ライフサイエンスコーパス: gamma-c

1 nd the common cytokine receptor gamma chain (gamma(c)).

2 m spinach chloroplasts (alpha(R)(3)beta(R)(3)gamma(C)).

3 ng null mutations of the common gamma chain (gamma(c)).

4 ubunit IL-2Rbeta and the common gamma-chain (gamma(c)).

5 sing IL-15/IL-2Rbeta and common gamma chain (gamma(c)).

6 and JT cells reconstituted with gamma c (JT/gamma c).

7 to the common cytokine receptor gamma chain, gamma(c).

8 es the common cytokine receptor gamma chain, gamma(c).

9 ceptor subunits IL-2R alpha, IL-2R beta, and gamma(c).

10 ha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/gamma(c).

11 to the common cytokine receptor gamma chain, gamma(c).

12 action between IL-2 and the shared receptor, gamma(c).

13 he common gamma chain of cytokine receptors, gamma(c).

14 graphene oxide with gamma-cyclodextrin (rGO/gamma-CD).

15 inclusion complexes with gamma-cyclodextrin (gamma-CD).

16 [Ta6Br12(H2O)6](2+), and gamma-cyclodextrin (gamma-CD).

17 native cyclodextrins (alpha-CD, beta-CD, and gamma-CD).

18 ation of a tight complex between TNP-Ado and gamma-CD.

19 antial interaction of the TNP hydrogens with gamma-CD.

20 ing an octahedral-type metallic cluster with gamma-CD.

21 d in the order FA/alpha-CD < FA/beta-CD < FA/gamma-CD.

22 the transverse channels formed from linking (gamma-CD)6 body-centered cuboids in three dimensions.

23 y, form body-centered cubic arrangements of (gamma-CD)(6) cubes linked by eight-coordinate alkali met

24 in is mediated by specialized populations of gamma-c aA receptors (GABAARs) that are selectively enri

25 carbonate in an alcohol solvent proceeds via gamma-C-alkylation rather than alpha-C-alkylation result

26 ith transcriptional activation of germline C(gamma), C(alpha), and C(epsilon) genes and triggers the

27 CSR from C( micro ) to multiple downstream C(gamma), C(alpha), and C(epsilon) genes through latent me

28 The common cytokine receptor gamma chain (gamma c), an essential component of the receptors for IL

29 emonstrate a functional requirement for both gamma c and the gamma c-associated Janus family tyrosine

30 y studying the specific interactions between gamma-CD and both types of inorganic units.

31 nd HP-gamma-CD; the complexes formed with HP-gamma-CD and HP-beta-CD had the greatest stability const

32 which supports specific interactions between gamma-CD and POM units.

33 Novel structures of gamma(c) and beta(c) complexes show us new twists, such

34 ork material composed of gamma-cyclodextrin (gamma-CD) and alkali metal salts--namely, CD-MOF.

35 ) mice have normal frequencies of CLPs, both gamma(c)(-/-) and IL-7R(alpha)(-/-) mice lack detectable

36 o receptors, IL-4R alpha/common gamma-chain (gamma(c)) and IL-4R alpha/IL-13R alpha1, and only the la

37 l shared cytokine signaling receptors-gp130, gamma(c), and beta(c).

38 R alpha makes no contacts with IL-2R beta or gamma(c), and only minor changes are observed in the IL-

39 and (2-hydroxypropyl)-gamma-cyclodextrin (HP-gamma-CD), and the effects of the complexation on the st

40 The fact that the -OCCO- moieties of gamma-CD are not prearranged in a manner conducive to en

41 ctional requirement for both gamma c and the gamma c-associated Janus family tyrosine kinase 3 (JAK3)

42 itude compared to free curcumin and curcumin:gamma-CD at pH 11.5.

43 rexpression of Jak3 enhanced accumulation of gamma(c) at the plasma membrane.

44 cular chemical complementarities between the gamma-CD-based ditopic cation and POM open a wide scope

45 IL-15-mediated RANTES production by Rag2(-/-)gamma(c)(-/-) bone marrow cells occurred independently o

46 IL-15 induced RANTES production by Rag2(-/-)gamma(c)(-/-) bone marrow cells, but the presence of gam

47 the P2, but not P1, sequence for binding of gamma C by the alpha(M)I-domain and suggest that the adh

48 A general regio- and stereoselective gamma-C-C bond formation is achieved using alpha-halocar

49 (+)T cell loss was inversely correlated with gamma(c)(+) CD8(+) T cells in individual tissues.

