ライフサイエンスコーパス: fundamental role

1 ptual learning and sensory plasticity have a fundamental role.

2 .), the spin-state degree of freedom plays a fundamental role.

3 This model underlies the fundamental role CHD6 facilitates by tethering cis-actin

4 Membrane remodeling plays a fundamental role during a variety of biological events.

5 al cortical malformations, demonstrating its fundamental role during brain development.

6 The transcription factor RUNX2 plays a fundamental role during embryogenesis and is aberrantly

7 indicate that periderm plays a transient but fundamental role during embryogenesis by acting as a pro

8 Lipid metabolism plays a fundamental role during influenza virus replication, alt

9 on demanded by low-voltage operation plays a fundamental role, enabling bulk trapping and leading to

10 Here we describe an unexpected fundamental role for ACKR1 in hematopoiesis and provide

11 synaptic autophagy, respectively, implying a fundamental role for Bassoon in the local regulation of

12 Here we identified a fundamental role for BATF in regulating the differentiat

13 Our results suggest a novel, fundamental role for cdG in controlling the function of

14 numerous cell lines, confirming a novel and fundamental role for cholesterol biosynthesis in regulat

15 ythms in humans and rodents has implicated a fundamental role for circadian rhythms in ageing and the

16 vide evidence that this mechanism reflects a fundamental role for DeltaNp63alpha in the normal wound-

17 These results demonstrate a fundamental role for DNA mechanics in mediating nucleoso

18 Our study has identified a fundamental role for GDF6 and BMP signaling in governing

19 at instruct dB1 circuit formation revealed a fundamental role for Lim-HD proteins in regulating their

20 Our findings suggest a fundamental role for mGluR5 in the development of Pv(+)

21 Recent studies have shown a fundamental role for microRNAs (miRNAs) in regulating im

22 These findings highlight a fundamental role for mTOR in epidermal morphogenesis tha

23 By revealing a novel and fundamental role for NG2(+) glia, our study brings new p

24 These findings demonstrate a fundamental role for NOS1-derived NO in regulating TLR4-

25 Our findings suggest a fundamental role for osteoblast dedifferentiation in rep

26 Importantly, these data reveal a fundamental role for paxillin in coordinating MT acetyla

27 candidate sirtuin substrates, and uncovers a fundamental role for sequestration of SIRT3 by ATP synth

28 nisms, including humans, have demonstrated a fundamental role for sleep in the formation of memories.

29 topenia with excessive bleeding, outlining a fundamental role for SLFN14 in platelet formation and fu

30 veloped for endemic regions, as it implies a fundamental role for stochastic transmission and local d

31 drial homeostasis, and establish a novel and fundamental role for Tctp in vertebrate neural circuitry

32 Taken together, our data demonstrate a fundamental role for the ancient 14-3-3 epsilon group me

33 These data suggest a fundamental role for the ancient TPC complex in traffick

34 This study uncovers a fundamental role for the skeletal muscle clock in muscul

35 This finding suggests a fundamental role for TNFSF15, a T-cell receptor gene inv

36 early development of cancer and establish a fundamental role for TSLP and Th2 cells in tumor immunit

37 Collectively, our findings uncover a fundamental role for VTA dopaminergic circuitry in the m

38 eir co-dependence on climate, establishing a fundamental role for water transport in the evolution of

39 Collagen plays a fundamental role in all known metazoans.

40 ese findings indicate that serotonin plays a fundamental role in arthritis through the regulation of

41 Thus, PSGL-1 plays a fundamental role in balancing viral control and immunopa

42 one surface and ligands on another, plays a fundamental role in biology and is key to the infection

43 VEGFR2 plays a fundamental role in blood vessel formation and in life t

44 This commitment decision plays a fundamental role in cancer and degenerative diseases and

45 Mechanics play a fundamental role in cell biology, but detecting piconewt

46 e main determinant of cell shape and plays a fundamental role in cell division [1-3], migration [4],

47 Acetyl-CoA plays a fundamental role in cell signaling and metabolic pathway

48 Electronically excited orbitals play a fundamental role in chemical reactivity and spectroscopy

49 the cellular level has been shown to play a fundamental role in circadian oscillations, influencing

