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1 elles, where membranes are tethered, but not fused.
2 ticular plate, and stereocilia elongated and fused.
5 amely IDTN, by end-capping with the naphthyl fused 2-(3-oxocyclopentylidene)malononitrile is synthesi
7 1,3-dicarbonyl compound to produce valuable fused 5,7-dihydroindolo[2,3-b]carbazoles through the fun
9 n we report the total synthesis of the trans-fused 8,12-guaianolide (+)-mikanokryptin in 10 steps fro
13 in's REC2 domain with the BCL-xL protein and fusing an interacting BH3 peptide to the C terminus.
15 sked about which types of cells are prone to fuse and whether other methods may identify a wider rang
16 we propose two new sparse PCA methods called Fused and Grouped sparse PCA that enable incorporation o
18 ollection of structurally diverse polycyclic fused and spiro-4-aminopyridines that are prepared in on
19 mly to groups that underwent FVC followed by FUSE, and 25 were assigned to groups that underwent FUSE
20 peat unit are synthesized, which extends the fused aromatic structure with two additional phenyl ring
22 es (PS), arising from maxillary prominences, fuse at the midline, forming the hard and soft palate.
23 eduction cascades furnish the cis- and trans-fused azadecalin subunits present in Aspidosperma and Ko
27 from isomers with linear connectivity of the fused benzene rings to those with cis- or trans-bent con
29 the syntheses of hitherto unreported imidazo-fused benzimidazoquinazolines via a deprotection-GBB rea
30 1-29), bearing different substituents on the fused benzo ring (Cl, NO2, NH2, CF3, ureido, amido, hete
32 ifferent products; a tricyclic N-heterocycle-fused beta-lactone and a bicyclic enamine derived from i
34 A series of bi- and tricyclic, N-heterocycle-fused, beta-lactones were first synthesized in racemic f
35 enantioselective synthesis of N-heterocycle-fused-beta-lactones from N-linked ketoacids is described
36 yl diphosphate into a previously unknown 5,7-fused bicyclic diterpene, coined "pseudolaratriene." Com
43 284 tricyclic compounds are classified into fused, bridged, and miscellaneous structures based on 54
47 iana) gynoecium consists of two congenitally fused carpels made up of two lateral valve domains and t
48 type I-F CRISPR-Cas systems that consist of fused cas8f and cas5f, cas7f, and cas6f genes and a shor
52 tionalized variety of N-substituted pyridine-fused chromeno and pyrano derivatives were obtained with
53 chromatographic method was performed using a fused-core C18 column, thereby avoiding the coelution of
54 -APCI(+/-)/QqQ/MS methodology, using a novel fused-core C30 column, for the apocarotenoids detection
55 romatography method with a C18 reverse-phase fused-core column has been developed for the determinati
56 electors (sub-2 mum fully porous and 2.7 mum fused-core particles) in the second dimension, together
58 We generate alternative architectures for fusing CRISPR to GPCRs utilizing the previously reported
60 that demonstrated formation of (hetero)aryl-fused cyclohexa-1,3-dienes upon acid-promoted cyclopropy
61 ive rhodium-catalyzed C-C activation of ring-fused cyclopentanones was achieved to afford efficient a
63 nTag) recruiting multiple copies of antibody-fused de novo DNA methyltransferase 3A (DNMT3A) (dCas9-S
65 ign of which was optimized for each printer: fused deposition molding (FDM), Polyjet, and digital lig
66 ) configurations using a conventional RepRap fused deposition moulding (FDM) 3D printer, which requir
68 eved for the synthesis of indole-cyclic urea fused derivatives through a double cyclization process f
69 The development and application of the arene-fused domino Michael/Mannich route to the tetrahydrocarb
71 e general high-yield routes for novel thieno-fused five- and six-membered nitrogen and oxygen heteroc
79 generation of fluorescent probes for PA, by fusing GFP to PA-binding domains, has provided direct ev
82 eactions for the synthesis of various thieno-fused heterocycles were cinnamyl bromide, 2-bromobenzyl
