ライフサイエンスコーパス: fusion gene

1 ) and viral entry (the G [attachment] and F [fusion] genes).

2 n of miR-99a and enhancing expression of the fusion gene.

3 in vivo in VCaP cells, which express the T/E fusion gene.

4 1-platelet-derived growth factor beta(PDGFB) fusion gene.

5 ining 22 base pairs, identified from BCR-ABL fusion gene.

6 genic expression of the Nup98-HoxD13 (NHD13) fusion gene.

7 ome 17, resulting in a classic bcr3 PML-RARA fusion gene.

8 dem duplication leading to an oncogenic BRAF fusion gene.

9 from a green fluorescent protein-beta globin fusion gene.

10 e basis of its molecular lesion, the BCR-ABL fusion gene.

11 from a green fluorescent protein-beta-globin fusion gene.

12 omosomal translocation generating a TEL-AML1 fusion gene.

13 somal translocation generating the PAX3-FKHR fusion gene.

14 h eosinophilia, which generates a CBFB-MYH11 fusion gene.

15 divergence relative to the tk portion of the fusion gene.

16 d transgenic mice that expressed a CALM-AF10 fusion gene.

17 as a potential recombination partner for the fusion gene.

18 s of metastatic PCCs/PGLs included the MAML3 fusion gene.

19 ed with an adenovirus containing a CD/HSV-TK fusion gene.

20 was highly increased in cells expressing the fusion gene.

21 em cell (LTHSC) by expression of the BCR-ABL fusion gene.

22 eukemia (ALL) and gives rise to the TEL-AML1 fusion gene.

23 -retinoic acid receptor alpha (PML-RARalpha) fusion gene.

24 ngement to generate constitutively activated fusion genes.

25 also enabled domain-function studies of BRAF fusion genes.

26 sing the MLL-AF6, -AF9, -AF10, -ENL, or -ELL fusion genes.

27 gH genes are main partners in a third of all fusion genes.

28 mor specimens, labeled with optical reporter fusion genes.

29 translocations, leading to identification of fusion genes.

30 ve" roles for AF4 and AF9 as partners in MLL fusion genes.

31 that patients have on average 5.5 expressed fusion genes.

32 DNMT3A is involved in the function of these fusion genes.

33 of cancer genomes and often create oncogenic fusion genes.

34 usion isoforms within tumorigenesis-relevant fusion genes.

35 CRISPR-mediated inactivation of FGFR3-TACC3 fusion genes.

36 ting to examine the in vivo functions of the fusion genes.

37 exons, discover novel transcripts and detect fusion genes.

38 Notably, EWS-FLI1 fusion genes acted in a positive feedback loop to mainta

39 ta2a subunit-green fluorescent protein (GFP) fusion gene (Adbeta2a) to increase Ca2+ influx or with A

40 romosomal translocation 3;21, leading to the fusion gene AML1/MDS1/EVI1 (AME), was observed in an ET

41 ERG gene as the established surrogate of ERG fusion genes among 262 prostate cancer biopsies from the

42 emia, we identified a transforming MLL-NRIP3 fusion gene and biallelic mutations in SETD2 (encoding a

43 (+/56M) mice, which expressed the Cbfb-MYH11 fusion gene and deactivated Chd7 in hematopoietic cells

44 al translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and

45 determined the importance of the CRTC1-MAML2 fusion gene and its downstream AREG-EGFR signaling in hu

46 Patients were negative for the FIP1L1-PDGFRA fusion gene and required prednisone monotherapy, 20 to 6

47 Increased synaptic and mitochondrial fusion genes and decreased fission genes were found in t

48 Fusion genes and fusion gene products are widely employe

49 study, we analyzed the status of TMPRSS2-ERG fusion genes and interstitial genes in tumors from a lar

50 d imaging have allowed identification of new fusion genes and propelled further characterization of p

51 drial fission genes, decreased expression of fusion genes and synaptic genes were found in the mutant

52 a has been described, landscape of expressed fusion genes and their clinical impact remains unknown.

53 The simulation of events known to create fusion genes and their resulting chimeric proteins is su

54 arrangements involving NUT, usually BRD4-NUT fusion genes and, less commonly, NUT-variant fusion gene

55 n that produces OspC within a tick (from the fusion gene) and during early mammalian infection (from

56 ed VCaP cells, which express the TMPRSS2:ERG fusion gene, and xenografts.

