ライフサイエンスコーパス: galactosyl

1 hydroxyl group of galactosyl residue of beta-galactosyl 1-->1 sphingosine (psychosine).

2 yme glucosyltransferase UDP galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha(1-3)galac

3 rase uridine 5'-diphosphate galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha(1-3)galac

4 L5), and (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyl

5 ase, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha2,6-sialylt

6 cribe the cloning of a UDP-galactose: beta-d-galactosyl-1,4-glucosylceramide alpha-1, 3-galactosyltra

7 nthesized by the enzyme UDP galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha(1-3)galact

8 d to be an AGP by precipitation with (beta-D-galactosyl)3 Yariv phenylglycoside and by amino acid com

9 (beta-D-glucosyl)3 and (beta-D-galactosyl)3 Yariv phenylglycosides, commonly known as Y

10 Here (beta-D-galactosyl)3 Yariv reagent was added to Arabidopsis thal

11 ARSA) activity toward the natural substrate, galactosyl-3-sulfate ceramide (or sulfatide), is perform

12 n substrate binding by directly ligating the galactosyl 6-hydroxyl.

13 ave abundant circulating anti-alpha (1,3-di)-galactosyl (alpha Gal) antibodies (anti-Gal).

14 tibodies are primarily directed to alpha-1,3-galactosyl (alpha Gal) residues on endothelial cell surf

15 nating tumor cell membranes to express alpha-galactosyl (alpha-gal) epitopes (i.e., Galalpha1,3Galbet

16 e mammalian species contain the disaccharide galactosyl-alpha-(1,3)-galactose (alpha-Gal).

17 The presence of the nonhuman galactosyl-alpha-(1,3)-galactose (Gal-alpha-(1,3)-Gal) c

18 ferase (alpha3GT) catalyzes the synthesis of galactosyl-alpha-1,3-beta-galactosyl structures in mamma

19 ediated through preformed antibodies against galactosyl-alpha-1,3-galactose (Galalpha-1,3-Gal) epitop

20 which were produced by cell lines expressing galactosyl(alpha1-3)galactosyl (alphaGal) sugars, were f

21 rom alphaGal-negative cells, indicating that galactosyl(alpha1-3)galactosylation sensitizes these vir

22 UDP-galactose:beta-galactosyl-alpha1,3-galactosyltransferase (alpha3GT) cat

23 r lysosomal processing of a precursor lipid, galactosyl-(alpha1-2)-galactosyl ceramide.

24 ve prepared in baboons high titer anti-alpha-Galactosyl (alphaGal) and anti-porcine aortic endothelia

25 ted by the interaction of natural anti-alpha-galactosyl (alphaGal) antibodies with alphaGal epitopes

26 ntibodies (NAbs) against a terminal alpha1-3 galactosyl (alphaGal) epitope have been identified as th

27 by cell lines expressing galactosyl(alpha1-3)galactosyl (alphaGal) sugars, were found to be less stab

28 We report several classes of galactosyl analogues with varied substitution at the ano

29 s (Arabidopsis thaliana) XyG, which contains galactosyl and fucosyl substituents, tomato (Solanum lyc

30 to be to provide for the interconversion of galactosyl and glucosyl groups.

31 Glycolipids containing alpha-linked galactosyl and glucosyl moieties have been shown to poss

32 entropy change of binding of the two groups (galactosyl and glucosyl) of oligosaccharides to the two

33 -exposed N-acetylneuraminyl, alpha- and beta-galactosyl, and N-acetylhexosaminyl sugars from human an

34 Conditions for demonstrating efficient galactosyl- and distal Kdo-transferase activities are no

35 residues become glycosylated in the form of galactosyl- and glucosylgalactosyl-hydroxylysine.

36 ion of these rice genes, including fucosyl-, galactosyl-, and acetyltransferases, in the correspondin

37 ecting donor animals with monoreactive alpha-galactosyl antibodies before transplantation.