50 pha) gene to express a codon-optimized human gamma(c) cDNA.

51 3, and downstream activation of STAT5, in JT/gamma c cells as well as BaF3/IL-21R alpha and primary s

52 Monoclonal antibodies specific for the gamma c chain effectively inhibited IL-21-induced growth

53 e that IL-21-mediated signaling requires the gamma c chain, and indicate that JAK3 is an essential tr

54 also identify an indirect role that another gamma (c) chain cytokine plays in schistosome developmen

55 Because the common gamma ( gamma (c)) chain cytokine interleukin (IL)-7 is also imp

56 es in the ER and interacts with the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R), t

57 ors: the alpha, beta and the "common gamma" (gamma(c)) chains.

58 The structure of the TNP-Ado:gamma-CD complex was determined by 2D nuclear magnetic r

59 e from that of the IL-2-IL-2Ralpha-IL-2Rbeta-gamma(c) complex, despite their different receptor-bindi

60 expressing the mouse IL-15Ralpha-IL-15Rbeta-gamma(c) complex, suggesting that this effect is specifi

61 Single-crystal XRD analysis reveals that POM:gamma-CD constitutes a highly versatile system which giv

62 This enthalpic mechanism utilized by gamma(c) contrasts with the favorable entropic mechanism

63 structural basis by which the ectodomain of gamma(c) contributes to binding six distinct cytokines i

64 th anti-CD3/CD28, cytokine secretion by both gamma c cytokine and anti-CD3/CD28 pretreated T cells wa

65 Exposure of gamma c cytokine pretreated T cells to PD-1 ligand-IgG h

66 These data suggest that gamma c cytokine-induced PD-1 does not interfere with cy

67 IL-15 belongs to the gamma(c) cytokine family and possesses similar propertie

68 statically expand in vivo in response to the gamma(c) cytokine IL-7, despite intact proximal signalin

69 Tofacitinib therapy strongly inhibits gamma(c) cytokine-induced JAK/STAT5 activation, whereas

70 ures of complexes of the common gamma-chain (gamma(c)) cytokine receptors and their cytokines have be

71 T cell proliferation, or survival driven by gamma c cytokines.

72 The common gamma-chain (gamma c) cytokines IL-2, IL-7, IL-15, and IL-21, which p

73 Finally, we show that other gamma(c) cytokines act similarly to IL-2 in up-regulatin

74 amma(c) subunit molecule is shared among all gamma(c) cytokines and clearly involved in T-cell functi

75 After whole-blood activation with the gamma(c) cytokines IL-2, IL-7, and IL-15, STAT5 phosphor

76 The common gamma-chain (gamma(c)) cytokines signal through the Janus kinase (JAK

77 The gamma(c)-cytokines are critical regulators of immunity a

78 These results support the use of gamma(c)-cytokines in cancer immunotherapy, and establis

79 amma(c)'s ability to recognize six different gamma(c)-cytokines.

80 eat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts.

81 normal mice and induces these genes in RAG2/gamma(c)-deficient mice.

82 ent of the IL-21 receptor (IL-21R) using the gamma c-deficient X-linked severe combined immunodeficie

83 gs) of all nonprotonated aromatic carbons (C(gamma), C(delta 2) and C(epsilon 2).

84 he C(alpha)-C(beta), C(beta)-C(gamma), and C(gamma)-C(delta) bond axes as indicated by (2)H line-shap

85 ither methyl group reorientation about the C(gamma)-C(delta) bond axis or by additional librational m

86 )-C(gamma)) and chi(2,1) (C(alpha)-C(beta)-C(gamma)-C(delta1)), we propose a detailed molecular model

87 Interleukin (IL)-21 is a gamma(c)-dependent cytokine produced by activated T cell

88 mically unique fashions for each ligand, the gamma(c)-dependent cytokines appear to seek out some sem

89 rejection of liver metastases, whereas other gamma c-dependent non-T non-B cells, possibly lymphoid d

90 cate that JAK3 is an essential transducer of gamma c-dependent survival and/or mitogenic signals indu

91 peptide duplicating the 365-383 sequence in gamma C, designated P3, efficiently inhibited clot retra

