ライフサイエンスコーパス: futile

1 tals have received ICU, some of which may be futile.

2 treatment that is medically inappropriate or futile.

3 on that causes PTEN degradation has remained futile.

4 int at which treatment with a statin becomes futile.

5 ment options that were previously considered futile.

6 spond, a Phase III trial would be considered futile.

7 c arrest (CA) has been considered by some as futile.

8 as those in whom mechanical ventilation was futile.

9 hyl diazoacetate catalyzed by Rh2(OAc)4 were futile.

10 e search for truth using language is totally futile.

11 re, physicians should consider the treatment futile.

12 urrent resuscitation efforts would likely be futile.

13 etter position us to finally make resistance futile.

14 ional cooperators that their efforts are not futile.

15 LCA based on dataset completion will remain futile.

16 is setting would have led to 47% (8/17) less futile (131)I treatments, but 29% of patients (5/17) wou

17 mediate catalysis on membranes and suppress futile adenosine triphosphatase cycles.

18 motility in the absence of cargo results in futile adenosine triphosphate hydrolysis.

19 When continued intensive care is futile, advanced life support should be withdrawn.

20 on (CPR) for >20 minutes has been considered futile after pediatric in-hospital cardiac arrests.

21 patient, critical care is often considered "futile." Although futile treatment is acknowledged as a

22 Efforts to minimize nonexistent risks are futile and a major source of persistent radiophobia.

23 clinical features in whom procedures may be futile and affect public reporting of mortality.

24 e care with a therapeutic purpose was deemed futile and brain death (BD) was a likely outcome.

25 s to find evidence of effectiveness to avoid futile and distressing treatment when possible.

26 dA and that MYH-initiated short-patch BER is futile and hence this BER must proceed to long-patch rep

27 rranted and that conservative treatments are futile and may be harmful.

28 f aggressive medical or surgical care may be futile and may unnecessarily prolong the suffering of fa

29 analization of BAO up to 48 hours was seldom futile and produced good outcomes in 50% of patients, wh

30 ) that together control partitioning between futile and productive pathways and their relative rates.

31 he notion that germline transcription is not futile and stress the flexibility in eukaryotic gene usa

32 irst ten patients, the study would be deemed futile and terminated.

33 ciding whether an operative procedure may be futile and the criteria for adequate consent by either a

34 e patients, most potential interventions are futile and transplantation of both an intestine and a li

35 the point of needing life-support is nearly futile, and in today's health care climate, not an optim

36 culiar molecules into viable leads are often futile, and much time can be wasted on the characterizat

37 ncer has been characterized as an expensive, futile, and self-induced illness.

38 tor activity is precisely regulated to avoid futile ATP consumption and to ensure proper intracellula

39 This feedback mechanism may curtail futile ATP consumption because ADP not only stimulates P

40 monomer along ssDNA with little slippage or futile ATP hydrolysis during translocation.

41 ar semiopen state hints at the origin of the futile ATP hydrolysis of MalFGK(2)-E.

42 ing translocation at low ATP but with little futile ATP hydrolysis.

43 ng that binding of the closed ring induces a futile, ATP-driven, ring-opening cycle.

44 Unexpectedly, in a futile attempt to compensate for the low glutathione, th

45 le inhibitor is upregulated, presumably in a futile attempt to halt proliferation; 6) among the G1/S

46 pensive) is required for every successful or futile attempt.

47 Repetitive, futile attempts at direct current cardioversion should b

48 at inhibits activation of Spo0A and prevents futile attempts to initiate sporulation.

49 In qin mutants, less Ago3 binds Aub, futile Aub:Aub homotypic Ping-Pong prevails, antisense p

50 g constants, concluding that the forward and futile back-electron transfer is in the normal region an

51 ctive dimer ring splitting within 435 ps and futile back-ET in 95 ps.

52 cited flavin moiety and the fast dynamics of futile back-ET without repair.

53 ceptors in two sensory circuits to terminate futile behavioral loops.

54 s its use as a scouting procedure to prevent futile blind (131)I therapy.

55 esire to proceed with a procedure considered futile by some members of the medical team as a result o

56 10 patients; p = 0.004) and rarely providing futile care (0.26 [0.07-0.95] vs providing futile care o

57 physician assistant ratios and provision of futile care are risk factors for severe burnout.

