ライフサイエンスコーパス: fusogenic

1 infectious particles and was constitutively fusogenic.

2 hich constitute a related genus and are also fusogenic.

3 r mutant SER viruses, which were found to be fusogenic.

4 e-forming compositions are frequently highly fusogenic.

5 lesterol to counteract HM and make membranes fusogenic.

6 one additional of these 147 combinations was fusogenic.

7 therefore preventing the virus from becoming fusogenic.

8 anges that are required for making the virus fusogenic.

9 ox shuffling prevents gp41 from assuming the fusogenic 6-helix bundle conformation.

10 ains of its fusion protein, RSV-F, to form a fusogenic 6-helix bundle that enables the virus to penet

11 We find that to be fusogenic a SNARE topology must support both basal fusio

12 n protein and could enable the infection and fusogenic abilities of a gp64-null prototype baculovirus

13 p41 is highly conserved and critical for the fusogenic ability of the virus.

14 ind to trans-SNARE complexes to direct their fusogenic action.

15 We evaluated the fusogenic activities of MV and VSV-FH in relationship to

16 Lastly, the fusogenic activities of the glycoproteins in the viral e

17 he fusion peptide inhibits both HA- and FHA2-fusogenic activities.

18 finding that chemically inert PFCs exhibited fusogenic activity and marked changes in membrane surfac

19 We propose a model in which a unique fusogenic activity at the C terminus of VgrG5 facilitate

20 responsible for the reported differences in fusogenic activity between these peptides.

21 oth the bovine and ovine orthologs displayed fusogenic activity by conferring infectivity on retrovir

22 codes a membrane-bound envelope protein with fusogenic activity ex vivo, is expressed at the placenta

23 ting and fusogenicity are separable and that fusogenic activity has been uncoupled from other protein

24 lly, gB palmitoylation was required for full fusogenic activity in human epithelial cells.

25 In addition, its fusogenic activity is significantly more resistant to re

26 Fusogenic activity of full-length protein expressed in M

27 cofusogen with gB but instead regulates the fusogenic activity of gB.

28 n immunodeficiency virus type I requires the fusogenic activity of gp41, the transmembrane subunit of

29 operate with myomaker and substitute for the fusogenic activity of mammalian myomixer.

30 of GTPase domain dimerization abolishes the fusogenic activity of MFN1.

31 The fusogenic activity of Minion is conserved in the human o

32 th annexin-binding protein S100A4, regulated fusogenic activity of syncytin 1.

33 nt on both CCR5 expression levels as well as fusogenic activity of the Env glycoprotein.

34 PL binds to ASGPR on the hepatocyte surface, fusogenic activity of the F-protein delivers the DNA int

35 ain plays little or no role in affecting the fusogenic activity of the fusion peptide.

36 servations to characterize the unprecedented fusogenic activity of the MPER-TMD junction.

37 e 221, but the gp41 changes did increase the fusogenic activity of the SIV envelope two- to threefold

38 CO2 sensitivity is caused by the fusogenic activity of the viral glycoprotein, which resu

39 lation between the mode of insertion and the fusogenic activity of these peptides.

40 ghts into the role of the MPER in regulating fusogenic activity of viral glycoproteins.

41 lmitoylation was not sufficient for complete fusogenic activity suggesting a function for other amino

42 can both proceed normally in the absence of fusogenic activity suggests that properly assembled and

43 Thus, the CMV gH/gL complex has inherent fusogenic activity that can be measured in certain cell

44 EFF-1 can confer potent fusogenic activity to nonfusing cell types.

45 Thus, myomaker and myomerger together confer fusogenic activity to otherwise non-fusogenic cells.

46 man or murine uPAR were engineered and their fusogenic activity was determined.

47 , Ala) residues resulted in complete loss of fusogenic activity with the N terminus and markedly redu

48 Here we conferred fusogenic activity without transdifferentiation to multi

49 d in induction of rapid cell death, enhanced fusogenic activity, and increased rates of spread in equ

50 the VgrG5 C-terminal domain is required for fusogenic activity, and we identify sequence motifs, inc

51 e retention of a significant fraction of the fusogenic activity, as long as the mutant proteins inter

52 ities may have unequal weights in triggering fusogenic activity, depending on the ratios of gB and gD

53 Its cognate receptor, required for its fusogenic activity, was searched for by a screening assa

54 ell surface expression but does not increase fusogenic activity, whereas mutation of another potentia

55 for purifying selection and conservation of fusogenic activity.

