ライフサイエンスコーパス: furyl

1 A)R antagonist [ZM241385 (4-(2-[7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5)triazin-5-ylamino]eth

2 lective AR antagonist, 5-amino-9-chloro-2-(2-furyl)-1, 2, 4-triazolo [1, 5-c] quinazoline (CGS-15943)

3 ylindazole derivative 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) is an allosteric stimula

4 plying nitrosocysteine, 3-(5-hydroxymethyl-2-furyl)-1-benzyl indazole (YC-1), and 8-bromo cGMP, all t

5 YC-1 [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] is an allosteric activator of

6 YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an HIF-1 inhibitor, reduced w

7 rol conditions, YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an NO-independent activator o

8 odium nitroprusside or 3-(5'-hydroxymethyl-2'furyl)-1-benzyl-indazole (YC-1).

9 CPP) or the activator 3-(5'-hydroxymethyl-3'-furyl)-1-benzylindazole (YC-1).

10 A(2A) receptor antagonist 4-(2-[7-amino-2-(2-furyl)[1,2,4-triazolo[2,3-a][1,3,5]triazin-5-ylamino]et

11 A(2A) receptor antagonist 4-(2-{7-amino-2-(2-furyl)[1,2,4]-triazolo[2,3-a] [1,3,5]triazin-5-ylamino}e

12 ype-specific antagonists [4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3-a][1,3,5]triazin-5-ylamino] e

13 tor antagonist ZM-241385 (4-[2-[7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3-a][1,3,5]triazin-5-ylamino] e

14 nonxanthine adenosine antagonist 9-chloro-2-(furyl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine(6 fold) b

15 selective inverse agonist 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]eth

16 HIF-inhibitor, YC-1 (3-[5'-Hydroxymethyl-2'-furyl]-1-benzyl-indazole), or vehicle three days before

17 (R)-N-[3-[5-(4-Fluorophenoxy)-2-furyl]-1-methyl-2-propynyl]-N-hydroxyure a (17c) was ide

18 (2A)-selective antagonist 4-(2-[7-amino-2-[2-furyl][1,2, 4]triazolo-[2,3-a][1,3,5] triazin-5-yl-amino

19 gonists including, (125)I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl- amino]e

20 ctive A(2A)AR antagonist, 4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl-amino]e

21 ) AR selective antagonist 4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5]triazin-5-yl-amino]e

22 With this approach, N-(4-chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine (N42FTA) was found to co

23 G 559), and ethyl 2-[3-hydroxy-5-(5-methyl-2-furyl)-2-oxo-4-(2-thienylcarbonyl)-2,5-dihydro-1H-pyrr o

24 ive suspected genotoxic compounds (i.e. 1-(2-furyl)-2-propanone, 2-acetylfuran, 2-acetyl-5-methylfura

25 olyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-furyl, 2-pyridyl, 2-indolyl, or 2-pyrrolyl) in the prese

26 lpyrrolyl) to regioselective 1,2-addition (2-furyl, 2:1).

27 ible and more easily oxidized ferrocenyl-bis-furyl-2-carboxylate (2) is found to more effectively bin

28 The synthesis of 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, a natural product with antileis

29 The strongest bases are 2,6-bis(3-methoxy-2-furyl)-4-dimethylaminopyridine and 2,6-di(2-dimethylamin

30 5-({[2 (methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (lapatinib), an inhibitor of Er

31 he synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly-Pro-Ala, we found that neither t

32 ce was used to stereoselectively convert the furyl alcohol into the 5-hydroxy-pyran-2-one.

33 hanistic studies involving deuterium-labeled furyl alcohol suggest that the oxidative rearrangement p

34 BuLi and addition to benzaldehyde provides a furyl alcohol that is converted to 2-phenyl 3-furfural u

35 etoester to enantioselectively form a chiral furyl alcohol.

36 ducts, these new oxidative rearrangements of furyl alcohols and furyl sulfonamides generate only one

37 zinc reagents (M-R) to 3-furfural provides 3-furyl alcohols in high yields.