50 ion by BRCA1 and BRCA2 originates from their fundamental role in controlling the assembly and activit

51 , plants, fungi and cyanobacteria and play a fundamental role in coordinating the homeostasis and beh

52 by the EMT inducers Snail1 and Zeb2 plays a fundamental role in defining embryonic territories in th

53 in different subcellular compartments play a fundamental role in determining FUS protein architecture

54 We show that the support plays a fundamental role in determining Ga nanoparticle phases,

55 s well as trans acting signals have played a fundamental role in determining NDE1 species specific sp

56 POINTS: Voltage-gated sodium channels play a fundamental role in determining neuronal excitability.

57 ipid and phosphorus storage compounds play a fundamental role in determining the marine biogeochemica

58 orientation of the organic molecules plays a fundamental role in determining the material electronic

59 y constrained, geometrical properties play a fundamental role in determining the network's behaviour,

60 MicroRNAs (miRNAs) have a fundamental role in diabetic heart failure.

61 d emergent lamellae and, we propose, plays a fundamental role in dictating the orientation of collage

62 tochromes of different families, and plays a fundamental role in diverse cellular processes involving

63 activity of nigral dopamine neurons plays a fundamental role in dopaminergic signaling.

64 ies") [1, 2] suggests that they might play a fundamental role in driving the movements and functionin

65 Breast milk (BM) is a biofluid that has a fundamental role in early life nutrition and has direct

66 Tumor cell migration has a fundamental role in early steps of metastasis, the fatal

67 ction (HER) is a critical process due to its fundamental role in electrocatalysis.

68 e regulation of synaptic homeostasis plays a fundamental role in ensuring normal and stable synaptic

69 he medial temporal lobe (MTL), which plays a fundamental role in episodic memory formation?

70 at carrier electrostatic interactions play a fundamental role in establishing dimensional crossover.

71 tness effects (DFE) of new mutations plays a fundamental role in evolutionary genetics.

72 Transparent conducting electrodes play a fundamental role in far-field PhotoVoltaic systems, but

73 ransporter KCC2, encoded by SLC12A5, plays a fundamental role in fast synaptic inhibition by maintain

74 Nutrition plays a fundamental role in fetal growth and birth outcomes.

75 Chromatin accessibility plays a fundamental role in gene regulation.

76 secretion from enteroendocrine cells plays a fundamental role in glucose homeostasis and could be tar

77 rain large portions of ice sheets and play a fundamental role in governing their response to atmosphe

78 Despite a fundamental role in health and disease, the direct quant

79 and cardiomyocyte regeneration, owing to its fundamental role in heart development and its potential

80 Mitochondria not only play a fundamental role in heart physiology but are also key ef

81 ipose tissue bridges body organs and plays a fundamental role in host metabolism.

82 that these cytokines play a broader and more fundamental role in host responses to infections beyond

83 protein-protein interactions, likely play a fundamental role in host-virus interactions.

84 ersity and increasingly recognized to have a fundamental role in human health.

85 ng immunomodulatory signals, may play a role fundamental role in immune homeostasis.

86 lular degradative pathway of autophagy has a fundamental role in immunity.

87 FoxP3(+) T regulatory (Treg) cells have a fundamental role in immunological tolerance, with transc

88 ocytes of the first-trimester decidua play a fundamental role in implantation and early development o

89 a component of the SWI/SNF complex, plays a fundamental role in induction by 1,25-dihydroxyvitamin D

90 er (Cu), an essential micronutrient, plays a fundamental role in inflammation and angiogenesis; howev

91 Neutrophils have a fundamental role in inflammatory responses and their con

92 , data indicate that biotype does not play a fundamental role in influencing alveolar BT, whereas oth

93 Macrophages play a fundamental role in innate immunity and the pathogenesis

94 We show that particularly Munc13-2 plays a fundamental role in LDCV exocytosis, but in contrast to

95 opment of cognitive enhancers because of its fundamental role in learning and memory.

96 op-down control of striatal activity plays a fundamental role in linking commitment-induced generosit

97 ctor (IGF)-1 signaling pathway (ISP) plays a fundamental role in long term health in a range of organ

98 iving biomass in the world oceans and play a fundamental role in maintaining life on our planet.

