ライフサイエンスコーパス: gallstone

1 risk factor, such as reflux esophagitis and gallstones.

2 a neoplasm in the group of patients without gallstones.

3 bile cholesterol and, thus, the formation of gallstones.

4 al inhibitor of initial biofilm formation on gallstones.

5 These cancers are associated with gallstones.

6 believed to be intermediates in formation of gallstones.

7 associated with the presence of cholesterol gallstones.

8 s frequently associated with the presence of gallstones.

9 iliary cholesterol secretion and cholesterol gallstones.

10 thogenic diet, all of the LIRKO mice develop gallstones.

11 equired for biofilm formation on cholesterol gallstones.

12 ol crystallization in biles of patients with gallstones.

13 tabolism and the pathogenesis of cholesterol gallstones.

14 as been demonstrated to be a risk factor for gallstones.

15 hanisms of previously noted risk factors for gallstones.

16 utput compared to WT mice, they still formed gallstones.

17 abdominal ultrasound examinations to detect gallstones.

18 It is also a core protein of cholesterol gallstones.

19 risks of hepatitis (21 [0.5%] vs 18 [0.4%]), gallstones (106 [2.3%] vs 106 [2.3%]), or cancer (438 [9

20 These results suggest that MI and gallstones, 2 seemingly unrelated diseases, are intrinsi

21 ice developed significantly more cholesterol gallstones (27%-80% prevalence) than Rag mice ( approxim

22 story of liver dysfunction (62 [27.4%]), and gallstones (53 [23.5%]) were commonly reported.

23 mia, fibrates may lead to the development of gallstones, a risk factor for pancreatitis.

24 isease, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer.

25 tals, for acute pancreatitis overall and for gallstone aetiology but not for alcoholic acute pancreat

26 month for acute pancreatitis overall or for gallstone aetiology, but for alcoholic acute pancreatiti

27 itals for acute pancreatitis overall and for gallstone aetiology, the study factors had limited impac

28 cholic acid (UDCA) prevents the formation of gallstones after bariatric surgery.

29 A and yihV-yihW) is a crucial determinant in gallstone and cholesterol biofilms but that expression o

30 rticipants (591 of 5928); of these, 6.8% had gallstones and 3.2% had cholecystectomy at baseline.

31 Gallstones and alcohol misuse are long-established risk

32 e long-term occurrence of clinical events of gallstones and associations between ultrasound observati

33 ncreatitis is associated with alcohol abuse, gallstones and bacterial infection.

34 nce inflammatory responses may predispose to gallstones and biliary tract cancer, suggesting the need

35 f chronic inflammation in the development of gallstones and biliary tract cancer, we examined the ris

36 Hence, gallstones and cholecystectomy are associated with the r

37 Colorectal cancer risk associated with gallstones and cholecystectomy decreased with increasing

38 Gallstones and cholecystectomy may be related to digesti

39 Gallstones and cholecystectomy were associated with incr

40 ship was found for both ultrasound-diagnosed gallstones and cholecystectomy.

41 ated that salmonellae form biofilms on human gallstones and cholesterol-coated surfaces in vitro and

42 onellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces in vitro.

43 atients might have higher risk in developing gallstones and conducted a population-based study to exa

44 bladder motility and cholesterol absorption, gallstones and expression of the mucin genes in gallblad

45 mization will be stratified for pre-existing gallstones and for type of surgery.

46 hat there are noncausal associations between gallstones and intestinal cancer.

47 search has focused on the pathophysiology of gallstones and on clarifying the underlying mechanisms o

48 absorption inhibitor ezetimibe could prevent gallstones and promote gallstone dissolution in mice and

49 y alleviate biofilm formation on cholesterol gallstones and the chronic carrier state.

50 pite the well-documented association between gallstones and the metabolic syndrome, the mechanistic l

51 er disease (most commonly viral hepatitis or gallstones) and underlying chronic liver disease.

52 myocardial infarction, urinary obstruction, gallstone, and sepsis.

