ライフサイエンスコーパス: fundamentally

1 Sickle cell disease is fundamentally a kinetic disorder, in which cells contain

2 large number of possible odors, demixing is fundamentally a probabilistic inference task.

3 The associated force - fundamentally, a quantum mechanical aspect of light - is

4 recognition behavior of the LWYIK motif is, fundamentally, a surface phenomenon but that partial pen

5 The structure of PtmT2 fundamentally advances the knowledge of bacterial TSs, t

6 ced the appearance of the masses but did not fundamentally affect stress-relaxation behaviour.

7 ng phytoplankton productivity is expected to fundamentally alter marine ecosystems as warming and fre

8 h with humans has suggested that live models fundamentally alter memory, not low-level attention.

9 bations in disease transmission patterns can fundamentally alter the regularity and spatiotemporal co

10 mal microRNAs in particular can potently and fundamentally alter the transcriptome of recipient cells

11 tial implications of anthropogenic change to fundamentally alter these processes.

12 Highly strained germanium with its fundamentally altered bandstructure has emerged as a pot

13 s by automated DNA and peptide synthesis has fundamentally altered biological research and medical pr

14 Condensin depletion also fundamentally altered chromosome arrangement in the poly

15 ulation of excitatory synaptic plasticity is fundamentally altered in PE animals.

16 This community-wide tropicalization fundamentally altered key ecological processes, suppress

17 Superresolution microscopy has fundamentally altered our ability to resolve subcellular

18 ridine thus modulated the system's behavior, fundamentally altering its response to the subsequent si

19 pacts on subsequent DP cell differentiation, fundamentally altering the potential of thymocyte progen

20 We find that PSF fundamentally alters the electrostatic environment withi

21 xygen substitution in the glycosidic linkage fundamentally alters the energetically accessible confor

22 we demonstrate that interfacial confinement fundamentally alters the energetics of cation-pi-mediate

23 the relationship and in the profession, and fundamentally alters the medical profession's role in so

24 the disease and has demonstrated that it is fundamentally an immunologic process that ultimately res

25 show multistepped transitions, targeted both fundamentally and for expanded data storage applications

26 A fundamentally and practically important question in this

27 Understanding vortex dynamics is fundamentally and technologically important, and the com

28 gulating leaf cuticle formation: one that is fundamentally associated with leaf expansion, independen

29 nt of affected patients and their relatives, fundamentally, based on the GIST genotype.

30 and behavior further suggests that DOCs can fundamentally be understood as pathological neuroenerget

31 and clitoris representations in line with a fundamentally bi-sexual layout [16] of the vertebrate br

32 In addition, the model fundamentally breaks the defense of modern text-based CA

33 Here we propose a device concept that fundamentally breaks this paradigm-the sensors remain do

34 The Langevin equation is, however, changed fundamentally by the smallest of multiplicative noises.

35 Fundamentally, cardiovascular MR can improve diagnosis o

36 Chronic GVHD is fundamentally caused by replacement of the host's immune

37 next-generation sequencing (NGS) studies are fundamentally challenging due to the presence of a very

38 This requirement is fundamentally challenging for airborne acoustics because

39 Cooperation, although widespread, is fundamentally challenging to explain evolutionarily, sin

40 This approach has the potential to fundamentally change clinical proteomics and personalize

41 medical care, and they have the potential to fundamentally change our approach to global health.

42 xpansion in scientific interest and may well fundamentally change our understanding of how viral repl

43 , P. australis invasion into a wetland could fundamentally change SOM dynamics and lead to the loss o

44 These delays can fundamentally change the dynamics of the virus at the ep

45 and how these factors are accounted for can fundamentally change the predicted impact of a spreading

46 nication bottleneck and has the potential to fundamentally change the way we interact with technology

47 resulting proliferation of primary producers fundamentally changed global ecology.

