ライフサイエンスコーパス: fungicidal

1 ctin-1(-/-) macrophages resulted in impaired fungicidal ability, low nitric oxide production, and ele

2 mycins are peptide-nucleoside compounds with fungicidal, acaricidal, and insecticidal properties beca

3 Echinocandins exert in vitro and in vivo fungicidal action against most Candida species and fungi

4 nditions are not available for testing their fungicidal activities (minimum fungicidal or lethal conc

5 In this study, the fungicidal activities of LL-37 peptide, ceragenin CSA-13

6 is known to have an inhibitory effect on the fungicidal activities of some proteins, parotid secretio

7 study evaluated the in vitro fungistatic and fungicidal activities of voriconazole, itraconazole, and

8 from the cerebrospinal fluid (CSF) or early fungicidal activity (EFA), as determined by results of s

9 Voriconazole showed similar or better fungicidal activity (MFC at which 90% of isolates tested

10 the echinocandins had a broader spectrum of fungicidal activity (MFCs at which 90% of strains are in

11 We have shown previously that amiodarone has fungicidal activity against a broad array of fungi.

12 The antiarrhythmic drug amiodarone has fungicidal activity against a broad range of fungi.

13 Results confirmed DC lysosome fungicidal activity against all cryptococcal serotypes.

14 ll cationic human salivary peptide with high fungicidal activity against C. albicans, however many st

15 5(+) splenocytes from both mouse strains had fungicidal activity against C. neoformans.

16 an ester to a C22 modified alkyl chain, has fungicidal activity against Candida albicans, Cryptococc

17 gland-secreted cationic peptide with potent fungicidal activity against Candida albicans.

18 5) is a cationic salivary protein with high fungicidal activity against Candida albicans.

19 n-3-yl)acetamide (87), which, in addition to fungicidal activity against Candida species, shows promi

20 Rustmicin has potent fungicidal activity against clinically important human p

21 cted AM from most donors demonstrated innate fungicidal activity against CN.

22 tion and phagocytosis, galectin-3 has direct fungicidal activity against opportunistic fungal pathoge

23 Several salivary proteins exhibit fungicidal activity against the opportunistic oral patho

24 administered in vivo modulates PMNL-mediated fungicidal activity against the pseudohyphal form of C.

25 CD40L-deficient patients exhibited defective fungicidal activity and reduced oxidative burst, both of

26 Hence, our data explain the strong, fungicidal activity and selectivity of B. subtilis QST71

27 of microbiological tests and agrees with the fungicidal activity and selectivity of FE.

28 autophagic factor LC3 demonstrate diminished fungicidal activity but increased cytokine production in

29 This novel process of fungicidal activity by a human salivary protein has high

30 Stimulation of human Mphi fungicidal activity by coculture with chloroquine or by

31 , micafungin, and anidulafungin) exert their fungicidal activity by inhibition of the synthesis of th

32 Loss of fungicidal activity by the addition of CaCl(2) or MgCl(2

33 ural class of amphiphilic peptide with rapid fungicidal activity caused by C. neoformans.

34 ficant reduction, and in most cases loss, of fungicidal activity compared with the uninfected AM.

35 cells and macrophages demonstrated impaired fungicidal activity compared with those from healthy con

36 and analgesic agents that together generate fungicidal activity in drug-resistant Candida albicans,

37 microbial membrane is electrostatic, as its fungicidal activity is inhibited by cations.

38 -Candida activity, we sought to determine if fungicidal activity might be regulated by extracellular

39 for monitoring of the growth inhibition and fungicidal activity of a drug.

40 The fungicidal activity of amphotericin B (AmB) was quantita

41 the production of superoxide anion, only the fungicidal activity of collagen-adherent monocytes was p

42 Thus, C. albicans Ssa2p facilitates fungicidal activity of Hst 5 in binding and intracellula

43 Fungicidal activity of Hst 5 is initiated by binding to

44 ficantly reduced intracellular transport and fungicidal activity of Hst 5, confirming its importance

45 unity by secreting GM-CSF, necessary for the fungicidal activity of neutrophils.

46 with membranes with MWCOs of >=1000 promoted fungicidal activity of parotid secretion, and this activ

47 e examined patterns of growth inhibition and fungicidal activity of posaconazole and tacrolimus, alon

48 Thus, the innate fungicidal activity of primary human AM is impaired afte

49 The in vitro fungicidal activity of SCH56592 was superior (minimum fu

50 The fungicidal activity of the three agents was similar (G m

51 t, zinc binding had limited effects on Hst 5 fungicidal activity or protease susceptibility.

