ライフサイエンスコーパス: funnel

1 oteins is observed, the so-called "hydration funnel".

2 chieve a target action (stacking a ring on a funnel).

3 (CE)] and ion transfer efficiency (e.g., ion funnels).

4 er of biological unfoldases represented as a funnel.

5 st point of a negatively charged cytoplasmic funnel.

6 ye1 binds with its TLD to the Pol II jaw and funnel.

7 l conversion through a nested intermolecular funnel.

8 facing funnel and a smaller periplasm-facing funnel.

9 aracteristics of a kinetic trap in a folding funnel.

10 ion (EESI) by spraying directly into the ion funnel.

11 APP C3-hydroxyl group within the active site funnel.

12 ket, and the gate between the pocket and the funnel.

13 ning of a hydrophobic gate at the end of the funnel.

14 s, as well as the characterization of energy funnels.

15 ation potential to which oxidative damage is funneled.

16 dynamics and unidirectional efficient energy funneling.

17 strong evidence for multidirectional energy funneling.

18 zed resonance in metallic nanoslits by light funneling.

19 The Mia40 role is to funnel a rough folding landscape, skipping the accumulat

20 lycocalyx facilitates integrin clustering by funnelling active integrins into adhesions and altering

21 ined by each handle-pair depict a 3D folding funnel and a kinetic topology in which the kinetics pert

22 n two domains, with a large cytoplasm-facing funnel and a smaller periplasm-facing funnel.

23 The closed channel has an empty cytoplasmic funnel and an extracellular funnel that is filled with a

24 led with transport media (TM) (sealed at its funnel and back entrance with a stopper) and the tissue

25 scale brain network topology is organized to funnel and concentrate information flow in the hippocamp

26 e an enhanced view of a G-quadruplex folding funnel and highlight the necessity to consider solvent v

27 pH sensor at the entrance of the cytoplasmic funnel and opening of a hydrophobic gate at the end of t

28 pleted CP zone does not propagate out of the funnel and remains localized.

29 co-translational translocation, the ribosome funnel and the channel of the protein translocation comp

30 adjustment for heterogeneities, we used both funnel and trim-and-fill analyses to identify a negligib

31 d drift tube bracketed by electrodynamic ion funnels and coupled to a high resolution quadrupole time

32 ure, the model presents a closed cytoplasmic funnel, and a periplasmic funnel of greater volume.

33 e extracellular cavity, open the cytoplasmic funnel, and result in a approximately 5 A vertical reloc

34 ce measurements, floating chambers, anchored funnels, and boundary model calculations.

35 by 2D polarization imaging using the single funnel approximation.

36 These proteins ultimately formed a funnel around the shedding cell that defined the site of

37 lations confirmed the existence of a binding funnel as the main bottleneck.

38 In this study, we use an ion funnel at ambient pressure to enhance the sensitivity of

39 a well-known mechanism in which enzymes are funneled between enzyme active sites through a physical

40 tive (i.e., which appear to lie closest to a funnel bottom).

41 ia and HSP90 pathways are interconnected and funneled by PRKD2 into the NF-kappaB/VEGF-A signaling ax

42 The dual-purpose drift tube/ion funnel can be coupled to various types of mass spectrome

43 robe size ( approximately 25 mum), the Micro-funnel can be implanted into live multicellular tumor sp

44 mains around a putative symmetry axis at the funnel centers, perpendicular to the membrane plane.

45 s adaptor PPFIA1, which we propose acts as a funnel combining FN secretion and recycling of active al

46 mobilization of a copper calix[6]azacryptand funnel complex on gold-modified electrodes is reported.

47 A conserved electronegative funnel connects this region to the intramembranous high-

48 aper with aspect ratios (funnel tip width to funnel depth) of 0.1 to 1.0.

49 tructure can be projected onto a theoretical funnel description.

