ライフサイエンスコーパス: gamma-catenin

1 but decreased nuclear levels of plakoglobin (gamma-catenin).

2 ripheral adaptors (e.g., ZO-1 and alpha- and gamma-catenins).

3 due to altered regulation of both beta- and gamma-catenin.

4 containing E-cadherin and alpha-, beta-, and gamma-catenin.

5 molecules E-cadherin and alpha-, beta-, and gamma-catenin.

6 immunoprecipitate well with alpha-catenin or gamma-catenin.

7 increased the association of E-cadherin with gamma-catenin.

8 n Ser-139) by up-regulating N/E-cadherin and gamma-catenin.

9 lasma membrane requires beta-catenin but not gamma-catenin.

10 l adhesion kinase, paxillin, E-cadherin, and gamma-catenin.

11 vl3, Fbxw-1, Cul1, CK1epsilon, CK1delta, and gamma-catenin.

12 SLUG, and down-regulation of E-cadherin and gamma-catenin.

13 elative to those lines that highly expressed gamma-catenin.

14 tenin gene family including beta-catenin and gamma-catenin.

15 nodal metastasis and expression of E-cad and gamma-catenin.

16 pan-cadherin, VE-cadherin, beta-catenin, and gamma-catenin.

17 of cytoplasmic proteins: alpha-and beta- or gamma- catenin.

18 association of ZO-1 with alpha-, beta-, and gamma-catenins.

19 signal levels for plakoglobin (also known as gamma-catenin), a protein that links adhesion molecules

20 DPAGT1 TCF/LEF sequence also interacted with gamma-catenin, a close homologue of beta-catenin, althou

21 fragments of VE-cadherin, beta-catenin, and gamma -catenin after post-CPB perfusion, indicating part

22 he first biochemical evidence that, in vivo, gamma-catenin also mediates interactions between classic

23 tion and Western blotting, the expression of gamma-catenin, an adherens junction protein, was decreas

24 rect interaction of Kindlin-2 with beta- and gamma-catenin and actin was demonstrated in co-immunopre

25 adherin-based complexes, including beta- and gamma-catenin and actin, components of adherens junction

26 acellular transducers of cadherin signaling, gamma-catenin and alpha-catenin predominate in the later

27 In contrast, gamma-catenin and CDH2 are expressed predominantly in th

28 ng directly and simultaneously with beta- or gamma-catenin and cortical actin filaments, Kindlin-2 st

29 n protein content, whereas modest changes in gamma-catenin and E-cadherin expression were recorded.

30 eport here that APC regulates both beta- and gamma-catenin and gamma-catenin functions as an oncogene

31 gamma-catenin and its DNA-binding partner LEF-1 indirect

32 the slit diaphragm ZO-1, alpha-, beta-, and gamma-catenin and P-cadherin.

33 We found 1) significantly more gamma-catenin and SHP-2 bound to the truncated than to t

34 sitive displaying increased interaction with gamma-catenin and vinculin compared with the endogenous

35 tyrosine phosphorylation levels of beta- and gamma-catenins and p120-Cas, and structural and function

36 Components of cell-cell (beta- and gamma-catenin) and cell-matrix (focal adhesion kinase an

37 the three major catenins (alpha-, beta-, and gamma-catenin) and enhanced Ca2+-dependent cellular cohe

38 e caspase-mediated cleavage of beta-catenin, gamma-catenin, and APC protein might contribute to pacli

39 ntration-dependent cleavage of beta-catenin, gamma-catenin, and APC protein, but not alpha-catenin or

40 endothelial (VE)-cadherin, beta-catenin and gamma-catenin, and associated mitogen-activated protein

41 l and vimentin; up-regulation of E-cadherin, gamma-catenin, and estrogen receptor alpha; and decrease

42 reduced expression for E-cad, beta-catenin, gamma-catenin, and p120 in squamous cell carcinomas but

43 ous expression for E-cad, alpha-, beta-, and gamma-catenin, and p120 were observed in 10%, 17%, 8%, 3

44 phosphorylation of beta-catenin, plakoglobin/gamma-catenin, and p120(cas) on tyrosine residues.

45 on proteins focal adhesion kinase, paxillin, gamma-catenin, and p120(Cas).

46 on of zonula adherens proteins, VE-cadherin, gamma-catenin, and p120(ctn).

