ライフサイエンスコーパス: galectin 4

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1 an adhesion/growth-regulatory galectin-3 and galectin-4.

2 gion between the two CRDs that is present in galectin-4.

3 nt of a distinct gene, Lgals4, which encodes galectin-4.

4 the first time a structural model for human galectin-4.

5 otein, identified it as the human homolog of galectin-4, a protein containing two carbohydrate bindin

6 ancer xenografts that express high levels of galectin-4 along with genetic signatures of EGFR-HER2 si

7 Our findings establish galectin-4 and C1GALT1-mediated glycosylation in a signa

8 Expression of both galectin-4 and galectin-6 is confined to the epithelial

9 Parallel changes in galectin-4 and O-glycosylation triggered aberrant recept

10 Such different localization of galectins-4 and -3 within T84 cells implies different ta

11 lly expresses two closely related galectins, galectins-4 and -6, each with two carbohydrate recogniti

12 RD) in each monomer, whereas others, such as galectin-4, are isolated as monomers and have two CRDs i

13 Galectin-4 binding to multiple receptor tyrosine kinases

14 ed to specific domains of lamellipodia, with galectin-4 concentrated in the leading edge and galectin

15 l suppression, and the T cell inhibition was galectin-4-dependent.

16 In vivo investigations established that galectin-4 expression enabled prostate cancer cells to r

17 Galectin-4 expression in clinical specimens of prostate

18 re we report that two innate immune lectins, galectin-4 (Gal-4) and Gal-8, which are expressed in the

19 Galectin-4 is a tandem-repeat galectin characterized by

20 hat can be identified through the binding of galectin-4 is created on local, but not systemic, memory

21 Galectin-4 is expressed at about equal levels in colon a

22 In confluent T84 cells, galectin-4 is mostly cytosolic and concentrated at the b

23 stingly, the reactivity of CD4(+) T cells to galectin-4 is precisely elicited under intestinal inflam

24 The galectin-4-mediated production of IL-6 is MHC class II i

25 The galectin-4-mediated stimulation of CD4(+) T cells is sho

26 In particular, human galectin-4, normally expressed in the healthy gastrointe

27 Notably, these effects of galectin-4 relied upon O-glycosylation mediated by C1GAL

28 The localization of galectin-4 suggests a role in cell adhesion which is als

29 es, we identify herein an epithelial lectin, galectin-4, that specifically stimulates IL-6 production

30 ed by the ability of immobilized recombinant galectin-4 to stimulate adhesion of T84 cells.

31 Here, we investigate galectin-4 using X-ray crystallography, small- and wide-

32 the course of studying mouse colon mRNA for galectin-4, we detected a related mRNA that encodes a ne

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