ライフサイエンスコーパス: fungiform

1 ste buds is vallate > foliate > > palate > > fungiform.

2 cate differences in morphogenetic control of fungiform and circumvallate papilla development and numb

3 e number, morphology, and spatial pattern of fungiform and circumvallate papillae and associated tast

4 in the epithelial basement membrane of early fungiform and circumvallate papillae in regions where ta

5 les, tenascin and laminin, in the developing fungiform and circumvallate papillae of fetal, perinatal

6 led to rapid loss of taste buds (TB) in both fungiform and circumvallate papillae, including disrupti

7 In fungiform and circumvallate papillae, the shift in tenas

8 Fungiform bud numbers in BDNF-OE mice are 35%, yet genic

9 spite a stereotyped patterned arrangement of fungiform buds as rows and columns on the tongue.

10 both wild-type and BDNF-OE mice exhibit, in fungiform buds, the same, "discrete" receptoneural patte

11 um of three types of gustatory papillae: the fungiform, circumvallate, and foliate.

12 e NT4/5 gene functions in the maintenance of fungiform gustatory papillae and raises the possibility

13 ignaling has established roles in supporting fungiform induction, development and patterning.

14 the tongue to stimulate either left or right fungiform, or left or right foliate papillae.

15 ng the development and spatial patterning of fungiform papilla and targeting of taste neurons to thes

16 , Wnt-beta-catenin signaling is critical for fungiform papilla and taste bud development.

17 lopment and maintenance of taste organs, the fungiform papilla and taste bud, and surrounding lingual

18 Fungiform papilla development progressed in half tongues

19 gue shape (E13) and results in a repatterned fungiform papilla distribution that does not respect nor

20 We observed that during fungiform papilla formation in mice, Shh and components

21 nd morphogenetic roles for Shh in tongue and fungiform papilla formation, but also suggest that Shh f

22 ults demonstrate a prominent role for Shh in fungiform papilla induction and patterning and indicate

23 o system for studying mechanisms involved in fungiform papilla morphogenesis in patterns on the anter

24 ctopic dickkopf1 (Dkk1) blocks initiation of fungiform papilla morphogenesis.

25 However, fungiform papilla morphology, number and innervation are

26 cyclopamine, jervine, or blocking antibody, fungiform papilla numbers doubled on the dorsal tongue w

27 distinctive roles for Wnt5a in tongue size, fungiform papilla patterning and development are shown a

28 A requirement for normal Shh signaling in fungiform papilla, taste bud and filiform papilla mainte

29 nnervation to the dorsal anterior tongue and fungiform papilla.

30 ation only in taste buds, whereas 43% of the fungiform papillae also had additional labeled innervati

31 Here, we report that Shh expression in fungiform papillae and formation of normal mature fungif

32 cell responses of 120 taste cells of the rat fungiform papillae and soft palate maintained within the

33 oth transgenic lines had severe reduction in fungiform papillae and taste bud number, primarily in th

34 Fungiform papillae and taste buds were reduced in number

35 gnaling has roles in forming and maintaining fungiform papillae and taste buds, most likely via stage

36 in causes massive overproduction of enlarged fungiform papillae and taste buds.

37 -/-) mice the abundance of axons innervating fungiform papillae and the normal numbers of geniculate

38 Fungiform papillae are epithelial specializations that d

39 Furthermore, on anterior tongue, the fungiform papillae are patterned in rows.

40 Fungiform papillae are repeated epithelial structures th

41 ustatory innervation and a reduced number of fungiform papillae at birth.

42 cells from mouse circumvallate, foliate, and fungiform papillae but not in a variety of other cells,

43 all taste buds disappeared in more posterior fungiform papillae by 15 days posttransection, the anter

44 -expressing cells per taste bud, whereas the fungiform papillae contained 3.06 and 0.23 cells per tas

45 form papillae and formation of normal mature fungiform papillae depend on signaling through Wnt and b

46 In addition, fungiform papillae developed on posterior oral tongue, j

47 Furthermore, fungiform papillae developed on these tongues on a cultu

48 that FGF signaling is a crucial regulator of fungiform papillae development.

