ライフサイエンスコーパス: galactosylation

1 nks to hydroxyproline through the galactose (galactosylation).

2 terminal sialylation, which is dependent on galactosylation.

3 a configuration suspected to prevent beta1,3 galactosylation.

4 The epimerase is required for glycoprotein galactosylation.

5 considerable variation in the extent of LPG galactosylation.

6 , but which maintains normal levels of Golgi galactosylation.

7 ia ni TN-5B1-4 cells are capable of terminal galactosylation.

8 ontain LeX antigens that are masked by alpha-galactosylation.

9 ting antenna can be converted into LacNAc by galactosylation and can then be enzymatically modified i

10 t correlation between levels of aberrant IgG galactosylation and disease activity (Spearman's rho = 0

11 Correlations between aberrant galactosylation and disease activity were assessed in th

12 A of specific pathogen-free mice showed more galactosylation and much lower polymerization.

13 tween a donor substrate and acceptor in both galactosylation and N-acetylglucosaminylation, since a c

14 Variations in their extent of galactosylation and sialylation could modulate IgG Fc-de

15 e (F241A, F243A, V262E, and V264E) increased galactosylation and sialylation of the Fc and, concomita

16 These results suggest that in vitro galactosylation and sialylation of therapeutic glycoprot

17 e (q < 0.01) and CRC mortality (q = 0.04 for galactosylation and sialylation).

18 d GN to define the relative contributions of galactosylation and sialylation, in relation to cryoglob

19 -protein interactions, rather than increased galactosylation and sialylation, modifies the Fc conform

20 d via stereoselective 1,2-cis- and 1,2-trans-galactosylations and beta-Kdosylation.

21 pressed in an Arabidopsis mutant lacking XyG galactosylation, and two of them resulted in the product

22 Roles for the gene products in WTA galactosylation are proposed.

23 Our findings identify aberrant IgG galactosylation as a dysregulated component of the humor

24 )-beta-D-galactosyl side chain and excessive galactosylation at an alternative xylose residue.

25 Our results demonstrated that lack of galactosylation, but not sialylation, enhanced the patho

26 alyltransferase ST6GalNAc-II, which prevents galactosylation by C1GalT1.

27 Decreased galactosylation, decreased sialylation (of fucosylated I

28 for lectin resistance, were found to have a galactosylation defect.

29 re independent of the state of intracellular galactosylation during spermatogenesis.

30 ered noncontiguous Hyp residues are sites of galactosylation, giving rise to the arabinogalactan hete

31 It was found that the pattern of galactosylation greatly influenced binding affinities, a

32 Although the mere extent of galactosylation had no effect on either the cryogenic an

33 ed that biantennary oligosaccharides lacking galactosylation had slightly faster clearance rates than

34 in particular differences in the pattern of galactosylation have been noted.

35 tematically examined the requirement for WTA galactosylation in a mouse oral-virulent strain by first

36 That IgG1 galactosylation is a predictor of immune activation is s

37 The degree of galactosylation is essential for the synthesis of the GG

38 The result is that the rate constant for galactosylation is increased but degalactosylation is sl

39 both core alpha1,6-fucosylation and beta1,4-galactosylation is the presence of a nonreducing termina

40 antibody displayed lower levels of terminal galactosylation leading to reduced asialoglycoprotein-re

41 Impaired galactosylation leads to a severe disorder with deformed

42 t oligoarabinosides (Hyp-arabinosides) while galactosylation leads to the addition of larger arabinog

43 thmatic children seemed to have reduced IgG1 galactosylation levels as well.

44 High IgG1 galactosylation levels correlated with low total IgE lev

45 This indicates that IgG1 galactosylation levels could be used as a biomarker for

46 IgG1 galactosylation levels were generally higher in more aff

47 was a significant predictor of reduced IgG1 galactosylation levels.

48 tance to both hexosaminidase and to in vitro galactosylation, O-GlcNAc moieties appear to be largely

49 Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1

50 Glucosylation and galactosylation of a panel of representative alcohol acc

51 GT31 glycosyltransferase likely involved in galactosylation of arabinogalactan proteins.

52 Enzymatic galactosylation of chilled platelets blocks alphaMbeta2

53 e Golgi, (ii) secretion from the cell, (iii) galactosylation of chondroitin sulfate (CS) chains, (iv)

54 abinosylation of contiguous Hyp residues and galactosylation of clustered noncontiguous Hyp residues.

55 etylglucosamine was abolished, the degree of galactosylation of core alpha1,6-fucose increased, and a

56 tion of the GPI precursor lipid or defective galactosylation of GPI intermediates in the endoplasmic

57 In contrast to the murine study, galactosylation of human platelets did not prevent the a

58 The galactosylation of Hyl(393) in alpha1(IV)382-393 and Hyl

59 ogether, these results strongly suggest that galactosylation of I-branch is a rate-limiting step in I

60 Our results confirm the aberrant galactosylation of IgG in RA patients as compared with h

61 lgi lumen; this in turn results in selective galactosylation of macromolecules.

62 cells is accompanied by an increase in alpha-galactosylation of membrane glycoproteins and a decrease

63 beta4GalT-6 contributes only slightly to the galactosylation of N-glycans and is also not involved in

64 herefore, beta4GalT-1 is a key enzyme in the galactosylation of N-glycans, but is not involved in gly

65 Our understanding of the defective galactosylation of O-linked glycans in the hinge region

66 These cytokines reduced galactosylation of the O-glycan substrate directly via d

67 In vitro galactosylation of the tGlcNAc proteins generated glycop

68 l elongation appears to be slightly reduced, galactosylation of the XyGs is not strictly required for

69 lytic anemia, we defined the contribution of galactosylation or sialylation to the pathogenic activit

70 ted that sialic acid modifications, alpha1-3-galactosylation, or sulfation did not mask epitopes for

71 duals did not produce IgA with the defective galactosylation pattern.

72 ity, and we propose that strain-specific LPG galactosylation patterns reflect differences in their ex

73 Although capping the beta-GlcNAc moieties by galactosylation prevents clearance of short-term-cooled

74 ements of etiolated hypocotyls revealed that galactosylation rather than fucosylation of the side cha

75 e cells, indicating that galactosyl(alpha1-3)galactosylation sensitizes these viruses as well as mamm

76 belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-a

77 revious in vitro studies have shown that the galactosylation status of laminin directly influences it

78 Further, aberrant IgG galactosylation substantially predated the onset of arth

79 Galactosylations using NIS/TfOH were generally alpha-sel

80 IgG-Fc glycoform with fucosylation and fully galactosylation was an independent factor for a total Kn

81 on, and C-reactive protein level on aberrant galactosylation was determined using multivariate analys

82 N-acetylglucosamine at the nonreducing ends, galactosylation was judged to be inefficient, prompting

83 On the other hand, galactosylation was much more efficient on beta1,6-linke

84 of IgA1, probably taking the form of reduced galactosylation, was confirmed in IgAN in this study.

85 ted galactosyltransferase produces efficient galactosylation when uridine diphosphate-galactose is ad

86 ith N-glycolyl neuraminic acid and extent of galactosylation (zero-, mono-, di-, and alpha(1-3)-galac