56 ctivate HBMEC membrane rafts and induce cell fusogenic activity.

57 ah virus fusion protein (NiV-F) modulate its fusogenic activity.

58 F protein on protein folding, transport, and fusogenic activity.

59 ed to the cell surface but which had reduced fusogenic activity.

60 y members (TMEM8a and TMEM8b) do not exhibit fusogenic activity.

61 ding superinfection, fibroblast killing, and fusogenic activity.

62 ncrease surface expression but does increase fusogenic activity.

63 e of purifying selection and conservation of fusogenic activity.

64 alian hosts by altering virion stability and fusogenic activity.

65 for purifying selection and conservation of fusogenic activity.

66 We investigated the effects of fusogenic agents by simply flowing these molecules into

67 es it possible to characterize rapidly novel fusogenic agents under well-defined conditions.

68 nts in the presence of low concentrations of fusogenic agents, when fusion was rare and probabilistic

69 Of the eight or more HAs forming a fusogenic aggregate, only two have to undergo the "essen

70 ons resulted in proteins that were much less fusogenic, although they were equally well expressed at

71 rus spreads faster than MV-Edm and is highly fusogenic and a potent oncolytic.

72 H7 avian influenza virus hemagglutinin in a fusogenic and attenuated NDV background.

73 infects cells expressing MV receptors and is fusogenic and effective against myeloma xenografts in mi

74 The goal of this study was to map the fusogenic and lytic domains of SP-B and assess the effec

75 tides alter structure within the bilayers of fusogenic and nonfusogenic lipid vesicles and 2), how fu

76 but both increased acyl chain order in both fusogenic and nonfusogenic vesicles.

77 cially enveloped Ad using cationic, neutral, fusogenic, and PEGylated lipids to form the envelopes an

78 from persistently infected cells are highly fusogenic, and this phenotype has been mapped to two mut

79 VSV-FH is not fusogenic at low CD46 density but requires less CD46 for

80 olvent channels of BRV, which makes BRV like fusogenic avian orthoreoviruses and aquareoviruses but u

81 that BRV is like nonfusogenic mammalian and fusogenic avian orthoreoviruses in having 150 copies of

82 eld, faster replication kinetics, and larger fusogenic capabilities but should be used in cancer type

83 ng negative correlation between the relative fusogenic capacities of these cytoplasmic-tail mutants a

84 wn to contain determinants that affect their fusogenic capacities.

85 ed to acidify, although they retained normal fusogenic capacity with nascent phagosomes.

86 Consistent with the extinction of fusogenic capacity, both FUS1 and HAP2 are degraded upon

87 Fusogenic cells are exposed to biochemical and biophysic

88 r confer fusogenic activity to otherwise non-fusogenic cells.

89 Fusogenic changes involve assembly of two heptad repeats

90 the opportunity for low-efficiency fusion by fusogenic complexes incorporating BoNT/A-cleaved SNAP-25

91 The samples were prepared under fusogenic conditions and contained equimolar amounts of

92 ing intact envelope glycoprotein (Env) under fusogenic conditions, we show that the N-HR peptide pref

93 These results indicate that activation to a fusogenic conformation is dependent on the interplay of

94 ffective even after hemagglutinin attained a fusogenic conformation or had induced membrane hemifusio

95 s during fusion using the beta-strand as the fusogenic conformation.

96 re part of the "pH sensor" that triggers the fusogenic conformational change in E, at the reduced pH

97 back, in a rearrangement that resembles the fusogenic conformational changes in enveloped-virus fusi

98 To gain insight into the nature of the fusogenic conformational changes in gB, we used several

99 that are very different from the large-scale fusogenic conformational changes in other viral fusion p

100 Further, HB80 inhibits the HA fusogenic conformational changes induced at low pH.

101 The reversibility of their fusogenic conformational transitions differentiates them

102 n different structures representing distinct fusogenic conformations help to explain how E protein (i

103 The fusogenic core assembly of human immunodeficiency virus

104 ns formed a six-helix bundle, similar to the fusogenic core structure of HIV-1 gp41.

105 nor can it inhibit the 6-HB formation of the fusogenic core.

