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1 edox modulation of a disulfide bridge on its gamma subunit.
2 uman ENaC, an effect mediated in part by the gamma subunit.
3 RNA specific to the endogenous translocating gamma subunit.
4 calcium channels were also associated with a gamma subunit.
5 n-dependent cleavage site (RKRK(186)) in the gamma subunit.
6 nd at a single extracellular site within the gamma subunit.
7 a locus distinct from its active site on the gamma subunit.
8 lpha subunit and at a single site within the gamma subunit.
9 ic protein consisting of an alpha, beta, and gamma subunit.
10 catalysis or, therefore, for rotation of the gamma subunit.
11 catch and induces a partial rotation of the gamma subunit.
12 ial myocytes express a functional BK channel gamma subunit.
13 e-interacting beta-subunit, and a regulatory gamma-subunit.
14 nd product release, inducing a torque on the gamma-subunit.
15 This process is enhanced by the gamma-subunit.
16 transiently stored as elastic energy in the gamma-subunit.
17 (Lys-189) in the extracellular domain of the gamma-subunit.
18 phabeta-dimers creates torque on its central gamma-subunit.
19 hate in the complete absence of the beta and gamma subunits.
20 vage of the extracellular loops of alpha and gamma subunits.
21 f the extracellular domains of the alpha and gamma subunits.
22 the requirement for the regulatory beta and gamma subunits.
23 residue found at the homologous position in gamma subunits.
24 relative protein content of alpha, beta, and gamma subunits.
25 explored the function of the alpha/beta and gamma subunits.
26 cluding Rho, Rap1, Rac, Cdc42, and G-protein gamma subunits.
27 oocytes injected with ENaC-alpha, beta, and gamma subunits.
28 lso contain auxiliary alpha2delta, beta, and gamma subunits.
29 f the extracellular domains of the alpha and gamma subunits.
30 ners that function in the place of G protein gamma subunits.
31 by furin-dependent cleavage of the alpha and gamma subunits.
32 nd M3 transmembrane helices in the alpha and gamma subunits.
33 ric G-protein consisting of alpha, beta, and gamma subunits.
34 pe cells and in cells lacking beta- and Snf4/gamma-subunits.
35 inhibited by the cone- and rod-specific PDE6 gamma-subunits.
36 KC consensus site on the alpha- or beta- and gamma-subunits.
37 es internalization of the alpha-, beta-, and gamma-subunits.
38 the extracellular domains of the alpha- and gamma-subunits.
39 rted a role for the heterotrimeric G protein gamma subunit 1 (Ggamma1) in mediating cardial-pericardi
40 ed of two alpha-subunits (68.8 kD each), one gamma-subunit (22.5 kD), and one delta-subunit (11.9 kD)
41 .1 kD each), one beta-subunit (56.0 kD), one gamma-subunit (24.8 kD), and one delta-subunit (13.9 kD)
42 lent residues in the nACh receptor delta and gamma subunits) abolished and severely attenuated functi
43 induction of "fetal" acetylcholine receptor gamma subunit (AChRgamma), reduction of "adult" AChRepsi
44 The conservation of primary structures of gamma-subunits across mammalian species suggests that th
46 rylation in mice and fibroblasts lacking the gamma subunit along with kinetic studies of recombinant
47 rin cleavage and the inhibitory tract in the gamma subunit (alphabetagammaR143A,DeltaE144-K186) showe
49 ontain an endogenous translocating G protein gamma subunit and exhibit receptor-induced Golgi fragmen
50 ndocytosis requires an activating FcgammaR's gamma subunit and involves astrocytic membrane loss of a
51 es of gold nanorods attached to the rotating gamma subunit and/or by increasing the viscosity of the
52 reonine phosphorylation of the ENaC beta and gamma subunits and abolished by inhibitors of (a) mitoge
53 t, contains three G alpha, one G beta, one G gamma subunits and phosducin-like protein BDM-1 that hav
55 haracterized, the identities of its beta and gamma subunits and their function in olfactory signal tr
57 ing for the observed torque generated on the gamma-subunit and its change due to mutation of this uni
58 ed of a single copy of an alpha-, beta-, and gamma-subunit and plays an essential role in water and s
59 C is enhanced by proteolytic cleavage of the gamma-subunit and putative release of a 43-amino acid in
60 rrangements disrupt interactions between the gamma-subunit and the C-terminal domain of the alpha(E)-