38 date to an unsaturated ester prepared from 3-furyl aldehyde; diastereoselective allylation of a beta-

39 intramolecular Diels-Alder cyclization of o-furyl(allylamino)arenes.

40 2-Furyl analog 16 showed selective activity against HUVEC,

41 Furyl analogue 36 is the most promising of the series.

42 to the clinically relevant milataxel (Ar = 2-furyl) and simotaxel (Ar = 2-thienyl) side chains.

43 s possessing the modified bases 6-(2-benzo[b]furyl)- and 6-(2-furyl)pyrrolocytosine (BFpC and FpC) ha

44 = 2- and 3-thiophenyl, 2-benzothiophenyl, 3-furyl, and 5-indolyl) were successfully added to aldehyd

45 xample, those based on p-F-phenyl, naphthyl, furyl, and benzyl moieties are found to require acid cat

46 lied to the cross-coupling of 2-pyrrolyl-, 2-furyl-, and 2-thienylsilanolates.

47 The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutr

48 um ylides with acetylenes opens a way to new furyl annelated phosphinolines or unusually substituted

49 ', the cytotoxicity decreases in the order 2-furyl approximately 2-methyl-1-propenyl > or = 2-methylp

50 , (2) stereoselective alpha-methylation, (3) furyl attachment, and (4) introduction of a 16-keto func

51 tial 5-endo-dig cyclization to give a cyclic furyl-Au intermediate.

52 ated reaction, beta-to-Au protonation of the furyl-Au species to give a Au-carbene intermediate compe

53 A sesamol-benzyne cycloaddition with a 3-furyl-benzoate followed by regiospecific lactonization p

54 adenosine receptors indicated that pyridyl, furyl, benzofuryl, and thienyl groups at the 4-position

55 of migrastatin is accomplished by the use of furyl carbinol in 13 linear steps from furfural with ~11

56 This reaction is found to be general even on furyl carbinols; however, it generates the rearranged po

57 ilizes an underassessed chemical behavior of furyl-containing amines to form a C-N bond via engaging

58 This compound has a furyl-delta-lactone core similar to that of Salvinorin A

59 decrease in methional and methyl 2-methyl-3-furyl disulfide content, and the increase of methionol.

60 l, dimethyl trisulfide and methyl-2-methyl-3-furyl disulfide.

61 anthiol, 2-furfurylthiol and, bis(2-methyl-3-furyl) disulfide were isolated only in the flavoring at

62 hyl-3-(methyldithio)furan and bis(2-methyl-3-furyl) disulphide.

63 thyl-3-methyldithiofuran, and bis(2-methyl-3-furyl)disulphide.

64 dG adducts with 8-substituents consisting of furyl ((Fur)dG), phenyl ((Ph)dG), 4-cyanophenyl ((CNPh)d

65 adducts with C(8)-substituents consisting of furyl ((Fur)dG), pyrrolyl ((Pyr)dG), thienyl ((Th)dG), b

66 t of the 6-phenyl ring with a 3-thienyl or 3-furyl group reduced the affinity at A3 receptors by 4- a

67 he first enantioselective total synthesis of furyl-hydroquinone-derived biologically potent natural p

68 of this proposed mechanism, we found that 3-furyl imines undergo the addition of organometallic reag

69 g topotecan, 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1), and flavopiridol.

70 On the contrary, under gold catalysis furyl-indoles were obtained as exclusive products from N

71 st, 4-(2-[7-amino-2- inverted question mark2-furyl inverted question mark inverted question mark1,2,

72 5-[(4, 5-dichloro-1H-imidazol-1-yl)methyl]-2-furyl inverted question markcarbonyl)-4 methoxybenzene-1

73 tric Noyori transfer hydrogenation of a beta-furyl ketoester to enantioselectively form a chiral fury

74 ryl-l-cysteine (FFT-S-Cys) and S-(2-methyl-3-furyl)-l-cysteine (MFT-S-Cys) in the Maillard reaction o

