTORC2 activit

154 analysis revealed differential expression of functionally important genes; including genes involved i

155 iption rather than the RNA product itself is functionally important in many cases.

156 he amphibian skin bacterial community may be functionally important in terms of disease-resistance, a

157 These findings define a novel and functionally important intracellular location of CD24; t

158 ber of immunodominant regions, which were in functionally important locations on the DENV NS1 protein

159 noamine oxidase A (MAOA) is a clinically and functionally important mediator of PCa bone and visceral

160 blueprint for future approaches to discover functionally important O-GlcNAcylation events on other K

161 common and rare variants in genes affecting functionally important pathways (such as melanogenesis)

162 lysosomes, these compartments contain other functionally important PIs.

163 predicted loops are almost exclusively where functionally important residues are located.

164 The functionally important switch loop of the trimeric multi

165 ) is in close vicinity to a structurally and functionally important TRPV3 region comprising an atypic

166 h can modulate other patterning processes in functionally important ways-emphasizes the need to integ

167 These effects were functionally important, as TGF-beta1 injection suppresse

168 y, the negative impact on T-cell activity is functionally important.

169 ein (FK506 binding protein) is inserted into functionally-inactivated point mutants of two target pro

170 ha produced in response to HSV and HIV, thus functionally inactivating pDC.

171 encoded proteins of co-infecting strains are functionally incompatible.

172 d their nested HEN domains are thought to be functionally independent because of the existence of fun

173 It is often thought that S-OPA1 is a functionally insignificant proteolytic product of L-OPA1

174 This gradient is functionally instructive, and represents a multistable,

175 n numbers similar to those in WT animals and functionally intact, and transfer of WT platelets did no

176 oreceptors expressing various opsins and can functionally integrate into congenitally blind mice.

177 he folk concept of "contempt" to argue for a functionally integrated model of attitudes and emotions

178 compartments are structurally registered and functionally integrated with one another.

179 as involved in word and face recognition are functionally integrated.

180 xigenic (appetite suppressing) brain systems functionally interact to regulate food intake.

181 and show that the TEX1 and MOS11 components functionally interact, affecting mRNA export and splicin

182 sults from this study demonstrate that MUC13 functionally interacts and activates HER2 at p1248 in PD

183 s with individual domains, we find that AAV2 functionally interacts predominantly with the second Ig-

184 that nuclear IGF-1R (nIGF-1R) physically and functionally interacts with some nuclear proteins, i.e.

185 is decreased in pet10Delta Moreover, Pet10p functionally interacts with the endoplasmic reticulum dr

186 Our findings that eIF4A functionally interacts with the PIC and plays important

187 nclude that the two neurotransmitters may be functionally interchangeable and that multiple receptor

188 se data demonstrate that kLANA and mLANA are functionally interchangeable for establishment and maint

189 The paralogue of Alx1, Alx4, was not functionally interchangeable with Alx1, but insertion of

190 Importantly, SL1 and SLC are functionally interchangeable, and separate exchanges of

191 Studies attempting to functionally interpret complex-disease susceptibility lo

192 s extend highly branched processes that form functionally isolated microdomains, facilitating local h

193 Functionally, KDM5A deficiency results in impaired trans

194 Functionally, KIBRA overexpression induced significant m

195 These miRNAs are functionally linked to particular steps of HCV life cycl

196 Our findings suggest that A-SAA is functionally linked to pulmonary inflammation in our O3

197 tivity, suggesting that these properties are functionally linked.

198 While adult islets are thought to contain functionally mature beta cells, recent analyses of trans

199 The generation of defined populations of functionally mature human GABAergic neurons represents a

200 ve adult hippocampal neural progenitors into functionally mature neurons.

201 from hippocampal memory engram cells, became functionally mature with time.

202 Functionally, mature WNT-5A attenuated canonical WNT-dri

203 /80(+) cells phagocytosed apoptotic cells as functionally matured macrophages, adhered to the newly f

204 mple single-joint arm and hand movements and functionally meaningful multi-joint movements.

205 conserved activity, emphasising the need to functionally measure the effect of divergence on enhance

206 Functionally, MKK3 stabilized MYC protein, enhanced its

207 We infer that stem eukaryotes shared functionally modern sterol biosynthesis genes with bacte

208 oligomers, resulting in conformationally and functionally modified species.

209 The OCP is structurally and functionally modular, consisting of a sensor domain, an

210 In addition, primary cilia seem to functionally modulate effects of EFS-induced cellular ca

211 Functionally, mPFC neuronal networks appeared to be affe

212 The recessive and functionally null I/LnJ H2-Ob allele supported the produ

213 sation whereby cerebellin-1 and neuroligin-3 functionally occlude each other during development of ca

214 tions the pro-anabolic effects of mTORC1 are functionally opposed to growth.

215 Functionally, optogenetic stimulation of these neurons p

216 es and in vitro-cultured adult reticulocytes functionally or at the molecular level, and importantly

217 The SMP domain of PDZD8 is functionally orthologous to the SMP domain found in yeas

218 To functionally polarize cells, these proteins must activat

219 leged folding level exists, TADs emerge as a functionally privileged scale defined by maximal boundar

220 stems, (3) elucidate the rules of synthetic, functionally programmable microbiome assembly, (4) deter

221 Pancreatic beta cells are functionally programmed to release insulin in response t

222 The elements of AMPAR functionally recruited by auxiliary subunits are, theref

223 The elements of the AMPAR that are functionally recruited by auxiliary subunits, stargazin

224 nt sepsis model, trabecular bone strength is functionally reduced within 24 hours and is associated w

225 l elements within the superenhancer were not functionally redundant and that all were required for no

226 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kina

227 one methyltransferase MET-2/SETDB1 also show functionally redundant sterility, increased germline apo

228 in revealed that PI3Kalpha and PI3Kbeta were functionally redundant with PI3Kdelta in Tconv.