52 In addition, the enhanced fungicidal activity seen after 18 h of treatment was no

53 sides of carvacrol and thymol exhibited more fungicidal activity than the other compounds.

54 Fungicidal activity varied in duration and effectiveness

55 licidin mCRAMP, killed C. albicans, but this fungicidal activity was dependent on culture conditions.

56 (Deltassa1 and Deltassa2) was observed, and fungicidal activity was further reduced to 20-30% in the

57 The enhancement of monocyte fungicidal activity was maintained over a 4-h period, wh

58 tained over a 4-h period, whereas macrophage fungicidal activity was maximum at 1 h.

59 ed Candida as efficiently as human Mphi, and fungicidal activity was not enhanced by the presence of

60 Little or no fungicidal activity was shown for Fusarium spp. (2 to >8

61 The effects of G-CSF on PMNL-mediated fungicidal activity were evaluated by administration of

62 ssays demonstrate that FK506 has synergistic fungicidal activity with caspofungin against echinocandi

63 major sphingoid bases of fungi, have potent fungicidal activity with remarkably high structural and

64 hat the amphipathic analogs exhibited a high fungicidal activity, a high propensity to form an alpha-

65 olonization through hyphal induction, direct fungicidal activity, and inhibition of candidal adherenc

66 histological evidence of enhanced macrophage fungicidal activity, and resolution of inflammation.

67 olarization macrophages favoring an enhanced fungicidal activity, demonstrated by the decreased CFU r

68 Although each mAb enhanced J774.16 cell fungicidal activity, differences were observed in the ab

69 his species was relatively resistant to rhBD fungicidal activity, its adherence to oral epithelial ce

70 clearance rate of cryptococcus, termed early fungicidal activity, measured in patients with a first e

71 clinical resolution of talaromycosis, early fungicidal activity, relapse of talaromycosis, developme

72 related strongly with parallel increments in fungicidal activity, suggesting that oxidants did contri

73 ibitory activity toward C. albicans AHAS and fungicidal activity, supporting the hypothesis that AHAS

74 gatively through immune exclusion and direct fungicidal activity.

75 ope binding receptors for Hst 5 that mediate fungicidal activity.

76 ently demonstrated to have novel broad range fungicidal activity.

77 ic ions found in saliva that influence Hst 5 fungicidal activity.

78 id ergosterol results in potent, synergistic fungicidal activity.

79 eaks 1 and 6 had substantial fungistatic and fungicidal activity.

80 in relation to membrane permeabilization and fungicidal activity.

81 onsistent with their fungistatic rather than fungicidal activity.

82 nificant reduction of their microbicidal and fungicidal activity.

83 luding human beta-defensins 1-3, have direct fungicidal activity.

84 presence of NK cells, resulting in increased fungicidal activity.

85 to 6-month mortality, clinical response, and fungicidal activity.

86 The extracts had fungistatic rather than fungicidal activity.

87 d reduced rates of PAF26 internalization and fungicidal activity.

88 channel formation is not required for potent fungicidal activity.

89 to activating stimuli and display increased fungicidal activity.

90 of NO synthase had little to no effect on DC fungicidal activity.

91 lasma-infected DC inhibited PL-fusion and DC fungicidal activity.

92 Ws of approximately 17000 and 4000 exhibited fungicidal activity.

93 plicating these ion movements in the toxin's fungicidal activity.

94 o and in vivo, the echinocandins are rapidly fungicidal against most Candida spp and fungistatic agai

95 st Aspergillus fumigatus, while also being a fungicidal against this organism.

96 xidizing thiocyanate to the bactericidal and fungicidal agent hypothiocyanite.

97 oxo-morpholin-3-yl)-acetamide derivatives as fungicidal agents against Candida species, additionally

98 ay, in part, explain the lack of efficacy of fungicidal agents during clinical disease.

99 ive target for antibacterial, herbicidal and fungicidal agents.We have solved the crystal structure o

100 suggest that earlier diagnosis, more rapidly fungicidal amphotericin-based regimens, and prompt immun

101 Human salivary histatins possess fungicidal and bactericidal activities.

102 Fungicidal and/or fungi static effects proved to be depe

103 microm) killed 80% of the wild-type cells in fungicidal assays at room temperature.

