ライフサイエンスコーパス: gamma-chain

1 ta chain and IL-2/IL-7/IL-15 receptor common gamma chain.

2 ein composed of one alpha, one beta, and one gamma chain.

3 imulation and is not DAP10/12 or Fc receptor gamma chain.

4 ed through association of an alpha, beta and gamma chain.

5 ic chain, and JAK3 is appended to the common gamma chain.

6 f the IL-21 receptor (IL-21R) and the common gamma-chain.

7 at expressed the IL-7Ralpha-chain and common gamma-chain.

8 lls expressing the IL-15Rbeta and the common gamma-chain.

9 d3 was dependent on expression of the common gamma-chain.

10 a has a substitution of Arg375 to Trp in the gamma-chain.

11 th the 7E9 antibody to the C terminus of the gamma-chain.

12 cells bearing the IL-2Rbeta-chain and common gamma-chain.

13 on protein and mRNA level of both alpha- and gamma-chain.

14 d the gammaA/gamma' variant with an extended gamma-chain.

15 the C-terminal halves of fibrinogen beta and gamma chains.

16 e or four ion pairs between thrombin and the gamma' chain.

17 vels of the alternatively spliced fibrinogen gamma' chain.

18 M) even though it does not interact with the gamma'-chain.

19 ated signaling subunits, such as FcepsilonRI gamma-chains.

20 th cells bearing human IL-15Rbeta and common gamma-chains.

21 ht multimer formations that can also contain gamma-chains.

22 induced by thrombin exosite 2 binding to the gamma' chains.

23 atalytic site induced by thrombin binding to gamma' chains.

24 mobilization via association with the common gamma-chain, a subunit that transmits signals upon ligat

25 As expected, fibrinogen alpha, beta, and gamma chains accounted for many of the most significant

26 mal (rFgn) and a deletion mutant lacking the gamma-chain AGDV sites (rFgn gammaDelta408-411).

27 nizing the HLA-A2-restricted T-cell receptor gamma-chain alternate reading-frame protein (TARP)(4-13)

28 an 90% of the constituent Aalpha, Bbeta, and gamma chain amino acid sequences.

29 IL-2 receptor subunit alpha (IL-2Ralpha) and gamma chain and also endogenous serine/threonine phospha

30 ine that shares the common cytokine receptor gamma chain and plays important roles for normal Ig prod

31 pansion of lymphocytes expressing the common gamma chain and the development of CD3(+) T lymphocytes.

32 r consisting of the common cytokine receptor gamma chain and the IL-21 receptor (IL-21R).

33 utant JAK3 (M511I) for binding to the common gamma chain and thereby suppresses its oncogenic potenti

34 al electrostatic complementarity between the gamma' chain and exosite II or if there are critical cha

35 Thrombin binds to the gamma'-chain and forms a higher affinity interaction wit

36 tion of the FcepsilonRI alpha-chain with the gamma-chain and beta-chain was markedly reduced.

37 ed with tyrosine phosphorylation of GPVI-FcR gamma-chain and CLEC-2.

38 ites in fibrin are not confined to its known gamma-chain and RGD motifs.

39 receptor complex glycoprotein VI (GPVI)-FcR gamma-chain and the C-type lectin-like receptor 2 (CLEC-

40 ontaining collagen receptor complex GPVI-FcR gamma-chain, and the von Willebrand factor receptor comp

41 gen (gamma'-Fg), a variant with an elongated gamma-chain, are resistant to lysis when compared with c

42 une receptors, but the common use of the FcR gamma-chain as their signaling subunit challenges the co

43 s IL-2, IL-7, and IL-15, while IL-4, another gamma-chain-associated cytokine, is thought to primarily

44 re regulated by the cytokine receptor common gamma-chain-associated cytokines IL-2, IL-7, and IL-15,

45 ylation events downstream of the Fc receptor gamma-chain-associated immunoreceptor tyrosine-based act

46 uences of the ligand-binding alpha-chains of gamma-chain-associated receptors.

47 In the absence of FcR gamma-chain association in P388D1 cells, the Ser(248)-Fc

48 y a single amino acid mutation in the common gamma-chain binding site on IL-15.