92 (-/-) bone marrow cells, but the presence of gamma(c) did not increase bone marrow cell sensitivity t

93 idual expression of the endogenous truncated gamma(c) did not lead to dominant-negative effects in th

94 Consistent with their identical IL-2Rbeta-gamma(c) dimer geometries, IL-2 and IL-15 showed similar

95 Surface gamma(c) distribution was differentially expressed on CD

96 Thus, unlike other cytokine receptors, gamma(c) does not require Jak3 for receptor membrane exp

97 a 377-395 and gamma 190-202 sequences in the gamma C domain of fibrinogen, respectively, blocked the

98 pha IIb beta 3 with the AGDV sequence in the gamma C-domain of fibrinogen and/or RGD sites in the A a

99 ese data suggest that the P3 sequence in the gamma C-domain of fibrinogen defines a previously unknow

100 in binding, recombinant wild-type and mutant gamma C domains were prepared, and their interactions wi

101 peptides spanning P3 and mutant recombinant gamma C-domains demonstrated that the P3 activity is con

102 ased numbers of NK cells; and absent in Rag2/gamma(c)-double-deficient mice, which lack T, B, and NK

103 Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-ce

104 CCAAT/enhancer-binding protein gamma (C/EBP gamma) is an ubiquitously expressed member

105 In response to IFN-gamma, C/EBP-beta undergoes phosphorylation at a critica

106 eas addition of 10 mM alpha-CD, beta-CD, and gamma-CD enhances fluorescence by factors of 2, 7, and 1

107 ownstream IgH constant region exons (e.g., C gamma, C epsilon, or C alpha), which affects switching f

108 h lymphocytes, for which IL-15/IL-2Rbeta and gamma(c) expression are essential.

109 ther in vitro experiments found that surface gamma(c) expression could be down-regulated following hi

110 However, surface gamma(c) expression was rapidly and significantly down-r

111 We found that gamma(c) expression was required to signal the different

112 ed provirus integration and new cell-surface gamma(c) expression.

113 ptor (IL-7Ralpha) and comparisons with other gamma(c) family members.

114 tinctive actions by different members of the gamma(c) family of cytokines.

115 role of cytokines of the common gamma-chain (gamma(c)) family in the determination of the effector he

116 eceptor structure in the common gamma-chain (gamma(c)) family of receptors and cytokines.

117 nfirmed the CD levels, being predominant the gamma-CD followed by alpha-CD, whereas very low beta-CD

118 affinity of the inner and outer faces of the gamma-CD for the polyoxometalate surfaces.

119 g 20 mM hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) for a number of important neuromessengers incl

120 gular lattices with a critical ratio gamma = gamma c = [Formula: see text], supporting previous theor

121 face, moving the C termini of IL-7Ralpha and gamma(c) from a distance of 110 A to less than 30 A at t

122 P2 did not decrease the binding function of gamma C further.

123 receptors interleukin (IL)-2R beta , common gamma (C gamma ) chain, IL-7R alpha , IL-15R alpha; and

124 ing an MFGS retrovirus vector containing the gamma(c) gene IL2RG pseudotyped with amphotropic, gibbon

125 mmon cytokine receptor gamma-chain (Rag2(-/-)gamma(c)(-/-)) genes indicated that uNK cells originate

126 pha or common cytokine receptor gamma chain (gamma(c)) genes were deleted in thymocytes just before p

127 ontains the entire human common gamma chain (gamma(c)) genomic sequence driven by the gamma(c) promot

128 en photoexcited D-/L-Trp enantiomers and rGO/gamma-CD giving rise to an enantioselective photolumines

129 e first example of enantioselective benzylic gamma-C-H arylations of alkyl amines, and proceeds with

130 ve beta-C-H bonds and benzylamine derivative gamma-C-H bonds has been developed.

131 With leucine, HAT from the alpha- and gamma-C-H bonds was observed.

132 Monoselective gamma-C-H olefination and carbonylation of aliphatic aci

133 25 has been achieved by preventing access to gamma-C-H positions for intramolecular insertion.

134 K(+) and Li(+) ions with gamma-cyclodextrin (gamma-CD) has been shown to substitute the K(+) ion site

135 (+) ratio was varied with respect to that of gamma-CD, have been conducted in order to achieve the hi

136 inactive IL-7Ralpha homodimer and IL-7Ralpha-gamma(c) heterodimer to the active IL-7-IL-7Ralpha-gamma

137 own to "trans-present" IL-15 to an IL-2Rbeta/gamma(c) heterodimeric receptor on responding cells to i

138 aft in immunodeficient Rag1(-/-) or Rag1(-/-)gamma(c)(-/-) hosts.