53 Larger, multiple, and older gallstones are associated with events.

54 Cholesterol gallstones are associated with slow intestinal transit i

55 Gallstones are common and contribute to morbidity and he

56 Gallstones are one of the most important risk factors fo

57 Although gallstones are recognized causes of gallbladder cancer,

58 Gallstones are the most common cause of acute pancreatit

59 rol persons subjected to cholecystectomy for gallstones as controls.

60 sporter, Abcg5/g8, is Lith9 in mice, and two gallstone-associated variants in ABCG5/G8 have been iden

61 fR mutant formed extensive biofilms on mouse gallstones at 7 and 21 days postinfection; DeltafimAICDH

62 as scanned with (n = 86) or without (n = 85) gallstones at CT by using 80, 100, 120, and 140 kVp.

63 tant for attachment to and/or persistence on gallstones at later points of chronic infection, whereas

64 Ten percent had awareness of their gallstones; awareness was associated with uncomplicated

65 These findings offer direct evidence that gallstone biofilms occur in humans and mice, which facil

66 Ezetimibe prevented gallstones by effectively reducing intestinal cholestero

67 t with ezetimibe promoted the dissolution of gallstones by forming an abundance of unsaturated micell

68 ategy for preventing or treating cholesterol gallstones by inhibiting intestinal cholesterol absorpti

69 erglycemia, atherosclerosis, and cholesterol gallstones can all be caused by insulin resistance.

70 ABCG5/8 and NPC1L1 expression was similar in gallstone carriers and controls regardless of p.D19H pre

71 cholesterol absorption but not synthesis in gallstone carriers was diminished by about 21% based on

72 ls 28%, P = 0.0347 and wild type controls to gallstone carriers with 19H allele 37%, P = 0.0030).

73 No one knows exactly what proportion of gallstones cause clinical events among subjects unaware

74 ithogenesis, we investigated the biliary and gallstone characteristics in male wild-type (WT), ABCG5(

75 s, American Society of Anesthesiology score, gallstone characteristics, local inflammation, blood los

76 ous adverse event in the intervention group (gallstones) could be attributable to rapid and excessive

77 The sensitivity for gallstone detection was significantly higher at 140 kVp

78 Fewer than 20% of subjects with gallstones develop clinical events.

79 Rapid weight loss is a major risk factor for gallstone development.

80 sk of coronary artery disease, hypertension, gallstones, diabetes, cancer, metabolic syndrome, and vi

81 astrointestinal cancers were associated with gallstone disease (11.2% of patients with gallstone dise

82 of study participants with (34) and without gallstone disease (134).

83 t-side colon cancer was also associated with gallstone disease (2.57% of patients with gallstone dise

84 Cholesterol gallstone disease (CGD) results from a biochemical imbal

85 rol crystallization and possibly cholesterol gallstone disease (CGD).

86 ssion, open cholecystectomy, and complicated gallstone disease (each P < 0.05).

87 cally different populations of patients with gallstone disease (GSD) and stone-free controls to ident

88 Gallstone disease (GSD) is a common gastrointestinal dis

89 Gallstone disease (GSD) is related to several diabetes r

90 atitis (OR 8.66; 1.05-71.48; P = 0.045), and gallstone disease (OR 3.29; 2.02-5.36; P < 0.0001).

91 The primary endpoint is symptomatic gallstone disease after 24 months, defined as admission

92 er UDCA reduces the incidence of symptomatic gallstone disease after Roux-en-Y gastric bypass or slee

93 me iron is associated with a greater risk of gallstone disease among men.

94 se also modifies the severity of symptomatic gallstone disease and its treatment.

95 Both gallstone disease and p.D19H of ABCG8 are associated wit

96 y lipid secretion plays an important role in gallstone disease and reverse cholesterol transport (RCT

97 emporal associations between screen-detected gallstone disease and specific cancers is limited.

98 cipants biennially reported their history of gallstone disease and whether they had undergone cholecy

99 The cumulative incidences of MI and gallstone disease as a function of age and increasing ge

100 andomized controlled trials with symptomatic gallstone disease as primary endpoint have not been cond

101 he identification of susceptibility loci for gallstone disease by use of animal models suggest geneti

102 Gallstone disease can lead to severe complications and o

103 Breast cancer had a weak association with gallstone disease depending on other factors (10.6% of p

104 Of these, 4,106 developed symptomatic gallstone disease during up to 34 years of follow-up.

105 ence interval: 2.39 to 3.39) for symptomatic gallstone disease for individuals with a genotype score

106 potential risk factors, the relative risk of gallstone disease for men in the highest quintile was 1.