99 The endothelium plays a fundamental role in maintaining vascular homeostasis by

100 N-Glycosylation plays a fundamental role in many biological processes.

101 RNA dynamics play a fundamental role in many cellular functions.

102 Given that autophagy has a fundamental role in many essential cellular functions, i

103 Recombination plays a fundamental role in meiosis, ensuring the proper segrega

104 r clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the

105 ese data demonstrate that sleep plays a more fundamental role in modulating behavioral plasticity tha

106 s a tumor suppressor, which not only plays a fundamental role in modulation of ECM integrity, but als

107 Epistatic interactions play a fundamental role in molecular evolution, but little is k

108 t microtubule (MT) growing ends, which has a fundamental role in MT polymerisation.

109 an activated myofibroblast state and play a fundamental role in myocardial fibrosis and remodeling.

110 mutations provide evidence that RIP plays a fundamental role in normal bone development.

111 ent chromatin-remodeling enzyme Snf2 plays a fundamental role in nucleosome repositioning and the exp

112 s9 genome editing to show that optix plays a fundamental role in nymphalid butterfly wing pattern dev

113 plied that rhythmic activity patterns play a fundamental role in odor coding.

114 Medical imaging plays a fundamental role in oncology and drug development, by pr

115 Categorization plays a fundamental role in organizing daily interactions with t

116 Cortical oscillations play a fundamental role in organizing large-scale functional br

117 Cellular potassium import systems play a fundamental role in osmoregulation, pH homeostasis and m

118 gether, we show that object tracking plays a fundamental role in perception of visual motion and posi

119 We conclude that botanic gardens play a fundamental role in plant conservation, but identify act

120 Glutathione (GSH) plays a fundamental role in plant defense-signaling network.

121 Abscisic acid (ABA) plays a fundamental role in plant response and adaptation to abi

122 Myelinating glia play a fundamental role in promoting the maturation of the axon

123 hese results suggest that osteoblasts play a fundamental role in propagating leukemia in the marrow a

124 Shelterin, a six-protein complex, plays a fundamental role in protecting both the length and the s

125 The OM plays a fundamental role in protecting Gram-negative bacteria fr

126 ne cathelicidin, induced by infection, has a fundamental role in protection against disease in vivo p

127 one marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for int

128 This complex plays a fundamental role in regulating cellular differentiation

129 dies show that nutrient availability plays a fundamental role in regulating CO2 exchange between the

130 Recent studies have shown that KLFs play a fundamental role in regulating diverse biological proces

131 Glucose (Glc) plays a fundamental role in regulating lateral root (LR) develop

132 xidase and eosinophil peroxidase, may play a fundamental role in regulating the recruitment of fibrob

133 Pre-mRNA splicing factors play a fundamental role in regulating transcript diversity both

134 n of cancer stem-like cells, and also play a fundamental role in regulating tumor heterogeneity, tumo

135 to the known chromatin modifications, play a fundamental role in regulating V(D)J recombination.

136 expressed in embryonic stem cells and has a fundamental role in regulation of development, glucose m

137 lts suggest that RNA chaperones might play a fundamental role in RNA evolution and evolvability.

138 The spliceosome plays a fundamental role in RNA metabolism by facilitating pre-R

139 mportant in photosynthetic cells but plays a fundamental role in roots and in heterotrophic cells of

140 e results suggest that PPO plays a novel and fundamental role in secondary metabolism and acts as an

141 Attention plays a fundamental role in selectively processing stimuli in ou

142 intraparietal area (LIP) of macaques plays a fundamental role in sensorimotor decision-making.

143 have demonstrated that EPAC proteins play a fundamental role in several physiological and pathophysi

144 uts from the hippocampus and amygdala play a fundamental role in shaping the activity of both NAcc D1

145 The genotype-fitness map plays a fundamental role in shaping the dynamics of evolution.

146 d we propose ways these kinases could play a fundamental role in skeletal muscle mechanotransduction.