139 We report that in humanized Rag2(-)/(-) gamma(c)(-)/(-) (hu-Rag2(-)/(-) gamma(c)(-)/(-)) mice, a

140 The formation of THY/gamma-CD-IC (1:1 and 2:1) was proved by experimental (X-

141 her preservation rate and stability than THY/gamma-CD-IC (1:1).

142 THY/gamma-CD-IC (2:1) exhibited higher preservation rate and

143 THY as observed in TGA and stability of THY/gamma-CD-IC (2:1) was higher, as shown by a modelling st

144 CD-IC-NF (2:1) than zein-THY-NF and zein-THY/gamma-CD-IC-NF (1:1).

145 :1) was higher than zein-THY-NF and zein-THY/gamma-CD-IC-NF (1:1).

146 It is worth mentioning that zein-THY/gamma-CD-IC-NF (2:1) preserved much more THY as observed

147 re, much more THY was released from zein-THY/gamma-CD-IC-NF (2:1) than zein-THY-NF and zein-THY/gamma

148 imilarly, antibacterial activity of zein-THY/gamma-CD-IC-NF (2:1) was higher than zein-THY-NF and zei

149 It was demonstrated that zein-THY/gamma-CD-IC-NF (2:1) was most effective in inhibiting th

150 electrospun zein nanofibrous webs (zein-THY/gamma-CD-IC-NF) were fabricated as a food packaging mate

151 s of the complete set of type I (IL-4R alpha/gamma(c)/IL-4) and type II (IL-4R alpha/IL-13R alpha1/IL

152 ECDs but a stronger association between the gamma(c)/IL-7Ralpha ECDs, similar to previous studies of

153 ly restored splenic architecture in Rag2(-/-)gamma(c)(-/-)-immunodeficient mice.

154 of chiral enantiomers to form complexes with gamma-CD in different molecular orientations as demonstr

155 ernary complex, IL-15 binds to IL-2Rbeta and gamma(c) in a heterodimer nearly indistinguishable from

156 resence of the receptor, it colocalized with gamma(c) in endosomes and at the plasma membrane.

157 es shape recognition code in order to engage gamma(c) in related fashions.

158 ng a catalytic amount of gamma-cyclodextrin (gamma-CD) in water has been developed to give substitute

159 Thymol (THY)/gamma-Cyclodextrin(gamma-CD) inclusion complex (IC) encapsulated electrospu

160 on of alloreactive CD4(+) T cells is largely gamma(c) independent.

161 sed to explain recently discovered IL-7- and gamma(c)-independent gain-of-function mutations in IL-7R

162 The IL-2/gamma(c) interface itself exhibits the smallest buried s

163 complex teaches that interfaces between the gamma(c) interleukins and their receptors can vary in si

164 etroviral-mediated transduction of wild-type gamma c into XSCID JT cells restored function to the IL-

165 In this report, we show that gamma c is also a required signaling component of the IL

166 The large enhancement by gamma-CD is attributed to its larger hydrophobic cavity,

167 escribed by R(-gamma(c)), where the exponent gamma(c) is approximately 5/3 independent of the dimensi

168 termed CD-MOFs, wherein gamma-cyclodextrin (gamma-CD) is linked by coordination to Group IA and IIA

169 The gamma(c) isoform is highly conserved in mammals, but it

170 lly, we identify a small 16-kDa subunit (the gamma(c) isoform) derived by an intron retention mechani

171 Both alpha and gamma(c) isoforms are predominantly expressed in many ra

172 onal antibody not only detects the alpha and gamma(c) isoforms but also several other isoforms in pan

173 ase activity assays using purified alpha and gamma(c) isoforms indicate that the latter negatively mo

174 Without gamma(c), Jak3 localized in the cytosol, whereas in the

175 ell line JT, and JT cells reconstituted with gamma c (JT/gamma c).