106 d not exhibit this RBE epitope were also non-fusogenic despite their ability to bind ephrinB2, oligom

107 usion intermediates that formed for the more fusogenic dioleoyl PC-containing liposomes did not inact

108 For less fusogenic distearoyl PC-containing liposomes at 4 degree

109 mutant, with deletions in the cleavage site, fusogenic domain, and spacing of heptad repeats 1 and 2,

110 are excluded from these domains, could form fusogenic domains with Chol.

111 , we developed a transducible, pH-sensitive, fusogenic dTAT-HA2 peptide that markedly enhanced TAT-Cr

112 pH than control virus to trigger fusion and fusogenic E1 conformational changes.

113 ifferent phases during initial generation of fusogenic E1 trimers.

114 facilitated the engagement of Irgm1 with its fusogenic effectors at the site of infection, thereby en

115 omplexin therefore cooperates with the other fusogenic elements of the synaptic fusion machinery duri

116 Syncytins are fusogenic envelope (env) genes of retroviral origin that

117 Importance: Syncytin genes are fusogenic envelope genes of retroviral origin, ancestral

118 Syncytin genes are fusogenic envelope protein (env) genes of retroviral ori

119 Thus, the fusogenic F protein resembles SNARE proteins involved in

120 recombinant NDV modified to contain a highly fusogenic F protein.

121 ggest that xlProminin-1 may serve as an anti-fusogenic factor in the regulation of disk morphogenesis

122 promoting vesicle-mediated translocation of fusogenic ferlin proteins to the plasma membrane.

123 h HA undergoes an irreversible switch to its fusogenic form in host endosomes, a crucial step for vir

124 essential for the generation of a mature and fusogenic form of the F protein.

125 ate, thereby preventing the formation of the fusogenic form of the gp41 ectodomain, which comprises a

126 rimerization is their likely topology in the fusogenic form of the intact gp41 protein.

127 in decreased cell surface expression of the fusogenic form, consistent with decreased stability of t

128 coat seems to be a specific conductor of the fusogenic forms of these SNAREs, suggesting how vesicle

129 n intermediate between the smooth mature and fusogenic forms.

130 nd cholesterol-independent structure for non-fusogenic FP-Hairpin was consistent with membrane insert

131 on of cholesterol-dependent FP structure for fusogenic FP34 and N70 and cholesterol-independent struc

132 de may be greatly simplified while retaining fusogenic function and minimizing membrane-permeablizing

133 se studies demonstrate that incorporation of fusogenic function into an oncolytic virus can significa

134 ledge, this is the first attempt to optimize fusogenic function of the HIV fusion peptide through seq

135 domain that we hypothesize is essential for fusogenic function.

136 , a well-characterized oncolytic HSV lacking fusogenic function.

137 Thus, BNAbs disrupt HIV-1 MPER fusogenic functions critical for virus entry into human

138 n wild type but to a greater degree than non-fusogenic fusion domain mutants.

139 f interest in proteoliposomes containing the fusogenic galactose-terminated F-glycoprotein of the Sen

140 ibosyltransferase fusion (Fcy::Fur)] and the fusogenic glycoprotein from gibbon ape leukemia virus (G

141 ecent work has suggested that gB is the sole fusogenic glycoprotein, regulated by interactions with t

142 Although gB is known to be a fusogenic glycoprotein, the mechanism by which gK is inv

143 in the interactions with entry receptors and fusogenic glycoproteins and with cellular proteins requi

144 ed a cell-based fusion assay to identify the fusogenic glycoproteins of CMV.

145 A hallmark of the fusogenic glycoproteins of these pathogens is refolding

146 nfection and the factors that may select for fusogenic gp120 variants during AIDS progression.

147 of inhibitor design is to prevent binding of fusogenic gp41 C-peptides to the trimeric coiled coil of

148 epeat (NHR) and prevent the formation of the fusogenic gp41 core between viral gp41 NHR and CHR, ther

149 fusion rate with the total concentration of fusogenic HA trimers and indicates that more than one HA

150 relates the fusion rate with the fraction of fusogenic HA trimers and leads to the conclusion that on

151 ipates in fusion through interactions with a fusogenic HA.

152 t antibody binding prevents formation of the fusogenic hairpin conformation of E, which together with

153 brane and binds to the HRB helices to form a fusogenic hairpin.