48 panied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes

49 f induced pluripotent stem cells (iPSCs) has fundamentally changed our view on developmental cell-fat

50 Integration of SSRS has fundamentally changed the indications for and type of su

51 While genomic research has fundamentally changed the way many specimens are collect

52 Therefore, the quantum nature of the proton fundamentally changes the superconducting phase diagram

53 The law fundamentally changes the way that health care providers

54 he effects, for example, charged lipids, and fundamentally changing the structures obtained.

55 Fundamentally, collective behavior must arise from the a

56 However, the observed ribosome profile is fundamentally confounded by transcriptional activity.

57 Because the m(6)A methylation machinery is fundamentally conserved throughout eukaryotes, our findi

58 anism of how Spt5/NGN promotes elongation is fundamentally conserved; however, the eukaryotic specifi

59 Mitotic precision fundamentally contributes to cell fate specification, ti

60 th remarkable mechanical properties that are fundamentally controlled by designing connectivity into

61 predicts that the directional anisotropy is fundamentally controlled by the bulk rock mineral geomet

62 eformation and magma reservoir evolution are fundamentally controlled by three-dimensional thermomech

63 formation sharing and memory updating, which fundamentally depends on communication.

64 ic and structural properties of nanocrystals fundamentally derive from crystal phase.

65 Here, we present fundamentally derived equations that reproduce the time

66 manipulation of polarization was found to be fundamentally determined by the microscopic origin in a

67 matter, as responses to climate change could fundamentally differ depending on the contributions of l

68 of deep-sea (2,000-6,500 m) species richness fundamentally differ from those found in coastal (0-20 m

69 S) and complex spike (CS) discharge, the two fundamentally different activity modalities of Purkinje

70 utput of the cerebellar cortex, manifest two fundamentally different activity modalities, complex spi

71 This is a fundamentally different approach because it accounts for

72 en together, these transformations provide a fundamentally different approach to azetidine synthesis

73 The spiraling cost of new drugs mandates a fundamentally different approach to keep lifesaving ther

74 Here a fundamentally different approach to produce nanopores in

75 rotein-binding and activation mechanisms are fundamentally different between GBA proteins and GPCRs,

76 een AF variants and ECG measurements suggest fundamentally different categories of mechanisms contrib

77 inhomogeneous concentrations that may afford fundamentally different chemical behavior compared to th

78 apical and basal cochlear regions to address fundamentally different coding deficits.

79 found to be anomalous, in the sense of being fundamentally different from conventional Brownian motio

80 le demonstrate that embryonic stem cells are fundamentally different from differentiated somatic cell

81 lectron solvation and delocalization that is fundamentally different from either of the constituent s

82 These pediatric low-grade gliomas (LGGs) are fundamentally different from IDH-mutant LGGs occurring i

83 que function to polyvinylpyrrolidone that is fundamentally different from its widely accepted role as

84 itioned stimulus (US) is often assumed to be fundamentally different from learning fear via instructi

85 Active subsidies are fundamentally different from passive subsidies, because

86 Tfh cells may be stingy cytokine producers, fundamentally different from Th1 or Th17 cells in the qu

87 otein (PrP) fibrils with structures that are fundamentally different from that of authentic PrP scrap

88 l chromatin organization of zygote nuclei is fundamentally different from that of other interphase ce

89 calculations, we discuss mechanisms that are fundamentally different from the conventional scheme and

90 ate that the stepping mechanism of dynein is fundamentally different from the stepping mechanisms of

91 As a result, modern marine ecosystems are fundamentally different from those in the distant past.

92 These results suggest fundamentally different functions of FSIs and LTSIs in s

93 nscriptome analysis showed that they possess fundamentally different gene expression profiles related

94 Our previous results show that a fundamentally different genetic variant, i.e., lifetime-

95 Engineering as a field has fundamentally different goals than biology, but the pers

96 sses involved in prolonged torpor may have a fundamentally different impact on memory in mammals and

97 lts show that the immune cell composition is fundamentally different in lung adenocarcinoma as compar

98 This superconducting exchange interaction is fundamentally different in origin from the various excha

99 s, quantum dots, colour centres or atoms are fundamentally different in their frequencies and bandwid

100 g of the drivers of population declines, and fundamentally different management actions to restore po

101 phic organic device (ENODe) operating with a fundamentally different mechanism from existing memristo

102 -BM3, leading to the same Kemp product via a fundamentally different mechanism.