176 h the process was most efficient in Rag2(-/-)gamma(c)(-/-)Kit(W/Wv) hosts, gamma(c)-mediated signals

177 Compound Rag2(-/-)gamma(c)(-/-)Kit(W/Wv) mutants lack competitive hematopo

178 some of the residual lymphoid development in gamma(c) KO mice and presumably in patients with X-linke

179 Injection of TSLP into gamma(c) KO mice induced the expansion of T and B cells.

180 e KO mice had a greater lymphoid defect than gamma(c) KO mice.

181 In contrast to interleukin-2Ralpha, gamma(c) localized poorly to the plasma membrane and acc

182 nt in Rag2(-/-)gamma(c)(-/-)Kit(W/Wv) hosts, gamma(c)-mediated signals alone played a key role in the

183 ing, the requirement for full-length Jak3 in gamma(c) membrane trafficking was remarkably stringent;

184 ng CD4(+) T cell reservoir of hu-Rag2(-)/(-) gamma(c)(-)/(-) mice.

185 Rag2(-)/(-) gamma(c)(-)/(-) (hu-Rag2(-)/(-) gamma(c)(-)/(-)) mice, as in humans, resting CD4(+) T ce

186 e prophylactic delivery of IL-15 to Rag2(-/-)gamma(c)(-/-) mice (mature T, B, and NK cell negative) a

187 al therapy (ART) in humanized (hu-) Rag2(-/-)gamma(c)(-/-) mice allows suppression of viremia below t

188 scid/gamma(c)(-/-) (NSG) and BALB/c Rag2(-/-)gamma(c)(-/-) mice are the most commonly used mouse stra

189 The data indicate that although gamma(c)(-/-) mice have normal frequencies of CLPs, both

190 We generated RAG2(-/-)gamma(c)(-/-) mice in which we replaced the gene encodin

191 gatively regulates phagocytosis, in Rag2(-/-)gamma(c)(-/-) mice on a mixed 129/BALB/c background, whi

192 We conclude that humanized BALB/c-Rag2(-/-)gamma(c)(-/-) mice represent a unique and valuable resou

193 In summary, hSIRPa-transgenic Rag2(-/-)gamma(c)(-/-) mice represent a unique mouse strain suppo

194 for the secretion of human IL-15 to Rag2(-/-)gamma(c)(-/-) mice resulted in significant increases in

195 bone marrow transplantation of the Rag2(-/-)gamma(c)(-/-) mice that restored the uNK cell population

196 Rag2(-/-) gamma(C)(-/-) mice transplanted with human hematopoietic

197 ly deleted in Rag2(-/-), but not in Rag2(-/-)gamma(c)(-/-) mice.

198 anted them into irradiated newborn Rag2(-/-) gamma(c)(-/-) mice.

199 hematopoietic stem cells in BALB/c-Rag2(-/-)gamma(c)(-/-) mice.

200 gements exhibit a common feature wherein the gamma-CD moiety interacts with the Dawson-type POMs thro

201 study, epitope mapping of antagonistic anti-gamma(c) monoclonal antibodies led to the identification

202 The hu-Rag2(-/-)gamma(c)(-/-) mouse may therefore facilitate testing of

203 ma 383-411 (P2-C) and gamma 377-411 produced gamma C mutants which were defective in binding to the a

204 IL-15-mediated RANTES production by Rag2(-/-)gamma(c)(-/-) myeloid bone marrow cells.

205 NOD/scid/gamma(c)(-/-) (NSG) and BALB/c Rag2(-/-)gamma(c)(-/-) mi

206 ared to control hu-HSC-transplanted NOD/SCID/gamma(c)(null) mice inoculated with equivalent high-tite

207 The plasma of the irradiated NOD/SCID/gamma(c)(null) mice transplanted with hu-HSC transduced

208 c/severe combined immunodeficient (NOD/SCID)/gamma(c)(null) mice with markedly different efficacies a

209 IV infection, we used the humanized NOD/SCID/gamma(c)(null) mouse model, which becomes populated with

210 r the alpha chain or the common gamma chain (gamma(c)) of the IL-7R.

211 Here, we examined expression and function of gamma(c) on T cells during SIV infection in Rhesus macaq

212 lant model, blocking both CD28/CD40L and the gamma(c) pathways induced prolonged skin allograft survi

213 n fits with structural data showing that its gamma-C peptide and eptifibatide exhibit comparable elec

214 es through remote protonation of the pyrrole gamma-C pi-bonds.

215 in (gamma(c)) genomic sequence driven by the gamma(c) promoter.