38 of renal fibroblasts with baboon anti-alpha-Galactosyl antibodies resulted in increased synthesis of

39 No sensitization of alpha-galactosyl antibody responses was observed.

40 4,6-O-Benzylidene-alpha-d-galactosyl azide crystallizes into two morphologically d

41 3), (G(M3), N-acetylneuraminosyl-alpha(2, 3)-galactosyl-beta(1,4)-glucosylceramide), were inactive in

42 oteins generated glycoproteins with terminal galactosyl-beta-1, 4-GlcNAc and thus permitted their iso

43 The glycosphingolipid, psychosine (d-galactosyl-beta-1,1' sphingosine), accumulates to microm

44 sy), glucosyl-beta1'1-sphingosine (Glu-Sph), galactosyl-beta1'1-ceramide (Gal-Cer), or lactosyl-beta1

45 ation of the major xenogeneic antigen, alpha-galactosyl, by injecting donor animals with monoreactive

46 ta 1,4GlcNAc beta 1, 4GlcNAc) and an alpha 3-galactosyl-capped trisaccharide (Gal alpha 1,3Gal beta 1

47 In contrast, a beta 4-galactosyl-capped trisaccharide (Gal beta 1,4GlcNAc beta

48 y high affinity) site binds both the alpha 3-galactosyl-capped trisaccharide and the two fucosylated

49 w affinity) site binds a nonfucosylated beta-galactosyl-capped trisaccharide.

50 GLD patients who lack the degradative enzyme galactosyl ceramidase.

51 Keratinocytes loaded with alpha-galactosyl ceramide (alpha-GalCer) could stimulate IFN-g

52 They react to the glycolipid alpha-galactosyl ceramide (alpha-GalCer) presented by CD1d, an

53 her species can present the glycolipid alpha-galactosyl ceramide (alpha-GalCer) to mouse natural kill

54 ll responses to the glycolipid antigen alpha-galactosyl ceramide (alpha-GalCer) were dampened by prio

55 ogs of the well known NKT cell agonist alpha-galactosyl ceramide (alpha-GalCer), bacterial glycolipid

56 ion with the NKT cell-specific agonist alpha-galactosyl ceramide (alphaGC), Sh2d1a-/- splenocytes did

57 IV-1 receptor proteins CD4, CCR5, CXCR4, and galactosyl ceramide (GalCer).

58 ctin binds sulfated proteoglycan, 3-sulfated galactosyl ceramide (sulfatide), and heparin.

59 using the previously cloned cDNA encoding a galactosyl ceramide 3-O-sulfotransferase, which we term

60 the CD1d molecule to bind and present alpha-galactosyl ceramide after lysosomal processing of a prec

61 in response to the model iNKT cell Ag alpha-galactosyl ceramide and expressed lower amounts of the T

62 ted with the NKT cell-specific agonist alpha-galactosyl ceramide and its analog PBS57.

63 simple strategy for the synthesis of beta-C-galactosyl ceramide and its new aza-variant analogue is

64 le for assembly or the ability to bind alpha-galactosyl ceramide and to present it to human NKT cells

65 Cell surface expression was detected for galactosyl ceramide but not for CC-chemokine receptor 5,

66 uding NKT cells not reactive with CD1d-alpha-galactosyl ceramide complexes.

67 The preparation of the glycosphingolipid galactosyl ceramide from an orthogonally protected five-

68 Alpha-galactosyl ceramide has been identified to be a potent s

69 By contrast, alpha-galactosyl ceramide induced cytokine secretion is depend

70 A beta-C-galactosyl ceramide was synthesized in a stereoselective

71 1) and recognize lipid antigens (e.g., alpha-galactosyl ceramide) presented by nonpolymorphic CD1 mol

72 Galactosyl ceramide, a glycosphingolipid, has been postu

73 ugh both Gal3ST-2 and Gal3ST-3 do not act on galactosyl ceramide, Gal3ST-3 is only moderately more ho

74 er T (NKT) cells mobilizing glycolipid alpha-galactosyl ceramide, used to mature splenic DCs, served

75 ion factor 21 and GATA3 expression and alpha-galactosyl ceramide-induced cytokine production in vivo.

76 levels of IL-4 following TCR ligation, alpha-galactosyl ceramide-stimulated NKT cells from the livers

77 bes a short and efficient synthesis of alpha-galactosyl ceramide.

78 ns (MLR), anti-CD3, and the glycolipid alpha-galactosyl ceramide.