61 termined by a small unique region within the gamma-subunit and this region contains two cysteine resi
62 a direct interaction between the alpha- and gamma-subunits and indicating that our structure may rep
63 omplex is composed of two alpha-, beta-, and gamma-subunits and represents the key enzyme for the bio
64 ongation factor (eEF) 1B (alpha-, beta-, and gamma-subunits) and eukaryotic translation initiation fa
66 the extracellular domains of its alpha- and gamma-subunits, and it was recently reported that ENaC a
67 zed threonine phosphorylation of the channel gamma subunit: and (c) characterize a common scientific
68 all GTPases and the heterotrimeric G protein gamma subunit are methylated on their carboxy-terminal c
70 oteolytic processing events of the alpha and gamma subunits are associated with channel activation.
71 eric G proteins composed of alpha, beta, and gamma subunits are central signal transducers mediating
73 ric G proteins, composed of alpha, beta, and gamma subunits, are activated by exchange of GDP for GTP
75 he equivalent residues in the chloroplast F1 gamma subunit, arginine 304 and glutamine 305, with alan
76 ed upon siRNA-mediated knockdown of the AP-1 gamma subunit, as predicted for the common AP-1-dependen
77 in association with inducing cleavage of the gamma subunit at gammaLys194, a site distal to the furin
79 proteins in enriched fractions, ATP-synthase gamma-subunit (AtpC) and Rubisco activase (RCA) were ide
80 rimeric complex composed of alpha, beta, and gamma subunits, belongs to the ENaC/degenerin family of
82 the transmembrane M3 helices of the beta and gamma subunits (betaMet-285, betaMet-288, and gammaMet-2
84 6-phosphate receptor homology domain of the gamma subunit binds and presents the high mannose glycan
86 ha subunits themselves and between alpha and gamma subunits, both of which were decreased in CRT hear
89 cting as a solid "pushrod" to push the rotor gamma subunit, but the short helix in F(1)(1/2)s would f
91 ound that modifying the Arabidopsis thaliana gamma subunit by mutating three highly conserved acidic
92 lcium/calmodulin-dependent protein kinase II gamma subunit (CaMKIIgamma), a component of the NMDA rec
94 Introduction of this region within the yeast gamma-subunit causes a defect in oxidative phosphorylati
95 none functional regulation of BK channels by gamma-subunits: channels either exhibit a full gating sh
97 ed and devoid of cone transducin (alpha- and gamma-subunits), cone phosphodiesterase, and G protein-c
98 s alphabetagamma complexes, whose regulatory gamma subunit confers energy sensor function by binding
99 tracellular finger domains of ENaC alpha and gamma subunits contain allosteric regulatory modules.
100 ontaining a glycogen-sensing domain, and the gamma subunits containing 2 regulatory sites that bind t
104 alpha decreased levels of alpha-, beta-, and gamma-subunits, decreased F0F1-ATPase activity, and hind
106 x-sensitive labeling studies showed that the gamma subunit disulfide/sulfhydryl couple in the modifie
107 , we show that elimination of the transducin gamma-subunit drastically reduces signal amplification i
108 h HdrABC and dissimilatory sulfite reductase gamma subunit (DsrC) to perform novel electron transfer
109 plasmic reticulum (ER) from alpha, beta, and gamma subunits, each with two transmembrane domains, a l
114 toward a subset of the acid hydrolases, the gamma subunit facilitates the addition of the second Glc
115 The eight members of the calcium channel gamma subunit family are integral membrane proteins that
116 ed that 6 of the 12 members of the G protein gamma subunit family translocate specifically from the P
118 at close to wild-type levels but require the gamma subunit for optimal phosphorylation of the rest of
120 strate that the two heterotrimeric G-protein gamma-subunits from Arabidopsis (Arabidopsis thaliana),
125 re gated by direct binding of G protein beta-gamma subunits (Gbetagamma), signaling lipids, and intra
126 r investigate the risk susceptibility by the gamma subunit gene family to SCZ, we conducted a large-s
127 e, we show that genetic deletion of the AChR gamma-subunit gene in mice leads to an absence of pre-pa
133 revealed phosphorylation of Ser(146) on the gamma subunit in response to wtPKC-alpha overexpression.