57 1, a known collaborator of HOX and NUP98-HOX fusion genes, and Mn1, a transcriptional coactivator inv

58 Many of these fusion genes, and other genetic aberrations are tumour s

59 Fusion genes are chromosomal aberrations that are found

60 Beta-alpha subunit fusion genes are found in the choanoflagellates, ichthyo

61 Chimeric fusion genes are highly prevalent in childhood acute lym

62 Oncogenic SS18-SSX family fusion genes are known to alter the composition of the B

63 To investigate whether the identified fusion genes are recurrent, we performed fluorescent in

64 hilic MPNs associated with PDGFRA and PDGFRB fusion genes are responsive to imatinib.

65 Although these fusion genes are well characterized as transcription fac

66 Mixed lineage leukemia (MLL) fusion genes arise from chromosomal translocations and i

67 ith t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3.

68 g can be used to investigate the etiology of fusion-gene-associated cancers.

69 ce that carry a modified human rhodopsin-GFP fusion gene at the normal mouse rhodopsin locus.

70 h-throughput data, which allows us to detect fusion genes at both transcript and genomic levels.

71 with the existing tools, IDP-fusion detects fusion genes at higher precision and a very low false po

72 Moreover, we predicted six in-frame fusion genes at sequenced duplication breakpoints; four

73 y the observation that for most known cancer fusion genes, at least one of the fusion partners appear

74 ications introduced to the probe site of the fusion gene-based assay allowed rapid virulence detectio

75 ever, these viruses escaped detection by the fusion gene-based real-time PCR test for virulence.

76 s a proto-oncogene well known as part of the fusion gene BCR-ABL1 in the Philadelphia chromosome of l

77 a unique entity defined by the presence of a fusion gene between the orphan nuclear receptor, CHN/NOR

78 contrast, embryos mutant for another muscle fusion gene, blown fuse (blow), have a normal number of

79 tary diseases caused by mutations in fission/fusion genes but also by aberrant mitochondrial morpholo

80 We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in mice from condi

81 We engineered a 5.7 kb miniDys-GFP fusion gene by replacing the dystrophin C-terminal domai

82 suggest that the retention of these tmk-dut fusion genes by certain baculoviruses could be related t

83 veral recent studies have reported that some fusion genes can escape microRNA regulation via 3'-untra

84 To provide a comprehensive and detailed fusion gene cartography and suggest new mechanisms of tu

85 Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not su

86 nterest to know the effects of the resulting fusion gene, CBFB-MYH11, on other lineages.

87 The fusion gene combines sequences encoding a strong transac

88 onstruction and validation of several triple fusion genes composed of a bioluminescent, a fluorescent

89 Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma

90 Here we describe methodology permitting fusion gene construction for functional evaluation.

91 d broadly, these tools will facilitate rapid fusion gene construction for subsequent functional chara

92 efore we leveraged the modular design of our fusion gene construction methodology to screen N-termina

93 The fusion gene containing the mouse C receptor 1-related ge

94 t 3' traps, we show that otherwise identical fusion genes containing a large first exon (804 nt) are

95 These unique fusion genes could be related to clinical phenotypes and

96 erences more than the coding sequence of the fusion gene created.

97 he expression of a single bifunctional yeast fusion gene, cytosine deaminase/uracil phosphoribosyltra

98 en implicated in Alzheimer disease, so these fusion gene data could explain a report of spastic parap

99 WWTR1 (protein is known as TAZ)-CAMTA1 (WC) fusion gene defines epithelioid hemangioendothelioma, a

100 roughput RNA sequencing identified recurrent fusion genes defining new molecular subgroups.

101 cripts that, to our knowledge, are the first fusion genes described in TGCT and may therefore potenti

102 Some highly expressed fusion genes detected by FusionQ are important biomarker

103 mputational features of existing methods for fusion gene detection and suggest directions for future

104 ecimens by Illumina RNA-sequencing, the STAR fusion gene detection pipeline, and GATK RNA-seq variant

105 d sequencing approach, IDP-fusion, to detect fusion genes, determine fusion sites and identify and qu

106 ve been made in computational approaches for fusion gene discovery over the past 3 years due to impro

107 for testing and benchmarking applications in fusion gene discovery.