103 In the cell membrane, a variety of fundamentally different mechanisms drive membrane protei

104 xplore whether these two patterns arise from fundamentally different mechanisms.

105 Here we present a fundamentally different method for producing narrow-band

106 own as multivariable sensors, emerged with a fundamentally different perspective for sensing to elimi

107 by distinct enzymatic pathways, which impart fundamentally different physiologic and pathophysiologic

108 ted aging of the brain, or is it caused by a fundamentally different process?

109 imals consume plants; but the term hides two fundamentally different processes.

110 ination and extinction rates are governed by fundamentally different processes: originations depend o

111 es iron-centered redox chemistry, leading to fundamentally different properties than corresponding lo

112 This represents a fundamentally different proposition in MacEtch whereby s

113 wever, FVIII and the bispecific antibody are fundamentally different proteins and subject to differen

114 es and disordered media models, suggesting a fundamentally different relation between disorder and ma

115 However, Firmicutes have a fundamentally different set of ribonucleases for mRNA de

116 ing trimming at the proteasome, tetraUb is a fundamentally different signal than shorter chains, and

117 that the lattice vibrations of Mg(OH)2 have fundamentally different signature peaks and dimensionali

118 This provides a fundamentally different strategy to circumvent multiple

119 f NRGs with distinct membrane topologies and fundamentally different targeting and processing propert

120 is confirmed that diet in the urban area was fundamentally different than in the other sites.

121 ences memory accuracy during encoding with a fundamentally different time-course than top-down reward

122 near molecular motors that operate through a fundamentally different type of mechanism.

123 ess results in a rich phase diagram with two fundamentally different types of percolation transitions

124 thus may contribute to heat conduction in a fundamentally different way than is described by the PGM

125 cells; however, iNKT TCRs recognize Ags in a fundamentally different way.

126 ual-pass NRGs regulate neuronal functions in fundamentally different ways.

127 tions in different amniotes were resolved in fundamentally different ways.

128 n boiling of two fluids FC-72 and water with fundamentally different wicking characteristics.

129 Although SHM and CSR are fundamentally different, their independent roles in regu

130 Our approach is fundamentally different.

131 e the enjoyment of sadness and horror may be fundamentally different.

132 of the bacteria to the two nanomaterials was fundamentally different.

133 these two adult axonal growth processes are fundamentally different.

134 The observed molecular recognition fundamentally differs from canonical promiscuous chapero

135 iosynthesis in C. acuminata is proposed that fundamentally differs from previously studied MIA pathwa

136 We ask: (1) Is task allocation fundamentally difficult, and thus costly?

137 translocation through intestinal barriers, a fundamentally distant yet important clinical phenomenon.

138 This work reveals a fundamentally distinct enantiomerization pathway availab

139 ieving anisotropic growth makes our approach fundamentally distinct from others.

140 les using a non-competitive approach that is fundamentally distinct from popular enrichment-based met

141 LCs and T cells indicate that lymphocytes of fundamentally distinct lineages can share core "immune m

142 Our findings demonstrate that two fundamentally distinct roles of context in fear memory r

143 inside eukaryotic cells, forming pools that fundamentally drive microtubule dynamics.