134 the alpha and/or beta subunits binds to the gamma subunit in the presence of AMP but not when ATP is
137 pe is not due to redundant roles for the two gamma subunits in the same signaling pathway but rather
138 the relationship between mallotoxin and the gamma subunits in their BK channel-activating effects in
139 We have here addressed the role of the Snf4 (gamma) subunit in regulating SNF1 protein kinase in resp
141 In response to torque-driven rotation of the gamma-subunit in the hydrolysis direction, the nucleotid
143 hat removal of the inhibitory tract from the gamma subunit, in the absence of alpha subunit cleavage,
144 g to multiple extracellular sites within the gamma-subunit, including (i) a high-affinity stimulatory
149 hat can consume ATP to drive rotation of the gamma-subunit inside the ring of three alphabeta-subunit
151 xin for binding at the alpha/delta and alpha/gamma subunit interfaces of the nAChR, with higher affin
152 rresponding to the fragment cleaved from the gamma subunit is a reversible inhibitor of endogenous EN
153 interaction site near the N terminus of the gamma subunit is important for recruitment, but not acti
154 aken together, we conclude that although the gamma subunit is not required for the binding of GABA or
156 6-phosphate receptor homology domain of the gamma subunit is required for optimal phosphorylation.
158 rmore, we observe that communication between gamma subunits is necessary for both regulatory roles.
160 t homologous sites within either the beta or gamma subunit knuckle domain resulted in little or no ch
161 In contrast, deletion of either the beta or gamma subunit knuckle domain within the alphabetagamma t
162 other at the interface between the alpha and gamma subunits (labeling of alphaM2-10 and gammaMet-299)
164 ociation of the complex; similarly, a mutant gamma-subunit lacking the [4Fe-4S] cluster is unable to
165 We demonstrate that loss of the laminin gamma subunit (LanB2) in the peripheral glia of Drosophi
166 ATPase, 2) interacts with alpha-, beta-, and gamma-subunits leading to increases in their phosphoryla
167 demonstrate that the knock-out of transducin gamma-subunit leads to a major downregulation of both al
168 cells by reducing mRNA expression of the BK gamma subunit leucine-rich repeat-containing protein 26
169 rexpressing wtPKC-alpha blocked decreases in gamma-subunit levels, maintained F0F1-ATPase activity, a
170 that the C-terminus of the photosynthetic F1 gamma subunit, like its mitochondrial counterpart, forms
172 ng enhanced green fluorescent protein in the gamma-subunit M3-M4 loop, which confirmed our nAChR beta
173 i clamp loader that exists in space as three gamma-subunits (motor) flanked by the delta' (stator) an
175 technique to identify the NADH dehydrogenase gamma subunit (nuoG) primer set that is sensitive and sp
176 2 in the alpha1 subunit of GlyRs and in the gamma subunit of alpha1beta2gamma2GABA(A)Rs and measured
178 te ligands bound to one or more sites in the gamma subunit of AMPK promote the formation of an active
179 nteraction between ERManI and gamma-COP, the gamma subunit of coat protein complex I (COPI) that is r
180 events injury-induced decreases in levels of gamma subunit of F0F1-ATPase, 2) interacts with alpha-,
181 c mice (TG-CRP) with either mice lacking the gamma subunit of FcgammaRI (FcRgamma(-/-)) or FcgammaRII
183 s bind at the interface between an alpha and gamma subunit of GABA(A)Rs, preferentially enhancing syn
184 tations in the GNPTG gene, which encodes the gamma subunit of GNPT, in affected subjects of Asian and
187 s possesses two homologues of the regulatory gamma subunit of the ATP synthase, encoded by the ATPC1
188 PII also bind to the yeast orthologue of the gamma subunit of the COPI coat complex (Sec21p), a known
189 ation of key functional features seen in the gamma subunit of the eukaryotic AMP-activated protein ki