79 osphingolipid, or a synthetic agonist, alpha-galactosyl ceramide.

80 aired following in vivo challenge with alpha-galactosyl ceramide.

81 of a precursor lipid, galactosyl-(alpha1-2)-galactosyl ceramide.

82 aded with a synthetic NKT cell ligand, alpha-galactosyl-ceramide (alpha-GalCer; KRN-7000) in five pat

83 into oligomers that were capable of binding galactosyl-ceramide and G(M1) gangliosides.

84 In vivo stimulation of iNKT cells by alpha-galactosyl-ceramide was effective in both preventing and

85 nistration of concanavalin A (ConA) or alpha-galactosyl-ceramide, which induce liver inflammation and

86 digestion indicated that the majority of the galactosyl component was in the furanoic conformation (b

87 l other genes in the biosynthetic pathway of galactosyl-containing complex oligosaccharides were more

88 exo-galactanase levels and the highest wall galactosyl content during the early stages of ripening,

89 Total cell wall galactosyl contents in the antisense fruit were not sign

90 as diminished with a concomitant increase in galactosyl-DHLNL.

91 rthermore, in the Borrelia burgdorferi alpha-galactosyl diacylglycerol-CD1d complex, TCR binding caus

92 elds of the glycosylations using fluorinated galactosyl donors indicated that the fluorine modificati

93 of anionic nucleophiles toward the covalent galactosyl-enzyme intermediate of the reactions catalyze

94 trophenyl beta-D-galactopyranoside through a galactosyl-enzyme intermediate that shows a high reactiv

95 everse of the reaction of azide ion with the galactosyl-enzyme intermediate.

96 f the beta-D-galactopyranosyl group from the galactosyl-enzyme intermediates of the galactosyl transf

97 catalysis of the reaction of water with the galactosyl-enzyme intermediates.

98 d GlcSph from the far more abundant isobaric galactosyl epimers naturally occurring in white matter.

99 Anti-Gal interacts with the alpha-galactosyl epitope (Ga1alpha1-3Galbeta1-4GlcNAc-R), whic

100 The synthetic free alpha-galactosyl epitope (Gal alpha1-3Gal beta1-4GlcNAc) was f

101 saged through these cells acquired the alpha-galactosyl epitope in association with the envelope glyc

102 se data suggest that expression of the alpha-galactosyl epitope on the surface of viruses may have im

103 -78 cells expressed high levels of the alpha-galactosyl epitope on their membrane surface, rendering

104 This carbohydrate structure (the alpha-galactosyl epitope) is expressed on the cells of most ma

105 t, like other retroviruses bearing the alpha-galactosyl epitope, HIV modified to express this epitope

106 nthetic disaccharide that contains the alpha-galactosyl epitope, indicating that virolysis is mediate

107 s that were manipulated to express the alpha-galactosyl epitope.

108 rase responsible for generation of the alpha-galactosyl epitope.

109 ten-fold less effective than the free alpha-galactosyl epitope.

110 Human immunity to alpha(1,3)Galactosyl epitopes (alpha Gal) may provide the means fo

111 ng natural antibodies recognizing alpha(1,3)-galactosyl epitopes (alphaGal) not present on human cell

112 e found to express very low amounts of alpha-galactosyl epitopes (Gal alpha1-3Gal beta1-4GlcNAc-R).

113 esulted in synthesis and expression of alpha-galactosyl epitopes (Gal(alpha)1-3Gal(beta)1-4GlcNAc-R)

114 nti-Gal antibody, which interacts with alpha-galactosyl epitopes (i.e., Gal alpha1-3Gal beta1-4GlcNAc

115 e carbohydrates, such as appearance of alpha-galactosyl epitopes as a result of up-regulation of the

116 d, as measured in ELISA with synthetic alpha-galactosyl epitopes linked to bovine serum albumin or wi

117 It is suggested that synthesis of alpha-galactosyl epitopes on freshly isolated human tumor cell

118 e immune system responds vigorously to alpha-galactosyl epitopes on xenografts by activating many B l

119 alpha-Galactosyl epitopes were synthesized in vitro on human t

120 if these cells express low numbers of alpha-galactosyl epitopes.