154 The fusogenic human immunodeficiency virus type 1 (HIV-1) gp

155 required for the formation of a consolidated fusogenic hydrophobic surface at the tip of the FL.

156 ability (the length of time that they remain fusogenic in an acidic environment) at higher pHs, but t

157 features of a bona fide syncytin gene: It is fusogenic in an ex vivo cell-cell fusion assay; it is sp

158 iruses (MACS1-br and MACS1-spln) were highly fusogenic in MDM and induced neuronal apoptosis.

159 ere stable in the presence of serum and were fusogenic in nature, with increased peptide alpha-helici

160 al mutant envelope glycoproteins were highly fusogenic in syncytium assays, and these all increased t

161 ggest that chlamydiae contained in small non-fusogenic inclusions will persist.

162 rgo large conformational rearrangements to a fusogenic intermediate and a more stable postfusion stat

163 DOPE promotes fusogenic, inverted hexagonal lipid structures while DOP

164 ycoprotein (Env) encoded by HERV-W is highly fusogenic, is naturally expressed in human placental syn

165 omprising cationic and neutral lipids plus a fusogenic lipid (PCat).

166 n in synaptic vesicles and with an optimally fusogenic lipid composition.

167 atory lipids that includes diacylglycerol, a fusogenic lipid that is produced through multiple metabo

168 ectedly linked by the generation of a common fusogenic lipid.

169 comprising different amounts of cationic and fusogenic lipids (10-30mol% DOTAP or 1,2-dioleoyl-sn-gly

170 sis requires both SNARE-complex proteins and fusogenic lipids, such as phosphatidic acid.

171 A cell-penetrating peptide-modified fusogenic liposomal membrane was coated on the core, whi

172 osome-based co-delivery system composed of a fusogenic liposome encapsulating ATP-responsive elements

173 The fusogenic liposome had a protein-DNA complex core contai

174 somal ATP promoted the drug release from the fusogenic liposome in the acidic intracellular compartme

175 Traditionally, such fusogenic liposomes are prepared by mixing lipids and li

176 Here we prepared fusogenic liposomes in situ, i.e., by addition of a lipi

177 cholesterol modified peptides yielded highly fusogenic liposomes.

178 d 5, exhibited significantly lower levels of fusogenic, lytic, and surface tension reducing activitie

179 lectively, our studies allow us to propose a fusogenic mechanism of genome delivery by STIV, in which

180 We used a similar approach to study the fusogenic mechanism of severe-acute-respiratory-syndrome

181 ertion mode is crucial for understanding its fusogenic mechanism.

182 41 provided crucial information on the viral fusogenic mechanism.

183 vaccines, based on gene transfer of a viral fusogenic membrane glycoprotein (FMG) into tumor cells,

184 r, tumor cells were transfected with a viral fusogenic membrane glycoprotein (vesicular stomatitis vi

185 ng of normal prostate tissue in situ using a fusogenic membrane glycoprotein along with the immune ad

186 Syncytia activate macrophages and fusogenic membrane glycoprotein-mediated cell killing ve

187 Expression of viral fusogenic membrane glycoproteins (FMGs) is a potent stra

188 its the unique and powerful ability of viral fusogenic membrane glycoproteins (FMGs) to couple concen

189 tiveness of P/V mutants can be enhanced by a fusogenic membrane protein without compromising sensitiv

190 blast fusion and associates with Myomaker, a fusogenic membrane protein.

191 gh cell-cell fusion requires the presence of fusogenic membrane proteins and actin-dependent cytoskel

192 Viral fusogenic membrane proteins have been proposed as tools

193 n the first 2 h after infection than for the fusogenic MHVs.

194 e lipid bilayer fusion or fusion assisted by fusogenic molecules.

195 o configuration as well as the addition of a fusogenic motif yielded a far more potent and stable BCL

196 shed in four different cell types and with a fusogenic mutant, the S757R mutant, derived from isogeni

197 termediate between that of wild type and non-fusogenic mutants.

198 re predict that the kinked helix is the most fusogenic of these three conformations.

199 ial entry mechanism is usually classified as fusogenic or endocytotic.

200 HA) from the native conformation to putative fusogenic or postfusion conformations populated at low p

201 droplets, with no restriction on the size of fusogenic partners.