144 To fundamentally elucidate the functions of TSPO, we first

145 This observation fundamentally expands the known range of gas-transport s

146 Uranyl polyoxometalate clusters are both fundamentally fascinating and potentially relevant to nu

147 ficiencies of off-the-shelf technologies are fundamentally flawed and inaccurate for the operating co

148 s and offering alternative cover stories are fundamentally flawed because they introduce new forms of

149 l IRE method and the NanoKnife System differ fundamentally from established ablations techniques, esp

150 suggested that spin polarization originates fundamentally from local atomic site asymmetries and the

151 Transport differs fundamentally from previous tunneling and hopping mechan

152 Charge transport in these materials differs fundamentally from that in crystalline semiconductors ow

153 olocene plant and animal assemblages differs fundamentally from that of assemblages over the past 300

154 entional minus-end-directed motility differs fundamentally from that of plus-end-directed stepping.

155 reactions of supported oxides, which differs fundamentally from the reduction of bulk or isolated oxi

156 for a ping-pong mechanism of PglC, differing fundamentally from the ternary complex mechanisms of rep

157 Fundamentally, gene regulation is linked to the flow of

158 mmendations presented and discussed here are fundamentally grounded in the understanding that, when p

159 ional tissues within microfluidic devices is fundamentally hindered by intratissue optical scattering

160 We also demonstrate that taxon choice can fundamentally impact tree topology and clade support in

161 This study addresses a fundamentally important and widely debated issue in the

162 niversal properties of topological phases is fundamentally important because these signatures are rob

163 ns with ssDNA binding proteins (SSBs) during fundamentally important biological processes including D

164 Amines are a fundamentally important class of biologically active com

165 The fundamentally important fluorescent imaging has one majo

166 step in homologous recombination, a process fundamentally important for accurate repair of damaged c

167 Hedgehog (Hh) signaling is fundamentally important for development and adult tissue

168 l translational regulatory mechanism that is fundamentally important for germline development.

169 APs when they reach each of the synapses are fundamentally important for information processing in th

170 ls triglyceride secretion is unknown, but is fundamentally important for lipid and energy homeostasis

171 t Lef1 regulates circuit development that is fundamentally important for mediating anxiety in a wide

172 es the global overturning circulation and is fundamentally important for oceanic uptake of carbon and

173 citability through tonic inhibition, and are fundamentally important for processes such as plasticity

174 RNA structures are fundamentally important for RNA function.

175 fication of microRNA (miRNA) target sites is fundamentally important for studying gene regulation.

176 The understanding of EOF hysteresis is fundamentally important for the accurate prediction of a

177 ge and differentiation state of each cell is fundamentally important for the ultimate delineation of

178 t of the cerebral vascular tree is novel and fundamentally important for understanding how regulation

179 w cell division orientation is determined is fundamentally important for understanding tissue and org

180 aging and avoidance of predators and is thus fundamentally important in adaptation, fitness, and surv

181 actions between oxygen and gold surfaces are fundamentally important in diverse areas of science and

182 differentiating represents a process that is fundamentally important in skeletal myogenesis.

183 in size, grain orientations and texture) are fundamentally important in understanding the cyclic crac

184 definitive thrombopoiesis, establishing that fundamentally important modifier loci remain unelucidate

185 results suggest that live bearing has been a fundamentally important precursor in the evolutionary or

186 s in vitro, providing key insights into this fundamentally important process.

187 apable of mediating a rarely encountered but fundamentally important reaction: beta-alkyl elimination

188 We expect that our dataset will serve as a fundamentally important resource for muscle biologists,

189 oil bodies and chloroplasts, highlighting a fundamentally important role for organelle interactions

190 est that gene activation and repression play fundamentally important roles in structuring the genome

191 These fundamentally important species and their conjugate acid

192 he microbiota in PSC etiopathogenesis may be fundamentally important, yet remains obscure.

193 tion of protein conformation and dynamics is fundamentally important.

194 These results fundamentally improve our understanding of the processes

195 n a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac deve

196 Here, we show theoretically that fundamentally in any excitable medium a region with a pr

197 Because they participate fundamentally in the predisposition to SAM, they have in

198 ays, visual representations may still differ fundamentally in the two pathways.