107 Participants with gallstone disease had higher all-cause mortality in age-

108 ies, although the effect of statins on human gallstone disease has been controversial.

109 In the US population, persons with gallstone disease have increased mortality overall and m

110 es of heme and non-heme iron and the risk of gallstone disease in a cohort of 44 758 US men from 1986

111 umption of saturated fatty acids and risk of gallstone disease in a cohort of 44,524 US men from 1986

112 sses of saturated fatty acids on the risk of gallstone disease in humans is unknown.

113 BCG8) confers susceptibility for cholesterol gallstone disease in humans.

114 aturated fatty acids may enhance the risk of gallstone disease in men.

115 hence risk of myocardial infarction (MI) and gallstone disease in opposite directions.

116 Screen-detected gallstone disease in the general population is associate

117 in STSL have been linked to lipid levels and gallstone disease in whites.

118 Gallstone disease is a hepatobiliary disorder due to bio

119 Gallstone disease is associated with p.D19H of ABCG8 as

120 l CT performed at 140 kVp may be useful when gallstone disease is of clinical concern.

121 The risk of gallstone disease may be increased in patients with CN s

122 y), fibrosis/cirrhosis (HR 5.11; 3.29-7.96), gallstone disease or cholangitis (HR 2.72; 2.55-2.91, an

123 nd rs4245791 were associated positively with gallstone disease risk, whereas the association for the

124 ery and ERCP, serving as a base for audit of gallstone disease treatment.

125 th gallstone disease (2.57% of patients with gallstone disease vs 0.96% without; hazard ratio, 2.04;

126 th gallstone disease (11.2% of patients with gallstone disease vs 6.64% without; hazard ratio, 1.50;

127 ing on other factors (10.6% of patients with gallstone disease vs 7.41% without; hazard ratio, 1.44;

128 y adjusted hazard ratio (HR) for symptomatic gallstone disease was 2.84 (95% confidence interval [CI]

129 Newly diagnosed gallstone disease was ascertained biennially.

130 We examined whether gallstone disease was associated with overall and cause-

131 Gallstone disease was defined as ultrasound-documented g

132 Gallstone disease was identified in 10% of participants

133 Corresponding HRs for symptomatic gallstone disease were 1.43 (95% CI: 0.99-2.05) overall,

134 1,140 consecutive patients with symptomatic gallstone disease were recruited during 2008-2010 at Kuo

135 ctiveness of three diagnostic strategies for gallstone disease with possible choledocholithiasis: non

136 well as protection against atherosclerosis, gallstone disease, and obesity.

137 er ABCG8 as a locus associated with risk for gallstone disease, but findings have not been reported f

138 smooth muscle (GBSM) function that occurs in gallstone disease, but their mechanism of action is unkn

139 t abdominal ultrasound examination to detect gallstone disease, but were not informed of their gallst

140 mated causal odds ratio (OR) for symptomatic gallstone disease, by instrumental variable analysis for

141 y index, race, admission acuity, complicated gallstone disease, hospital teaching status, and open ve

142 low-up, we documented 2350 incident cases of gallstone disease, of which 1387 cases required cholecys

143 his locus to a more diverse ethnic group for gallstone disease, susceptibility to biliary cancer, and

144 pplications in cholestatic liver disease and gallstone disease, two serious health concerns for human

145 yperhomocysteinemia can occur in cholesterol gallstone disease, we hypothesized that this may result

146 In this large-scale GWAS of gallstone disease, we identified 4 loci in genes that ha

147 evated BMI and increased risk of symptomatic gallstone disease, which is most pronounced in women.

148 nd prostate cancers were not associated with gallstone disease.

149 st MI, but increases the risk of symptomatic gallstone disease.

150 BMI) is associated with an increased risk of gallstone disease.

151 cipients with asymptomatic and uncomplicated gallstone disease.

152 undergo open cholecystectomy for complicated gallstone disease.

153 contributing factor in the manifestation of gallstone disease.