229 mes), many of which have been categorized as functionally redundant.

230 By contrast, teleost fish functionally regenerate their retina following injury, a

231 Caveolin-1 acts as a scaffolding protein to functionally regulate signaling molecules.

232 ry FEF inactivation decreases all aspects of functionally related activity in the SC.

233 ncreased sympathetic nerve activity, whereas functionally related enzymes that do not alter polySia e

234 The correlations between many functionally related genes change over different biologi

235 Moreover, we demonstrate the use of functionally related pairs of circulating noncoding RNAs

236 including four highly mutated genes that are functionally related to the target of rapamycin complex

237 ation characterized by hypo-synchronicity of functionally-related/hyper-synchronicity of functionally

238 These phenotypic changes are functionally relevant as ischemic macrophages triggered

239 With this model, we can identify functionally relevant circuit motifs and generalize the

240 al phenotypic traits in their offspring in a functionally relevant context using a fully factorial de

241 As such, functionally relevant differences in averaged power acro

242 they underscore a role for Sts in regulating functionally relevant immune response pathways.

243 The functionally relevant random-coil-alpha-helix transition

244 ce, the field is now ripe for systematic and functionally relevant studies of the development and evo

245 We identify Groucho/TLE as a functionally relevant substrate, whose ubiquitylation by

246 H2, all of which are validated as direct and functionally relevant targets of miR-141.

247 o the challenges in both identifying all the functionally relevant variants and accurately estimating

248 en functional site features suggest distinct functionally-relevant clusters.

249 view, we introduce an emerging field we term functionally-relevant morphological profiling with great

250 sory gain along acoustic dimensions that are functionally-relevant-here, formant frequencies that are

251 This indicates that M1 and M2 can functionally replace each other in some, but not all, as

252 oviding tonic microbial stimulation that can functionally replace intestinal bacteria.

253 rt the conclusion that the HTLV-1 CA NTD can functionally replace the HIV-1 CA CTD, but the HIV-1 CA

254 RhoB relocalized to the plasma membrane and functionally replaced RhoA with respect to invasion, clo

255 Functionally, repression of CPT1A is critical for tumor

256 severely compromised activity, which can be functionally rescued via blocking RNF8-MIWI interaction

257 ay all be regulated both developmentally and functionally, restricting their utility.

258 functionally-related/hyper-synchronicity of functionally-segregated large scale networks and an abno

259 ng D1 agonists with better pharmacokinetics, functionally selective D1 ligands, and D1R positive allo

260 ptor and adenosine A2A receptor ligands with functionally selective properties between Gs and Golf si

261 Functionally, selective competitive antagonists of apeli

262 Functionally, serine 34/35 phosphorylation enhances auto

263 MLCP activity may arise from functionally shared roles between MYPT1 and MBS85, resul

264 le hematopoietic stem cells (HSCs) have been functionally shown to generate all mature cell types for

265 c DNA and showed affinities similar to other functionally significant PU.1 interactions.

266 hese structures have been demonstrated to be functionally significant.

267 aHUS cohort identified another family with a functionally-significant mutation in INF2 In this family

268 annotation system for the identification of functionally similar enzymes from diverse sequence backg

269 sm based on comparison with structurally and functionally similar enzymes, and the applications of th

270 finding gene-gene network modules which are functionally similar in nature in the case of breast can

271 Functionally similar leukocyte populations were grouped

272 Functionally similar sets of families tend to follow sim

273 gher-order interactions between TADs sharing functionally similar states.

274 Y, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked homologs whose deficiency

275 instem and medial cerebellar structures were functionally spared.

276 requires bidirectional interactions between functionally specialized brain regions.

277 arise from the selective synchronization of functionally specialized but widely distributed cortical

278 to find the FFA and subsequently many other functionally specialized cortical regions.

279 ation of most PP2A gene families, members of functionally specialized subclades quickly revert to sin

280 the majority of these variants have not been functionally studied.

281 ough a quadrupolar-ion interaction cannot be functionally substituted by aromatic, non-polar, or pola

282 ssociated activator of morphogenesis 1), and functionally suppresses Dvl --> Daam1 cascade during CE.

283 Although they are often molecularly and functionally symmetric, recent work has found that pre-

284 Missense changes were functionally tested for their pathogenicity by assaying

285 Functionally, Tet3 is required for robust axon regenerat

286 en characterized in detail biochemically and functionally, the basic properties of TMPRSS13 remain un

287 Functionally, this resulted in reduced nutrient transpor

288 tside of minimal enhancer regions can evolve functionally through mechanisms other than changes in tr

289 Functionally, tumor cells incubated with LGRFYAASG-pen s

290 Zymoseptoria tritici secretes many functionally uncharacterized effector proteins during in

291 well-demonstrated applications, but they are functionally underutilized.

292 f them are previously annotated promoters of functionally unrelated genes, and like typical enhancers

293 how that Drosophila wing disc cells carrying functionally unrelated loser mutations (Minute and mahjo

294 Here we describe an approach to functionally validate identified variants through differ

295 in which genes implicated by expression are functionally validated as being relevant for complex tra

296 analyses in independent human datasets, five functionally validated genes-GPATCH2L, UHRF1BP1L, PTPRH,

297 ical potential, almost none of which are yet functionally validated.

298 candidate regulatory elements have yet to be functionally validated.

299 lenge as the majority of them lie outside of functionally well-defined protein coding regions.

300 Polbeta directly interacted functionally with the mitochondrial helicase TWINKLE.