190 he N terminus of zeta blocks rotation of the gamma subunit of the F1-ATPase of P. denitrificans by a
191 pathways by inducing the degradation of the gamma subunit of the inhibitor of kappaB kinase complex
192 acid residues near the C-terminus within the gamma subunit of the mitochondrial ATP synthase form a "
195 1, ASIC3, TRPV4, TRPA1, the alpha, beta, and gamma subunits of ENaC, and the two pore K+ channels (TR
196 suggest that palmitoylation of the beta and gamma subunits of ENaCs enhances interactions of their r
197 in the cytoplasmic segments of the beta and gamma subunits of Fc epsilon RI by the Src tyrosine kina
198 l modification of Met to Asp was reported in gamma subunits of human fetal Hb Toms River (gamma67(E11
199 auxiliary metabolic genes for the alpha and gamma subunits of reverse dissimilatory sulfite reductas
204 family of small GTPases, nuclear lamins, the gamma-subunit of heterotrimeric GTPases, and several pro
206 ypertension due to mutations in the beta- or gamma-subunit of the epithelial sodium channel (ENaC).
207 The recombinant mAb 131 is specific for the gamma-subunit of the fetal AChR to which it bound with s
208 e observed where certain mutations in the F1-gamma-subunit of the two-sector F1Fo-ATP synthase allow
210 dle syndrome, a mutation of the beta- and/or gamma-subunits of ENaC produces an activated ion channel
213 mplex (ODC) also antibodies to the beta- and gamma-subunits of F1F0-ATPase (anti-beta, anti-gamma) oc
217 nation of the effect of various parts of the gamma-subunit on free energy surfaces of F1-ATPase.
218 own to induce the 40 degrees rotation of the gamma-subunit only when the betaE subunit is empty, wher
220 ndividual or multiple subunits revealed that gamma subunit palmitoylation has a dominant role over be
222 sducin beta-subunit without its constitutive gamma-subunit partner sufficiently stresses the cellular
223 retinal phosphodiesterase (PDE6) inhibitory gamma-subunit (PDEgamma) plays a central role in vertebr
224 clic GMP phosphodiesterase (PDE6) inhibitory gamma-subunit (PDEgamma) stimulates GTPase activity of t
225 for the C-terminal region of the inhibitory gamma subunit (Pgamma), known to directly inhibit PDE6 c
227 ction of phosphodiesterase-6 (PDE6) with its gamma-subunit (Pgamma) is pivotal in vertebrate phototra
228 hosphodiesterase (PDE6), is regulated by its gamma-subunit (Pgamma), whose inhibitory constraint is r
230 photoreceptor cells contains two inhibitory gamma-subunits (Pgamma) which bind to the catalytic core
231 ytic heterodimer but also for its regulatory gamma-subunits (Pgamma) whose inhibitory action is relea
232 tructure prediction of the N terminus of the gamma subunit places gammaCys-33 within an alpha-helix a
233 such as Ras, most Rho GTPases, and G protein gamma subunits, plays an essential role in determining t
235 s peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adip
236 e valine-modified chloroplastic ATP synthase gamma-subunit precursor elicited significantly stronger
237 nic PKA activity and levels of PKA catalytic gamma subunit protein were significantly lower in granul
238 rms and regulators, G-protein alpha-and beta,gamma-subunits, protein kinase A subtypes and the phosph
239 n of fragments of chloroplastic ATP synthase gamma-subunit proteins, termed inceptin-related peptides
240 meric G proteins composed of alpha, beta and gamma subunits regulate a number of fundamental processe
241 E) 6 complex, made up of alpha, beta and two gamma subunits, regulates intracellular cGMP levels by h
242 that thioredoxin-dependent reduction of the gamma-subunit regulatory disulfide modulates the proton
243 ase complex involves rotation of the central gamma subunit relative to the catalytic sites in the alp
244 act, and electron microscopy of the isolated gamma subunit revealed a distinct alteration in conforma
247 ions, and to make compensatory new ones, the gamma-subunit rotates through 25 degrees -30 degrees .