199 pathways, the two pathways may still differ fundamentally in their roles in visual information repre

200 combinations for which the OECD 308 test is fundamentally inappropriate.

201 ench pathway in phase-change memory involves fundamentally inefficient energy conversion events; and

202 nally hard problems wherein this paradigm is fundamentally inefficient.

203 l nuclear structure and which is expected to fundamentally influence nuclear function.

204 The results of these studies are fundamentally influenced by these supporting structures.

205 es substantially across the human genome and fundamentally influences evolution and incidence of gene

206 ization induced by ultrafast laser pulses is fundamentally interesting and promises unprecedented spe

207 ral aesthetics and intriguing properties are fundamentally interesting.

208 Autophagy is fundamentally involved in cell degradation, but there is

209 The insular cortex is fundamentally involved in the processing of interoceptiv

210 ationic disorder and associated band tailing fundamentally limit device performance.

211 henomena, but their geometry and reciprocity fundamentally limit the integration of optical devices.

212 owever, the energy dissipation pathways that fundamentally limit the performance of these systems is

213 g with the emission spectrum, which together fundamentally limit their effective usage.

214 f nonlinear silicon photonic devices remains fundamentally limited at the telecom wavelength region d

215 f low-abundance proteins using antibodies is fundamentally limited by binding kinetic rates.

216 on through a sub-wavelength size aperture is fundamentally limited by the wave nature of light.

217 providing necessary spatial resolution, are fundamentally limited in data acquisition rates and ener

218 This fundamentally limits their packing density.

219 onalize the squares of the frequencies to be fundamentally linear in their scaling across transition

220 organs) of the genitourinary (GU) system are fundamentally linked by the developmental origin of mult

221 at virus induced membrane rearrangements are fundamentally linked to the viral replicative machinery.

222 t a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining th

223 ave been treated independently, but they are fundamentally linked.

224 ns, assuming that perception and control are fundamentally linked.

225 RNA-ligand interaction, kinetic effects pose fundamentally more challenging problems due to the enorm

226 A fundamentally more powerful prospect is that such quantu

227 act, we show that the multiplex structure is fundamentally more powerful than individual layers in pr

228 o tissues in the body is key to implementing fundamentally new and potentially transformative strateg

229 to inhibit cells selectively, illustrates a fundamentally new approach for controlling the fate of c

230 estions in membrane biology and illustrate a fundamentally new approach for systematic in vivo invest

231 As a fundamentally new approach to bioconjugation this method

232 A fundamentally new approach to determine these critical c

233 Here we present a fundamentally new approach to dynamic elastography using

234 c shifts is specific to isomers, providing a fundamentally new approach to the characterization of ch

235 The development of fundamentally new approaches for lignin depolymerization

236 well below the diffraction barrier bringing fundamentally new capabilities to biochemical sensing, s

237 and transition-metal catalysis gives rise to fundamentally new cooperative reactivity and enables the

238 ularly interesting owing to the emergence of fundamentally new excitations such as Majorana fermions.

239 We present here a fundamentally new method of optical read-out of the trap

240 dous diversity observed in nature, there are fundamentally new modes of interaction to be discovered

241 sult in primary phenotypes, thus providing a fundamentally new molecular approach for controlling cel

242 They reveal a fundamentally new property of the radical pair-based mag

243 unique conformations of the GPCR that afford fundamentally new receptors, capable of novel pharmacolo

244 Reversible structural dynamics indicate a fundamentally new role for inhibitory synaptic remodelin

245 The data demonstrate fundamentally new roles of TMEM16A in differentiated epi

246 A fundamentally new working principle into the field of se

247 Together, our studies suggest that fundamentally non-linear computations enable social cont

248 The trend relies on a fundamentally nonlinear dynamo process and is compatible

249 Three distantly related, fundamentally nonphotosynthetic dinoflagellates, Noctilu

250 h flexible, multi-spectral optical response, fundamentally not achievable using periodic architecture

251 We describe a fundamentally novel feat of animal genetic engineering:

252 thus our ability to study evolution depends fundamentally on having precise measurements of mutation

253 ional genomic and epigenomic research relies fundamentally on sequencing based methods like ChIP-seq

254 e of a phenotypically plastic allele depends fundamentally on the environmental regime.