58 or-performance environment, the provision of futile care can also harm the hospital population as a w

59 e of antibiotics for those who are receiving futile care can be considered unethical by egalitarian t

60 ians do not have a responsibility to provide futile care even if a patient or surrogate insists on it

61 was to examine ways in which the delivery of futile care in the ICU can cause harm to patients other

62 The delivery of futile care is not only an individual patient decision,

63 g futile care (0.26 [0.07-0.95] vs providing futile care often; p = 0.041) were independently associa

64 r 1-5 patients per shift and those providing futile care rarely also had a lower depersonalization sc

65 However, nurses scored higher on futile care than physicians (t = 2.051; p = 0.042), wher

66 posed of 14 items referring to four factors: futile care, poor teamwork, deceptive communication, and

67 m to patients other than those receiving the futile care.

68 with surrogate decision makers and providing futile care.

69 ted in this article, can be used to identify futile cases in which expected outcome is too poor to ju

70 or outcome, but the authors have encountered futile cases only rarely.

71 suffering, and limit use of ICU resources in futile cases.

72 ily conserved, even though its potential for futile catalytic cycling is low due to its sluggish cata

73 est that an increased expression of sEH is a futile central nervous system response in protection aga

74 irectional swimming but is at risk of giving futile circular swimming paths in the presence of biolog

75 gene from the chromosome, thereby ending the futile cleavage cycle that otherwise prevents detection

76 Flies avoid futile climbing attempts by processing parallax-motion v

77 of this enzyme, which is necessary to avoid futile competition between synthesis and degradation, is

78 f such systems independently of their use as futile consumers of oxygen.

79 fense against oxygen toxicity through their "futile" consumption of oxygen.

80 Futile critical care was associated with delays in care

81 Our studies reveal that the zebrafish gene futile cycle (fue) is required in the zygote for male pr

82 This protein is related to zebrafish futile cycle (Fue), a nuclear envelope (NE) constituent

83 This apparent futile cycle allows eggs to maintain elevated cytoplasmi

84 xperimental conditions and identified a high futile cycle between oxaloacetate and pyruvate, indicati

85 tose-binding site of MalF likely generated a futile cycle by preventing maltose from binding to MalFG

86 The zebrafish futile cycle gene is shown to encode a maternally expres

87 emingly opposed functions and explains how a futile cycle is avoided-cytoplasmic p300/CBP E4 activiti

88 ional functional modalities on the enzymatic futile cycle mechanism that include stochastic amplifica

89 this phenomenon is not exclusively due to a futile cycle of abortive TLS followed by exonucleolytic

90 involvement of the proofreading subunit in a futile cycle of base insertion/excision with the UmuC st

91 presence of free fatty acids and leads to a futile cycle of Ca(2+) accumulation and release when exo

92 ir target biosynthetic machinery involving a futile cycle of cell wall synthesis and degradation, the

93 persist to the next cell cycle, leading to a futile cycle of centriole formation and disintegration.

94 These findings link a futile cycle of creatine metabolism to adipose tissue en

95 e metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and beta-ox

96 iglycerides to the liver, which results in a futile cycle of enhanced VLDL production and increased k

97 AC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, whic

98 rom the gluconeogenic process and prevents a futile cycle of glucose phosphorylation.

99 gulatory role of GltC may be prevention of a futile cycle of glutamate synthesis and degradation in t

100 s the mitochondrial inner membrane, create a futile cycle of nutrient oxidation without generating AT

101 sequence are not cleaved, thereby avoiding a futile cycle of removal and readdition of these essentia

102 erted to PC and TAG, and appeared to be in a futile cycle of synthesis and degradation.

103 f enduring lipid droplets that prevented the futile cycle of TAG biosynthesis/lipolysis and instead c

104 Collectively, the data reveal a futile cycle of unregulated transcription, siRNA product

105 MMR-mediated damage tolerance and futile cycle repair processes are discussed, as well as

106 rate, can decompose to produce H(2)O(2) in a futile cycle that consumes NADPH.