154 admission or hospital visit for symptomatic gallstone disease.

155 iron intake in relation to the occurrence of gallstone disease.

156 th infants and adults as well as cholesterol gallstone disease.

157 and rectal cancers were not associated with gallstone disease.

158 isms that were associated independently with gallstone disease.

159 identify additional genetic risk factors for gallstone disease.

160 Roux-en-Y gastric bypass develop symptomatic gallstone disease.

161 erol metabolism may be involved in pediatric gallstone disease.

162 ing 5,647 with MI and 3,174 with symptomatic gallstone disease.

163 sition, such as that observed in cholesterol gallstone disease.Due to the challenges in directly stud

164 CG8 has been identified as a risk factor for gallstone disease; this variant has been associated with

165 tive benefits of frequent nut consumption on gallstone diseases are observed in both sexes.

166 etimibe could prevent gallstones and promote gallstone dissolution in mice and reduce biliary cholest

167 ocumented 2468 incident cases of symptomatic gallstones during 597 699 person-years of follow-up.

168 l absorption and pathogenesis of cholesterol gallstone, dyslipidemia, and diabetes.

169 e evidence that Helicobacter species promote gallstone formation and hepatobiliary tumors in laborato

170 This metabolic trait precedes gallstone formation and is a feature of ethnic groups at

171 are markedly predisposed toward cholesterol gallstone formation due to at least two distinct mechani

172 etic locations of Lith loci, which influence gallstone formation in mouse models.

173 e severity of and shortened the interval for gallstone formation in PKCbeta(-/-) mice and was associa

174 Gallstone formation in the mutant mice was accompanied b

175 Cholesterol gallstone formation is a complex process mediated by gen

176 ether rapid weight reduction can precipitate gallstone formation is still debated.

177 2A(-/-) mice fed a lithogenic diet had rapid gallstone formation, an increased cholesterol saturation

178 high-density lipoprotein (HDL) cholesterol, gallstone formation, and obesity.

179 ersecretion as the mechanism for cholesterol gallstone formation, thereby drawing a link between "pos

180 stinal cholesterol absorption contributes to gallstone formation, we explored whether the potent chol

181 derived cholesterol from plasma to bile, and gallstone formation, which works independently of the AB

182 , including hypersensitivity to diet-induced gallstone formation.

183 tion, all of which enhance susceptibility to gallstone formation.

184 nd influences susceptibility to diet-induced gallstone formation.

185 Ls are detected to control mouse cholesterol gallstone formation.

186 asis and for the pathogenesis of cholesterol gallstone formation.

187 ry cholesterol secretion, and the absence of gallstone formation.

188 lular subset was responsible for cholesterol gallstone formation.

189 s high levels of biliary cholesterol promote gallstone formation.

190 nalysis was performed to evaluate the 5-year gallstone-free survival rates for the 2 cohorts.

191 as significant biofilms were not detected on gallstones from Escherichia coli infected gallbladders.

192 nd bacterial biofilms could be visualized on gallstones from these carriers whereas significant biofi

193 ur group was significantly lower than in the gallstone group (p < 0.05).

194 PP7 and was higher in the tumour than in the gallstone group.

195 Pathogenesis of gallstones (GS) is multifactorial and multiple genetic a

196 Patients with gallstones had a high frequency of preneoplastic lesions

197 Individuals with gallstones had a similar increase in risk of death as th

198 Biofilm formation on gallstones has been demonstrated to be a mechanism of pe

199 Dominant etiologies include gallstones, hepatic sequestration, viral hepatitis, and

200 t Sample from 2004 to 2009 was performed for gallstone ileus cases treated surgically by enterotomy w

201 Gallstone ileus is a mechanical bowel obstruction caused

202 Gallstone ileus is a rare surgical disease affecting mai

203 from 2004 to 2009, 3268 (0.095%) were due to gallstone ileus-an incidence lower than previously repor

204 ased study to examine the risk of developing gallstone in osteoporotic patients in Taiwan.

