ライフサイエンスコーパス: gain access to

1 ernative mechanism by which tumors cells may gain access to a blood supply.

2 are, patients with nonemergent problems must gain access to a complex, interdependent ambulatory care

3 trast two-dimensional objects in particular, gain access to a predominantly left-lateralized language

4 trained to press one lever (seeking; SL) to gain access to a second lever (taking; TL) linked with f

5 ubiquitination of DSL ligands allows them to gain access to a select, Epsin-dependent, endocytic path

6 obesity also showed increased willingness to gain access to a sucrose cue.

7 ty of the SPROUTS database is the ability to gain access to a variety of structural analyses at one p

8 sely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spi

9 ses such as HIV have a daunting challenge in gaining access to a new host predominantly through the p

10 ogic mechanism through which SZ chondrocytes gain access to active TGF-beta: the synovium and articul

11 A central question is how nuclear substrates gain access to an enzyme in the ER.

12 external protons permeate TRPM2 channels to gain access to an intracellular site that regulates chan

13 ing that tissues permissive for ERV activity gain access to an otherwise silenced source of regulator

14 both human and mouse lung adenocarcinomas by gaining access to an endosomal compartment within tumor

15 chain particle possessed a unique ability to gain access to and accumulate at glioma sites.

16 anochain) that possesses a unique ability to gain access to and be deposited at micrometastatic sites

17 nsport from cells requires that they readily gain access to and function within interstitial fluid.

18 onducting hemichannels that allow protons to gain access to and leave buried carboxyl groups on the p

19 Here we review how viruses gain access to and spread in the well-protected CNS, wit

20 is important in understanding how the ligand gains access to and is released from the active site of

21 h predation to a floral simulation strategy, gaining access to, and visually attracting, a novel reso

22 Most compartments that viruses gain access to are under active surveillance by one or m

23 holin-mediated disruption of the membrane to gain access to attack the cell wall, signal anchor relea

24 what stimuli will and what stimuli will not gain access to awareness.

25 roup members is essential for individuals to gain access to benefits from engaging in intergroup conf

26 cles can overcome barriers and allow them to gain access to biological systems.

27 e capacity of this opportunistic pathogen to gain access to BL receptors, leading to a successful col

28 Testing whether CMV gained access to brain through nonspecific vascular disr

29 e receptor-mediated uptake or whether enzyme gains access to brain storage by another route when brai

30 t in retinal disease, mislocalized rod opsin gains access to cAMP signaling, which leads to neuritic

31 e mechanism by which LPS from these bacteria gains access to caspase-11 in the cytosol remains elusiv

32 Our results raise a possibility that E1A may gain access to cellular promoters through PLDLS-dependen

33 spindle assembly commences when microtubules gain access to chromatin after nuclear envelope breakdow

34 The mechanism by which pioneer TFs gain access to chromatin remains an important unanswered

35 y factors and transcriptional machinery must gain access to chromatin to extract genetic information.

36 oplasm in interphase cells; thus, it may not gain access to chromosomes until mitosis.

37 Condensin I gains access to chromosomes only after the nuclear envel

38 toplasm from interphase through prophase and gains access to chromosomes only after the nuclear envel

39 ired rats to solve a new puzzle every day to gain access to cocaine, which they then self-administere

40 requiring animals to solve daily puzzles to gain access to cocaine.

41 where Bcd influences chromatin structure to gain access to concentration-sensitive targets at high c

42 gher-tier cortical areas, including hMST, to gain access to conscious perception.

43 o the nucleolar proteome database and hence, gain access to continually updated results.

44 can be challenging due to the difficulty of gaining access to conventional diagnostic matrices of bl

45 mechanism whereby pathogenic autoantibodies gain access to cryptic B cell epitopes.

46 ism by which toxins without a binding moiety gain access to cytosolic ribosomes is not known.

47 ery has to overcome this physical barrier to gain access to damaged DNA and repair DNA lesions.

48 e nucleotide excision repair (NER) machinery gains access to damaged chromatinized DNA templates and

49 hods and technology, we are able to reliably gain access to data in larger quantities, dimensions and

50 nt of shared online informatics resources by gaining access to data where it is being analyzed.