108 the Eml4-Alk inversion, express the Eml4-Alk fusion gene, display histopathological and molecular fea

109 Fusion transcripts are formed by either fusion genes (DNA level) or trans-splicing events (RNA l

110 stoma-c-ros-oncogene1 (FIG-ROS1(S); FIG-ROS) fusion gene dramatically accelerates ICC development and

111 ications that aid in the perpetuation of MLL fusion gene driven oncogenic programs are being defined,

112 We examine how these fusion genes dysregulate the BCL-2 family of proteins, p

113 ffectors of morphogenesis including the cell fusion gene eff-1.

114 The BRD3-NUT fusion gene encodes a protein composed of two tandem chr

115 This fusion gene encodes for CXCR4/MAML2 protein chimera in w

116 with either SSX1 or SSX2, with the resulting fusion gene encoding an aberrant transcriptional regulat

117 ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep sequencing da

118 cinia virus (VACV) carrying a light-emitting fusion gene enters, replicates in, and reveals the locat

119 karyotes are the result of the two ancestral fusion genes evolving by an assortment of gene fissions,

120 To study the effects of the fusion gene EWS-FLI1 on development and tumor formation,

121 The oncogenic fusion gene EWS-WT1 is the defining chromosomal transloc

122 Patients carrying the AML1-ETO fusion gene exhibit an accumulation of granulocyte precu

123 ndmA, ndmB, and ndmD were cloned as His(6) fusion genes, expressed in Escherichia coli, and purifie

124 hRNA decreases Ser536 phosphorylation in T/E fusion gene expressing cells.

125 inducible system for the fine control of gfp-fusion gene expression and for protein depletion experim

126 ent for the stimulation of G6Pase-luciferase fusion gene expression by PGC-1alpha.

127 Chromosome 6, either entirely or around the fusion gene expression locus, demonstrated a copy number

128 Using YFP-fusion gene expression vectors, interaction between 14-3

129 lized beta-catenin, and up-regulated Bcr-abl fusion gene expression.

130 Expression of the fusion gene FIP1-like 1/platelet-derived growth factor r

131 ma patient carries a novel transmembrane ALK fusion gene: FN1-ALK.

132 njections of adeno-associated virus carrying fusion genes for channelrhodopsin-2 and YFP, in either t

133 The ETV6-RUNX1 fusion gene, found in 25% of childhood acute lymphoblast

134 KT2440 with stable expression of an arsM-gfp fusion gene (GE P. putida), which was inserted into the

135 reviously shown that AML1/MDS1/EVI1 (AME), a fusion gene generated by a t(3;21)(q26;q22) translocatio

136 KIT mutations cooperate with CBFB-MYH11, the fusion gene generated by inv(16), for leukemogenesis.

137 It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in h

138 Moreover, a BCAM-AKT2 fusion gene generated via chromosomal translocation usin

139 ediator of signaling from the FGFR1 chimeric fusion genes generated by translocation in SCLL.

140 Plasmid DNA vaccines encoding the fusion genes generated robust immune responses against o

141 growth factor receptor alpha (PDGFRA) (F/P) fusion gene has been identified as a cause of clonal hyp

142 rangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromo

143 ol carrier protein SCP-x/pro-SCP-2 gene is a fusion gene having two initiation sites that generate a

144 bE-null (mybE-) strain express an ecmAO:lacZ fusion gene (i.e. a reporter construct containing the ec

145 K3, as well as 20 previously uncharacterized fusion genes identified in The Cancer Genome Atlas datas

146 ctivated in lymphomagenesis induced by FGFR1 fusion genes, implying that Src kinase inhibitors may of

147 (10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients.

148 ecently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leuk

149 BCAM-AKT2 is the only fusion gene in HGSC that is proven to translate an aberr

150 To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo, we gener

151 8 promoter drives expression of the PML-RARA fusion gene in myeloid cells, a Myc allele is gained in

152 e tested a superpromoter-beta-glucuronidaseA fusion gene in stably transformed tobacco (Nicotiana tab

153 sion, we determined if expression of the F/P fusion gene in the presence of transgenic T-cell IL-5 ov

154 that expression of the NUP98-HOXD13 (NHD13) fusion gene in transgenic mice results in an invariably

155 re, coexpression of miR-125b and the BCR-ABL fusion gene in transplanted cells accelerated the develo

156 Finally, knockdown of the fusion gene in VCaP cells resulted in inhibition of prol

157 )(q22.1;q21) translocation, results in a new fusion gene in which a portion of CXCR4 is linked to the