104 vities of these constructs were evaluated in fungicidal assays toward Candida albicans blastoconidia

105 tifungal mechanism in vivo, both binding and fungicidal assays were carried out using S. cerevisiae i

106 reas mouse Mphi do require acidification for fungicidal but not fungistatic activity.

107 abolished this activity, indicating that the fungicidal component was salt sensitive.

108 r screening chemical libraries for Nmt-based fungicidal compounds with relatively little activity aga

109 nal growth-based assays; and is specific for fungicidal compounds.

110 m inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) at 250 mug/mL.

111 m inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) varied from 0.28 to 2.25

112 l inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) were established against

113 cytes without eukaryotic cytotoxicity at its fungicidal concentration.

114 peptide is endocytically internalized at low fungicidal concentrations (2.0-5 microM).

115 At high fungicidal concentrations (20 microM), PAF26 internaliza

116 are not available for evaluating the minimum fungicidal concentrations (MFCs) of antifungal agents.

117 Minimum fungicidal concentrations (MFCs) were determined by subc

118 MICs and minimum fungicidal concentrations (MFCs) were determined in each

119 l activity of SCH56592 was superior (minimum fungicidal concentrations [MFCs], 0.25 to 4 microgram/ml

120 internalization and antifungal action at low fungicidal concentrations was energy-dependent, primaril

121 Most existing models for the fungicidal control of plant diseases do not explicitly i

122 Given the need for fungicidal drugs, we propose that inhibitors of Stp1, Sr

123 s a target for development of a new class of fungicidal drugs.

124 ans and hence is a target for development of fungicidal drugs.

125 In this study, we demonstrate the fungicidal effect of these compounds as well as their ki

126 ficity of these responses indicates that the fungicidal effect was Nmt-dependent.

127 are strongly synergistic and exhibit potent fungicidal effects in combination.

128 Importantly, our studies demonstrated fungicidal effects of itraconazole and 25-thialanosterol

129 us, A. terreus was resistant to the in vitro fungicidal effects of safely achievable concentrations o

130 DNA preceded detectable neutrophil-mediated fungicidal effects.

131 es the CCR2-mediated massive accumulation of fungicidal ExMs derived from circulating Ly-6C(high) mon

132 lysis of T1/ST2(-/-) mice revealed increased fungicidal exudate macrophages in the lungs and decrease

133 ngal N-acylated cyclic hexapeptides that are fungicidal for candida strains and fungistatic for asper

134 exclusively of D-amino acids) were potently fungicidal for yeast-phase C. albicans.

135 Elevated level of an active fungicidal form of saponin, dAA in the husks possibly in

136 sts that blocking mannose synthesis could be fungicidal in the mammalian host and thus an excellent t

137 for the concerted action of magainin 2, the fungicidal lipopeptide class of surfactins from Bacillus

138 In contrast, the fungicidal lipopeptides surfactin, fengycin, and iturin

139 is study investigated the mechanism by which fungicidal nitroimidazole compounds modulate AC activity

140 tant population of fungus, is treated with a fungicidal or fungistatic drug.

141 testing their fungicidal activities (minimum fungicidal or lethal concentrations [MFCs]).

142 may therefore serve as useful antibacterial, fungicidal, or herbicidal agents.

143 oformans, at least in part via generation of fungicidal oxidants.

144 The addition of sodium chloride to dialyzed, fungicidal parotid secretion abolished this activity, in

145 c biomaterial with inherent bactericidal and fungicidal properties can be considered as an appealing

146 in the NADPH oxidase that normally produces fungicidal reactive oxygen species.

147 se data extend and corroborate the available fungicidal results for the three agents.

148 From a fungicidal screen, we identified 2-(2-oxo-morpholin-3-yl

149 he expression of EcoPrrC in budding yeast is fungicidal, signifying that PrrC is toxic in a eukaryon

150 view of the trehalose pathway as a selective fungicidal target for use in antifungal development.

151 cumulation of T6P, which makes this enzyme a fungicidal target.

152 Salivary protein histatin 5 (Hst 5) is fungicidal toward Candida albicans, the causative agent

153 All fungicidal treatments induced an increase in AFB2 produc

154 or less (5b, 6h, 6i), and two (5b, 6i) were fungicidal, unlike a standard antifungal drug fluconazol