50 a focused ion beam (FIB) instrument, and the funnel design had a constant 5 degrees taper with aspect

51 An "off-axis" ion funnel design has been developed to reduce the source co

52 is work, we developed and investigated a new funnel design that aims to seamlessly couple to SLIM at

53 I source incorporates a keyhole geometry ion funnel design which facilitates axial ion focusing, accu

54 Metabolites collected in the Micro-funnel device were then extracted by a microscale sampli

55 the glyoxylate cycle and gluconeogenesis but funneled directly into fatty acid biosynthesis.

56 Direct binding via the binding funnel dominates the binding kinetics, and only approxim

57 effects in the affected nerves which likely funnel down to common clinical features.

58 apacity and operating the electrodynamic ion funnel (EDIF) at approximately 4 Torr, a single pumping

59 AH-MN reveals a hierarchical modularity with funnel effects in structure/function and intimate associ

60 expected from a perfect antenna, LH2s showed funneling efficiencies close to unity.

61 In contrast, CPs showed lower average funneling efficiencies, greatly varying from molecule to

62 ates, using a single parameter called energy funneling efficiency (epsilon).

63 hree ideal QD monolayers can provide exciton funneling efficiency above 80% from the most distant lay

64 It funnels electrons coming from NADH and ubiquinol to cyto

65 The ion funnel enables a much higher proportion of ions to exit

66 and photocatalysis, where it is necessary to funnel energy or charge to specific regions within the s

67 kbone can be used to quickly and efficiently funnel energy to chromophores with localized energy mini

68 We examined whether simulations based on funneled energy functions can also describe fluctuations

69 This funneled energy landscape is the result of foldable prot

70 This view does not match the funneled energy landscape paradigm of a very large numbe

71 The funneled energy landscape theory implies that protein st

72 SPA (SPecificity and Affinity) based on our funneled energy landscape theory.

73 fold into three-dimensional structures in a funneled energy landscape.

74 d that protein folding can be described by a funneled energy landscape.

75 Simulations based on perfectly funneled energy landscapes often capture many of the kin

76 In contrast to models based on perfectly funneled energy landscapes that contain only contacts fo

77 t proteins fold through parallel pathways on funneled energy landscapes, although experimental detect

78 In the base-to-tip direction, the funnel exhibits a lower ion conductance and a higher ele

79 hat aims to seamlessly couple to SLIM at the funnel exit.

80 ed a microscale collection device, the Micro-funnel, fabricated from biocompatible fused silica capil

81 The electrodynamic ion funnel facilitates efficient focusing and transfer of ch

82 In this work a new SLIM "flat funnel" (FF) module has been developed and demonstrated

83 drainage methods (centrifugation and Buchner funnel filtration) were used to compare the final overal

84 tractor networks, we have uncovered that the funneled flux landscape is crucial for the emergence and

85 Post-drift, an ion funnel focuses the radially spread pulses of ions into t

86 es but was later further optimized to create funneled folding landscapes for individual monomeric pro

87 , whereas, in the tip-to-base direction, the funnel has a higher ion conductance and a lower electroo

88 pulsed ion injection to IMS based on the ion funnel has provided considerably increased ion currents

89 ent approach that leads to a molecular-scale funnel, having an effective chromophore concentration of

90 electrode was used to direct ions to an ion funnel HPIF at a pressure of 9-10 Torr.

91 rthogonal higher pressure electrodynamic ion funnel (HPIF) and an ion funnel trap combined with a tri

92 In particular, our work supports the actin-funneling-hypothesis explanation of protrusion speed enh

93 simulations further showed that a hydration funnel (i.e., a gradient in retardation of hydrogen bond

94 pHDock produces successful local docking funnels in approximately half (79/161) the protein compl

95 The asymmetric geometry of the nanofluidic funnel induces not only ion current rectification but al

96 In this study, a dual ion funnel interface consisting of an orthogonal higher pres

97 I-generated ions into an electrodynamic dual-funnel interface results in increased sensitivity charac

98 led to a QTOF mass spectrometer using an ion funnel interface to evaluate the m/z range transmitted a

99 ial S-lens interface and an in-line dual-ion funnel interface.

100 Electrodynamic ion funnel interfaces for electrospray ionization (ESI) have

101 allows the CP zones to propagate out of the funnel into the adjoining channels.

