ライフサイエンスコーパス: gamma-butyrolactone

1 mmetric intermediate ultimately derived from gamma-butyrolactone.

2 its counterparts, gamma-hydroxybutyrate and gamma-butyrolactone.

3 erted to a variety of biologically important gamma-butyrolactones.

4 h a high proportion of (E)-alpha-benzylidene-gamma-butyrolactones.

5 gamma-trifluoromethylated cis-fused bicyclic gamma-butyrolactones.

6 ee-step synthesis of two naturally occurring gamma-butyrolactones.

7 ,2-acyl migrations delivering bridged, spiro-gamma-butyrolactones.

8 rig cyclization reactions to provide hydroxy-gamma-butyrolactones.

9 s were screened in the context of generating gamma-butyrolactones.

10 nolides, gamma-hydroxycyclohexenones, and/or gamma-butyrolactones.

11 Many streptomycetes produce extracellular gamma-butyrolactones.

12 mfetamine, ephedrine, gamma-hydroxybutyrate; gamma-butyrolactone, 1,4-butanediol, flunitrazepam, keta

13 MA), 221 (10%) used gamma-hydroxybutyrate or gamma-butyrolactone, 175 (8%) used methamphetamine, and

14 lactone, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolac

15 lactone, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolac

16 tes, S. coelicolor A3(2) and S. griseus: (1) gamma -butyrolactones; (2) a complex cascade of mostly u

17 y enriched 5-substituted alpha-exo-methylene gamma-butyrolactones 3a-i.

18 1b, 1f, 1j, and 1l forms alpha-exo-methylene-gamma-butyrolactones 5b, 5f, 5j, and 5l in moderate to g

19 ovides the disubstituted alpha-exo-methylene gamma-butyrolactones 6a and 6b with good to excellent le

20 e transformed to the trans-4,5-disubstituted gamma-butyrolactones 7a, 7l, and 7p.

21 sA is required for A-factor synthesis of the gamma-butyrolactone A-factor and consequently for strept

22 clopropyl carbinols to form alpha-alkylidene-gamma-butyrolactones (ABLs) is reported.

23 ns contrasts with other reports that loss of gamma-butyrolactones abolishes antibiotic production.

24 d with (TGM/DBA) or without (TGM) a dimethyl-gamma-butyrolactone acrylate (DBA)-containing lactone ri

25 ation results in predominantly 5-substituted gamma-butyrolactones along with a small amount of buteno

26 A variety of gamma-butyrolactone analogues also modulate GABA-induced

27 synthesis, and evaluation of alpha-methylene-gamma-butyrolactone analogues and their evaluation as an

28 alpha-Methylene-gamma-butyrolactone and alpha-methylene-delta-valerolact

29 ry involved in the ring-opening reactions of gamma-butyrolactone and delta-valerolactone, the conform

30 Novel 5-(1'-hydroxy)-gamma-butyrolactone and gamma-butyrolactam subunits were

31 logous aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams with aldehy

32 s with activated ketones and imines provides gamma-butyrolactones and lactams, respectively.

33 deletion mutant of scbR also failed to make gamma-butyrolactones and showed delayed Red production.

34 g epsilon-caprolactone, delta-butyrolactone, gamma-butyrolactone, and D, L, meso, and racemic lactide

35 tors that negatively regulates metabolism of gamma-butyrolactone, and its repressing function is reli

36 gmentation reactions to provide butenolides, gamma-butyrolactone, and/or beta,gamma-epoxycyclohexanon

37 y the federal government, 1,4-butanediol and gamma-butyrolactone, another precursor of gamma-hydroxyb

38 ting enantioenriched, densely functionalized gamma-butyrolactones are of high synthetic utility, as h

39 alpha-Alkylidene-gamma-butyrolactones are readily prepared by the palladi

40 ts are versatile latent carbonyls from which gamma-butyrolactones, beta-hydroxy methyl ketones, and b

41 ntly transcribed gene, scbR, which encodes a gamma-butyrolactone binding protein.

42 latory genes, which are related to genes for gamma-butyrolactone-binding proteins.

43 A method of preparing enantiopure hydroxy-gamma-butyrolactones containing multiple contiguous ster

44 2.8 +/- 2.4 kcal/mol for beta-propiolactone, gamma-butyrolactone, delta-valerolactone, and epsilon-ca

45 d carbamates, as well as tetrahydrofuran and gamma-butyrolactone derivatives, without erosion of enan

46 ed lactonization to afford the corresponding gamma-butyrolactones, each as a single isomer.

47 highly selective NHC-catalyzed synthesis of gamma-butyrolactones from the fusion of enals and alpha-

48 However, the bioderived five-membered gamma-butyrolactone (gamma-BL) is commonly referred as '

49 tion of the biorenewable "non-polymerizable" gamma-butyrolactone (gamma-BL) to a high-molecular-weigh

50 gamma-butyrolactone (GBL) (750 mg/kg i.p.) increased DOP

51 ces these processes are under the control of gamma-butyrolactone (GBL) autoregulatory systems.