51 where otherwise normal tissue was removed to gain access to deeper hippocampal pathology in patients

52 ol II) must break the nucleosomal barrier to gain access to DNA and transcribe genes efficiently.

53 on requires that RNA Polymerase II (RNAP II) gain access to DNA in the context of chromatin.

54 rations must occur for DNA repair factors to gain access to DNA lesions and restore original chromati

55 roviding the entry port for exogenous DNA to gain access to DNA receptors associated with the cytopla

56 r chromatin remodeling may facilitate NER in gaining access to DNA damage in nucleosomes.

57 Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor ne

58 Open states that enable P450 enzymes to gain access to electrons located in the FMN-domain are f

59 How commensals gain access to epithelial soma through densely packed mi

60 HIV-1 Gag protein gains access to ESCRT directly by binding Alix, an ESCRT

61 tinylation assays indicate that GPI-PLC does gain access to extracellular VSG, suggesting that this m

62 Claisen rearrangement is a known protocol to gain access to functionalized allenes through the [3,3]-

63 am innovators may face considerable costs to gain access to gene-oriented technologies.

64 cessing centers where many different enzymes gain access to genomic substrates by exploiting direct i

65 hways by which intracellular aqueous protons gain access to Glu(in).

66 ucing the effective dose of toxin capable of gaining access to glycolipid and glycoprotein receptors

67 f smectite veins along which CO2-rich fluids gained access to grain interiors.

68 use of health information and services: (1) gaining access to health information, (2) navigating in

69 Application of chemical synthesis to gain access to high purity hPTH as well as more stable a

70 echanisms employed by bacterial pathogens to gain access to host iron sources, the role of iron in ba

71 ite on CR1 by which P. falciparum merozoites gain access to human erythrocytes in a non-sialic acid-d

72 ID requires single-stranded DNA and needs to gain access to Ig loci, with RNA pol II transcription po

73 opportunities for academic psychiatrists to gain access to important resources.

74 sure that only fully mature, immunogenic DCs gain access to inductive sites, where they might prime e

75 re, we determined whether antibodies rapidly gain access to integrin overexpressed on the abluminal (

76 -the process by which trainees in any region gain access to international training (electronic or in-

77 has to complex with DNA-binding molecules to gain access to intracellular DNA sensors.

78 x1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it driv

79 pus erythematosus, a major route whereby DNA gains access to intracellular TLR9, and thereby activate

80 How does the FEF gain access to ipsilateral information?

81 sh environment is an efficient mechanism for gaining access to iron.

82 he ability of the recombination machinery to gain access to its chromosomal substrates.

83 cus, to allow the recombination machinery to gain access to its chromosomal substrates.

84 breach the membrane of a target host cell to gain access to its cytoplasm.

85 e receives protons from water molecules that gain access to its hydrophobic environment and transduce

86 ter it reaches the nucleus by allowing it to gain access to its target genes.

87 d for an antisense oligonucleotide to enter, gain access to its target mRNA, and exert activity in a

88 P14 associates with the membrane as a way of gaining access to its membrane soluble substrate.

89 The data indicate that flecainide rapidly gains access to its binding site when the channel is ope

90 iferase is released from the viral lumen and gains access to its substrates is light emitted and read

91 mechanism by which this virus recognizes and gains access to its target cell is still largely unknown

92 y of attachment factors used by the virus to gain access to key cell types involved in pathogenesis a

93 ure suggests that neonatal facilities should gain access to laser technology and laser-trained ophtha

94 model in which core first requires DGAT1 to gain access to LDs, and then LD-localized core interfere

95 dy entry by the ability of CD8(+) T cells to gain access to lesional epithelium.

96 the TCR signal and how the repair machinery gains access to lesions imbedded in stalled RNA polymera

97 us and provide an efficient means for HIV to gain access to lymph node T cells.

98 ropic superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial-lymp

99 group of aminoaldehydes is also required to gain access to lysosomes where their cytotoxic actions a

100 kine receptor CCR7, how other T cell subsets gain access to medullary areas during their normal devel

101 ntracellular antigens have been described to gain access to MHC class II loading after macroautophagy

102 es the issue of whether this enzyme needs to gain access to nascent DNA before its packaging into nuc

103 we examine the mechanism by which antibodies gain access to neuronal tissues to control infection.