84 d under triazole-NHC control to give unknown fused heterocyclic skeletons, pyrrolo[3,2-c][1,2,4]triaz
91 inclusions of aggregated RNA-binding protein fused in sarcoma (FUS) are hallmarks of ALS and frontote
92 lasmic inclusions of the RNA-binding protein fused in sarcoma (FUS) represent one type of membraneles
93 DR derived from the RNA granule protein FUS (fused in sarcoma) to a multivalent poly-Src homology 3 (
95 ch for efficient targeted DNA methylation by fusing inactive Cas9 (dCas9) with an engineered prokaryo
98 ve the efficacy of CD20-targeted therapy, we fused interleukin 21 (IL-21), which induces direct lymph
99 e pressurization, the individual CsPbBr3 NCs fuse into 2D nanoplatelets (NPLs) with a uniform thickne
100 tion retinotopically, but the axon terminals fuse into a glomerular structure in the central brain wh
104 8H[12]CPP and a bent 12H[18]CPP, which were fused intramolecularly with two and three 1,4-dimethoxyb
106 olving the mixed lineage leukemia (MLL) gene fuse it in frame with multiple partner genes creating no
108 , desensitization of neurons in the Kolliker-Fuse (KF), a key area in the respiratory circuit, was ex
109 t are capable of selectively and efficiently fusing large numbers of aromatic rings, yet such methods
110 stigational optoacoustic imaging device that fuses laser optical imaging (OA) with grayscale ultrason
114 employs an entropy-based utility function to fuse many basic partitions to a consensus one that agree
116 new type of biological coating is created by fusing membrane material from two different cells, provi
117 fusogen can replace HAP2/GCS1 in one of the fusing membranes, indicating that HAP2/GCS1 and EFF-1 sh
118 .4% of dysplastic lesions per lesion whereas FUSE missed 25.0% per lesion (P = .0001); FVC missed 75.
121 scopy, and simulations in silico showed that fused mitochondria become critical for inheritance and t
122 le-aged flies have more elongated, or 'hyper-fused' mitochondria, and show that induction of mitochon
123 f Drp1 enhances the recruitment of Parkin to fused mitochondrial networks and the rate of mitophagy a
126 nhanced levels of active Rac in adherent and fusing myoblasts, as well as triggered lamellipodia, spr
127 Herein, a facile synthesis of intricate fused N-heterocycles is disclosed by employing C-H activ
129 sts provided access to bicyclic beta-lactone-fused, N-heterocycles in moderate to good yields (up to
132 SNARE-decorated proteoliposomes that cannot fuse on their own, we now demonstrate that full fusion a
133 matic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40)
134 longitudinal phenotypes by incorporating the fused penalty, which requires that the differences betwe
136 trategy allows facile access to extended CBD-fused pi-systems with tunable local antiaromaticity and
142 fficient approach for the synthesis of benzo-fused pyridoindolone derivatives via a one-pot copper ca
145 s at the position 4, gives the corresponding fused pyrrolecarboxylic acid derivatives in high yields.
146 s was described for the synthesis of various fused quinoline, benzoquinoline, and naphthoquinoline de
147 dual-membrane-coated nanoparticles from the fused RBC membrane and platelet membrane is demonstrated
149 ell known are the contributions of the benzo-fused relative of the cyclopentadienyl ligand, the inden
150 diagnostic categories and provide suboptimal fused representations using the same set of modalities f
154 rpenes with unprecedented 6/11/5 and 6/6/7/5 fused ring systems when transiently co-expressed with a
157 on involving spontaneous ring expansion of a fused-ring benzazirine into a seven-membered ring cyclic
159 ended conjugation into the electron-donating fused-ring units in nonfullerene acceptors is a promisin
160 Previously undescribed [4.4.0] and [5.3.0] fused-ring-containing products were obtained when santon
161 lar coupling to form a helical ZrPAH with 16 fused rings (from a precursor with no fused rings).