47 fragment was unable to bind to beta-catenin, gamma-catenin, and p120, suggesting that this cleavage e

48 tion of VE-cadherin-associated beta-catenin, gamma-catenin, and p120-catenin by modulating the quanti

49 he tyrosine phosphorylation of beta-catenin, gamma-catenin, and p120-catenin complexed with VE-cadher

50 rin complex (VE-cadherin, alpha-, beta-, and gamma-catenin, and p120/p100) localizes to adherens junc

51 of tyrosine phosphorylation of beta-catenin, gamma-catenin, and p120ctn, as well as the dissociation

52 ain (occludin, ZO-1, cadherin, beta-catenin, gamma-catenin, and platelet-endothelial cell adhesion mo

53 dherin family of proteins, alpha-, beta- and gamma-catenins, and cytoskeletons.

54 that proteolysis and altered localization of gamma-catenin are early markers for the response of cell

55 Both beta- and gamma-catenins are reported to link classical cadherins

56 lopment, cadherin-2 and its binding partner, gamma-catenin, are preferentially expressed by OSN axons

57 Taken together, we identify gamma-catenin as a novel regulator of HAI-1, which is a

58 -dependent gene transcription and highlights gamma-catenin as a potentially novel tumor suppressor pr

59 he parental cells resulted in proteolysis of gamma-catenin as evaluated in membrane pellet preparatio

60 ne phosphorylation inversely correlates with gamma-catenin association; 4) PECAM-1 recruits gamma-cat

61 hanism involving the interaction of Tcf with gamma-catenin at the DPAGT1 promoter.

62 ent reduction in OB-cadherin, alpha-catenin, gamma-catenin, beta-catenin, vimentin and galectin-3 pro

63 e cytosolic domain upstream of the beta- and gamma-catenin binding motifs of E-cadherin.

64 The beta- and gamma-catenin binding site resides within the F1 and F3

65 adherins to the actin cytoskeleton, but only gamma-catenin binds to the desmosomal cadherins, which l

66 Similar findings have been obtained for gamma-catenin but not alpha-catenin.

67 red expression of E-cad or alpha-, beta-, or gamma-catenins but coincided with the up-regulation of a

68 n of E-cadherin by 42%, beta-catenin by 37%, gamma-catenin by 136%, and desmoglein 3 by 300%, whereas

69 This study shows that gamma-catenin can function as an inhibitor of beta-caten

70 This effect on E-cadherin/gamma-catenin complexes was shared with the nonisoform s

71 y cisplatin treatment, including cleavage of gamma-catenin, could affect the ability of cells to inte

72 No mutations of the gamma-catenin (CTNNG1), GSK-3alpha (GSK3A), or GSK-3beta

73 Our results show that gamma-catenin-dependent cadherin function is required fo

74 of the beta-catenin/TCF7L2 complex, whereas gamma-catenin down-regulates it.

75 patterns of alpha-catenin, beta-catenin, and gamma-catenin, during definition of the cardiac cell pop

76 However, knocking-down gamma-catenin expression had no effect.

77 Moreover, transfection of these cells with a gamma-catenin expression plasmid reduced the elevated TC

78 stic variables, E-cad and alpha-, beta-, and gamma-catenin expression were of positive prognostic val

79 enin protein content in NSCLC cells with low gamma-catenin expression.

80 confocal microscopy, which showed a loss of gamma-catenin from adherens plaques after cisplatin trea

81 the first time, the separation of N-cadherin/gamma-catenin from N-cadherin/beta-catenin complexes and

82 ell as the dissociation of alpha-catenin and gamma-catenin from VE-cadherin.

83 C regulates both beta- and gamma-catenin and gamma-catenin functions as an oncogene.

84 Cells transfected with the gamma-catenin gene are sensitive to cisplatin compared w

85 In addition, gamma-catenin had a distinctive localization to the vert

86 and several amino-terminal mutated forms of gamma-catenin had similar transforming activity.

87 tions and like binding to APC, evidence that gamma-catenin has an important role in cancer has been l

88 Though beta- and gamma-catenin have analogous structures and functions an

89 state levels of alpha- and beta-catenins and gamma-catenin in K5-expressing ECs were drastically redu

90 ant cells may indicate an important role for gamma-catenin in mediating or modulating the toxicity of

91 Expression of gamma-catenin in NSCLC cells resulted in reduced cell mi

92 2 expression closely parallels that seen for gamma-catenin in OSN axons.

93 of cells to cisplatin, and reduced levels of gamma-catenin in resistant cells may indicate an importa

94 Uncleaved cytoplasmic gamma-catenin increased under the same conditions.

95 at selective disruption of the CBP/beta- and gamma-catenin interactions using ICG-001 leads to differ

96 how that: 1) not only beta-catenin, but also gamma-catenin is associated with PECAM-1 in vitro and in

97 elieve this novel vimentin-linked N-cadherin/gamma-catenin junction provides the tensile strength nec

98 n was associated exclusively with N-cadherin/gamma-catenin junctions.