102 ly expected for aggregation, PrP dimers were funneled into a thermodynamically stable misfolded state

103 ion and at a counting fence where smolts are funnelled into high densities].

104 teral portal, adjacent to the membrane, that funnels ions to the channel pore.

105 able of simultaneously functioning as an ion funnel is demonstrated in proton transfer reaction mass

106 perimental characterization of a DC-only ion funnel is described herein.

107 The cytoplasmic funnel is empty, while the extracellular funnel is fille

108 mic funnel is empty, while the extracellular funnel is filled with a plug domain.

109 The cerebellum funnels its entire output through a small number of pres

110 In the funneled landscape, proteins fold to their native states

111 onsistent with multiple stochastic routes on funnel landscapes, and it gives good agreement with the

112 2 and i+3 monomers, forming a sophisticated, funnel-like architecture.

113 potential energy landscapes have a distinct funnel-like bias toward the folded hairpin state, consis

114 destabilized by our optimization, making the funnel-like binding energy landscape more biased toward

115 reveal that well folded peptoids can exhibit funnel-like conformational free energy landscapes simila

116 trap, which is consistent with the idea of a funnel-like landscape.

117 of homodimeric Na(+)-PPase forms an unusual funnel-like structure with a catalytic site in the cytop

118 be mapped in the nonequilibrium region of a "funnel-like" free-energy landscape.

119 ribution to the full free energy, it appears funnel-like.

120 The PPAD active site is a funnel located on one of the cylinder bases.

121 We also show that the presence of the funnel makes the tension along the backbone of the subst

122 lysine ring that defines the wide end of the funnel may selectively allow cation diffusion into the c

123 ved at an affordable computational cost make funnel metadynamics a valuable method for drug discovery

124 Furthermore, funnel metadynamics unveils important information about

125 veloped a metadynamics-based approach, named funnel metadynamics, that allows the ligand to enhance t

126 sing an innovative free-energy method called funnel-metadynamics (FM), which we have recently develop

127 ng absolute binding free-energy estimated by funnel-metadynamics simulations and solution NMR experim

128 wing body of theoretical work showing that a funneled, minimally frustrated energy landscape is suffi

129 The funnel model involves the shuttling of periplasmic subst

130 In the Foldon Funnel Model, proteins fold in units of secondary struct

131 problem that systematically extracts simple funnel models of actual proteins using ensembles of stru

132 n, dissolution and partition in a separating funnel; moreover, it gives higher recoveries, comparable

133 was originally parameterized by enforcing a funneled nature for a database of dimeric interfaces but

134 rostatic forces, but to what extent does the funneled nature of protein energy landscapes play a role

135 closed cytoplasmic funnel, and a periplasmic funnel of greater volume.

136 ry production in streptomycetes involves the funneling of environmental and physiological signals to

137 The long-range funneling of oxidative damage to sites of low oxidation

138 this architecture would favor the efficient funneling of pectinases at convergent points within the

139 f the triads revealed an efficient, stepwise funneling of the excitation energy from the primary dono

140 hich are also responsible for the subsequent funneling of the excitation energy to the reaction cente

141 unctional hypothesis is that this convergent funneling of the full blend of pectinases constitutes a

142 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcr

143 he landscape, quantifying the degrees of the funneling of the underlying potential and flux landscape

144 Here we show how funnelling of cellular resources, after global transcrip

145 ly modify the band-gap, leading to efficient funnelling of excitons towards isolated strain-tuned qua

146 cesses have been proposed to account for the funnelling of gas towards the galactic centre to feed th

147 nd analysis; in practical terms, a broadband funnelling of infrared radiation with fractional bandwid

148 of broadband light absorption and efficient funnelling of photogenerated excitons to points of maxim

149 These results illuminate how the folding funnels of natural proteins arise and provide the founda

150 hamber is linked to the fourth channel by a 'funnel' of charged residues.