158 gy, we found generation of the Dnajb1-Prkaca fusion gene in wild-type mice to be sufficient to initia

159 ified 58 putative functional and predominant fusion genes in 54.1% of patients (n = 125), 31 of which

160 fication of anaplastic lymphoma kinase (ALK) fusion genes in approximately 50% of IMTs and the role o

161 , there is a growing interest in the role of fusion genes in common epithelial tumors after the disco

162 Surprisingly, expression of fusion genes in E. coli and S.

163 ne, previously shown to be the 3'-partner of fusion genes in endometrial stromal tumors, is also recu

164 d whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3 fusion

165 SNP-chip is a powerful tool to identify fusion genes in human cancers.

166 letions that generate chimeric ATAD3B/ATAD3A fusion genes in individuals from four unrelated families

167 Using FusionMap to characterize fusion genes in K562 chronic myeloid leukemia cell line,

168 Expression of PAX5-fusion genes in murine bone marrow cells blocked develop

169 We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR,

170 xpression of Mtk and Drs promoter-luciferase fusion genes in S2 cells.

171 prostate cancer highlights the importance of fusion genes in solid tumor development and progression.

172 are characterized by the presence of EWS/ETS fusion genes in the absence of other recurrent genetic a

173 n CAN/NUP214 lead to expression of different fusion genes including DEK-CAN, CAN-ABL, and SET-CAN.

174 me, and another two lines carrying PVT1-CHD7 fusion genes, indicating that CHD7 may be recurrently re

175 re systems, and expression of the TEL-PDGFRB fusion gene induces myeloproliferative disease (MPD) in

176 study, we report that expression of the DB7 fusion gene inhibits both intracellular NADH oxidoreduct

177 fusion genes and, less commonly, NUT-variant fusion genes involving BRD3 or still-uncharacterized gen

178 nstruction strategy, we validated five novel fusion genes involving MET, NTRK2, and BRAF kinases that

179 al subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively.

180 The BCR-ABL1 fusion gene is a driver oncogene in chronic myeloid leuk

181 The SET-NUP214 (TAF1/CAN) fusion gene is a rare genetic event in T-cell acute lymp

182 The FIP1L1-PDGFRA fusion gene is a recurrent molecular lesion in eosinophi

183 Fusion gene is an important class of therapeutic targets

184 suggest that expression of the ZNF198/FGFR1 fusion gene is associated with specific PAI-2-mediated r

185 al translocation that generates a PAX3-FOXO1 fusion gene is associated with the development of alveol

186 The original structure of the fusion gene is conserved in all anthropoid lineages, but

187 The fusion gene is disrupted by an oligonucleotide containin

188 A PQN-47::GFP fusion gene is expressed in many neurons, vulval precurs

189 The TMPRSS2/ERG (T/E) fusion gene is present and thought to be an oncogenic dr

190 The TMPRSS2/ERG (T/E) fusion gene is present in the majority of all prostate c

191 The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive inf

192 The oncogenic mechanism in these fusion genes is akin to CDH11-USP6, with the USP6 coding

193 ugh formation and expression of the PAX-FKHR fusion genes is thought to be the initiating event in th

194 truncated ERG (DeltaERG), encoded by the ERG fusion gene, is stabilized by evading SPOP-mediated dest

195 ion that generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangemen

196 The T/E fusion gene isoforms differentially increase expression

197 We found that T/E fusion gene isoforms differentially increase NF-kappaB-m

198 zation of multiple alternatively spliced T/E fusion gene isoforms which have differential effects on

199 YWHAE-FAM22 fusion gene knockdowns were performed with shRNAs and si

200 roup of patients presented with MLL or NUP98 fusion genes leading to up-regulation of the HOX A clust

201 Expression of a NUP98-HOXD13 (NHD13) fusion gene leads to myelodysplastic syndrome in mice.

202 RNA-mediated knockdown of MEIS1 in human MLL-fusion gene leukemia cell lines resulted in reduced cell

203 ception of the presence of the FIP1L1-PDGFRA fusion gene, little is known about predictors of imatini

204 to FGFR-selective agents, the presence of a fusion gene may aid in selection of patients for FGFR-ta

205 Expression of the DB7 fusion gene may reduce protein translation to impair bra

206 ts and providing evidence that expression of fusion genes may be common in tumors.