248 tionship between the catalytic mechanism and gamma subunit rotation, the pre-steady-state kinetics of
251 ecular dynamics simulations of torque-driven gamma-subunit rotation in the F1-ATPase rotary motor.
252 ential for ATP synthesis, and cannot convert gamma-subunit rotation into the conformational changes i
254 in an EF hand of CaM and in a region of the gamma subunit sharing high sequence similarity with the
256 s partially rescued by overexpression of the gamma subunit, suggesting a role for this region in gamm
257 a - 1, alpha -2/delta, beta, and gamma), the gamma subunit that comprises an eight-member protein fam
258 lular allosteric regulatory subdomain of the gamma subunit that has an important role in conferring t
259 le alpha or beta, and it is instead the F(1) gamma subunit that initiates the release of the chaperon
261 ) proteins have been identified as auxiliary gamma subunits that elevate the voltage sensitivity of r
262 ed alterations of the Gal83 (beta) and Snf4 (gamma) subunits that relieve glucose inhibition, and we
263 with the beta-subunit and the other with the gamma-subunit that appear to be necessary for the struct
264 nd a concomitant 120 degrees rotation of the gamma-subunit, the interface closes further to the alpha
265 ein-protein interactions with its inhibitory gamma-subunit, the prenyl-binding protein (PrBP/delta),
267 TP molecules induces rotation of the central gamma-subunit, thereby forcing the site to transform thr
268 es of the catalytic beta-subunits act on the gamma-subunit through repulsive van der Waals interactio
269 edox modulation of a disulfide bridge on the gamma-subunit through the ferredoxin-thioredoxin regulat
273 ral elements for differential binding of the gamma-subunit to the GAFa domains of the alpha- and beta
279 membrane dissociation rates among different gamma-subunit types to differentially control betagamma-
282 Driven by a proton flux, the F1 asymmetric gamma subunit undergoes a stepwise rotation inside the a
283 is, immunoreactivity to ENaC alpha, beta and gamma subunits was detected both by Western blot and imm
284 ta-subunit and sucrose nonfermenting4 as the gamma-subunit was constructed to examine functional aspe
285 es, Arg304 and Gln305, in the chloroplast F1 gamma subunit were changed to leucine and alanine, respe
287 attempts to disrupt genes encoding beta and gamma subunits were unsuccessful, suggesting an essentia
288 gG- and IgM-antibodies against the beta- and gamma-subunits which had been recombinant expressed in E
289 of epithelial Na(+) channel (ENaC) alpha and gamma subunits, which associated with a lower baseline p
291 xperiments probing different segments of the gamma-subunit, which resolves a long-lasting controversy
292 requires intact C termini in ENaC beta- and gamma-subunits, which contain PY motifs used to target E
293 -ray structure is enforced sterically by the gamma subunit whose orientation is stabilized by interac
294 ents in oocytes expressing channels carrying gamma subunits with both a mutation in the furin cleavag
295 nonequivalence of human Hb alpha, beta, and gamma subunits with respect to redox reactivity and may
298 P bind competitively to a single site in the gamma subunit, with their respective phosphate groups po
300 sm is coupled to the rotation of the central gamma subunit working as a ratchet but with structural d
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