104 in determining which blood-borne components gain access to neurons.

105 not the major route by which blood prolactin gains access to neurons in the brain.

106 Second, the new route was employed to gain access to new alpha,beta-unsaturated ketones and co

107 in major clades such that some lizard clades gained access to new resources, which in turn led to muc

108 tigated the mechanism by which Ty1 integrase gains access to nuclear DNA as a model for how other ret

109 Ibeta (DLAD) but the mechanism by which DLAD gains access to nuclear DNA remains unknown.

110 exes that must act on it; how such complexes gain access to nucleosomal DNA is not known.

111 How proteins gain access to nucleosomal DNA target sites in vivo is n

112 le and undertake diel vertical migrations to gain access to nutrient-rich deeper layers at night and

113 its host cell to avoid immune clearance and gain access to nutritional resources.

114 MRN gains access to occluded DNA ends by removing Ku or othe

115 ique "plug-and-play" approach to efficiently gaining access to orphan pathways that may open avenues

116 2 and reveal how MDM2-interacting repressors gain access to p53 target promoters and repress transcri

117 hat the E1A-12 N terminus prevents PKAc from gaining access to p65 to account for Ser(276) hypophosph

118 t did not label most normal blood vessels or gain access to pancreatic ducts or intestinal smooth mus

119 quiescent CD44(lo)CD62L(hi) T reg cells that gain access to paracrine IL-2 produced in the T cell zon

120 etabolites than cells in which the PGs could gain access to PG15DH only via PGT.

121 ng, aphids inject saliva into plant tissues, gaining access to phloem sap and eliciting (and sometime

122 scular mycorrhizal (AM) symbiosis, the plant gains access to phosphate (Pi) and nitrogen delivered by

123 of entry and the adhesive mechanisms used to gain access to PLNs remain poorly defined.

124 ne has raised concerns over their ability to gain access to privileged sites in the body.

125 interacting with health care providers, and gaining access to proper health care.

126 vectors which, although no longer capable of gaining access to receptors on target cells, may be able

127 ng burrows in the sediment, most probably to gain access to reduced sulphur.

128 osit that the first shift enables infants to gain access to redundant audiovisual speech cues that en

129 eover, in mice, human IgG from the periphery gained access to relevant areas in the hippocampus and b

130 isotype antibodies that are not expected to gain access to renal cyst lumens.

131 PCNA is not required in vitro for pol eta to gain access to replication complexes at forks stalled by

132 ocial anointing has functions beyond that of gaining access to resources.

133 effect terminator read-through, lambdaQ must gain access to RNA polymerase (RNAP) via a promoter-rest

134 lowing nucleotide excision repair enzymes to gain access to sites of damage.

135 frees them to shift attention to the eyes to gain access to social cues.

136 spinal hyperexcitability enables A fibers to gain access to specific spinal circuitry, via heterosyna

137 crucial juncture at which developing B cells gain access to splenic follicles, become responsive to T

138 inding mode of SSB, thereby allowing RecQ to gain access to ssDNA and facilitating DNA unwinding.

139 nsights into the mechanism by which proteins gain access to ssDNA bound by SSB, as demonstrated by ex

140 ract with SSB, could use this interaction to gain access to ssDNA by first interacting with the SSB C

141 , generally due to colonizing organisms that gain access to sterile sites via disrupted epithelial ba

142 hat many SSIs occur as a result of pathogens gaining access to surgical wounds either hematogenously,

143 ansported to IMS-facing membrane leaflets to gain access to tafazzin, identifying a previously unknow

144 al cells, to cross this thin barrier, and to gain access to target cells and tissues, leading to syst

145 Lipoprotein-TAG may gain access to target cells by lipoprotein lipase (LPL)

146 a novel mechanism(s) utilized by B virus to gain access to target cells.

147 These ribosomes appear to gain access to the 3' UTR via a mechanism that does not

148 Thus, AID does not gain access to the 5' and constant regions of Ig genes.

149 lecules can exploit the secondary channel to gain access to the active site and modify the transcript

150 s necessary for the lipophilic substrates to gain access to the active site.