202 ated by introducing point mutations in the F fusogenic peptide (G3A) or at a distal site near the F t

203 ring a nuclear localizing sequence SV40 or a fusogenic peptide (HIV-1Tat 40-60 or octa-arginine) link

204 ted that the coiled-coil domains present the fusogenic peptide in a conformation or geometry favorabl

205 To test the hypothesis that trimerization of fusogenic peptide is related to optimal fusion, we have

206 eveals key amino acid residues and a minimal fusogenic peptide motif that is necessary for promoting

207 As the N-terminal region of gp120, the fusogenic peptide of gp41, and the PTMR of gp41 show hig

208 with the hypothesis that oligomerization of fusogenic peptide promotes membrane fusion, possibly by

209 The fusogenic peptide sequences HIV-1Tat 40-60 and octa-argi

210 properties of ccX31 versus the monomeric X31 fusogenic peptide.

211 ended triple-helical coiled-coil domains and fusogenic peptides.

212 rimer in a prefusion-like state at and below fusogenic pH.

213 inetic curves that correlated with the NiV-F fusogenic phenotypes, validating NiVLPs as suitable vira

214 tes the perturbations, consistent with their fusogenic phenotypes.

215 A novel type of pH-sensitive, "fusogenic" pHLIP-liposomes was developed, which could be

216 ZM1 exhibited a markedly fusogenic plaque morphology and harbored two HN gene mut

217 ant HPF3 virus variant (ZM1) with a markedly fusogenic plaque morphology that harbored two HN gene mu

218 ces in the six helix bundle structure of the fusogenic portion (gp41) of the HIV envelope glycoprotei

219 -activated gD, and (iii) upregulation of the fusogenic potential of gB following its interaction with

220 specificity of PI(3,5)P(2) in regulating the fusogenic potential of intracellular organelles.

221 e (R(+) Env), which is known to suppress the fusogenic potential of the Env protein in other suscepti

222 fusion assay required a balance between the fusogenic potential of the VZV glycoproteins and the fus

223 ted on the core, which had an acid-triggered fusogenic potential with the ATP-loaded liposomes or end

224 ression, Env incorporation into virions, Env fusogenic potential, and viral susceptibility to neutral

225 l columns, myc and VE-cadherin, in Notch1(-) fusogenic precursors, and bound to the myc promoter and

226 t the gK/UL20p protein complex modulates the fusogenic properties of gB and gH via direct physical in

227 olecule-1 (ICAM-1) augments the adhesive and fusogenic properties of myogenic cells.

228 may function to regulate the trafficking or fusogenic properties of the inclusion.

229 eras revealed differences in the budding and fusogenic properties of the M and G proteins, respective

230 These enhanced fusogenic properties of viruses encoding a glycine at po

231 For this reason synthetic lipids with fusogenic properties such as 2-dioleoyl-sn-glycero-3-pho

232 purifying selection and conservation of its fusogenic properties, over 30 millions years of evolutio

233 The fusogenic property of ICAM-1-ICAM-1 interactions was res

234 It involves incorporation of antibody and fusogenic protein as two distinct molecules into the len

235 membrane protrusions, which in turn promoted fusogenic protein engagement and plasma membrane fusion.

236 led invasive membrane protrusions in driving fusogenic protein engagement during cell-cell fusion.

237 The refolding of the prototypic fusogenic protein hemagglutinin (HA) at the pH of fusion

238 ducts and kinetics, rSOF is a heterodivalent fusogenic protein that uses a docking site to displace a

239 from the paramyxovirus parainfluenza virus 5 fusogenic protein, F, forms an N-terminal TM helix, whic

240 itial and final conformations of a prototype fusogenic protein, influenza hemagglutinin (HA), involve

241 Both fusogenic proteins and actin cytoskeletal rearrangements

242 Because fusogenic proteins and lipids concentrate in a ring at t

243 Although cellular fusogenic proteins and the actin cytoskeleton are implic

244 The role of the water-soluble regions of fusogenic proteins has been extensively studied, but the

245 Class I viral fusogenic proteins have an N-terminal hydrophobic fusion

246 Fusogenic proteins increase the intrinsically slow rate

247 Annexins are Ca(2+)-binding, membrane-fusogenic proteins with diverse but poorly understood fu

248 Fusogenic proteoliposomes, containing charged lipids and

249 s as an important cofactor that promotes the fusogenic restructuring of pre-fusion complexes and like

250 We find that, even though the fusogenic sites support multi-cell adhesions, triploid z

251 avity in the HRA trimeric coiled coil in the fusogenic six-helix bundle (6HB) structure.

