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1 LT gene encoding Gb3/CD77 synthase (alpha1,4-galactosyltransferase).
2 the lgt2 gene of D4, which encodes beta(1-4)-galactosyltransferase.
3 the product of one of these genes encodes a galactosyltransferase.
4 transferase and the lgt2 encodes a beta(1-4) galactosyltransferase.
5 It is the first pH-sensitive method for galactosyltransferase.
6 port here a new pH-indicator-based assay for galactosyltransferase.
7 tively, using domains from mannosidase-1 and galactosyltransferase.
8 ly distinguished from the trans-Golgi marker galactosyltransferase.
9 ans bre-5, which encodes a putative beta-1,3-galactosyltransferase.
10 m for the substrate binding of the alpha1, 3-galactosyltransferase.
11 em containing equal amounts of epimerase and galactosyltransferase.
12 nd a UDP-galactose dependent (1-->6)-alpha-D-galactosyltransferase.
13 antigen is not synthesized in the absence of galactosyltransferase.
14 ar to be regulated by the specificity of the galactosyltransferase.
15 f UDP-galactose:glucosylceramide beta(1-->4)-galactosyltransferase.
16 B gene encoding the terminal oligosaccharide galactosyltransferase.
17 ity of another Mn-dependent enzyme, beta-1,4-galactosyltransferase.
18 matically galactosylated by bovine beta(1,4)-galactosyltransferase.
19 ctive toward T-synthase but not another beta-galactosyltransferase.
20 conversion of UDP-Gal to UDP, using 1-4-beta-galactosyltransferase.
21 ntaining conserved domains of core-1 beta1,3-galactosyltransferases.
23 this phenotype using Mutant [core 1 beta1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida gly
25 evated levels of the long isoform of beta1,4-galactosyltransferase 1 (GalT), a proportion of which is
26 rystallographic structures of bovine beta1,4-galactosyltransferase 1 and human glucuronyltransferase
28 es are due largely to the vertebrate beta1,4-galactosyltransferase-1 (beta4Gal-T1), which is found as
30 osaminyltansferase-7 (beta3GnT7) and beta1,4-galactosyltransferase-4 (beta4GalT4), in the production
31 n by knockdown of the gene encoding beta-1,3-galactosyltransferase 5 (beta3GalT5) in the globo-series
32 sylceramide (LacCer) synthesized by beta-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the
34 GAG) biosynthetic enzymes, the human beta1,4-galactosyltransferase 7 (hbeta4GalT7) is characterized b
36 ese-dependent enzymes, most notably beta-1,4-galactosyltransferase, a Golgi enzyme essential for bios
37 because of mutation of the gene for ceramide galactosyltransferase, a key enzyme for galactosphingoli
38 omologue of cj1136, which encodes a putative galactosyltransferase according to the annotation of the
39 nephropathy indicated a decrease in beta1,3-galactosyltransferase activity and an increase in N-acet
41 ydrolase but has recently been shown to have galactosyltransferase activity in Arabidopsis thaliana.