49 Taken together, our data suggest that common gamma-chain binding-dependent activation of the shared I

50 ion of negatively charged amino acids in the gamma' chain, both individually and collectively, to thr

51 w that Fcgr3-rs interacts with the common Fc-gamma chain but that Fc receptor-mediated phagocytosis a

52 C-terminal QAGDV sequence of the fibrinogen gamma-chain by alphaIIb beta3 inhibits the ability of th

53 in a serine-to-proline substitution near the gamma chain C-terminus (S378P).

54 a3 binds to a KQAGDV motif at the fibrinogen gamma-chain C terminus and to RGD motifs present in loop

55 The fibrinogen gamma-chain C-terminal (residues 144-411) fusion protein

56 of fibrinogen contains a differently spliced gamma chain called gamma', which presents itself mainly

57 e middle of each coiled-coil adjacent to the gamma chain carbohydrate attachment site.

58 The common gamma chain (CD132) is a subunit of the interleukin (IL)

59 -17 cells express IL-15Ralpha and the common gamma chain (CD132), yet lack the IL-2/15Rbeta chain (CD

60 mRNA for IL-7R alpha (CD127) and its common gamma chain (CD132).

61 iable speed with a few members of the common gamma-chain (CD132) family of cytokines, the speed of pr

62 omposed of IL-7Ralpha (CD127) and the common gamma-chain (CD132) to transmit its signal.

63 ls expressing IL-2/IL-15Rbeta and the common gamma-chain (CD132), but did not block IL-15 action in c

64 The glycoprotein (GP) VI/Fc receptor gamma-chain complex is a central regulator of these proc

65 plays an important role in GPVI-Fc receptor gamma-chain complex-mediated platelet activation, and is

66 ich is expected to block signaling involving gamma chain-containing cytokines including interleukins

67 though each of the individual charges in the gamma' chain contributes only incrementally to the overa

68 Our results show that gamma-chain cross-linking contributes significantly to c

69 To study the contribution of FXIIIa-induced gamma-chain cross-linking on fibrin structure and functi

70 /Q399N/K406R and gammaK406R) that modify the gamma-chain cross-linking process.

71 rations that primarily block alpha-, but not gamma-, chain crosslinking decreased RBC retention in cl

72 n in clots formed with fibrinogen that lacks gamma-chain crosslinking sites, but not in clots that la

73 through T cell antigen receptors and common gamma chain cytokine receptors.

74 genes associated with type I IFN and common gamma chain cytokine signaling in CD4 T cell subsets and

75 by effector T cells was dependent on common gamma-chain cytokine activation of the mTOR pathway, whi

76 p is provided via IL-21 production, a common gamma-chain cytokine closely related to IL-2.

77 most recently described member of the common gamma-chain cytokine family, is produced by activated CD

78 has indicated that CD8 T(mem) use the common gamma-chain cytokine IL-15 for their steady-state mainte

79 at IL-2-mediated up-regulation of the common gamma-chain cytokine receptor and perforin, and activati

80 he need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thus STAT5

81 ral signaling mediators activated via common gamma-chain cytokine receptors.

82 IL-21, a common gamma-chain cytokine secreted by activated CD4+ T cells,

83 f ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrease CD8

84 This report addresses the role of gamma-chain cytokine signals in regulating CD4(+) T cell

85 ycle proteins are independent of Jak3/common gamma-chain cytokine signals.

86 s of Foxp3 induction in Treg precursors upon gamma-chain cytokine stimulation.

87 IL-15 is a common gamma-chain cytokine that has been shown to be more acti

88 response is induced via IL-2 receptor common gamma chain cytokines and a Janus kinase 3 (JAK3)-depend

89 The common gamma chain cytokines interleukin (IL)-2 and IL-7 are im

90 For example, common gamma-chain cytokines (CGCC), such as interleukin-7 (IL-

91 bryostatin 1/ionomycin and sequential common gamma-chain cytokines (IL-7/IL-15 + IL-2).

92 cells during homeostatic expansion driven by gamma-chain cytokines and exerted a durable, yet reversi

93 The common gamma-chain cytokines IL-15 and IL-7 have been shown to

94 All gamma-chain cytokines signal through JAK-3 and JAK-1 act

95 signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 exp

96 ant, but IL-4, IL-7, and IL-15, other common gamma-chain cytokines, could sustain Foxp3 expression.