147 in ligand TPD1 (TAPETUM DETERMINANT1) play a fundamental role in somatic and reproductive cell differ

148 SIS RECEPTOR-LIKE KINASE (SERK) gene plays a fundamental role in somatic embryogenesis of angiosperms

149 racellular matrix (ECM) proteins that play a fundamental role in supporting the structure of various

150 gic synapses, NMDA receptors (NMDARs) have a fundamental role in synaptogenesis, synaptic plasticity,

151 ARP1) as a key novel target of mTORC1 with a fundamental role in terminal oligopyrimidine (TOP) mRNA

152 e ERM family (ezrin, moesin, radixin) play a fundamental role in tethering the membrane to the cellul

153 expansion of regulatory T (Treg) cells has a fundamental role in the achievement of immunological tol

154 inic acetylcholine receptors (nAChRs) play a fundamental role in the attentional circuitry throughout

155 Dissolved organic carbon (DOC) plays a fundamental role in the biogeochemistry of glacier ecosy

156 al properties--and are also likely to play a fundamental role in the biology of the lipid.

157 aques and intracellular tangles as playing a fundamental role in the course and progression of the di

158 Defects in epigenetic regulation play a fundamental role in the development of cancer, and epige

159 s one species-expected stimulus that plays a fundamental role in the development of emotion neurocirc

160 ld with a two-level system, and has played a fundamental role in the development of quantum optics an

161 on of Earth's continental crust has played a fundamental role in the development of the planet.

162 Radiological imaging plays a fundamental role in the diagnosis and monitoring of rheu

163 In spite of their usefulness and fundamental role in the diagnosis, X-ray still remains a

164 These plasmas play a fundamental role in the dynamics of ultra-massive astrop

165 hat may explain how the capsid protein has a fundamental role in the early part of the viral lifecycl

166 Bacterial symbiosis has played a fundamental role in the evolution of eukaryotes.

167 ical and chemical systems, where they play a fundamental role in the exchange of substances at the ce

168 forward in our analysis on the basis of its fundamental role in the function and dynamic regulation

169 Thus, they have the potential to play a fundamental role in the future of nanoelectronics, optoe

170 Macrophages play a fundamental role in the immune system by engulfing forei

171 been defined in dendritic cells and plays a fundamental role in the induction of CD8(+) T cell immun

172 The microbiota plays a fundamental role in the induction, education, and functi

173 polyunsaturated fatty acids (PUFAs), have a fundamental role in the initiation and signaling of the

174 novel transcriptional regulator that plays a fundamental role in the orchestrated cellular response t

175 that the lung inflammatory response plays a fundamental role in the outcome of RSV infection.

176 Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatiti

177 ce and increased neurotoxic cytokines have a fundamental role in the phenotype and treatment of certa

178 a indicate that DEG/ENaC ion channels play a fundamental role in the postsynaptic regulation of excit

179 asing evidence suggests that the CNS plays a fundamental role in the predisposition to develop differ

180 et sites in the central nervous system has a fundamental role in the regulation of energy homeostasis

181 me, such as protein phosphorylation, plays a fundamental role in the regulation of stemness and diffe

182 genome structures such as local loops play a fundamental role in the regulation of transcription, alt

183 crotubules organized by centrosomes - play a fundamental role in the spatial coordination of animal c

184 Electrostatic interactions play a fundamental role in the structure and function of protei

185 disease have now shown that platelets play a fundamental role in the tissue recruitment of leucocytes

186 nsient structure, so-called channel, plays a fundamental role in the transition.

187 The atmosphere plays a fundamental role in the transport of microbes across the

188 ersification to yield a system that exerts a fundamental role in the unique biology of Chlamydia spec

189 cies and electron-phonon interaction plays a fundamental role in their dynamics.

190 ptical emissivity of these compounds plays a fundamental role in their heat balance.

191 ical methods and computational models play a fundamental role in this difficult task, as they allow t

192 ects midway into the synaptic cleft, plays a fundamental role in this process.

193 ion with regulatory T (Treg) cells playing a fundamental role in this process.

194 While mitochondrial morphology plays a fundamental role in tissue development and homeostasis,

195 ective migration of eukaryotic cells plays a fundamental role in tissue growth, wound healing and imm

196 Despite their fundamental role in tissue morphogenesis and tissue home

197 ticity induced by innate immunity may play a fundamental role in transdifferentiation during wound he

198 ze stabilization reflexes, emphasizing their fundamental role in transforming sensory information int

199 s remains inadequate even though they take a fundamental role in transport properties.