166 dicity by comparing harmonics generated from fused silica and crystalline quartz, which contain the s
167 proposed for efficient laser modification of fused silica and sapphire by means of a burst of femtose
168 resis-UV instrument using a polyimide coated fused silica capillary and an in-house designed flow-cel
169 pump-probe X-ray diffraction measurements on fused silica crystallizing to stishovite on shock compre
172 (ES) containing acetonitrile (ACN) inside a fused-silica capillary that was dipped into the sample.
173 It is still unclear whether vesicles that fuse spontaneously or following evoked release share sim
175 providing a workable access to imidazolidine-fused sulfamidates, sulfamides, and benzosultams bearing
181 nase interaction reporter to intracellularly fuse the coding sequences of two interacting proteins an
184 hese results demonstrate a new approach that fuses the concepts of medicinal chemistry and protein de
186 products of intrachromosomal rearrangements fusing the 3' coding portion of the EGFR gene to the 5'-
189 optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV
190 ility of hFGF21 were tested and optimised by fusing the protein with one of eight tags: hexahistidine
195 unit just by changing the orientation of the fused thiophenes from upward to downward, resulting in t
198 sist of CD16A binding human antibody domains fused through a flexible linker to an engineered one-dom
199 high yields, where three naphthalenoids are fused through two CBDs in linear, angular, and bent regi
201 Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone.
202 We show that at least three vesicles need to fuse to induce the phagophore shape, consistent with exp
203 mouse corneal epithelial cells were found to fuse to keratocytes in vitro and to induce myofibroblast
204 ich retain meristematic properties and later fuse to produce the female reproductive structures vital
205 that plasma-derived exosomes preferentially fuse to TCR-activated T cells and autologous parent cell
206 ring the regenerative phase, only axons that fuse to their distal counterparts contribute to function
209 red construct in which a kinase substrate is fused to a bipartite nuclear localization signal (bNLS)
210 y split CpG MTase (sMTase) with one fragment fused to a catalytically-inactive Cas9 (dCas9) that dire
211 form of TRAIL, FasL or CD40L is genetically fused to a high-affinity anti-fluorescein scFv antibody
212 f a tumor vasculature-homing peptide (CGKRK) fused to a pro-apoptotic peptide [D(KLAKLAK)2] coated on
213 scent tags are protein sequences that can be fused to a protein of interest to render it fluorescent.
214 g human cell lysate and purified target mRNA fused to a reporter was used to identify active zwitteri
215 erase with an elastin-like polypeptide (ELP) fused to a short recognition sequence in E. coli, we sho
216 inant HIV glycoprotein 120 (gp120) construct fused to a small portion of herpes simplex virus 1 (HSV-
217 CRY2 linked to DNMT3A-CD or TET1-CD and CIB1 fused to a Transcription Activator-Like Element (TALE) l
222 cs characterized by a 10-membered carbocycle fused to an anthraquinone, both of polyketide origin.
224 ngle-chain dimers (fused to B2M) or trimers (fused to B2M and a peptide antigen), without surface exp
225 ace expression of HLA-E single-chain dimers (fused to B2M) or trimers (fused to B2M and a peptide ant
226 (AAV) encoding Abeta42 and Abeta40 peptides fused to BRI2 protein by intraocular injection in C57BL/
227 chemical design), their modularity in being fused to create multimodal nanomaterials (spanning multi
230 ysis of SH-SY5Y cells overexpressing SLC30A9 fused to enhanced green fluorescent protein demonstrated
231 humanized recombinant monoclonal antibodies fused to Env gp140, were administered as a boost with po
233 enzyme was split into two moieties that were fused to FKBP (FK506-binding protein) and FRB (rapamycin
234 assemble and rotate when FliG is genetically fused to FliF, for which the accepted number is 25.