207 y, concomitant deletion of the mitochondrial fusion gene Mfn1 completely rescued heart dysfunction, l

208 nd decreased expression of the mitochondrial fusion genes Mfn1 (mitofusin 1), Mfn2 (mitofusin 2), Opa

209 genes Drp1 and Fis1 were down-regulated, and fusion genes Mfn1, Mfn2 and Opa1 were up-regulated relat

210 Mutations in the mitochondrial fusion gene Mfn2 cause the human neurodegenerative disea

211 clude MLL, AF4, and both MLL-AF4 and AF4-MLL fusion genes; miR-221 down-regulates CDKN1B.

212 and unknown partners, identifying the novel fusion gene MLL-DIAPH2 in the process.

213 the expansion of this information; over 2700 fusion gene mutations are now described.

214 such as the multiple variants of TMPRSS2:ERG fusion gene mutations in prostate cancer (PCa), are prom

215 ally updated, a greater emphasis on curating fusion gene mutations is driving the expansion of this i

216 sed in RMS with PAX3-FOXO1 compared with the fusion gene-negative RMS (t-test; P < 0.0001).

217 ChimerPub includes 2767 fusion genes obtained from text mining of PubMed abstrac

218 muXg elevated the adaptor protein TRAF-6 and fusion genes OC-STAMP and DC-STAMP expression in preoste

219 ALK fusion genes occur in a subset of non-small-cell lung ca

220 The NUP98-HOXD13 (NHD13) fusion gene occurs in patients with myelodysplastic synd

221 , implicating mutations in the mitochondrial fusion genes OPA1 and MFN2 in the pathogenesis of multis

222 by mutations in the canonical mitochondrial fusion genes OPA1 and MFN2, respectively.

223 These include the inhibition of the fusion gene or its protein product, and pathways related

224 to TGCT malignancy, such as the existence of fusion genes or aberrant fusion transcript expression, w

225 Genomic deletions can create oncogenic fusion genes or cause the loss of tumor suppressing gene

226 ve breast cancer and underpinned by specific fusion genes or hotspot mutations, which may be of diagn

227 re available on 83 major cancer genes and 49 fusion gene pairs (19 new cancer genes and 30 new fusion

228 scription and translocation of RUNX1 and ETO fusion gene partners, opening a novel window to understa

229 isease driven by expression of the oncogenic fusion gene PAX3-FOXO1A.

230 Fusion genes play important roles in tumorigenesis.

231 (AR)-regulated expression of the TMPRSS2:ERG fusion gene plays an early role in prostate cancer (PC)

232 itive CRPC are comparable with the levels in fusion gene-positive primary PC, consistent with the con

233 ne(s) that might cooperate with the AML1-ETO fusion gene produced by t(8;21), we developed a set of s

234 EWS/FLI1 is a fusion gene product generated by a chromosomal transloca

235 The translocation results in a fusion gene product, PML-RARalpha, in which the PML gene

236 Fusion genes and fusion gene products are widely employed as biomarkers a

237 genomic events in human cancer because their fusion gene products can drive the development of cancer

238 nd was successfully applied for non-invasive fusion gene profiling in patient urine samples with subs

239 sistent with the in vitro studies on the DB7 fusion gene, protein translation activity is decreased i

240 ated mice that express a functional FADD:GFP fusion gene reconstituting normal embryogenesis and lymp

241 The MLL-AF6 fusion gene represents the most common leukemogenic fusi

242 FOXO1 in RMS cell lines with and without the fusion gene, respectively.

243 A novel CBFA2T3-GLIS2 fusion gene resulting from a cryptic inversion of chromo

244 xpress the PAX3-FKHR or PAX7-FKHR (PAX-FKHR) fusion genes resulting from the t(2;13) or t(1;13) chrom

245 nts containing the AtHD2C:beta-glucuronidase fusion gene revealed that AtHD2C was constitutive expres

246 lification to simultaneously detect multiple fusion gene RNAs within a short sample-to-answer timefra

247 , we show here that mutation in the myoblast fusion gene rolling pebbles (rols) dominantly suppresses

248 ld facilitate clinical and basic studies for fusion gene screening in clinical specimens, as it can b

249 Using a synthetic BCR-ABL fusion gene sequence target, we examined samples contain

250 ral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect t

251 ix Y short-arm genes and created a Zfy2/Zfy1 fusion gene spanning the deletion breakpoint [4, 5].

252 express chromosomal translocation-generated fusion genes, SS18-SSX1 or SS18-SSX2 in most cases.