121 selective, but more beta-selective using the galactosyl fluoride and depending on the acceptor used.

122 human Ig is due to natural Abs specific for galactosyl (Gal)alpha1-3Gal.

123 yl galactosyl globoside (SGG) and disialosyl galactosyl globoside (DSGG), which specifically bound ur

124 only to GM1 and asialo-GM1 (Gg4) but also to galactosyl globoside (Gb5) as well.

125 ress two extended globoseries GSLs, sialosyl galactosyl globoside (SGG) and disialosyl galactosyl glo

126 od group-related glycosphingolipid, sialosyl galactosyl globoside (SGG), has recently been implicated

127 that VVH displays a preference for terminal galactosyl groups including N-acetyl-d-galactosamine and

128 ing of 3 with the peracetylated glucosyl and galactosyl halides 12a,b and 26 afforded, after saponifi

129 e 99m Tc diethylenetriamine pentaacetic acid-galactosyl-human serum albumin for evaluation of functio

130 Injection of biotinylated galactosyl-human serum albumin reduced the circulating l

131 and a decrease in hydroxylysine and glucosyl-galactosyl hydroxylysine.

132 the first-generation protocol, per-O-benzyl galactosyl iodide was efficiently coupled with activated

133 rence between the reactivity of glucosyl and galactosyl iodides.

134 ), mainly allolactose, 6-galactobiose and 6'-galactosyl lactose.

135 actose [Gal-beta(1 --> 6)-Glc] and 6'-O-beta-galactosyl-lactose [Gal-beta(1 --> 6)-Gal-beta(1 --> 4)-

136 thetic fluorescent acceptors with a terminal galactosyl, lactosyl or N-acetyl-lactosaminyl moiety.

137 as -2.0-fold more active in forming 3'-alpha-galactosyl Lewis a than Lewis b.

138 ve in forming Lewis x, Lewis y, and 3'-alpha-galactosyl Lewis x, respectively.

139 GALS1 specifically formed beta-1,4-galactosyl linkages and could add successive beta-1,4-ga

140 an enzyme that hydrolyzes internal endo-beta-galactosyl linkages in keratan sulfate, and glycoconjuga

141 repeating phosphodisaccharide (consisting of galactosyl-mannose)) and LPG coincubated with LPG-neutra

142 ccumulation of glycosphingolipids with alpha-galactosyl moieties consisting predominantly of globotri

143 ycosphingolipids that have terminal a-linked galactosyl moieties in vascular endothelial cells causes

144 nd volkensin was based on their affinity for galactosyl moieties.

145 ities, and in particular a compound having a galactosyl moiety at C-4 of the nonreducing GlcNAc moiet

146 tion coordinate involves the movement of the galactosyl moiety deep into the active site pocket.

147 n in lactose permease is directed toward the galactosyl moiety of lactose.

148 lts provide strong confirmation that the non-galactosyl moiety of permease substrates abuts Ala(122)

149 ative LT, LT(G33D) was unable to bind to the galactosyl moiety of Sepharose 4B or GM1 but did retain

150 e, Glu537, is seen to covalently bind to the galactosyl moiety.

151 ecific hydrophobic interactions with the non-galactosyl moiety.

152 (lyso-Gb3) by hydrolyzing the terminal alpha-galactosyl moiety.

153 bound to its putative ganglioside receptor, galactosyl-N-acetylgalactosaminyl (N-acetyl-neuraminyl)

154 ing that virolysis is mediated by anti-alpha-galactosyl natural Ab.

155 patic functional imaging study using [99mTc-]galactosyl-neoglycoalbumin (99mTc-NGA).

156 ith 99mTC-diethylenetriaminepentaacetic acid galactosyl-neoglycoalbumin.

157 receptor-binding radiopharmaceutical, 99mTc-galactosyl-neoglycoalbumin.

158 charge paired and form H-bonds with specific galactosyl OH groups.

159 lpha2-->1 Sph, other lyso-phospholipids, and galactosyl- or lactosyl-Sph did not block such adhesion,

160 )-galactosidic linkage was installed using a galactosyl phosphate donor with high selectivity.