151 Microorganisms gain access to the airways and respiratory epithelial su

152 eta'-site is relatively better positioned to gain access to the BACE1 catalytic cavity.

153 tethered biotin prosthetic group must first gain access to the biotin carboxylase domain and become

154 Viral infections often gain access to the body of their host by exploiting area

155 exist in the sera of AD individuals and can gain access to the brain interstitium.

156 Following acute brain injury, albumin may gain access to the brain parenchyma.

157 To gain access to the brain, HIV-1 must migrate through bra

158 ccharide (LPS) to immunized mice, antibodies gain access to the brain.

159 ux pump inhibitors, demonstrating that ADEPs gain access to the cell but that export occurs.

160 ng attachment to a cell surface, in order to gain access to the cell interior.

161 limiting cell membrane allowing the virus to gain access to the cellular replication machinery.

162 To gain access to the central nervous system (CNS), GBS mus

163 A major route for peripheral information to gain access to the cerebellum is via ascending climbing

164 e must be proteolyzed before collagenase can gain access to the cleavage site.

165 Previously, we showed that pneumococci can gain access to the CNS through a nonhematogenous route w

166 Rp must find a way to open it up in order to gain access to the covered template.

167 s viral penetration of cellular membranes to gain access to the cytoplasm and deliver the genome to t

168 iruses must traverse the nuclear envelope to gain access to the cytoplasm and, ultimately, to exit ce

169 From the ER lumen, the toxin must gain access to the cytoplasm, where it enzymatically ina

170 anscriptionally active subvirion particle to gain access to the cytoplasm.

171 sought to determine how assembled tau seeds gain access to the cytosol and whether this access trigg

172 hagy pathway to defend against microbes that gain access to the cytosol or reside in pathogen-modifie

173 s dislocation or retrograde translocation to gain access to the cytosol.

174 e ER membrane and selective ER components to gain access to the cytosol.

175 ocessing pathway in which exogenous antigens gain access to the cytosolic MHC class I processing mach

176 somal DNA lesions, the repair machinery must gain access to the damaged DNA in the context of chromat

177 Viruses can gain access to the decidua and placenta by ascending fro

178 ion synthesis (TLS), but how TLS polymerases gain access to the DNA template remains poorly understoo

179 ns, presumably so that necessary factors can gain access to the DNA.

180 zed at P2 but not at P9, E. coli K1 bacteria gain access to the enterocyte surface in the mid-region

181 ediated reconfiguration of the holoenzyme to gain access to the enzyme during early elongation.

182 To gain access to the gene-containing portion of the barley

183 advantage of endodermal tissue remodeling to gain access to the gonadal mesoderm and are unable to mi

184 Ferrichrome may gain access to the higher-affinity site through endocyto

185 D8+ T cell lines have suggested that Mtb Ags gain access to the HLA-I pathway in an alternate vacuola

186 The mechanisms by which Mtb-derived Ags gain access to the HLA-I-processing pathway are incomple

187 suggests that, as in rodents, external cues gain access to the homeostatic control circuits of the h

188 eal a means whereby intracellular Salmonella gain access to the host cell cytosol from within its mem

189 ique intracellular biology that allows it to gain access to the host cell cytosol, Listeria monocytog

190 Retroviruses must gain access to the host cell nucleus for subsequent repl

191 d pore formation, (ii) innate immune stimuli gain access to the host cytoplasm through the YopBD pore

192 or proteins traverse eukaryotic membranes to gain access to the host cytosol.

193 t promoter, thereby allowing the bacteria to gain access to the host cytosol.

194 Other retroviruses gain access to the host ESCRT components by utilizing a

195 xins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert v

196 The simulation reveals that water molecules gain access to the internal sites by a transient aqueduc

197 biological tools; however, their ability to gain access to the intracellular environment is limited.

198 ken of the Snieckus hydroborating reagent to gain access to the key trifluoroborate needed for the ma

199 breach the intestinal epithelial barrier and gain access to the lamina propria.

200 MC develops when malignant cells gain access to the leptomeningeal space, producing sever

201 ow hydrophobic signals engage the channel to gain access to the lipid bilayer.