200 ll4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesi

201 edators, and pollinators, Hymenoptera play a fundamental role in virtually all terrestrial ecosystems

202 in the lateral hypothalamic area and plays a fundamental role in wakefulness and arousal.

203 it binds DNA and actin--two biopolymers with fundamental roles in almost all biological processes.

204 otein (RNP) granules are ubiquitous and have fundamental roles in biology and RNA metabolism, but the

205 Neutrophils play fundamental roles in both acute and chronic inflammatory

206 protein-DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bac

207 Precise control of gene expression plays fundamental roles in brain development, but the roles of

208 y is a regulated self-digestion pathway with fundamental roles in cell homeostasis and diseases.

209 olases are a diverse enzyme class that plays fundamental roles in CNS metabolism and signaling.

210 egulator of cellular metabolism and also has fundamental roles in controlling immune responses.

211 Epigenetic modifiers have fundamental roles in defining unique cellular identity t

212 and local ice shelf and seabed geometry play fundamental roles in determining the response of the Ant

213 Additionally, p53 has fundamental roles in differentiation and development; ne

214 The Notch signaling pathway plays fundamental roles in diverse developmental processes.

215 lmost every aspect of cellular life and have fundamental roles in DNA repair, transcription, heat sho

216 Rotary ATPases play fundamental roles in energy conversion as their catalyti

217 Mutations play fundamental roles in evolution by introducing diversity

218 ually every species and every cell, and play fundamental roles in functions ranging from metabolism t

219 relative size of daughter cells should play fundamental roles in gametogenesis and embryogenesis.

220 t chromatin-remodeling complex that performs fundamental roles in gene regulation, cell lineage speci

221 mplifying, yet tightly regulated system with fundamental roles in immune surveillance and clearance.

222 Epigenetic inheritance mechanisms play fundamental roles in maintaining cellular memory of gene

223 ome to trillions of microorganisms that have fundamental roles in many aspects of human biology, incl

224 translational modifications of histones play fundamental roles in many biological functions.

225 modifications are epigenetic marks that play fundamental roles in many biological processes including

226 annels, both ligand- and voltage-gated, play fundamental roles in many physiologic processes.

227 RNA helicases play fundamental roles in modulating RNA structures and facil

228 tely dividing NG2(+) pericytes and glia play fundamental roles in post-SCI tissue remodeling.SIGNIFIC

229 These biophysical interactions play fundamental roles in processes ranging from cellular dev

230 that is activated by anabolic signals, plays fundamental roles in regulating lipid biosynthesis and m

231 co/endoplasmic reticulum Ca(2+) -ATPase play fundamental roles in regulation of ion transport in vert

232 it became gradually apparent that they play fundamental roles in regulation of physiological functio

233 orophyll, heme, and bacteriochlorophyll play fundamental roles in the energy absorption and transduct

234 amics and flexibility of cell membranes play fundamental roles in the functions of the cells, i.e., s

235 Lipids have fundamental roles in the structure, energetics, and sign

236 nes encode mainly transcription factors with fundamental roles in tissue specification.

237 her, graviperception and reaction woods play fundamental roles in tree architecture, posture control,

238 Its fundamental role is to maintain cellular homeostasis and

239 Its fundamental role is to package the genome in a sufficien

240 Despite their fundamental role, little is known about the intracellula

241 Due to this fundamental role, mutations in PCNA that profoundly impa

242 eptor (delta-OR), revealing the presence and fundamental role of a sodium ion in mediating allosteric

243 This new and unexpected insight into the fundamental role of a zinc transporter in mammalian pulm

244 Our findings provide strong evidence for the fundamental role of AIRE and pGE, namely, central tolera

245 The fundamental role of AOX in metabolizing xenobiotics is a

246 The fundamental role of bacterial TBDR in nutrient uptake mo

247 Our analyses reveal not only the fundamental role of CBL1 in the adjustment of central tr

248 Our findings demonstrate a fundamental role of CNS CD11c(+) cells in the attraction

249 tute a definitive account, demonstrating the fundamental role of cPLA2alpha to eicosanoid formation a