42 jection of zebrafish beta4GalT1 mRNA returns galactosyltransferase activity to control levels and res
43 -terminal region of FT85 abolishes Skp1 beta-galactosyltransferase activity with minimal effects on t
44 lumen with a K(m) of 2.7 microm;(c) detected galactosyltransferase activity(ies) in the lumen of the
51 why family GT6 members, like bovine alpha1,3-galactosyltransferase (alpha1,3-GalT), have a nucleophil
54 Disruption of the gene encoding pig alpha1,3-galactosyltransferase (alpha1,3GT) by homologous recombi
55 because of the inactivation of the alpha1,3-galactosyltransferase (alpha1,3GT) gene in these species
56 the UDP-galactose:beta-galactoside-alpha1-3-galactosyltransferase (alpha1,3GT) gene, which ablated t
58 hich requires the enzyme product of alpha1,3-galactosyltransferase (alpha1,3GT), are sugar chains on
60 the function of PgtA, a dual function beta3-galactosyltransferase/alpha2-fucosyltransferase that con
64 The retaining glycosyltransferase, alpha-1,3-galactosyltransferase (alpha3GT), is mutationally inacti
66 Notably, two domains harbored by beta-1,3 galactosyltransferase, an essential enzyme in forming pl
67 demonstrated an increase in overall beta(1,3)galactosyltransferase and alpha(2,3)sialyltransferase ac
68 ian beta1,4-galactosyltransferase or beta1,4-galactosyltransferase and alpha2,6-sialyltransferase gen
69 ectors designed to express mammalian beta1,4-galactosyltransferase and alpha2,6-sialyltransferase gen
70 the porcine submaxillary gland core 1 beta 3-galactosyltransferase and alpha2-fucosyltransferase exhi
71 tracts with [3H]galactose in the presence of galactosyltransferase and subsequent analyses of sacchar
72 ntiviral vector expressing porcine alpha 1,3 galactosyltransferase and transplanted into lethally irr
73 eins that are lipooligo/polysaccharide alpha-galactosyltransferases and alpha-glucosyltransferases.
75 from the pIgR, asialoglycoprotein receptor, galactosyltransferase, and CD89 is constitutively expres
76 cleus, the medial/trans-Golgi by fusion with galactosyltransferase, and the mitochondrial matrix by u
78 ids predominant in photosynthetic membranes, galactosyltransferases associated with these membranes t
79 n-dependent kinases related to the mammalian galactosyltransferase-associated protein kinase p58, and
80 transgenic animals with a heterozygous alpha-galactosyltransferase background (Tg Gal-/+), and from n
81 and/or resialylated TNFR-IgG using beta-1,4-galactosyltransferase (beta1,4GT) and/or alpha-2,3-sialy
84 then demonstrate that among various beta1, 4-galactosyltransferases (beta4Gal-Ts), beta4Gal-TI is mos
86 method to assay UDP-Gal:beta-d-GlcNAcbeta1,4-galactosyltransferase (beta4GalT-I) enzymatic activity.
90 form of the N-terminal region exhibits beta-galactosyltransferase but not fucosyltransferase activit
91 strongly inhibited modification by the PgtA galactosyltransferase but not the fucosyltransferase.
92 We have also confirmed the identity of the galactosyltransferase by inserting the cDNA in frame int
93 ion catalyzed by lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC) from Neisseria meningitid
95 ate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via incre
96 e Golgi-targeting mechanisms of core 1 beta3 galactosyltransferase (C1GalT1) and core 2 beta1,6-N-ace
98 that there are three different sets of lipid galactosyltransferases capable of galactoglycerolipid bi
102 zyme to generate GCs, UDP-galactose:ceramide galactosyltransferase (CGT(-/-)), exhibit severe postnat
103 he axonal protein NCP1 or the glial ceramide galactosyltransferase (CGT) display disruptions in AGJs
104 at encodes the enzyme UDP-galactose:ceramide galactosyltransferase (Cgt), which is responsible for ca
107 g galactose alpha 1,3 galactose in alpha 1,3 galactosyltransferase deficient (gal knockout) mice usin
108 were used as heart graft donors to alpha1,3-galactosyltransferase deficient (GalT KO; B6, H-2) recip
109 ow cells (BMC) were transplanted to alpha1,3-galactosyltransferase deficient (GalT-/-) mice condition
111 s for an anti-Gal IgM antibody into an alpha-galactosyltransferase-deficient (Gal-/-) background.
114 a similar splenic subpopulation of alpha1, 3-galactosyltransferase-deficient and wild-type mice.