49 which is the main activation pathway during fungiform papillae development; however, this effect doe

50 Fungiform papillae did not develop on pharyngeal or vent

51 Taste cells of fungiform papillae did not show immunoreactivity for pre

52 single circumvallate papilla, regions where fungiform papillae do not typically develop.

53 were sustained, TB were not restored in all fungiform papillae even with prolonged recovery for seve

54 In addition, fungiform papillae formed in the tongue cultures in the

55 In the rat, taste buds of the fungiform papillae had fewer gustducin-positive cells (3

56 Most (57%) of the fungiform papillae had labeled innervation only in taste

57 initial formation and early morphogenesis of fungiform papillae in a patterned array.

58 nor does the tongue retain competency to add fungiform papillae in atypical locations.

59 The Shh protein was in all fungiform papillae in embryonic tongues, and tongue cult

60 erefore, robust, reproducible development of fungiform papillae in patterns is supported in rat tongu

61 ed tongue results in an increased density of fungiform papillae in the mutant tongues.

62 buds, and stratified squamous epithelium of fungiform papillae in the tongue, as well as in skeletal

63 al Wnt paths in regulating tongue growth and fungiform papillae is proposed in a model, through the R

64 Fungiform papillae must contain long-lived, sustaining o

65 w it encompasses additional phenotypes (e.g. fungiform papillae number, bitterness of quinine) and em

66 lso expressed in the nail bed epithelium and fungiform papillae of dorsal tongue epithelium.

67 curs in vibrissae follicles, in filiform and fungiform papillae of oral mucosa.

68 erally and appear to originate in the dorsal fungiform papillae of the tongue epithelium.

69 an irreversibly alter number and location of fungiform papillae on anterior tongue and elicit papilla

70 petence of dorsal lingual epithelium to form fungiform papillae on both anterior and posterior oral t

71 rmates and made quantitative analyses of all fungiform papillae on the anterior tongue, the single ci

72 colocalized within papilla placodes and the fungiform papillae per se, have opposing inhibitory and

73 ut most of the additional innervation in the fungiform papillae remained.

74 s chorda tympani fibers to distinguish their fungiform papillae targets from non-gustatory epithelium

75 In all fungiform papillae that form under various culture condi

76 umbers of embryonic taste buds in developing fungiform papillae until birth are not correlated with t

77 In addition, the size and number of fungiform papillae were greatly reduced in Lef1 knockout

78 Fungiform papillae were initially present on tongues of

79 No degenerative deficits of fungiform papillae were observed for the first 3 weeks o

80 Remaining fungiform papillae were selectively concentrated in the

81 However, these remaining fungiform papillae were smaller in appearance and many d

82 ithelial targets of gustatory neurons (i.e., fungiform papillae) before their innervation, and BDNF o

83 ngs from isolated taste cells showed that in fungiform papillae, aldosterone increased the number of

84 three subunits in nearly all taste cells of fungiform papillae, and in about half of the taste cells

85 gue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low leve

86 60, there was 63% decrease in the number of fungiform papillae, and remaining papillae were smaller

87 ate neurons approach their target cells, the fungiform papillae, beginning on E13.5, at which time we

88 bute not only to maintenance of filiform and fungiform papillae, but also to taste buds.

89 apillae was significantly lower than that of fungiform papillae, especially for beta and gamma subuni

90 s BMPs or noggin induce increased numbers of fungiform papillae, in a concentration-dependent manner,

91 uding reduced growth rate, reduced number of fungiform papillae, spinal abnormalities, and sensory an

92 mice, in which taste neurons innervated only fungiform papillae, taste neurons in BDNF-OE and NT4-OE

93 In early fungiform papillae, tenascin immunoreactivity is very we

94 To explain the loss of nerve innervation to fungiform papillae, the facial nerve of developing anima

95 In mice, individual taste buds reside in fungiform papillae, which develop at mid-gestation as ep

96 ns in BDNF-OE and NT4-OE mice innervated few fungiform papillae.