161 The galactosyl pyranose motif therefore offers many opportun

162 d FUT2, a pair of GDP-L-fucose:beta(1-->4)-D-galactosyl-R 2-alpha-L-fucosyltransferase enzymes (EC 2.

163 Linkage analysis of galactosyl residue by methylation, liquid secondary ion,

164 it preferentially to the 2-O-position of the galactosyl residue closest to the reducing end of the re

165 rbing the hydrophobic alpha face of the beta-galactosyl residue leads to complete loss of binding to

166 tional Kdo residue is attached to O-6 of the galactosyl residue of 1.

167 p of glycerol and to the 6-hydroxyl group of galactosyl residue of beta-galactosyl 1-->1 sphingosine

168 The terminal galactosyl residue of one branch of the triantennary oli

169 (r) Fucosylation by alpha 1,2-L-FT of the galactosyl residue which occurs on the antennary structu

170 of which lacks the Kdo linked to O-6 of the galactosyl residue, another that lacks the galacturonic

171 osaminyl or, alternatively, a terminal alpha-galactosyl residue.

172 of neutral sphingolipids with terminal alpha-galactosyl residues and subsequent accumulation in sever

173 rush borders, with both sialic acid and beta-galactosyl residues apparently involved.

174 suggest that N-linked glycans with terminal galactosyl residues facilitate cell surface binding and

175 ty to hydrolyze terminal, nonreducing beta-D-galactosyl residues from beta-D-galactosides.

176 ty was confirmed via a quantified release of galactosyl residues from cell wall fractions containing

177 SFR2 processively transfers galactosyl residues from the abundant monogalactolipid t

178 ses associated with these membranes transfer galactosyl residues from UDP-Gal to diacylglycerol.

179 Galactosyl residues had slightly higher levels of O-acet

180 ts glycan antennae bear terminal nonreducing galactosyl residues in alpha1-3 linkage.

181 oes not indiscriminately fucosylate terminal galactosyl residues in complex-type N-glycans, but it fa

182 lation of material containing terminal alpha-galactosyl residues in cultured embryonic fibroblasts de

183 iae that bind to two receptors: beta1-linked galactosyl residues in glycosphingolipids and the phosph

184 -deutero-methylation analysis indicated that galactosyl residues in the polysaccharide backbone are 3

185 lpha face that is uniquely displayed by beta-galactosyl residues is essential to the recognition of t

186 The presence of subtending galactosyl residues markedly enhance the activities of X

187 fers beta1,6-linked GlcNAc preferentially to galactosyl residues of N-acetyllactosamine close to nonr

188 ansfer of fucose from GDP-fucose to terminal galactosyl residues on xyloglucan side chains.

189 orescent-labeled lectin specific for alpha-D-galactosyl residues showed accumulation of substrate in

190 ntly more radiolabel from [2-(3)H]Man into L-galactosyl residues suggesting that the mutation increas

191 ulate glycosphingolipids with terminal alpha-galactosyl residues that come from intracellular synthes

192 l linkages and could add successive beta-1,4-galactosyl residues to the acceptor.

193 esent multivalent sialylated and/or sulfated galactosyl residues under the conditions of the binding

194 de chains vary in length from one to over 20 galactosyl residues, and they are partly substituted wit

195 beta-GlcNAc are substituted with two and one galactosyl residues, respectively.

196 most part to changes in expression of alpha-galactosyl residues.

197 4-mannan backbone substituted with alpha-1,6-galactosyl residues.

198 ed with single-unit (1 --> 6)-alpha-linked D-galactosyl residues.

199 pha-1,3-linked 4,6-O-(1-carboxyethylidene)-D-galactosyl residues.

200 ate, 4-p-coumaroylquinic acid, quercetin-3-O-galactosyl-rhamnosyl-glucoside, kaempferol-3-O-glucosyl-

201 g: Cys148 hydrophobically interacts with the galactosyl ring, while Glu126 and Arg144 are charge pair

202 Nuclear imaging techniques ((99m)Tc-galactosyl serum albumin scintigraphy and (99m)Tc-mebrof

203 of replicating promastigotes is mediated by galactosyl side chain (scGal) modifications of phosphogl

204 f a conserved alpha-L-fucosyl-(1-->2)-beta-D-galactosyl side chain and excessive galactosylation at a

205 compounds such as lyso-phosphatidylcholine, galactosyl-Sph (psychosine), and lactosyl-Sph at 0.5-10

206 leads to a progressive accumulation of some galactosyl-sphingolipids in the brain.