235 airs of coiled-coil units were strategically fused to generate three chains that were predicted to pr
236 ansgenic cells expressing variants of POMP10 fused to GFP demonstrate that the N-terminal membrane-sp
238 an be steered towards entities predominantly fused to graphene edges through two pyrrole rings by the
239 , the N-terminal region of SS4 alone or when fused to GS conferred a patchy subchloroplastic localiza
240 ated variant of CRISPR-Cas9 proteins (dCas9) fused to heterologous transactivation domains can act as
243 tidine affinity tags (His-tags) are commonly fused to proteins to aid in their purification via metal
244 we utilize nuclease-deactivated Cas9 protein fused to repetitive peptide epitopes (SunTag) recruiting
247 d the catalytically inactive dSpCas9 protein fused to the amino-terminus of the transposase enzyme de
248 induced by means of immunization with NtCFlg fused to the C-terminus of Bet v 1 inhibited binding of
249 uorescent protein (iRFP670), with the latter fused to the DNA repair protein O(6)-methylguanine-DNA-m
250 (sP-selectin) or as a disulfide-linked dimer fused to the Fc portion of mouse immunoglobulin G (sP-se
251 ng domains from autolysins and lysins can be fused to the Fc region of human IgG, creating a fully fu
252 assays, the reporter fragments are directly fused to the interacting proteins, eliminating the possi
255 MERS-CoV S1 domain of the MERS-CoV S protein fused to the RABV G protein C terminus (BNSP333-S1).
256 We show here that serine integrases can be fused to their cognate RDFs to create single proteins th
258 ducible catalytically inactive Cpf1 nuclease fused to transcriptional activation domains to tune the
259 omes can arise if an existing sex chromosome fuses to an autosome or an autosome acquires a new sex-d
261 restoration needed: 1) single unit porcelain-fused-to-metal (PFM) crowns (SCs) and 2) 3- to 4-unit PF
262 f tetrahydro[6]cycloparaphenylene (4H[6]CPP) fused together through two 1,4-dimethoxybenzene units in
264 Similar treatment of the related thiadiazolo-fused tricycles, i.e. 9-aryl-5H,7H-[1,2,5]thiadiazolo[3,
266 8Pd3{Si(i)Pr3}6](2-) (1) with a core of face-fused twinned icosahedra, Ge18Pd3, and two sets of three
267 efiting from the pi-conjugation extension by fusing two phenyls, IDTN shows stronger molecular aggreg
268 validation, we reveal that hornerin, an S100 fused-type protein, is highly expressed on pancreatic tu
270 de novo design and synthesis of N-heteroaryl-fused vinyl sultams as templates for programming chemica
271 colonoscopy times were similar (21.2 min for FUSE vs 19.1 min for FVC; P = .32), but withdrawal time
273 were found to slowly and spontaneously fully fuse with activation energies of approximately 30 kBT Ou
274 rgo-laden transport carriers that ultimately fuse with an adjacent ER-Golgi intermediate compartment
275 ch the membranes of secretory granules (SGs) fuse with each other to form a channel through which the
277 show that liposomes and chromaffin granules fuse with GUVs containing activated SNAREs with only few
278 as a regrowing axon is able to recognize and fuse with its own detached axon segment, thereby rapidly
279 sm, undergo intracellular transport and then fuse with lysosomes, endosomes and multivesicular bodies
280 arge number of TGN-derived membrane vesicles fuse with one another to form the partitioning membrane.
281 -1 particles and compromise their ability to fuse with target cells, an effect that is antagonized by
282 ochondria escape from these compartments and fuse with the endogenous mitochondrial network, while so
284 ted within endosomes and released when these fuse with the plasma membrane, whereas ectosomes bud dir
286 ase isoform 2 (AHA2) that is translationally fused with a fluorescent protein and examined its cellul
290 Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividi
296 owed that treatment with the Kalpha2 peptide fused with the TAT peptide significantly inhibited IAV r
297 two sperm delivered by the pollen tube (PT) fuses with the egg cell to form the zygote, whereas the
299 reasingly acidic and proteolytic, ultimately fusing with lysosomes, in a process termed "phagosome ma
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