107 w that a single-player system may escape the futile cycle trap by limiting transfer of reducing equiv

108 rylation of X-5-P by Pho13p might generate a futile cycle with xylulokinase overexpression.

109 ed ultrasensitivity in a kinase/phosphatase "futile cycle" has been a paradigmatic example of collect

110 2014) report that memory T cells activate a "futile cycle" of de novo fatty-acid synthesis and concur

111 birth-death process, an example of enzymatic futile cycle, and a stochastic switch model.

112 3R calcium channel leads to an ATP-depleting futile cycle, resulting in activation of the energy sens

113 back to cysteine sulfinic acid and AMP in a futile cycle.

114 sterol actively effluxed by ABC1, creating a futile cycle.

115 t bifunctional activities without creating a futile cycle.

116 Further experiments confirmed this futile cycle; cells without FepB transported FeEnt acros

117 malate into oil is low and that flux through futile cycles (wasting ATP) is low, which contrasts with

118 on of alternative electron flow pathways and futile cycles in energy rebalancing.

119 urthermore, the ED pathway does not generate futile cycles in organisms that fix CO2 via the Calvin-B

120 evious reported noise-induced bistability in futile cycles is found to have originated from the kinas

121 flux systems, protects cells from continuous futile cycles of Ca(2+) across the inner mitochondrial m

122 Subsequent futile cycles of DNA mismatch repair can lead to a p53-a

123 Viomycin inhibition also promotes futile cycles of GTP hydrolysis by EF-G.

124 We suggest that these result from futile cycles of recombinational elongation and truncati

125 d therefore to drug resistance by preventing futile cycles of translesion synthesis and mismatch corr

126 It is hypothesized that futile cycles of translesion synthesis past cisplatin-DN

127 e that adipocytes lack GyK and thereby avoid futile cycles of triglyceride breakdown and resynthesis

128 iggering transcription-coupled repair (TCR), futile cycles of which may lead to repeat expansion or c

129 which inhibit modularity, through enzymatic futile cycles that consume energy, typically in the form

130 c regulatory properties for the formation of futile cycles were further considered in the model, resu

131 which has implications for the coherence of futile cycles within an integrated tissue.

132 To avoid infinite futile cycles, folded LRP6 molecules undergo palmitoylat

133 (bio)chemical-reaction mechanisms, enzymatic futile cycles, the external noise may induce a bistable

134 -AT target genes, as NF-ATs are subject to a futile cycling across the nuclear envelope owing to enga

135 yeast glycolysis and the coupled pathways of futile cycling and glycogen and trehalose synthesis (whi

136 duction of beta-lapachone by NQO1 leads to a futile cycling between the quinone and hydroquinone form

137 Calcineurin suppresses this futile cycling by a non-catalytic mechanism involving th

138 osphate-1-kinase coupled with the absence of futile cycling implies an undetermined mechanism of coor

139 and histochemical measurements, we show that futile cycling in roots of barley (Hordeum vulgare) seed

140 ell maintenance costs, in agreement with the futile cycling model of ammonium toxicity.

141 e turnover and suggesting that CD36 promotes futile cycling of fatty acids into triglyceride.

142 In conclusion, high futile cycling of fatty acids is important for maintaini

143 Elevated futile cycling of hepatic lipids was also observed.

144 By this mechanism, SLN promotes the futile cycling of SERCA, contributing to muscle heat pro

145 This led to futile cycling the LLO pathway, exacerbated by GDP-manno

146 k(HR) estimates glucose/glucose-6-phosphate futile cycling, along with glucose recycling through the

147 te in the protocol but was timed to minimize futile cycling, since phosphorylase a became inhibited b

148 omote uncoupling of the Serca pump and cause futile cycling.

149 t they are coordinately regulated to prevent futile cycling.

150 coli, these functions are separated to avoid futile cycling.

151 d neutral invertase, associated with minimal futile cycling.

152 embrane domains MalF and MalG that generated futile cycling; although interaction with MBP stimulated

153 gulate an activated FBPase in order to avoid futile cycling?

154 Our study fundamentally revises the futile-cycling model by demonstrating that NH3 is the ma

155 cosylase, may be intricately involved in the futile cytotoxic repair induced by m6dG.