205 respectively; P = .02) and the presence of a gallstone in the gallbladder infundibulum (78% and 22% f

206 s acute cholecystitis) and the presence of a gallstone in the gallbladder infundibulum are associated

207 , the Cox regression analysis of the risk of gallstone in the osteoporosis and comparison cohorts yie

208 ium double mutant formed a mature biofilm on gallstones in a test tube assay and in a new, gallstone-

209 Statins also prevent the formation of gallstones in animal studies, although the effect of sta

210 eeks, 90% Apobec-1(-/-) mice developed solid gallstones in comparison with 16% wild type controls.

211 Spillage of gallstones in the abdominal cavity may rarely occur duri

212 te is highly associated with the presence of gallstones in the gallbladder of infected carriers upon

213 form biofilms on the surfaces of cholesterol gallstones in the gallbladders of mice and human carrier

214 Dropped gallstones in the peritoneal and extra-peritoneal cavity

215 describe an unusual case of infected spilled gallstones in the right sub-phrenic space, prospectively

216 mechanism causing an increased incidence of gallstones in these patients have as yet not been identi

217 ated that salmonellae form biofilms on human gallstones in vitro.

218 increased biliary cholesterol secretion and gallstones in WT, but not ABCG5(-/-)/G8(-/-) or ABCG8 (-

219 The incidence of gallstones increased from 9% in control mice to 95% in P

220 allstones in a test tube assay and in a new, gallstone-independent assay using cholesterol-coated Epp

221 The formation of cholesterol gallstones is a complex process involving contributions

222 dical and contact dissolution of cholesterol gallstones is chronicled.

223 astatin for the resolution and prevention of gallstones is promising, but larger studies are needed.

224 ion of heme and non-heme iron on the risk of gallstones is unknown.

225 epatocellular damage, TG2(-/-) mice had more gallstones, jaundice, and ductal proliferation than wild

226 n mice identified a susceptibility locus for gallstones (Lith6) spanning the Apobec-1 locus, the stru

227 There was an association between gallstones more than 5 years old and acute cholecystitis

228 and sex-matched children (n = 82) and adult gallstones (n = 187) served as controls.

229 liver function values in serum (n = 28) and gallstones (n = 46) of consecutively cholecystectomized

230 -year follow-up period, 114 and 311 cases of gallstone occurred in the osteoporosis and comparison co

231 as found to be significantly associated with gallstones (odds ratio [OR] = 2.9, P = 0.0220, 95% confi

232 osing the mice to development of cholesterol gallstones on a lithogenic diet.

233 dary endpoints consist of the development of gallstones on ultrasound at 24 months, number of cholecy

234 is study was to determine if screen-detected gallstones or cholecystectomy are associated with occurr

235 disease was defined as ultrasound-documented gallstones or evidence of cholecystectomy.

236 iopancreatography (ERCP) in 59 patients with gallstone, other benign disease, tumour, and primary scl

237 itis (26.6%), choledocholithiasis (5.7%), or gallstone pancreatitis (2.4%).

238 end that patients with an initial episode of gallstone pancreatitis receive cholecystectomy.

239 consensus among surgeons that patients with gallstone pancreatitis should undergo cholecystectomy to

240 ents in the treatment of patients with acute gallstone pancreatitis with regards to the timing of ERC

241 oscopic management of choledocholithiasis in gallstone pancreatitis, a newer approach in the endoscop

242 In mild gallstone pancreatitis, laparoscopic cholecystectomy per

243 formed within 48 hours of admission for mild gallstone pancreatitis, regardless of resolution of abdo

244 ble for the onset of clinical biliary (i.e., gallstone) pancreatitis and creates highly reproducible

245 likely to be crucial factors in cholesterol gallstone pathogenesis, rather then merely the result of

246 l absorption as well as de novo synthesis in gallstone patients stratified according to 19H risk alle

247 Lipid changes in gallbladder biles of gallstone patients vs overweight subjects without gallst

248 Of the 350 gallbladder specimens from gallstone patients, hyperplasia was found in 32%, metapl

249 arcinoma patients, being only 19% of that in gallstone patients.

250 G8 (-/-) mice displayed the same biliary and gallstone phenotypes.

251 tumour plus PSC group was also lower than in gallstone plus other benign disease group (p < 0.05).