75 henyl)-N'-[2-[([5-[(dimethylamino)-methyl]-2-furyl]-m ethyl)-sulfanyl]ethyl]urea) (CAP-1), is well to

76 A), 2-furfural (F), 5-methylfurfural (MF), 2-furyl methyl ketone (FMC), 2-furoic acid (FA), and for 3

77 henyl)-N'-{2-[({5-[(dimethylamino)-methyl]-2-furyl}-methyl)- sulfanyl]ethyl}-urea) (CAP-1) using a co

78 '-bis(diethylamino)-2-{[(1E)-(4,5-dimethyl-2-furyl)methylene]amino}spiro[isoindole-1,9'-xanthen]-3(2H

79 pound 1, nicotinic acid [5-(3-bromophenyl)-2-furyl]methylene-hydrazide; compound 2, 4-fluoro-benzoic

80 benzoic acid [5-(3-trifluoromethyl-phenyl)-2-furyl]-methylene-hydrazide] were selected for further an

81 he construction of diverse functionalized (2-furyl)methylthioether derivatives via base-promoted S-H

82 sn-2 acyl group that incorporates a terminal furyl moiety (oxPC-furan).

83 ts in vivo, the presence of an unsubstituted furyl moiety was a cause of some concern.

84 ities that could arise from an unsubstituted furyl moiety, an optimization effort was undertaken with

85 e first optimized to remove an unsubstituted furyl moiety, with the aim of avoiding the potential met

86 stituted 7-deazapurine derivatives bearing a furyl or ethynyl group at position 7, were significantly

87 tannane precursors for the synthesis of 5-(2-furyl, or 2-thienyl, or 2-pyrrolyl)uracil nucleosides, w

88 o be involved in the insertion of 2 into the furyl-Pd bond.

89 2beta-Carbomethoxy-3beta-(4'-(3-furyl)phenyl)nortropane (1) was synthesized along with t

90 d compounds and then encapsulating bis[tri(2-furyl)phosphine]palladium(II) dichloride in a biocompati

91 ino-7-[2-(4-fluorosulfonyl)phenylethyl]-2-(2-furyl)-pryazolo[4,3-epsilon]-1, 2,4-triazolo[1,5-c]pyrim

92 ioligand [3H]-5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo [4,3-epsilon]-1,2,4-triazolo[1,5-c)pyrim

93 antagonists (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5 -c]pyrimidine

94 4) but not by 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidine

95 or SCH58261 [5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidine]

96 ic antagonist 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-epsilon]-1,2,4-triazolo[1,5-c] pyrim

97 Cp-60 (2-amino-6-[(2-aminophenyl)thio]-4-(2-furyl)pyridine-3, 5-dicarbonitrile) and Cp-62 (N'1-( inv

98 modified bases 6-(2-benzo[b]furyl)- and 6-(2-furyl)pyrrolocytosine (BFpC and FpC) have been synthesiz

99 The pendant furyl ring of NBF remains intact during the initial curi

100 -substitution" (CEIS) in which the gold(III)-furyl sigma-bond produced by furan auration acts as a nu

101 As demonstrated with the beta-(2-furyl)-substituted analogue 1b, beta-aryl-alpha-nitro-al

102 beta-Furyl-substituted anti-alpha-(difluoromethyl)-beta-amino

103 ination of an aza-Achmatowicz oxidation of a furyl-substituted benzenesulfonamide followed by a conju

104 NPs were functionalized on the surface by a furyl-substituted carbene through an insertion reaction.

105 idative rearrangements of furyl alcohols and furyl sulfonamides generate only one regioisomer in each

106 dition of organometallic reagents to provide furyl sulfonamides.

107 nynone in a different manner, yielding alpha-furyl sulfone and stereodefined vinyl sulfone in toluene

108 anisms of transition-metal free reactions of furyl, thienyl and indolyl trifluoroborates with benzhyd

109 to the hit [pyrimidin-2-yl]amino-furo[3,2-b]furyl-urea scaffold were selected for structure-activity

110 identified [pyrimidin-2-yl]amino-furo[3,2-b]-furyl-urea/amide hit chemical scaffolds.