99 VE-cadherin, beta-catenin, and gamma-catenin levels were significantly greater in the a

100 Furthermore, the data imply beta- and gamma-catenin may have distinct roles in Wnt signaling a

101 junctions in transfected SW480 cells; and 5) gamma-catenin may recruit PECAM-1 into an insoluble cyto

102 We conclude that gamma-catenin-mediated CDH2 adhesion may influence OSN t

103 Therefore, targeting gamma-catenin-mediated HAI-1 expression might be a usefu

104 ecifically, the epithelial genes E-cadherin, gamma-catenin, MTA3, and estrogen receptor alpha (ERalph

105 Moreover, the affects of gamma-catenin on cell migration were observed to be p53-

106 e identified a novel role for the affects of gamma-catenin on non-small cell lung cancer (NSCLC) cell

107 c) interacts, in cytoplasm and nucleus, with gamma-catenin, one of its desmosomal partners, and with

108 tion of RK3E cells by mutant beta-catenin or gamma-catenin or after ligand-induced activation of a be

109 on N-cadherin was linked to vimentin through gamma-catenin or beta-catenin we developed an innovative

110 ation of catenins (beta-catenin, plakoglobin/gamma-catenin, or p120(cas)) with E-cadherin.

111 In common with beta-catenin and plakoglobin (gamma-catenin), p120(ctn) contains a central Armadillo r

112 in (cadherin-5), desmoglein, alpha, beta and gamma catenin, p120(ctn) and alpha-actinin.

113 in, alpha (alpha)-, beta (beta)-, and gamma (gamma)-catenin, p120, p27, and adenomatous polyposis col

114 1, GTPase-activating protein, beta-catenin, gamma-catenin, p120cas, SHP-1, and SHP-2.

115 mutations alter regulation of both beta- and gamma-catenin, perhaps explaining why the frequency of A

116 We show that E-cadherin, beta-catenin, and gamma-catenin (plakoglobin) are all concentrated in cave

117 gamma-Catenin (Plakoglobin), a well-described structural

118 beta-Catenin and gamma-catenin (plakoglobin), vertebrate homologs of Dros

119 with intracellular catenins (alpha-, beta-, gamma-catenin/plakoglobin and p120CAs).

120 We show here that beta-catenin, gamma-catenin/plakoglobin, and p120-Cas are all signific

121 1 stimulates E-cadherin binding to beta- and gamma-catenin, promotes cytoskeletal association of the

122 , a histone deacetylase inhibitor, increased gamma-catenin protein content in NSCLC cells with low ga

123 Treatment of NSCLC cells expressing reduced gamma-catenin protein with 5-aza-2'-deoxycytidine (5aza2

124 in the NSCLC cell lines that underexpressed gamma-catenin relative to those lines that highly expres

125 The Kindlin-2 binding sites for beta- and gamma-catenin reside within its F1 and F3 subdomains.

126 junctions by inducing cleavage of beta- and gamma-catenin, resulting in cell detachment.

127 ZO-1) and adherens complex (alpha, beta, and gamma catenins) revealed diminished intensity and redist

128 gamma-Catenin's transforming activity, like beta-catenin

129 We find that joint inactivation of beta- and gamma-catenin scrambles motor neuron settling position i

130 Furthermore, the re-expression of gamma-catenin sensitized NSCLC cells to c-MET inhibitor-

131 ary NSCLC tumors revealed negligible to weak gamma-catenin staining in approximately 30% of the speci

132 However, in contrast to beta-catenin, gamma-catenin strongly activated c-Myc expression and c-

133 e closely related family member plakoglobin (gamma-catenin) that maintained both adherens junctions a

134 the intercalated disc with alpha-actinin and gamma-catenin, the latter being a known disease gene for

135 mma-catenin association; 4) PECAM-1 recruits gamma-catenin to cell-cell junctions in transfected SW48

136 xpression and c-Myc function was crucial for gamma-catenin transformation.

137 Cleavage of gamma-catenin was specific to cisplatin treatment in tha

138 By contrast, gamma-catenin was weakly expressed or absent in several

139 These cleavages of beta-catenin and gamma-catenin were apoptosis-dependent, not mitosis-depe

140 tically, the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyt

141 ugh changes in E-cadherin, beta-catenin, and gamma-catenin were identified in individual cell lines.

142 d apoptosis and cleavage of beta-catenin and gamma-catenin were inhibited by the pan-caspase inhibito

143 However, the tumor suppressive affects of gamma-catenin were not fully understood.

144 dherin recruits alpha- and beta-catenins and gamma-catenin, which interact with the actin cytoskeleto