151 Three RNA-binding domains form an open funnel on one face of the catalytic domain that allows R

152 folding landscapes of membrane proteins are funneled once the proteins' topology within the membrane

153 ion introduction through ring electrode ion funnels or more conventional ion optics to SLIM can invo

154 e new device, termed a periodic focusing ion funnel (PF IF), provides an efficient alternative to the

155 riction, large proteins are released through funnel plasmodesmata in discrete pulses, a phenomenon we

156 ted to the protophloem by a unique class of 'funnel plasmodesmata'.

157 ication bias risks were assessed by means of funnel plot analysis.

158 ication bias risks were assessed by means of funnel plot analysis.

159 d publication bias was assessed using Begg's funnel plot and Egger's regression test.

160 A funnel plot and Egger's test did not suggest significant

161 y of publication bias was assessed using the funnel plot and Egger's test for small-study effects.

162 Funnel plot and heterogeneity analyses were also perform

163 Funnel plot and meta-regression assessed heterogeneity a

164 The funnel plot and the Egger's test (p=0.44) showed no evid

165 Funnel plot asymmetry among SLC6A3 studies was identifie

166 The presence of funnel plot asymmetry suggested that publication bias wa

167 hes, sample size and intervention effects on funnel plot asymmetry, using empirical datasets and illu

168 Examination of the funnel plot did not provide evidence of publication bias

169 as assessed via Begg's and Egger's tests and funnel plot inspection.Findings from 12 RCTs (n = 609 pa

170 partly influenced by further development of funnel plot methodology.

171 Visual inspection of a funnel plot revealed no publication bias, which was conf

172 Dissemination bias was evaluated by funnel plot visualization and trim-and-fill analysis.

173 st for heterogeneity between studies, Begg's funnel plot, and Egger test to assess publication bias,

174 sted and corrected for publication bias by 3 funnel plot-based methods.

175 pital trust level, and contrasted these in a funnel plot.

176 ween-trial heterogeneity and an asymmetrical funnel plot: Trial size, blinded outcome assessment, and

177 e of publication bias was evaluated by using funnel-plot analysis.

178 est for both omega-3 and folic acid studies; funnel plots also revealed asymmetry (reflecting potenti

179 Publication bias was evaluated with funnel plots and Begg test.

180 Publication bias was evaluated by using funnel plots and Egger's and Begg's tests.

181 Publication bias was assessed with funnel plots and Egger's intercept.

182 We used funnel plots and Egger's linear regression to test for p

183 ore, and publication bias was assessed using funnel plots and Egger's statistic.

184 ics and I and publication bias assessed with funnel plots and Egger's test.

185 We assessed reporting bias with funnel plots and heterogeneity with the I statistic.

186 tatistics, publication bias was assessed via funnel plots and the Begg and Egger tests, and methodolo

187 Publication bias was evaluated with funnel plots and the Egger method.

188 Funnel plots are practical tools, easy to use, and offer

189 on visual or statistical examination of the funnel plots for either disease management or health beh

190 Control limits for funnel plots for the Standardised Mortality Ratio (SMR)

191 Funnel plots have become a standard graphical methodolog

192 More widespread application of funnel plots in surgery will help to overcome some of th

193 We used funnel plots of the hazard ratio to assess bias.

194 We found that funnel plots of the Standardized Mean Difference (SMD) p

195 Funnel plots revealed a symmetrical distribution with no

196 Funnel plots showed no evidence of publication bias (P =

197 Funnel plots suggested reporting bias, and sensitivity a

198 We conclude that funnel plots using the SMD in combination with the SE ar

199 n was performed to analyze heterogeneity and funnel plots were applied to evaluate publication bias.

200 Funnel plots were asymmetric with a bias toward lower od

201 e outcomes and performance, which means that funnel plots will most likely play an increasingly impor

202 s the principles and existing application of funnel plots within surgery and emphasizes their advanta

203 ta by using a random-effects model, examined funnel plots, and explored heterogeneity by using meta-r

204 Study quality analyses, funnel plots, and trim-and-fill analyses uncovered no ca

205 l for publication bias was explored by using funnel plots, Begg's and Egger's tests, and Duval and Tw

206 the potential bias of small studies, we used funnel plots, the Begg rank correlation test, and the Eg

207 Publication bias was corrected for using funnel plots, the Egger regression test, and a trim and

208 Publication bias was assessed using funnel plots.

209 We excluded relevant sources of bias by funnel plots.

210 tential publication bias was evaluated using funnel plots.