216 structure of the IL-15-IL-15Ralpha-IL-2Rbeta-gamma(c) quaternary complex, IL-15 binds to IL-2Rbeta an

217 K(+)-ion sites and accounting for the cation/gamma-CD ratio in CD-MOF-1.

218 -13, tumor necrosis factor-alpha, interferon-gamma, C-reactive protein, and procalcitonin were measur

219 IL-2 and IL-15, despite usage of common beta gamma c receptor chains.

220 eir receptors to bind the shared, activating gamma(c) receptor.

221 rkable progress in the structural biology of gamma(c) receptors and their cytokines or interleukins,

222 t IL-15 in trans to low-affinity IL-15R beta gamma(c) receptors on memory CD8(+) T cells.

223 eta receptors, as well as IL-2 with beta and gamma(c) receptors proceeds through enthalpy-entropy com

224 he mechanism may also be applicable to other gamma(c) receptors that form inactive homodimers and het

225 ned whether Jak3 and the common gamma chain (gamma(c)) reciprocally regulate their plasma membrane ex

226 into a composite binding site for the final gamma(c) recruitment.

227 /- 6) M(-1) for phenol and alpha-, beta- and gamma-CD, respectively, as compared to 87 and 214 M(-1)

228 in the common cytokine-receptor gamma chain (gamma(c)), resulting in disruption of development of T l

229 ype I complex reveals a structural basis for gamma(c)'s ability to recognize six different gamma(c)-c

230 eceptor, IL-15Ralpha and IL-2/IL-15Rbeta and gamma(c) shared with IL-2.

231 for IL-2 and IL-15 in assembling quaternary gamma(c) signaling complexes and an antiparallel interlo

232 gamma(c) signaling in the tumor-bearing host was importa

233 cells expressing Runx3d could arise without gamma(c) signaling, but these cells were developmentally

234 s disease and suggesting that blocking IL-21/gamma(c)-signaling pathways may provide a means for cont

235 found that CD28/CD40L costimulation and the gamma(c) signals are differentially involved in prolifer

236 CD8(+) T cells are highly dependent on the gamma(c) signals for survival, expansion, and functional

237 ulatory Foxp3(+)CD4(+) T cells which require gamma(c) signals for survival.

238 n vivo, and targeting both costimulatory and gamma(c) signals may be highly effective in certain cyto

239 L) costimulation and the common gamma-chain (gamma(c)) signals, a shared signaling component by recep

240 manner reminiscent of the structures of some gamma-CD solvates, but with added crystal stability impa

241 promote the palladium-catalyzed amination of gamma C(sp(3) )H and C(sp(2) )H bonds of secondary amide

242 le light photoredox catalysis enables direct gamma- C(sp(3))-H alkylation of saturated aliphatic carb

243 of Pd(II)-catalyzed, picolinamide-assisted, gamma-C(sp(2))-H activation and Z-selective arylation of

244 (3))-H bonds afforded moderate yields of the gamma-C(sp(2))-H and gamma-C(sp(3))-H bisarylated cinnam

245 d arylation of an allylamine containing both gamma-C(sp(2))-H and gamma-C(sp(3))-H bonds afforded mod

246 a six-membered palladacycle is favored over gamma-C(sp(2))-H bond functionalization when both positi

247 (2))-H bonds of benzoic acid derivatives and gamma-C(sp(2))-H bonds of benzylamine derivatives has be

248 Pd(II) -catalyzed arylation of gamma-C(sp(3) )-H bonds of aliphatic acid-derived amides

249 rogen-atom transfer (HAT) processes to guide gamma-C(sp(3) )-H chlorination.

250 we disclose a general strategy for aliphatic gamma-C(sp(3) )-H functionalization guided by a masked a

251 methylation or gamma-CH arylation step, the gamma-C(sp(3) )H amination provided access to complex py

252 The gamma-C(sp(3))-H arylation arose from the Pd(II)-catalyz

253 Pd(II)-catalyzed gamma-C(sp(3))-H arylation of primary amines is realized

254 reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecular amidation and

255 moderate yields of the gamma-C(sp(2))-H and gamma-C(sp(3))-H bisarylated cinnamylamines.