252 These patients are prone to gallstones, portal hypertension and possible surgical co

253 formation of undesirable assemblies such as gallstone precursors, and how they can stabilize free-fl

254 tically significant increases in cholesterol gallstone prevalence compared with uninfected mice (81%

255 layed biliary lipid secretion rates and high gallstone prevalence rates similar to WT mice without an

256 ve provided insight into the pathogenesis of gallstones, primary biliary cirrhosis, and primary scler

257 ent views of the pathogenesis of cholesterol gallstones, promote further research on the pathways inv

258 ile-induced biofilm formation on cholesterol gallstones promotes gallbladder colonization and mainten

259 In most cholesterol gallstone-prone humans, lithogenic bile carries large qu

260 Factors associated with gallstone-related acute hospitalization included male se

261 imilarly shaped association with risk of non-gallstone-related acute pancreatitis as that observed fo

262 naire at baseline, and cases of incident non-gallstone-related acute pancreatitis were identified by

263 men and 111 cases in women) of incident non-gallstone-related acute pancreatitis were identified.

264 may be associated with decreased risk of non-gallstone-related acute pancreatitis.

265 h and lean fish separately, with risk of non-gallstone-related acute pancreatitis.

266 atients with their 2-year risk of developing gallstone-related complications, allowing patients and p

267 ity Hospital, Geneva, Switzerland, for acute gallstone-related conditions with an intermediate risk o

268 s of care and modeled their risk of emergent gallstone-related hospitalization or cholecystectomy at

269 The 2-year emergent gallstone-related hospitalization rate was 11.1%, with a

270 Beyond gallstone-related morbidity we found a strong positive a

271 e C57L, C57BL/6, and SWR mice but not in the gallstone-resistant AKR mice.

272 (e.g., between plasma campesterol levels and gallstones risk; and between immunoglobulin A and juveni

273 experiments using Nramp1(+/+) mice harboring gallstones showed that only the DeltaycfR mutant formed

274 r 2, P < .05 for each reader), regardless of gallstone size (<1.0 cm vs > or =1.0 cm in diameter, P <

275 tone disease, but were not informed of their gallstone status.

276 lstones; subjects were not informed of their gallstone status.

277 nical events among subjects unaware of their gallstone status.

278 Gallstone subclasses shared enhanced cholesterol synthes

279 study population comprised 664 subjects with gallstones; subjects were not informed of their gallston

280 nfection; DeltafimAICDHF was not observed on gallstone surfaces after the 7-day-postinfection time po

281 we hypothesize that bile-induced biofilms on gallstone surfaces promote gallbladder colonization and

282 analyzed data from the Swedish Registry for Gallstone Surgery and Endoscopic Retrograde Cholangiopan

283 also registered in the Swedish registry for gallstone surgery and ERCP (GallRiks) and correlations b

284 Thirty-day follow-up of both gallstone surgery and ERCP is mandatory, as is an additi

285 is a validated national quality registry for gallstone surgery and ERCP, serving as a base for audit

286 s observation prompted us to compare dietary gallstone susceptibility in Apobec-1(-/-) mice and conge

287 metabolic syndrome and increased cholesterol gallstone susceptibility.

288 Male gallstone-susceptible C57L mice were fed a lithogenic di

289 became elevated during cholelithogenesis in gallstone-susceptible C57L, C57BL/6, and SWR mice but no

290 s in Taiwan have a higher risk of developing gallstone than the general population.

291 fed a lithogenic diet developed cholesterol gallstones that supported biofilm formation during persi

292 However, we hypothesize that in addition to gallstones, the gallbladder epithelium aids in the estab

293 for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 wer

294 All consecutive patients with gallstones undergoing cholecystectomy from 2007-2011 wer

295 The prevalence of gallstones was 7.1% and of cholecystectomy was 5.3%.

296 ne system in the pathogenesis of cholesterol gallstones was not considered a valid topic of research

297 ty markers in circulation, a 58% increase in gallstone weight, a 40% increase in hepatic cholesterol

298 tone patients vs overweight subjects without gallstones were examined before (day 0) and at 30 days a

299 Gallbladder biles and gallstones were examined by microscopy.

300 suggesting a possible causal association of gallstones with GBC.

301 were also significantly high in people with gallstones without cholecystectomy.