97 GVHD, caused by T cells activated by common gamma-chain cytokines, each represent therapeutic target

98 Other common gamma-chain cytokines, IL-4, IL-7, or IL-15, do not shar

99 Foxp3(-) cells to IL-2, but not other common gamma-chain cytokines, resulted in Stat5 phosphorylation

100 tion with physiologic stimuli such as common gamma-chain cytokines, Toll-like receptor (TLR) 2 ligand

101 te peptide stimulation or exposure to common gamma-chain cytokines.

102 ion of NKG2C(bright) NK cells was FcepsilonR gamma-chain defective and highly responsive to Ab-driven

103 ID gamma (with interleukin-2 (IL-2) receptor gamma chain deficiency) mice also revealed the ATRA plus

104 In CD132 (common gamma-chain)-deficient hosts, pmel-1 CD8(+) T cells unde

105 OD) wild-type or SCID/NOD Fc receptor common gamma chain-deficient (FcRgamma(-/-)) mice.

106 this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(-/-) mi

107 betic severe combined immunodeficient common gamma chain-deficient stem cell factor (huNSG) mice exhi

108 trol B16F10 tumor growth, but only in common gamma-chain-deficient host mice.

109 Therefore, we used alymphoid Rag- and common gamma-chain-deficient mice as recipients and observed ho

110 s but lacking their own activating FcgammaR (gamma-chain-deficient mice).

111 ruitment, synovitis, and bone destruction in gamma-chain-deficient mice.

112 al microbiota, adaptive immunity, and common-gamma chain-dependent signaling.

113 part, from their ability to bind to a novel, gamma chain-dependent, activating IgG Fc receptor, Fcgam

114 activation of these cells in the absence of gamma-chain-dependent cytokine signals induces an altern

115 we examine in detail the role of Jak3/common gamma-chain-dependent cytokines in promoting cell cycle

116 direct impact of IL-2 and IL-15, two common gamma-chain-dependent cytokines, on CD8(+) T-cell exhaus

117 The gamma' chain differs from the gammaA chain in its C-term

118 ain to the shared IL-2/IL-15Rbeta and common gamma-chains displayed on the surface of T cells and NK

119 ollowing IRI in immunodeficient RAG-2/common gamma-chain double-knockout mice, suggesting that the ch

120 plasmic region of the CD3zeta or Fc receptor gamma chain, effectively redirected T cell cytotoxicity

121 ion motif (ITAM) adaptor protein Fc receptor gamma-chain, even though the canonical ITAM signaling wa

122 DCs from mice lacking the Fc receptor gamma chain exhibited an activated phenotype in vitro.

123 Approximately 7-15% of the fibrinogen gamma chain exists as the highly anionic gamma' variant

124 gamma chain expression was very low in tumors expressing

125 These erythrocytes demonstrated 60%-70% gamma-chain expression (vs. < 10% for negative control)

126 d protection from infection all required FcR gamma-chain expression on DC.

127 IL-2 and IL-15 are common gamma-chain family cytokines involved in regulation of T

128 IL-7, a member of the common gamma-chain family of cytokines, is essential for B and

129 MyD88 and FcR common gamma-chain (Fcer1g, FcRgamma) elicit proinflammatory re

130 Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid artery

131 ceptor signaling, which utilizes Fc-receptor gamma-chain FcRgamma-Syk.

132 in Mincle or its adapter protein Fc receptor gamma chain (FcRgamma) produced severely reduced amounts

133 yrosine-based activation motif on the common gamma chain (FcRgamma).

134 activation of T cells (LAT), or Fc receptor gamma-chain (FcRgamma-chain) were used for these studies

135 ying a homozygous mutation in the fibrinogen gamma chain (Fibgamma390-396A) had a striking 50% reduct

136 FcgammaRIII, required association of the FcR gamma-chain for optimal expression and function on myelo

137 L-15, a cytokine family that uses the common gamma-chain for signaling.

138 ceptor beta-chain CD122, forming with common gamma-chain functional high-affinity IL-2 receptors.

139 which IL-7Ralpha or common cytokine receptor gamma chain (gamma(c)) genes were deleted in thymocytes

140 vgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by the ga

141 merization with the common cytokine receptor gamma chain (gamma(c)), the protein whose expression is

142 completely treat tumor in lymphopenic common gamma chain (gamma(c))-deficient hosts.