115 from animals with the transgene in an alpha-galactosyltransferase-deficient background (Tg Gal-/-),
116 s study, we take advantage of the ability of galactosyltransferase-deficient knockout (GT-Ko) mice to
117 nd (Tg Gal-/+), and from nontransgenic alpha-galactosyltransferase-deficient littermates (Gal-/-) dem
121 DP-galactose 4-epimerase, EC ) and alpha1, 3-galactosyltransferase (EC ) with an N-terminal His(6) ta
122 osyl-1, 4-N-acetyl-D-glucosaminide alpha(1-3)galactosyltransferase (EC 2.4.1.151) or simply alphaGT.
125 ing effect on Drosophila melanogaster core 1 galactosyltransferase enzyme activity and a predominant
126 uorescent or biotin tags using an engineered galactosyltransferase enzyme and [3 + 2] azide-alkyne cy
127 zymatic approach that exploits an engineered galactosyltransferase enzyme to selectively label O-GlcN
134 formatics, but its identification as a beta4-galactosyltransferase family member was experimentally c
135 p is predicted to be a member of the beta1,3-galactosyltransferase family, and Pvg3p-green fluorescen
136 ains exists among other members of the beta3-galactosyltransferase family, recombinant enzyme did not
138 gene family that includes: murine alpha1, 3-galactosyltransferase, Forssman (Gb(5)) synthase, and th
139 in both organisms, and a bifunctional alpha-galactosyltransferase from CAZy family GT77 mediates the
141 e changed the donor requirement of alpha1, 3-galactosyltransferase from UDP-galactose to UDP-glucose
144 re of the catalytic domain of bovine beta1,4-galactosyltransferase (Gal-T1) co-crystallized with UDP-
147 mammals, humans lack a functional alpha-1,3-galactosyltransferase (GalT) gene and produce abundant a
148 s-mediated gene transfer of porcine alpha1,3 galactosyltransferase (GalT) is able to induce tolerance
149 the characterization of a zebrafish beta1,4-galactosyltransferase (GalT), which has substantial homo
152 ucosylceramide synthase and LacCer synthase (galactosyltransferase, GalT-2) inhibitor, inhibited LPS/
154 otype were linked to variation of a putative galactosyltransferase gene (beta-(1,3)galT); mutagenesis
156 as a result of up-regulation of the alpha1,3-galactosyltransferase gene and concomitant reduction in
157 homozygous for the knockout of the alpha1-3 galactosyltransferase gene appear to express low but det
159 -accelerating factor transgenic or alpha-1,3-galactosyltransferase gene knockout miniature swine.
160 urvival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express
163 availability of pigs homozygous for alpha1,3-galactosyltransferase gene knockout, and improved immuno
164 mammals, duplication of the ancestral beta4-galactosyltransferase gene occurred over 250 million yea
166 nerated by homologous disruption of alpha1,3-galactosyltransferase gene, is capable of producing natu
168 l antibodies (Abs) in baboons after alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pig heart
170 ic cardiac xenotransplantation from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) swine to b
171 radiated human or wild type (WT) or alpha1,3-galactosyltransferase gene-knockout (GT-KO) pig PBMC in
172 rombotic microangiopathy (TM) after alpha1,3-galactosyltransferase gene-knockout (GTKO) pig organ tra
173 in response to wild-type (WT) and alpha-1,3-galactosyltransferase gene-knockout (GTKO) porcine aorti
174 in baboons after Tx of livers from alpha1,3-galactosyltransferase gene-knockout (GTKO, n=1) or GTKO
175 s from genetically engineered pigs (alpha1,3-galactosyltransferase gene-knockout [GTKO] pigs and pigs
177 peracute rejection did not occur in alpha1,3-galactosyltransferase gene-knockout kidney xenografts.