156 The net result was a futile damage-induced DNA synthesis which converted a ga

157 mechanism prevents trapping of the enzyme in futile degradation attempts and ensures that the energy

158 ch in turn mispairs with thymine, triggering futile DNA mismatch repair (MMR) and ultimately cell dea

159 3-proficient human glioma cells, TMZ-induced futile DNA MMR resulted not in apoptosis but rather in p

160 s-links and reveal that cross-links induce a futile DNA synthesis cycle that may constitute a signal

161 er with the hairpin promotes dissociation of futile EF-G and thus causes multiple EF-G driven translo

162 ast tracking of MLPs for degradation without futile engagement of the cytosolic folding machinery.

163 tory responses including feedback as well as futile "feed-forward" elicitation in the case of fatty a

164 to 49.1%]), both erythropoietin groups were futile (first dosing regimen: 17/35 [48.6%; 95% CI, 31.4

165 deal with telomere damage may be ultimately futile for aging fibroblasts but useful for cancer cells

166 tion under these conditions is assumed to be futile for autophagy.

167 The 'futile' fuel cycle resulting from expression of GyK in a

168 s us that von Pettenkofer was more than this futile gesture.

169 ources, the provision of ICU care, even when futile, has been viewed as an individual patient decisio

170 when the anaesthetist believes surgery to be futile, he or she must consider and understand the basis

171 f Pi from the hydrolysis site, which avoided futile hydrolysis cycles of eIF4AI.

172 helicase either undergoes backward movements/futile hydrolysis or unwinds DNA with a variable bp-step

173 n, thus between productive recombination and futile hydrolysis.

174 that physicians should regard a treatment as futile if empirical data show that the treatment has les

175 dvanced super-resolution microscope would be futile in providing biological insight into subcellular

176 Performing CPR for >20 minutes is not futile in some patient illness categories.

177 Treatment is futile in some patients, but it is difficult to identify

178 Helicobacter pylori incites a futile inflammatory response, which is the key feature o

179 ndent NFkappaB regulation was confirmed with futile inhibition of AP-1 and SP-1 in TNF receptor muted

180 active, inactive, or engaged in assembly of futile initiation complexes.

181 al to and use of hospice, and reduced use of futile intensive care.

182 motif in the transfer peptide is to prevent futile interactions with the Sec apparatus.

183 ppearance on synaptic vesicles could lead to futile interactions with vesicle-SNARE proteins.

184 Clinicians should not provide futile interventions.

185 tic evidence indicated that Bcl-x(L) reduces futile ion flux across the inner mitochondrial membrane

186 ciding whether an operative procedure may be futile is examined.

187 Diagnostic laparoscopy reduced the number of futile laparotomies in patients with suspected advanced-

188 Futile laparotomy occurred in 10 (10%) of 102 patients i

189 The primary outcome was futile laparotomy, defined as a PCS with residual diseas

190 of oxidative phosphorylation can result from futile leak conductance through the inner mitochondrial

191 t differential diagnosis between HAS and HE, futile LT can be avoided by taking into consideration th

192 ain (PSIDeltaAB mutant) exhibit extended but futile mating attempts.

193 CO to providing potentially inappropriate or futile medical services should not be considered suffici

194 The broader metabolic implications of this futile metabolic cycling are discussed in detail.

195 )-methylthioguanine (S(6)mG) in DNA, and the futile mismatch repair triggered by replication-induced

196 ins (UCPs) oppose this phenotype by inducing futile mitochondrial respiration that is uncoupled from

197 rstood, but is proposed to be due to loss of futile MMR activity and/or replication stalling [3] [4].

198 rtially stems from the drug's induction of a futile NQO1-mediated redox cycle that causes high levels

199 ge by inhibiting certain actions, especially futile or dangerous challenges to dominant figures, acti

200 ny ICU admission on a case-by-case basis for futile or inadvisable care, thereby maintaining an open

201 licts that may be inappropriately prolonging futile or unwanted treatments and are perceived to be be

202 aintain viable replication forks or suppress futile origin firing when DNA polymerase is inhibited, l

203 The analysis was focused on futile outcome (3-month or in-hospital mortality) and lo

204 national ALPPS Registry, a risk analysis for futile outcome (defined as 90-day or in-hospital mortali

205 prediction to assess the individual risk of futile outcome after ALPPS surgery and can be used to av

206 Futile outcome occurred in 37 patients (22%).

207 Among 528 ALPPS patients from 38 centers, a futile outcome was observed in 47 patients (9%).

208 comorbidities were independent predictors of futile outcome.