52 of neuronal impulse flow and DA release with gamma-butyrolactone (GBL) increased DA concentrations in

53 In the gamma-butyrolactone (GBL) model of DA autoreceptor funct

54 wever, abolition of DA neuronal activity [by gamma-butyrolactone (GBL) treatment or transection of th

55 lformamide (DMF), dimethyl sulfoxide (DMSO), gamma-butyrolactone (GBL), and water.

56 reated with the nerve impulse flow inhibitor gamma-butyrolactone (GBL).

57 3-Hydroxy-gamma-butyrolactone has been identified as one such chem

58 g cyclopropyl ring to access fused tricyclic gamma-butyrolactones has been described.

59 The stereochemistry of these hydroxy-gamma-butyrolactones has been established using NOE spec

60 acted from culture fluids, but differed from gamma-butyrolactones in being alkali resistant.

61 n isatin-derived spirocyclic alpha-methylene-gamma-butyrolactone is a suitable core for optimization

62 t part of the cluster directs synthesis of a gamma-butyrolactone-like autoregulator.

63 That putative gamma-butyrolactone material was not produced when orf18

64 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurring and bio

65 ese results indicate a complex mechanism for gamma-butyrolactone-mediated regulation of antibiotic bi

66 rived renewable gamma-methyl-alpha-methylene-gamma-butyrolactone (MMBL).

67 from a solution of CH(3)NH(3)I and PbI(2) in gamma-butyrolactone on a 400 nm thick film of TiO(2) (an

68 The chemical synthesis of poly(gamma-butyrolactone) (PgammaBL) through the ROP process

69 Additionally, they show that the gamma-butyrolactones probably interact at two different

70 oregulator in addition to being required for gamma-butyrolactone production.

71 ation of three further bld genes and several gamma-butyrolactone receptor genes have led to new ideas

72 ces lividans, we showed that TylP, a deduced gamma-butyrolactone receptor, downregulated reporter gen

73 uences, similar to the targets for authentic gamma-butyrolactone receptors, in the promoters of tylP,

74 Peripherally, C75, an alpha-methylene-gamma-butyrolactone, reduces adipose tissue and fatty li

75 Gamma-butyrolactones regulate secondary metabolism and,

76 ized Streptomyces homologue CprB, which is a gamma-butyrolactone regulator.

77 with analogous functions to the better known gamma-butyrolactone regulatory molecules.

78 ne, 3-phenylbutyraldehyde, and alpha-hydroxy-gamma-butyrolactone, relying on cyanoborohydride for cou

79 rate and 3,4-dihydroxybutyric acid+3-hydroxy-gamma-butyrolactone, respectively, molecules with potent

80 well as the stereoselective attachment of a gamma-butyrolactone ring to a tetracycle core structure

81 lineC bond and a highly stable five-membered gamma-butyrolactone ring.

82 Addition of the gamma-butyrolactone SCB1 of S. coelicolor resulted in lo

83 mpounds and in the synthesis of a diffusible gamma-butyrolactone, SCB1, that can elicit precocious Ac

84 ethylene-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone, Sharpless kinetic resolution, Sharp

85 ndicate that the lack of polymerizability of gamma-butyrolactone should be attributed to the low stra

86 CF sigma factors, antibiotic biosynthesis, a gamma-butyrolactone signalling system, members of the ac

87 These led to a revised gamma-butyrolactone structure for the metabolite.

88 ompound (N55) with a new N-linoleoyl-2-amino-gamma-butyrolactone structure was purified from fenugree

89 ng roles for the respective gene products in gamma-butyrolactone synthesis.

90 nolactone (template I) and 4,4-disubstituted gamma-butyrolactone (template II), with the latter produ

91 ereoselective hydrogenation of exo-methylene-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone,

92 hat AttK, AttL, and AttM collectively covert gamma-butyrolactone to succinate.

93 These gamma-butyrolactones underwent intramolecular radical cy

94 gamma-Butyrolactone, unlike delta-valerolactone, does no

95 r describes an enantioselective synthesis of gamma-butyrolactones, using the N-tolyl-substituted oxaz

96 ral synthetic strategy to cis-fused bicyclic gamma-butyrolactones via the retro-Diels-Alder reaction/

97 ompared for the stereoselective synthesis of gamma-butyrolactones via the sequence of N-acylation, C(

98 after the diethyl phosphonate derivative of gamma-butyrolactone was treated with potassium hexamethy

99 kenyl- or homoalkynyl-alpha,beta-unsaturated gamma-butyrolactones was found to accelerate the rate of

100 oxyoxol-2-ene (C(5)-1), the enol tautomer of gamma-butyrolactone, was generated in the gas phase as t

101 n to give the corresponding tetracyclic cage gamma-butyrolactones, which were employed as precursors

102 by the reaction of optically pure 3-hydroxy-gamma-butyrolactone with a primary amine to give an amid

103 -enals to racemic alpha-keto esters, forming gamma-butyrolactones with three contiguous stereocenters

104 A scbA mutant produced no gamma-butyrolactones, yet overproduced two antibiotics,