202 gest a model in which gammaherpesviruses may gain access to the mature B cell compartment by recurren

203 everal techniques to penetrate the shells to gain access to the meat inside.

204 G and that the PAG uses the NRA as a tool to gain access to the motoneurons generating vocalization.

205 sive pneumococcal disease, S. pneumoniae can gain access to the myocardium, kill cardiomyocytes, and

206 on and suggest that HIV-1 subviral particles gain access to the nucleus by interacting directly with

207 xploits the host nuclear import machinery to gain access to the nucleus, where capsid assembly and ge

208 in to recruit the receptor importin beta and gain access to the nucleus.

209 We demonstrate that TgMYST-B can gain access to the parasite nucleus and acetylate histon

210 ling indicates that the target peptide might gain access to the PDHK active center through the open b

211 dCII is released and/or phagocytic proteases gain access to the periplasm, and SodCII is degraded.

212 ch suggests unfolding as the prerequisite to gain access to the periplasm.

213 A key unresolved issue is how ions gain access to the pore, because the structure reveals t

214 tein DAF to open the tight junction barrier, gain access to the primary receptor CAR, and activate vi

215 d phenotypic characteristics of T cells that gain access to the prostate and induce leukocyte recruit

216 rotation of NADP(+) permits the substrate to gain access to the reactive flavin peroxyanion intermedi

217 the agent crossing an epithelial barrier to gain access to the recipient nervous system.

218 ty that imposes constraints on which enzymes gain access to the recombination intermediate, thereby c

219 hat fork regression allows repair enzymes to gain access to the replication-blocking lesion, allowing

220 tRNA shape-mimicry enables the viral IRES to gain access to the ribosome tRNA-binding sites and form

221 of the polymerase, the large protein (L) to gain access to the RNA.

222 AM fungi colonize root epidermal cells to gain access to the root cortex, and this requires the re

223 cked 50S ribosomal subunit, allowing RrmJ to gain access to the substrate nucleotide U2552, and where

224 This suggested that microbiome products that gain access to the systemic circulation, rather than bei

225 corneal epithelial cell-derived exosomes may gain access to the underlying stromal fibroblasts upon d

226 Attempts have been made to gain access to the vinigrol structural framework by way

227 nd blood, demonstrating that instilled ricin gained access to the circulation.

228 acuoles, from which the bacteria escaped and gained access to the cytosol of adjacent cells.

229 on conditions during this transformation, we gained access to the natural products as well as two epi

230 VSV gained access to the nervous system through peripheral n

231 The TiO2 nanotubes were believed to have gained access to the nuclear machinery and caused increa

232 Both radionuclides gained access to the seminiferous tubules.

233 Both AQP2 and AQP3 gained access to the surface plasma membrane in insect l

234 tubular reabsorption of macromolecules, that gained access to the tubular lumen on glomerular filtrat

235 o ascertain why these donors with ESRD never gained access to the waiting list.

236 ractions between PBP 2a and the cell wall in gaining access to the active site in the inhibition proc

237 ency (slope = -0.6 to -1.0), indicating that gaining access to the base lesion provides a substantial

238 esters Daxx in the nucleus, prevents it from gaining access to the cytoplasm, from binding to and act

239 e by an energy-independent process, directly gaining access to the cytoplasm.

240 transporter, FepA, as a receptor and, after gaining access to the cytoplasmic membranes of sensitive

241 re more efficient than wild-type bacteria in gaining access to the host cell cytosol and in initiatin

242 e first description of a secreted proteinase gaining access to the inside of a cell and altering intr

243 tablishes a chronic infection in its host by gaining access to the memory B-cell reservoir, where it

244 infections can pose a threat to pregnancy by gaining access to the placenta and fetus, and clinical s

245 ls exiting the intravascular compartment and gaining access to the renal tubular space, we reasoned t

246 e to show that phagocyte-derived H(2)O(2) is gaining access to the Salmonella cytoplasm.

247 ions, thereby inhibiting S. typhimurium from gaining access to the systemic circulation.

248 If AID gains access to the 5' and 3' regions that are unmutated

249 it has not been clear how p-hydroxybenzoate gains access to the buried active site.