211 sual or analytical detection of asymmetry in funnel plots.

212 atistic and evaluated publication bias using funnel plots.

213 bias) was determined by Egger regression and Funnel-plotting.

214 While the funneled potential landscape is often crucial for the st

215 vides an efficient alternative to the rf ion funnel providing high ion transmission with fewer electr

216 P1' glutarate occupies the spacious entrance funnel rather than the conserved glutamate-binding S1' p

217 of ozone into the high-pressure trapping ion funnel region preceding the IMS cell.

218 egments on opposite sides of the cytoplasmic funnel, revealed pH-dependent interactions consistent wi

219 first time the use of a radio frequency ion-funnel (RFIF) in the reaction region (drift tube) of a p

220 This rectangular ion funnel (RIF) was initially evaluated by ion simulations,

221 A very small funnel right below the TLC tip collected the solvent and

222 , each decay mechanism contains factors that funnel RNA substrates to abundant exo- and/or endonuclea

223 e ring that constricts the narrow end of the funnel serves as a broad cation selectivity filter, wher

224 The orthogonal ion injection into a funnel shaped separation region can greatly reduce space

225 evealed a toroidal homotrimer with a central funnel-shaped channel for tracking along the DNA, and a

226 These results suggest a funnel-shaped energy landscape for protein interactions,

227 e structure, a principle that is captured in funnel-shaped energy landscapes.

228 the authors show that DNA injected through a funnel-shaped entrance more efficiently enters the nanoc

229 et al. now present a crystal structure of a funnel-shaped octameric apoptosome complex from the nema

230 Such funnel-shaped potential energy landscapes may be typical

231 e that molecular crystallization can involve funnel-shaped potential energy landscapes through a deta

232 ry motifs, which make possible the design of funnel-shaped protein folding energy landscapes leading

233 d key residues in the positively charged and funnel-shaped substrate access tunnel that gated substra

234 In contrast, HPAO-2 has a wide funnel-shaped substrate channel, which also contains a s

235 ew device operation motifs including quantum-funnel solar cells, non-contact chromophore pumping from

236 tif may provide specificity in inhibition to funnel specific olfactory information, such as food and

237 The basic idea is to funnel spins from a large area of spin Hall material int

238 , an intramembrane protease, using perfectly funneled structure-based models that implicitly account

239 on of 91% at 400-2,500 nm and the microscale funnel structures lead to average reflection of 7% at 2.

240 oscale gaps (0-200 nm) as well as microscale funnel structures.

241 g, may line the channel's cytoplasmic-facing funnel surface, stabilize the channel's overall structur

242 ing pocket, the gate and finally to the AcrB funnel that connects AcrB to TolC.

243 that the microtubule forms an electrostatic funnel that guides the dynein's microtubule binding doma

244 mpty cytoplasmic funnel and an extracellular funnel that is filled with a small helical domain, calle

245 les, to the formation of a pinched liposomal funnel that may impinge on the apparently unperturbed vi

246 icro-traps that confine bacteria using micro-funnels that open into trapping chambers.

247 , whereby the electrostatic field acts as a 'funnel' that sweeps the GABA molecules towards the bindi

248 pe has a volcano shape, rather than a simple funnel, that folding is two-state (single-exponential) w

249 tion extracts suppresses these fluctuations, funneling the complex into a single conformation on the

250 nce of the position of the Schnauzenorgan in funneling the fish's self-generated electric field.

251 s on the conformational space, progressively funneling the molecule to the native state.

252 that this type of motor should be capable of funneling the photon energy into specific rotary modes,

253 us creating additional plus (+) subsites and funneling the polymeric substrate through the tunnel-sha

254 used by the detailed-balance-breaking, which funnels the downhill migration of excitons.