252 that is exposed between two C helices in the fusogenic six-helix bundle conformation of gp41.

253 ion by interfering with the formation of the fusogenic six-helix bundle structure.

254 brane SNARE, syntaxin, for assembly into the fusogenic SNARE complex.

255 embly pathway that leads to formation of the fusogenic SNARE complex.

256 gulates viral entry by assembling a specific fusogenic SNARE complex.

257 c vesicle secretion requires the assembly of fusogenic SNARE complexes.

258 to the cell division plane, transformed into fusogenic SNARE complexes.

259 al concept of how Sec24 isoforms can recruit fusogenic SNARE subunits to keep them functionally apart

260 ubstituting for or binding to a subunit of a fusogenic SNAREpin to form a nonfusogenic complex.

261 to other class I viral fusion proteins, the fusogenic stalk domain spontaneously refolds into its po

262 ertion of independently folding domains into fusogenic stalk domains may be a common feature of class

263 Besides inducing the fusogenic state of hemagglutinin, low pH cues softened t

264 In the fusogenic state, this pocket is occupied by key amino ac

265 pproximately 2 log10 higher than that of the fusogenic strain A59 in astrocytoma DBT cells.

266 rstanding of the molecular basis of the gp41 fusogenic structural transitions and thereby guide ratio

267 ocytosis of ZGs resulting from a decrease in fusogenic STX-4 SNARE complexes.

268 Baboon reovirus (BRV) is a member of the fusogenic subgroup of orthoreoviruses.

269 esisting forces from fusion partners put the fusogenic synapse under high mechanical tension, which h

270 Thus, a more fusogenic target membrane effectively blocks nonproducti

271 en adjacent membranes; it was, however, less fusogenic than Ca2+ at comparable concentrations.

272 do suggest that small oligomers may be more fusogenic than either monomers or large aggregates.

273 ave undergone content loss appear to be more fusogenic than intact vesicles.

274 a cell-cell fusion assay, line 19 F was more fusogenic than Long F.

275 the fusion peptide (P/V-CPI(-)-G3A) was more fusogenic than the parental P/V-CPI(-) mutant.

276 a central TM region leucine (L507A) was more fusogenic than the unmodified F protein while retaining

277 8, and TM189 mutants were significantly more fusogenic than TM185 and TM186 but remained significantl

278 the C terminus is required for Env to become fusogenic, this restriction of Env function may serve to

279 Because many viruses are fusogenic, this study suggests that viruses, including t

280 hich convert a prehairpin gp41 trimer into a fusogenic three-hairpin bundle.

281 og 1B (Vti1b)], leading to the assembly of a fusogenic trans-SNARE complex involving vesicle-associat

282 Given that gp41 fusogenic transformation is characterized by the hexamer

283 However, the dynamic nature of the fusogenic trimer has made the determination of its struc

284 helices, thereby preventing formation of the fusogenic trimer of hairpins.

285 ers that are similar to the predicted "open" fusogenic trimer.

286 Prior to formation of a fusogenic "trimer-of-hairpins" structure, gp41 transient

287 he reorganization of E protein monomers into fusogenic trimers in the acidic environment of endosomes

288 conditions, the mature virus forms transient fusogenic trimers of E glycoproteins that engage the lip

289 us has been captured during the formation of fusogenic trimers.

290 However, these fusogenic truncated Env mutants are inefficiently incorp

291 cell fusion can be achieved by engineering a fusogenic viral membrane glycoprotein complex.

292 influence morphogenesis to produce maximally fusogenic virus.

293 need for mechanisms to control the spread of fusogenic viruses in normal versus tumor cells.

294 The fusogenic VSV also conferred a significant survival adva

295 The results suggest that fusogenic VSV can be developed into an effective and saf

296 In vivo, administration of fusogenic VSV into the hepatic artery of Buffalo rats be

297 In vitro characterization of the recombinant fusogenic VSV vector on human and rat HCC cells showed e

298 The F protein of aMPV subtype A was highly fusogenic, whereas those from subtypes B and C were not.

299 t with endocytic compartments but instead is fusogenic with a subset of sphingomyelin-containing exoc

300 ubunits with Asp or Asn at position 324 were fusogenic with coreceptor chimeras containing either the