97 papillae > nasoincisor duct and epiglottis > fungiform papillae.

98 relationship between nerve and taste buds in fungiform papillae.

99 nique tongue lesion, which comprises swollen fungiform papillae.

100 tory axons to correctly locate and innervate fungiform papillae.

101 s play essential roles in the development of fungiform papillae.

102 ssion of BDNF and NT4 disrupt innervation to fungiform papillae.

103 before or during the initial innervation of fungiform papillae.

104 yte response to denervation of taste buds in fungiform papillae.

105 the tongue that matched the distribution of fungiform papillae.

106 ing from the foliate, vallate, and posterior fungiform papillae.

107 (Ca(2+)(I)) induced by acidic stimuli in rat fungiform papillae.

108 the cornified tips of the filiform (but not fungiform) papillae of the dorsal tongue and in the supe

109 e of Shh, we used an in vitro model of mouse fungiform papillary development to determine the effects

110 y restricted to developing circumvallate and fungiform papillary epithelia.

111 catenin signaling is activated in developing fungiform placodes and taste bud cells.

112 Fungiform taste bud degeneration after chorda tympani ne

113 spatiotemporal functions of beta-catenin in fungiform taste bud development.

114 mutant mice had a higher frequency of failed fungiform taste bud differentiation.

115 The current study examines fungiform taste bud distribution and structure in adult

116 A mouse fungiform taste bud is innervated by only four to five g

117 To clarify age-related changes in fungiform taste bud volume, the current study investigat

118 ta are the first to characterize adult mouse fungiform taste buds and subsequent degeneration after u

119 Rat fungiform taste buds are more responsive to salts than t

120 In contrast, hamster fungiform taste buds are more sensitive to sweet-tasting

121 Hamster fungiform taste buds contained twice as many gustducin-e

122 Most fungiform taste buds fail to become innervated when BDNF

123 the postnatal development and maintenance of fungiform taste buds in mice carrying a deletion of NT4/

124 culate ganglion cells that innervated single fungiform taste buds were quantified in the tip- and mid

125 Degenerating fungiform taste buds were smaller due to a loss of taste

126 Fungiform taste buds were visualized and measured with t

127 By injecting single fungiform taste buds with lipophilic retrograde neuroana

128 CT and IX-CT rats, there was regeneration of fungiform taste buds, although in both groups there were

129 We counted the number and diameter of fungiform taste buds, the prevalence of poorly different

130 of the nerve to regenerate and a loss of all fungiform taste buds.

131 ally undetectable by immunohistochemistry in fungiform taste buds.

132 e obtained whole-cell recordings from single fungiform taste cells of rat pups to examine the develop

133 ly 20% of the total outward current of mouse fungiform taste cells was composed of K(ATP) channels.

134 The adult fungiform taste papilla is a complex of specialized cell

135 responses was investigated in cultured human fungiform taste papillae (HBO) cells with five arginyl d

136 Fungiform taste papillae form a regular array on the dor

137 Only egfr(-/-) fungiform taste papillae had robust gustatory innervatio

138 regulating the number and spatial pattern of fungiform taste papillae on embryonic rat tongue, during

139 c anterograde pseudorabies virus labeling of fungiform taste papillae to infect single or small numbe

140 Fungiform taste papillae were examined for allele-specif

141 of taste cells in circumvallate, foliate and fungiform taste papillae.

142 emoved, stained with methylene blue, and the fungiform taste pores counted on both sides.

143 nilateral apical Na+ fluxes in polarized rat fungiform taste receptor cells and by chorda tympani tas

144 ntigen, are expressed by significantly fewer fungiform than vallate taste cells in the rat.