209 E1 species, putatively generated through its futile oxidative cycling, that incurs endoplasmic reticu

210 NQO1 catalyzes a futile oxidoreduction of beta-lap leading to reactive ox

211 eached sufficiently high levels, the use of "futile" oxygen consumption became too bioenergetically c

212 ion of therapy beyond which continued use is futile, particularly in a population of patients admitte

213 NK2 interfered with JNK1 activation via its "futile" phosphorylation by upstream kinases.

214 r initial diagnostic laparoscopy can prevent futile primary cytoreductive surgery (PCS) by identifyin

215 ted cells, detached kinetochores remain in a futile reattachment/detachment cycle that prevents congr

216 n of only the budget surplus for "costly yet futile" recovery plans can provide sufficient funding to

217 slope, termed the in vivo glucose-dependent futile recycling rate constant k(HR).

218 The futile redox cycle rapidly consumes O2, rendering standa

219 boquinone lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates

220 ly targets cancer cells through a process of futile redox cycling that decreases intracellular reduci

221 Futile redox cycling, which is suppressed in wild-type h

222 at disrupts redox balance in cancer cells by futile redox cycling.

223 ed NAD(P)H levels that refuel NQO1-dependent futile redox drug recycling.

224 to the corresponding catechol to generate a futile redox-cycle.

225 al trapping of neuronal NOS (nNOS) through a futile regenerating pathway.

226 ge and PARS, triggering an energy-consuming, futile repair cycle leading to cellular energy depletion

227 and activation of PARS, an energy-consuming futile repair cycle, play a central role in ONOO--mediat

228 MR system is thought to promote toxicity via futile repair of alkylated mispairs.

229 of 0, 1, 2, 3, 4 and 5 were associated with futile risk of 2.7%, 4.9%, 8.6%, 15%, 24%, and 37%.

230 sed or open complexes, resulting in repeated futile scanning.

231 (3) Use of the term "futile" should be restricted to the rare situations in w

232 together have been proposed to constitute a futile SMM cycle that stops the free Met pool from being

233 k 24--maximized the early discontinuation of futile therapy and minimized premature treatment discont

234 y inappropriate" should be used, rather than futile, to describe treatments that have at least some c

235 r the high metabolic cost of this apparently futile transcriptional cycle could be justified by a mor

236 nsolved, resulting in an important amount of futile transfers for thrombectomy.

237 Futile transmembrane NH3/NH4(+) cycling in plant root ce

238 waiting list mortality and to a potentially futile transplant that utilizes an ECD for a critically

239 ize the risk of severe posttransplant BI and futile transplantation.

240 al should be identified, aiming to eliminate futile transplantation.

241 had a good chance of success, thus avoiding futile transplants.

242 Intriguingly, the significance of these futile transport cycles of VEGFR2 remains unclear.

243 s less likely to contain a patient receiving futile treatment compared with an ICU with available bed

244 care is often considered "futile." Although futile treatment is acknowledged as a misuse of resource

245 bjective was to evaluate delays in care when futile treatment is provided.

246 ility case, and the only clear legal rule on futile treatment is the traditional malpractice test, wh

247 atients of whom 123 were assessed to receive futile treatment.

248 and contained at least one patient receiving futile treatment.

249 ained at least one patient who was receiving futile treatment.

250 , using family influence (16%), not offering futile treatments (13%), and referring to other physicia

251 RNA levels, implying increased turnover in a futile tRNA cycle.

252 otors from individual flagella and prevent a futile tug-of-war.

253 e Arg in developing embryos, thus avoiding a futile urea cycle.

254 after ALPPS surgery and can be used to avoid futile use of ALPPS.

255 sing the underlying causes of the disease is futile; we need to invest in prevention.

256 It is best to consider a situation futile when the patient is terminally ill, the condition

257 onally reared sheep by nasal swabbing proved futile with existing selective media because of extensiv