180 We examined pathologic changes in alpha1,3-galactosyltransferase gene-knockout pig kidneys transpla
181 ononuclear cells from wild-type and alpha1,3-galactosyltransferase gene-knockout pigs) and anti-Gal I
182 s that do not express Gal epitopes (alpha1,3-galactosyltransferase gene-knockout pigs) might remove t
186 from SLA identical wild type (WT), alpha1, 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monoph
187 RISPR/Cas9 system to inactivate the collagen galactosyltransferase GLT25D1 and GLT25D2 genes in osteo
189 odifying enzyme possessing LH, hydroxylysine galactosyltransferase (GT), and galactosylhydroxylysine-
190 eins to express high levels of human beta1,4-galactosyltransferase (GT, E.C. 2.4.1.38) and/or alpha2,
191 tosaminyltransferase (GTA) and alpha-(1-->3)-galactosyltransferase (GTB) catalyze the final step in A
195 ain SS1 or SS1::0826kan, in which a beta-1,4-galactosyltransferase (HP0826), an LPS biosynthetic enzy
196 se 2, Drosophila melanogaster core 1 beta1,3-galactosyltransferase, human alpha2,3-sialyltransferase,
199 ona pellucida glycoprotein, ZP3, via beta1,4-galactosyltransferase I (GalT I), a lectin-like receptor
200 of sperm lacking the long isoform of beta1,4-galactosyltransferase I (GalT I), a sperm surface protei
202 d forms of five of the biosynthetic enzymes: galactosyltransferase I and glucuronosyltransferase I, r
204 zymes of the pathway (xylosyltransferase and galactosyltransferase I) show that the assembly of the p
205 5B2, which encode glucuronosyltransferase I, galactosyltransferase I, and the 3'-phosphoadenosine 5'-
206 the zebrafish ortholog of mammalian beta1,4-galactosyltransferase I, beta4GalT1, and its requirement
212 g in late pachytene spermatocytes, the beta4-galactosyltransferase-I (beta4GalT-I) gene is transcribe
213 evidence suggests that ZP3 binds to beta-1,4-galactosyltransferase-I (GalTase) on the sperm surface.
215 d-galactosyl-1,4-glucosylceramide alpha-1, 3-galactosyltransferase (iGb(3) synthase) from a rat place
218 indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan b
222 ave cloned Gb(3) synthase, the key alpha1, 4-galactosyltransferase in globo-series glycosphingolipid
223 ent or by knocking down the relevant enzyme, galactosyltransferase in Sb(R)LD (KD Sb(R)LD), compromis
224 indicate a gatekeeper function for the beta3-galactosyltransferase in the PgtA dual reaction, and ide
226 , suggesting that the disrupted genes encode galactosyltransferases in plant cell wall synthesis.
228 conclude that the R2866 lgtC gene encodes a galactosyltransferase involved in synthesis of the 4C4 e
231 DP-galactose:glycoprotein-alpha-GalNAc beta3-galactosyltransferase) is most sensitive to the presence
232 s specific client T-synthase (Core 1 beta1-3-galactosyltransferase) is required for folding of the en
234 the absence of alphaGAL epitopes, humans and galactosyltransferase knock-out (GALT/ KO) mice express
236 e report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a to
238 demonstrated that skin grafts from alpha-1,3 galactosyltransferase knockout (GalT-KO) miniature swine
239 previously reported life-supporting alpha1,3-galactosyltransferase knockout (GalTKO) thymokidney xeno
241 this treatment was demonstrated in alpha1,3-galactosyltransferase knockout mice producing anti-Gal a
242 This hypothesis was tested in alpha-1,3-galactosyltransferase knockout mice, which produce anti-
246 llagen type IV alpha-1 (COL4A1) and Beta-1,3-galactosyltransferase-like (B3GALTL) have been reported
248 re swine with a null allele of the alpha-1,3-galactosyltransferase locus (GGTA1) by nuclear transfer
250 nsertions in the genes encoding the putative galactosyltransferase (lpcA) and the distal Kdo-transfer
252 binds to the acceptor site of human beta1-4-galactosyltransferase much like the acceptor trisacchari
253 with the previously characterized xyloglucan galactosyltransferase, MUR3, but is required for galacto
254 d its serum-sensitive phenotype and that the galactosyltransferase mutant retained its serum-resistan
256 nsertionally inactivated the gene encoding a galactosyltransferase necessary for serotype O1 O-antige
258 family Pasteurellaceae and the LgtB and LgtE galactosyltransferases of Neisseria meningitidis and N.