250 ure reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive ty

251 ached by blockade by a lipid acyl chain that gains access to the channel cavity through intramembrane

252 Previous data have shown that the virus gains access to the CNS by infecting olfactory sensory n

253 orferi, the causative agent of Lyme disease, gains access to the CNS.

254 Precisely how cellular DNA gains access to the cytoplasm remains to be determined.

255 L. monocytogenes gains access to the cytosol of infected cells, where sec

256 which likely serve as depots from where SV40 gains access to the cytosol.

257 for intrauterine transmission in which ZIKV gains access to the fetal compartment by directly infect

258 Mycobacterium tuberculosis extracellular DNA gains access to the host cell cytosol via the ESX-1 secr

259 ssentially dispensable once L. monocytogenes gains access to the host cell cytosol.

260 human immunodeficiency virus type 1 (HIV-1) gains access to the interior of the target cell, host ce

261 ynamic, providing an explanation of how cAMP gains access to the ligand binding sites that, in the cr

262 infection and persistence proposes that EBV gains access to the memory B cell compartment via GC rea

263 that intestinal epithelium-derived "self-Ag" gains access to the mucosal immune system, leading to Ag

264 ficient mouse chimeras, we demonstrate HSV-1 gains access to the murine brain stem and subsequently b

265 y, cofactor in the incorrect oxidation state gains access to the mutase active site and is not releas

266 The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cl

267 However, it is not clear how Keap1 gains access to the nucleus.

268 Taken together, these data argue that TgGCN5 gains access to the parasite nucleus by interacting with

269 in concert with the Sec incorporation domain gains access to the ribosomal A site.

270 ng amounts of lipids, we establish that SecA gains access to the SecYEG complex via a lipid-bound int

271 ay be one of the crucial steps by which ZIKV gains access to the site of spermatozoon development and

272 s, little is known about how CHIKV binds and gains access to the target cell interior.

273 state in which the fusion machinery on gp41 gains access to the target cell membrane.

274 a functional uptake pathway in which the SSO gains access to the targeted RNA.

275 RNA structures become unstable and ribosomes gain access to their binding sites in the mRNAs.

276 ly are relatively hydrophobic molecules that gain access to their blocking site on the sodium channel

277 mechanism by which gene regulatory proteins gain access to their DNA target sites is not known.

278 on by assisting transcriptional machinery to gain access to their sites in chromatin.

279 epair or modify bases in double-stranded DNA gain access to their substrates by base flipping.

280 but the majority of the vascular plants also gain access to these mineral nutrients through endosymbi

281 arget populations in developing countries to gain access to these potentially life-saving medicines.

282 osine deaminase (AID) that initiates SHM not gain access to these regions, or does AID gain access, b

283 ogical analysis coupled with live imaging to gain access to these relationships in ferrets infected w

284 ivores and fungivores that evolve resistance gain access to these resources and can also gain protect

285 s commonly postulated that plasma cells only gain access to these signals within specialized regulato

286 Yet, circulating antibodies must somehow gain access to these tissues to mediate their antimicrob

287 The olefin is mechanistically critical to gain access to this 14-electron, monovalent Ir intermedi

288 o rapidly access the microcirculation and to gain access to this highly anticoagulant environment.

289 ich microbes bypass host iron restriction to gain access to this metal across the host vacuolar membr

290 virus nuclear antigen 1 (EBNA1) was found to gain access to this pathway by autophagy.

291 existing programs and did not help patients gain access to timely PCI.

292 pend first on its ability to enter cells and gain access to TLR9 and second on its capacity to form a

293 er evidence, suggests that AID may similarly gain access to transcribed S regions and V exons in vivo

294 sm and binds to the 40S ribosomal subunit to gain access to translating mRNAs, MERS-CoV nsp1 was dist

295 ven basic models to explain how odour inputs gain access to transmodal representations required for n

296 es and other macromolecular therapeutics can gain access to tumor cells via leaky tumor vessels.

297 On the other hand, by gaining access to tunneling through individual dopants,

298 ganism that can cause severe disease when it gains access to underlying tissues.

299 sing a wide range of severe diseases when it gains access to underlying tissues.

300 meable to substrate peptide; water molecules gain access to zinc through a polar, central channel tha