143 IL-2Rbeta, and the common cytokine receptor gamma chain (gamma(c)).

144 cells expressing IL-15/IL-2Rbeta and common gamma chain (gamma(c)).

145 The common gamma-chain (gamma c) cytokines IL-2, IL-7, IL-15, and I

146 rystal structures of complexes of the common gamma-chain (gamma(c)) cytokine receptors and their cyto

147 The common gamma-chain (gamma(c)) cytokines signal through the Janu

148 cuses on the role of cytokines of the common gamma-chain (gamma(c)) family in the determination of th

149 unliganded receptor structure in the common gamma-chain (gamma(c)) family of receptors and cytokines

150 he receptor subunit IL-2Rbeta and the common gamma-chain (gamma(c)).

151 21, IL-2 shares the common cytokine receptor gamma chain, gamma(c), which is mutated in humans with X

152 ghly related to the common cytokine receptor gamma chain, gamma(c).

153 nd IL-15 shares the common cytokine receptor gamma chain, gamma(c).

154 ine that shares the common cytokine receptor gamma-chain, gamma(c), with IL-2, IL-4, IL-7, IL-9, and

155 Cytokines that use the common gamma chain gammac are critical for lymphoid development

156 nt mice lacking the cytokine receptor common gamma chain (gammac(-/-)) and carrying a human stem cell

157 tion-activating gene 2 (Rag2) and the common gamma chain (gammac) (Rag-gammac(-/-)), which lack gut-a

158 oietic cells that associates with the common gamma chain (gammac) and is required for signaling for a

159 2 (IL-2) and IL-15 signal through the common gamma chain (gammac) and through IL-2 receptor beta-chai

160 IL-2 and IL-15, members of the gamma chain (gammac) family of cytokines, are prominentl

161 cy (XSCID) is due to mutations in the common gamma chain (gammac) gene and is identical clinically an

162 Interestingly, common gamma chain (gammac) knockout mice have been shown to ha

163 ations in the IL2RG gene encoding the common gamma chain (gammac) of receptors for interleukins 2 (IL

164 a (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits.

165 cted to interleukins that recruit the common gamma chain (gammac) receptor, including IL-9.

166 The common gamma chain (gammac)-binding cytokine interleukin (IL)-2

167 ver, Foxp3 lethality was prevented by common gamma chain (gammac)-dependent cytokine signals that wer

168 Common gamma chain (gammac)-receptor dependent cytokines are re

169 We show that common gamma chain (gammac)-using cytokines, namely IL-2, IL-7,

170 L-7 is heterodimeric, consisting of a common gamma chain (gammac, encoded by Il2rg) and an alpha subu

171 rus vector expressing interleukin-2 receptor gamma-chain (gammac) complementary DNA successfully rest

172 CID caused by mutations affecting the common gamma-chain (gammac) cytokine signaling pathway and mice

173 T and NK cell populations relative to other gamma-chain (gammac) cytokines has not been fully define

174 Tim-3 was induced by the common gamma-chain (gammac) cytokines IL-2, IL-7, IL-15, and IL

175 ciated with hyporesponsiveness of T cells to gamma-chain (gammac) cytokines known to influence T cell

176 -gamma) response and upregulation of several gamma-chain (gammac) cytokines known to promote the acti

177 in mice lacking both the Rag2 and the common gamma-chain (gammac) genes (Rag2(-/-)gammac(-/-)), indic

178 The common gamma-chain (gammac) is a key component of multiple cyto

179 The common gamma-chain (gammac) plays a central role in signaling b

180 TGF-beta) that did not signal via the common gamma-chain (gammac) receptor but that, like IL-7 and IL

181 f natural killer (NK) cells relies on common gamma-chain (gammac)-dependent cytokines, in particular

182 ignals through the type I (IL-4Ralpha/common gamma-chain [gammac]) and the type II (IL-4Ralpha/-13Ral

183 rom cytokine receptors containing the common gamma-chain, gammac.

184 a (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors.

185 T-cell receptor-gamma chain gene rearrangement identified a clonal popul

186 here they recombine their TCR beta-chain and gamma-chain gene loci.