259 the addition of either galactose by beta1,3-galactosyltransferase or a terminal sialic acid by a N-a
261 nsect cell lines that have mammalian beta1,4-galactosyltransferase or beta1,4-galactosyltransferase a
262 tter, no obvious homologues of known beta1-4-galactosyltransferase or beta1-2- or beta1-6-N-acetylglu
263 bohydrate-active enzyme database family GT4 (galactosyltransferases) or to family GT64 (C-terminal do
264 ongly influenced UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5 (B4GALT5) expressio
266 the asialoglycoprotein receptor or beta-1, 4-galactosyltransferase, previously described on HT-29 cel
268 identification on gels of a putative 51 kDa galactosyltransferase protein, and the isolation, clonin
269 ccharides have relied on the use of beta-1,3-galactosyltransferases recently cloned and characterized
270 o knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core
271 iously yielded iGb(3) synthase, the alpha1,3-galactosyltransferase required in isoglobo-series GSL.
272 f culmination, cells lacking AgtA, an alpha3-galactosyltransferase required to extend the trisacchari
273 was demonstrated unambiguously as a beta-1,3 galactosyltransferase responsible for converting GM2-lik
274 nt of a group of putative bacterial beta-1,3-galactosyltransferases revealed the presence of two cons
275 P-P-LU-galactan, catalyzed by a bifunctional galactosyltransferase (Rv3808c) capable of adding altern
276 he X-linked gene that encodes core 1 beta1,3-galactosyltransferase-specific chaperone 1 (C1GALT1C1, a
277 equences found in previously described beta3-galactosyltransferases, suggesting this enzyme is only d
278 rior studies suggested that the core 1 beta3-galactosyltransferase (T-synthase) is a specific client
280 lNAc-transferases (GALNT), the core 1 beta-3-galactosyltransferase (T-synthase), three alpha2-6-sialy
281 the primary follicle stage of core 1 beta1,3-galactosyltransferase (T-synthase; generates core 1-deri
282 ions 310-322) which is also found in beta1,4-galactosyltransferases (termed the Gal/GalNAc-T motif).
283 ositionally and shown to encode a xyloglucan galactosyltransferase that acts specifically on the thir
284 smic reticulum for T-synthase, a Golgi beta3-galactosyltransferase that generates the core 1 O-glycan
285 cated that Rv3789 interacts in vivo with the galactosyltransferase that initiates the elongation of t
286 GalT5 is a previously unidentified zebrafish galactosyltransferase that is essential for proper patte
287 e inactivation of the gene encoding alpha1-3 galactosyltransferase, the enzyme that synthesizes the g
288 ing protein, or subsequently modified with a galactosyltransferase to build more complex carbohydrate
289 f beta-galactosides using a bacterial beta-4-galactosyltransferase/-UDP-4'-gal-epimerase fusion prote
294 d lysosomal trafficking of the Golgi protein galactosyltransferase was sortilin independent and occur
295 hemically characterized a bacterial beta-1,3-galactosyltransferase (WbiP) from Escherichia coli O127,
296 ecretory pathway compartments (p63, p53, and galactosyltransferase) were not stained by antibodies in
297 pes 6A/6B have wciNalpha, encoding alpha-1,3-galactosyltransferase, whereas serotypes 6C/6D have wciN
298 sferases that includes vertebrate beta(1, 4)-galactosyltransferases, which create galactose-beta(1, 4
299 rized grafts in the combination of alpha 1,3-galactosyltransferase wild-type (GalT(+/+)) and deficien
300 he detergent solubilisation of the fenugreek galactosyltransferase with retention of activity, the id
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