255 The microbiome is fundamentally one of the most unique organs in the human

256 ansitions] light-sheet (LS) nanoscope, which fundamentally overcomes the diffraction barrier in the a

257 In this issue, Kvainickas et al. fundamentally question the current retromer model and de

258 This finding fundamentally redefines what is known about the natural

259 gher eukaryotes, Plasmodium parasites have a fundamentally reduced unfolded protein response machiner

260 Here, we introduce MINFIELD, a strategy for fundamentally reducing bleaching in STED/RESOLFT nanosco

261 g-range GABAergic inputs to dopamine neurons fundamentally regulate behavioral responses to cocaine.

262 whether sex differences in LV mechanics are fundamentally regulated by differences in adrenergic con

263 Here, we fundamentally reinterpret this record and extract the li

264 hitecture of the brain is both beautiful and fundamentally related to its function, extending from gr

265 emerging regenerative medicine therapies are fundamentally reliant on high-quality adherent cell cult

266 ize distribution of the world's vertebrates, fundamentally reordering the structure of life on our pl

267 vidence that exposure to new information can fundamentally reorganize the neural circuit supporting a

268 e development of CRISPR/Cas9 technology-have fundamentally reshaped our approach to biomedical resear

269 ifting resources and demands, resulting in a fundamentally restructured immune system in older indivi

270 Such a modification is expected from a fundamentally semi-classical theory of gravity and can,

271 r model predicts that neuronal responses are fundamentally shaped by "explaining away," a divisive co

272 l 'bloom' nature of primary productivity and fundamentally shifted it towards a more intra-annually v

273 r results demonstrate that MDC1 also plays a fundamentally significant role in maintenance of genomic

274 oscopic and computational techniques reveals fundamentally similar features between the model NiAz sy

275 ision of one cell into two, is thought to be fundamentally similar in most animal cell divisions and

276 This suggests that fundamentally similar mechanisms may underlie segmentati

277 and human engineering in solving problems in fundamentally similar ways.

278 This report describes a fundamentally simpler and more robust PCR design that dy

279 Infants' reasoning about food preferences is fundamentally social: They generalize food preferences a

280 wever, it is a great challenge to understand fundamentally the complex interaction of rapidly solidif

281 Fundamentally, the loss of Mg in the calcite may reduce

282 Fundamentally, the possibility of pathway selection cont

283 Fundamentally, there is a discrepancy between iceberg po

284 More fundamentally, these results suggest that neuromotor noi

285 Fundamentally, this review builds on our earlier 2005 re

286 Fundamentally, this study indicates that computational e

287 Fundamentally, this study shows that small hydrogen-bond

288 tive models of future coastal change we need fundamentally to know how rapidly coasts have been erodi

289 fective and safe in vivo mRNA delivery could fundamentally transform clinical practice.

290 discovery in the biomedical sciences that is fundamentally transforming the way that we understand, d

291 Flexible information routing fundamentally underlies the function of many biological

292 ueous-based applications, it is necessary to fundamentally understand and control nanoparticle disper

293 the two structural analytical techniques for fundamentally understanding catalysis.

294 Our results may provide a paradigm for fundamentally understanding the high Tc in ferromagnetic

295 on with near unity quantum efficiency is not fundamentally understood.

296 mparisons between related structures, and to fundamentally unite this family of compounds.

297 s responsible for chemical signaling remains fundamentally unknown.

298 Pain is fundamentally unpleasant and induces a negative affectiv

299 esults integrate previous models and provide fundamentally valuable structural information regarding

300 n; the mouse has not only taught us how they fundamentally work, but also how their dysfunction can b