207 hesized that the accumulation of psychosine (galactosyl-sphingosine) in the TWI CNS may result in the

208 s the synthesis of galactosyl-alpha-1,3-beta-galactosyl structures in mammalian glycoconjugates.

209 nes and Staphylococcus aureus) or containing galactosyl substituents (those of Listeria spp. and Lact

210 The statistical distribution of galactosyl substituents along the mannan backbone, and t

211 ivity on galactomannan with a high degree of galactosyl substitution and was shown to be endo-acting

212 26 epitope has been identified as a beta-1,6-galactosyl substitution of beta-1,4-galactan requiring m

213 ctosyltransferase, MUR3, but is required for galactosyl-substitution of xyloglucan at a different pos

214 these piglets had markedly reduced alpha 1,3 galactosyl sugar epitopes.

215 idase-treated Lfs lacked detectable terminal galactosyl sugars.

216 e laminin binding to collagen IV, to bind to galactosyl sulfatide, and to selectively convert alpha-s

217 We now show that SC expression of galactosyl-sulfatide, a Lm-binding glycolipid, precedes

218 ination of affinity chromatography on beta-D-galactosyl-Synsorb and ion-exchange chromatography on DE

219 icity of galectin-1 for eight different beta-galactosyl terminal disaccharides was studied using mole

220 ciency leads to impaired catabolism of alpha-galactosyl-terminal lipids such as globotriaosylceramide

221 ; EC ) leads to impaired catabolism of alpha-galactosyl-terminal lipids such as globotriaosylceramide

222 lectin activity of the protein toward beta1-galactosyl-terminated glycoconjugates.

223 ctin-like activity in interacting with beta1-galactosyl-terminated glycoconjugates.

224 Asialofetuin, the beta1-galactosyl-terminated glycoprotein inhibitor of VCC-indu

225 the full chemical affinity of azide ion for galactosyl transfer from the mutant enzyme which lacks t

226 presents the requirement for the coupling of galactosyl transfer from the native enzyme to the thermo

227 m the galactosyl-enzyme intermediates of the galactosyl transfer reactions catalyzed by E461G and E46

228 ignificant prolongation of heterotopic alpha Galactosyl transferase "knock-out" and human CD46 transg

229 e biosynthetic enzyme UDP-galactose:ceramide galactosyl transferase (CGT) are incapable of synthesizi

230 Mycobacterium tuberculosis being a putative galactosyl transferase (GalTr) implicated in galactan sy

231 o modify the porcine gene encoding alpha 1,3 galactosyl transferase (GGTA1).

232 nces of a rat sialyl transferase and a human galactosyl transferase along with the Arabidopsis homolo

233 s were transduced with an exogenous alpha1-3-galactosyl transferase gene, which codes for the termina

234 We also show that the activity of galactosyl transferase II (GalT-II, B3GalT6), a key enzy

235 sing human serum on wild-type (WT) and alpha-galactosyl transferase knockout (GalTKO)/hCD46-transgeni

236 By using alpha-galactosyl transferase knockout (GT-/-) mice, which make

237 osphorylcholine (ChoP), and lic2, a putative galactosyl transferase that adds the terminal galactose

238 osyl transferase A (pgtA), which encodes the galactosyl transferase that catalyzes the synthesis of t

239 mutants, we found that lgtE, which encodes a galactosyl transferase that is required for elongating t

240 -like protein 2, alpha-lactalbumin, beta-1,4-galactosyl transferase, and poly-Ig (immunoglobulin) rec

241 s have been generated that possess disrupted galactosyl-transferase (GGTA1) genes.

242 a lepidopteran insect cDNA encoding a beta4-galactosyl-transferase family member.

243 Arabidopsis encode XyG-specific fucosyl and galactosyl transferases, respectively.

244 The AGP-unreactive alpha-galactosyl Yariv reagent (alpha GalY) had no biological