250 Despite the fundamental role of CTC within the metastatic cascade, t

251 Altogether, our results suggest a fundamental role of dendritic spines in shaping Cl(-) di

252 These results testify to a fundamental role of detritus channels specifically and m

253 etic flexibly in U. bilobatum highlights the fundamental role of ecological pressures on integrative

254 latory networks to date, and illustrates the fundamental role of enhancers in controlling patterning,

255 Despite the fundamental role of fertilization, the basic mechanisms

256 This review examines the fundamental role of glia in the regulation of glutamate,

257 n together, the presented data demonstrate a fundamental role of inner envelope KEA1 and KEA2 and thy

258 s are peculiar conducting systems, where the fundamental role of interactions leads to exotic, emerge

259 ailed kinetic investigations demonstrate the fundamental role of kinetic parameters in the expression

260 In this Review, we discuss the fundamental role of mechanical interactions between cell

261 These findings identify a fundamental role of miR-144-3p in the rescue of impaired

262 Our study reveals the fundamental role of mRNA secondary structures in gene ex

263 Junction sequence analysis suggested fundamental role of nonhomologous end joining mechanism

264 ion of deadenylated mRNAs and demonstrates a fundamental role of oligo-U-tail as a molecular mark for

265 yeast, and zebrafish models to elucidate the fundamental role of PYROXD1 in skeletal muscle.

266 echanics in a quantum state and observed the fundamental role of quantum entanglement in facilitating

267 These findings support the fundamental role of remote sensing as an effective lens

268 Here, we discovered a fundamental role of S-phase protein kinase 2 (Skp2) in t

269 eric nervous system during inflammation, the fundamental role of serotonin (5-HT) in enteric neuroimm

270 GFbeta, but the mechanisms that regulate the fundamental role of SnoN in TGFbeta-induced EMT are not

271 One fundamental role of sperm is to activate the oocyte at f

272 As the evidence indicating the fundamental role of such processes in thermosensation bu

273 of ocular neovascularization and indicate a fundamental role of TGF-beta signaling in the pathogenes

274 The fundamental role of the brain-specific myelin transcript

275 This work highlights the fundamental role of the DeltamAFM in the exchange bias a

276 By studying FePt, we unravel the fundamental role of the electronic structure.

277 Our results reveal a fundamental role of the external pore in the allosteric

278 A fundamental role of the Hsp90 chaperone in regulating fu

279 rent concepts of human sociality highlight a fundamental role of the hypothalamic peptide oxytocin (O

280 g research over the past decade identified a fundamental role of the intestinal microbiome on human h

281 This review will discuss the fundamental role of the matrix in cardiac development, h

282 in an HCV nonstructural protein and reveal a fundamental role of the NS4A TM domain in coordinating H

283 Given the fundamental role of Toll-like receptors (TLRs) and compl

284 ced ant genomes and its structure suggests a fundamental role of transposable elements (TEs) in adapt

285 key autoimmune disease phenomena such as the fundamental roles of innate immunity, sex differences in

286 and their impact on our understanding of the fundamental roles of metabolism in cellular physiology.

287 In this article, we summarize the fundamental roles of microRNAs (miRNAs) in the regulatio

288 f mammalian heart regeneration and highlight fundamental roles of the extracellular matrix in cardiac

289 lm microstructural analysis demonstrates the fundamental roles of the pi-conjugated core fluorocarbon

290 s, blogs, social network platforms, - play a fundamental role on the evolution of the public opinion.

291 The microbiota plays a fundamental role on the induction, training, and functio

292 Besides the fundamental role played by chemokines and their receptor

293 ngineering of nanomaterials, focusing on the fundamental role played by surface chemistry in controll

294 nal bonds taking into account the increasing fundamental role played by the surface).

295 cal environment remains limited, despite the fundamental role soil physical structure plays in ensuri

296 This work provides an insight into the fundamental role that membrane-mediated ion-channel coop

297 e review mounting evidence demonstrating the fundamental role that white matter connections play in c

298 The fundamental roles that the stomach plays in ingestion an

299 dinated) as the active sites and attribute a fundamental role to external (and flexible) oxygenated l

300 findings suggest that the hypothalamus has a fundamental role, via hypothalamic microinflammation, in