187 e chain reaction analyses of T-cell receptor gamma-chain gene rearrangements in six patients and cyto

188 ed by expressing a hybrid TCR containing TCR-gamma chain germ-line complementarity determining region

189 Because Hep II C3 PEA substitution and gamma-chain GlcNAc OAc addition have been reported to ne

190 Approximately 50% of gamma-chain GlcNAc was present in its 3-OAc-substituted

191 The Fc receptor (FcR) gamma-chain has been shown to be up-regulated in T cells

192 The gamma-chain Hep II contains two phosphoethanolamine (PEA

193 unlike GHRPam, not at all to the homologous gamma-chain hole.

194 In human platelets, Fc receptor gamma-chain IIa (FcgammaRIIa) has been identified as an

195 the gene encoding the Interleukin-2 receptor gamma chain (IL-2Rgamma), leading to a lack of functiona

196 ends on expression of interleukin-2 receptor gamma chain (IL-2Rgammac), IL-15, and the major histocom

197 mously or in collaboration with other common gamma chain (IL-4 and IL-7) and IL-6/IL-12 family cytoki

198 The IL-2R common gamma-chain (IL-2Rgamma) is shared by receptors for seve

199 questioned whether the restriction of IL-2R gamma-chain (Il-2rgamma)-dependent cytokine signaling on

200 s interleukin (IL)-2R beta , common gamma (C gamma ) chain, IL-7R alpha , IL-15R alpha; and prolifera

201 bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, investigat

202 in the interleukin 2 (IL-2) receptor common gamma chain (IL2rg(null)) into mice that were already de

203 ding the human interleukin 2 receptor common gamma chain (IL2RG) gene and the efficient derivation of

204 ressing mutations in the IL2-receptor common gamma chain (IL2rg) gene, including NOD-scid IL2rgamma(n

205 e report that the germ-line gene for the TCR gamma chain in a chondrichthyan, the sandbar shark (Carc

206 ory and effector memory subsets and of the C gamma chain in all maturation subsets of CD8+ T cells.

207 which is involved in increased expression of gamma chain in HepG2 cells that are transfected with Bbe

208 y of hnRNP A1 leads to the overexpression of gamma chain in HepG2 cells that overexpress the Bbeta ch

209 nals through receptors containing the common gamma chain, induced expression of IL-10 in the IL-2-dep

210 harges plays a profound role in the thrombin-gamma' chain interactions.

211 In Q398N/Q399N/K406R, cross-links with any gamma-chain involvement were completely absent, and only

212 The cross-linking of gamma chains is known to involve the reciprocal linkages

213 ts genetically deficient in mature NK cells (gamma-chain knock out) also showed decreased severity of

214 e as well as humanized NOD Scid IL2 receptor gamma chain knockout (NSG) human leucocyte antigen (HLA)

215 etic severe combined immunodeficiency common gamma chain knockout-bone marrow-liver-thymus humanized

216 KO]) or only the inhibitory FcgammaRIIb (FcR gamma-chain KO).

217 e T cell activation, which was absent in FcR gamma-chain KO, but strikingly more pronounced in Fcgamm

218 odels that tonic signals derived from the Fc-gamma chain lead to Syk-dependent activation of STAT3 an

219 The presence of the gamma' chain modulates thrombin and FXIII activity, infl

220 without gamma-chain or by coexpression with gamma-chain mutants, was associated with significant imp

221 ing of IL-13 to IL-13Ralpha1, neither common gamma-chain nor IL-13Ralpha1 contributed significantly t

222 ocompromised NOD/SCID interleukin-2 receptor gamma chain null (Il2rg(-/-)) mice, can increase the det

223 unodeficient NOD/SCID/interleukin 2 receptor gamma chain null mice.

224 kedly higher level in NOD/SCID/IL-2 receptor gamma chain-null (NSG) mice compared with cytokine-induc

225 c cells and binds specifically to the common gamma chain of a subfamily of cytokine receptors that in

226 osine kinase that associates with the common gamma chain of cytokine receptors and is recurrently mut

227 The cell surface-expressed gamma chain of the high affinity receptor for IgE (Fceps

228 s-links between Gln(398) and Lys(406) on the gamma chains of fibrin (the positive control of the stud

229 methionine residues on the alpha, beta, and gamma chains of fibrinogen.