253 linicomolecular risk score that incorporated fusion gene status (negative and PAX3/FOXO1 and PAX7/FOX

254 with metastases at diagnosis, independent of fusion gene status and RMS subtype (n = 120; P = 0.039).

255 Discussion continues on the use of fusion gene status to risk stratify alveolar rhabdomyosa

256 tion scheme that incorporated the PAX3/FOXO1 fusion gene status was derived from 287 patients with RM

257 not add new prognostic information over the fusion gene status, which is simpler to assay.

258 eir prognostic value was encapsulated by the fusion gene status.

259 ting for altered expression of an Snrpn-EGFP fusion gene strategy.

260 search options and graphic representation of fusion gene structure.

261 ts with translocations that create oncogenic fusion genes such as PML-RARA, RUNX1-RUNX1T1, and MLL-AF

262 enic studies with mice that harbor Plp1-lacZ fusion genes suggest that Leydig cells are the source of

263 ith or without induction of a ubiquitin-APE1 fusion gene suggested that monoubiquitination enhanced t

264 cormorant isolate sequence, and the revised fusion gene test successfully identified all 22 isolates

265 or the presence of a prognostically relevant fusion-gene than did seven other OASIS methods in the an

266 everse transcription-PCR assay targeting the fusion gene that is specific for virulent isolates ident

267 ly of tumors expresses aberrant EWSR1- (EWS) fusion genes that are derived from chromosomal transloca

268 We also identify recurrent fusion genes that significantly impact both progression-

269 s in a cancer cell line and identified three fusion genes that were corroborated by RNA-seq data.

270 ant transgenic mouse expressing a Ube3a(YFP) fusion gene, that the maternal Ube3a(YFP) allele is upre

271 After translocation, two fusion genes [the DISC1-Boymaw (DB7) and the Boymaw-DISC

272 To detect fusion genes, the current bioinformatics tools heavily r

273 Based upon phylogenetic analysis of the fusion gene, these viruses were related to lentogenic cl

274 umor, share a common class of tumor-specific fusion genes thought to be key mediators of tumor biolog

275 colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorag

276 anced green fluorescent protein (muDys/eGFP) fusion gene together with a tamoxifen-inducible form of

277 s, real-time quantitative-based detection of fusion gene transcripts or breakpoints, and multiparamet

278 The fusion gene transcripts promoted proliferation, invasion

279 n the 5' region of the alternatively spliced fusion gene transcripts.

280 of pediatric astrocytomas with KIAA1549-BRAF fusion genes typifying low-grade astrocytomas and (V600E

281 Wld(s) mice have a triplication of the fusion gene Ube4b/Nmnat and a phenotype of axon protecti

282 Monitoring for PML-RARA fusion gene was conducted after induction and throughout

283 The fusion gene was mutually exclusive with EGFR, PDGFR, or

284 yotic supergroups, suggesting that a subunit fusion gene was present in the last common ancestor of a

285 induced by expression of EWS-FLI1 or EWS-ERG fusion genes was potentiated by PARP1 inhibition in ESFT

286 ansfected with this miRNA cluster and/or MLL fusion gene, we identified 363 potential miR-17-92 targe

287 Two homologs of the tmk-dut fusion gene were separately introduced into the Autograp

288 istinct members of this family, GUS reporter fusion genes were constructed, and plants expressing the

289 Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, wi

290 Several expressed in-frame fusion genes were identified but none was recurrent.

291 A total of 222 resultant fusion genes were separately electroporated into fertili

292 rons, fission genes were down-regulated, and fusion genes were up-regulated, suggesting that Mdivil d

293 and/or prostate cancers that express the T/E fusion gene, where the NF-kappaB pathway might be target

294 We replaced the exon 2-GFP fusion gene with a cDNA encoding the 4-repeat isoform of

295 human disease, i.e., activation of Pax3:Fkhr fusion gene with either p53 or Cdkn2a inactivation.

296 the telomeric "half" was reduced to a single fusion gene with functional properties distinct from its

297 al translocations involving PDGFRB result in fusion genes with constitutively activated receptor tyro

298 that were compiled from public resources of fusion genes with experimental evidences.

299 KB represents a knowledgebase including 1066 fusion genes with manual curation that were compiled fro

300 onal in Leydig cells, a battery of Plp1-lacZ fusion genes with partial deletion of Plp1 intron 1 sequ