255 To see whether the ring complex funnels the energy of multiple ATP hydrolysis events to

256 Interaction with PX funnels the free-state equilibrium of NT by stabilizing

257 sible; the interaction with pre-existing gas funnels the gas into nuclear regions (<1 kpc) to form ne

258 rylates and activates the enzyme Nth1, which funnels the storage carbohydrate trehalose into central

259 rationalized by the principle of an "energy funnel", the carotenoids still pose many open questions.

260 ion mechanisms with geographic features that funnel them toward Mexican overwintering sites, a remark

261 sms to usurp the host's metabolic resources, funneling them towards the production of virion componen

262 sector we find the landscape is indeed very funneled: Thermodynamic landscape analysis indicates tha

263 othesized that AQP3 transports glycerol and "funnels" this primary alcohol to PLD2 to form a pro-diff

264 that the uncatalyzed and catalyzed pathways funnel through a common monosolvated-monomer-based inter

265 pon a fraction of the population, birth is a funnel through which all individuals must pass.

266 unknown whether these changes are ultimately funneled through a stable corticospinal output channel o

267 tion, and learned associative prediction-are funneled through brain mesocorticolimbic circuits involv

268 K transcriptional response in human cells is funneled through Integrator, an RNA polymerase II-associ

269 Energy collected by the chlorosome is funneled through the FMO to the RC.

270 ends into the channel, and consequently, the funnel tip exhibits charge-selective properties, which r

271 constant 5 degrees taper with aspect ratios (funnel tip width to funnel depth) of 0.1 to 1.0.

272 se that PelC functions as an electronegative funnel to guide the positively charged Pel polysaccharid

273 the parasite for pyrimidine nucleotides are funneled to uracil and then phosphoribosylated to UMP in

274 ates of pigments can result in robust energy funneling to the initial excitation conditions and tempe

275 polyol region lining a channel interior that funnels to its narrowest region at the C3-hydroxyl group

276 via upper pathways that act as a "biological funnel" to convert heterogeneous substrates to central i

277 Instead, multistep "energy funneling" to trapped, localized polarons is the probabl

278 nfolding events and the landscape is locally funneled toward "ideal" chromosome structures that repre

279 es of natural foldable proteins are strongly funneled toward the native state.

280 nnectivity actively shapes information flow, funneling traffic towards some nodes and away from other

281 ess ion manipulations (SLIM) employed an ion funnel trap (IFT) to accumulate ions from a continuous e

282 electrodynamic ion funnel (HPIF) and an ion funnel trap combined with a triple quadrupole mass spect

283 ignificantly improved performance for an ion funnel trap upon adding helium; the signal intensities f

284 on ejection into the drift tube from the ion funnel trap.

285 reviously reported charge capacity of an ion funnel trap.

286 s: (a) Panel traps were superior to multiple-funnel traps, (b) bark beetles and woodborers were captu

287 ty and orientation were examined using Emlen funnel trials.

288 ed to a high transmission electrodynamic ion funnel, two focusing collision quadrupoles, a large 19 m

289 ns (IOL) cartridge and pulled further in the funnel using 25 G end-grasping forceps.

290 A 3D folding funnel was proposed in the 1990s to explain the fast kin

291 morphae (i.e., trapdoor spiders, tarantulas, funnel web spiders, etc.) is one of three main lineages

292 proteins, Hadronyche versuta (Blue Mountains funnel-web spider) neurotoxin (Hvt) and onion leaf lecti

293 icient pumping of fluids through nanofluidic funnels when a symmetric AC waveform is applied.

294 Here, a binding funnel, which increasingly confines the translational as

295 The concept of a folding funnel with kinetic traps describes folding of individua

296 veals an overall downhill but rugged binding funnel with multiple pathways.

297 hat the landscape of the protein is a triple funnel with two folded structures and one misfolded stru

298 that the folding energy landscapes are more funneled with binding, indicating that binding helps fol

299 sfolded domains are part of the same folding funnel, with commitment to one structure or the other oc

300 energy surface is canyon-like, with a smooth funnel within a two dimensional subspace capturing over