256 ylamine containing both gamma-C(sp(2))-H and gamma-C(sp(3))-H bonds afforded moderate yields of the g

257 nd that enables Pd(II)-catalysed coupling of gamma-C(sp(3))-H bonds in triflyl-protected amines with

258 rt an efficient method for the alkylation of gamma-C(sp(3))-H bonds of picolinamide-protected aliphat

259 Pd(II)-catalyzed olefination of gamma-C(sp(3))-H bonds of triflyl (Tf) and 4-nitrobenzen

260 essive arylation/intramolecular amidation of gamma-C(sp(3))-H bonds.

261 th the BDG-directed functionalization of the gamma-C(sp(3))-H bonds.

262 ve arylation/intramolecular amidation of the gamma-C(sp(3))-H bonds.

263 The common gamma(c) subunit molecule is shared among all gamma(c) c

264 span the entire length of the IL-2R beta and gamma(c) subunits.

265 IL-4 signaling through IL-4R alpha/gamma(c) suppresses Ca2T6 and SPRR gene expression in no

266 gamma(c)(+) T cells were mainly functional as evidenced

267 ) from this strain contained one molecule of gamma-C(tag) per Pol III* assembly, indicating that the

268 a containing a C-terminal biotinylation tag (gamma-C(tag)) was provided in trans at physiological lev

269 A pronounced destabilization of the gamma C-terminal helix during hydrolysis-driven rotation

270 epitope exposure, AGDV, like the fibrinogen gamma C-terminal peptide and RGD, caused integrin extens

271 Channels with a truncated alpha, beta,or gamma C terminus were not inhibited by arachidonic acid

272 c) heterodimer to the active IL-7-IL-7Ralpha-gamma(c) ternary complex whereby the two receptors under

273 Here we have identified a sequence within gamma C that mediates binding of fibrinogen to platelets

274 ed to the identification of Asn-128 of mouse gamma(c) that represents another potential contact resid

275 The common gamma-chain (gamma(c)) that functions both in ligand binding and sign

276 leukin-2 (IL-2) receptor common gamma chain (gamma(c)) that is activated by multiple T-cell growth fa

277 th the common cytokine receptor gamma chain (gamma(c)), the protein whose expression is defective in

278 with HP-alpha-CD, beta-CD, HP-beta-CD and HP-gamma-CD; the complexes formed with HP-gamma-CD and HP-b

279 f IL-2 wedges tightly between IL-2R beta and gamma(c) to form a three-way junction that coalesces int

280 D-MOF-4 displays a channel structure wherein gamma-CD tori are perfectly stacked in one dimension in

281 Therefore, RAG2(-/-)gamma(c)(-/-) TPO-humanized mice represent a useful mode

282 Thus, gamma(c)-transduced cytokine signals are required for cy

283 gh these mice had normal lymphocyte numbers, gamma(c)/TSLPR double KO mice had a greater lymphoid def

284 2O)6](2+) ion is closely embedded within two gamma-CD units to give a supramolecular ditopic cation,

285 eric livers in immunodeficient BALB-DeltaRAG/gamma(c) -uPA (urokinase-type plasminogen activator) mic

286 lectively, these data favor a model in which gamma(c) utilizes a common mechanism for its interaction

287 itored for integration and expression of the gamma(c) vector and for functional immunological recover

288 gamma-CD was found to be highly efficacious in carrying

289 However, gamma(c) was expressed at comparable levels on the surfa

290 acking Jak3, and plasma membrane turnover of gamma(c) was independent of Jak3.

291 Two possible structures of FA/gamma-CD were suggested, the first one being analogous t

292 desalted by ultrafiltration in the presence gamma-CD, were concentrated on-capillary by large-volume

293 conditions is quantitatively described by R(-gamma(c)), where the exponent gamma(c) is approximately

294 re the common cytokine receptor gamma chain (gamma(c)), which is mutated in humans with X-linked seve

295 es the common cytokine receptor gamma chain, gamma(c), which is mutated in humans with X-linked sever

296 ng the common cytokine receptor gamma chain, gamma(c), which is mutated in X-linked severe combined i

297 ed the common cytokine receptor gamma chain, gamma(c), which suggested a possible competition between

298 arithm of the folding rates also scale as R(-gamma(c)), with deviations only being seen for very smal

299 es the common cytokine receptor gamma-chain, gamma(c), with IL-2, IL-4, IL-7, IL-9, and IL-15.

300 hoid progenitors by the expression of normal gamma(c), XSCID is a good candidate disease for therapeu