230 ion of either BALB/c mice lacking the common gamma-chain of Fc receptors (FcgammaR(-/-)) or mice gene

231 Animals lacking both the signal-transducing gamma-chain of IgG receptors and SHIP or Ig and SHIP pro

232 ve therapeutic gene IL2RG, which encodes the gamma-chain of the interleukin-2 receptor, in a mouse mo

233 ombination activating gene 2 [Rag2], and the gamma-chain of the receptor for IL-2 [Il-2rgamma]) with

234 The degradation of the alpha-, beta-, and gamma-chains of fibrin and the appearance of peptide fra

235 ulation factor XIII (FXIIIa) cross-links the gamma-chains of fibrin early in clot formation.

236 The equivalent position in gamma-chains of human fibrin(ogen) is occupied by a lysi

237 noncovalent association with the Fc receptor gamma chain on human and murine platelets and serves as

238 s to study the effects of fibrinogen and its gamma' chain on APC resistance.

239 ing competency, either by expression without gamma-chain or by coexpression with gamma-chain mutants,

240 ts segregated on the basis of use of the TCR gamma-chain or delta-chain indicated the existence of th

241 complex of IL-4Ralpha with either the common gamma-chain or the IL-13R chain alpha1 (IL-13Ralpha1).

242 maRI, FcgammaRIII, FcgammaRIV, or FcR common gamma chain, or inhibitory FcgammaRIIB.

243 The gamma chain "out loop" contained within each coiled-coil

244 tation as observed for the clumping factor A.gamma-chain peptide complex.

245 experiments were performed using immobilized gamma' chain peptides with charged-to-uncharged amino ac

246 64H and gammaD364A, which have nonfunctional gamma-chain polymerization sites to prevent the dominant

247 A motif in the Fg gamma chain previously shown to be central to the alpha(

248 More importantly, common cytokine receptor gamma-chain(-/-)RAG(-/-) animals deficient in NK cells,

249 D bearing a null mutation in the IL-2 common gamma chain receptor (NSG) mice as animal models of huma

250 Nonobese diabetic (NOD)-scid interleukin-2 gamma chain receptor (NSG) readily engraft with human im

251 Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis

252 sed and functions in synergy with the common-gamma chain receptor family.

253 cell differentiation defect in interleukin-2 gamma-chain receptor (IL2RG)/JAK3 severe combined immuno

254 erleukin-21 (IL-21) is a recently identified gamma-chain receptor cytokine family member that promote

255 IL-33 is a gamma-chain receptor-independent cytokine of the IL-1 su

256 ry, possibly by repressing the expression of gamma-chain receptors and the downstream effector of the

257 R1 expression by signals via TCRs and common gamma-chain receptors was essential for naive CD4(+) T c

258 tissue in unconditioned allogeneic RAG2(-/-) gamma-chain(-/-) recipients.

259 ite, identified previously within fibrinogen gamma chain residues 207-235, is a high-affinity site an

260 y apo(a)-binding site within the sequence of gamma chain residues 287-411.

261 exosite II or if there are critical charged gamma' chain residues involved.

262 of FXIII-A2B2 to murine fibrinogen that has gamma-chain residues 390-396 mutated to alanines (Fibgam

263 ains, 226KDa for beta chain and 338.5KDa for gamma chain, respectively.

264 stals showed mostly intact native alpha- and gamma-chain sequences (the native beta chain is blocked)

265 e-arginine interaction can also occur in the gamma-chain setting.

266 erotrimeric receptor IL-2/IL-15Rbeta and the gamma chain shared with IL-2 and the cytokine-specific I

267 Conversely, C57BL/6 mice lacking the gamma-chain shared by activating FcgammaR had enhanced s

268 atures are induced in CTCL T cells by common gamma chain signaling cytokines such as IL-2 and do not

269 interleukin 15 and common cytokine receptor gamma chain signaling for their development.

270 RI effector functions, including Fc receptor gamma-chain signaling and intracellular calcium mobiliza

271 IL-21 is a member of the common gamma-chain signaling family of cytokines.

272 2(-/-) splenocytes but not Rag2(-/-) common gamma chain(-/-) splenocytes.

273 mine and lysine residues on fibrin alpha and gamma chains stabilize the fibrin clot and protect it fr

274 motif (ITAM) incorporated into the accessory gamma-chain subunit that associates with FcgammaRIA and

275 Cytokines that signal through the common gamma-chain suppressed T(reg) cell-induced apoptosis.

276 nding from the central region, and the short gamma chain "tail" extending from each distal globular r

277 -21R in conjunction with the common receptor gamma-chain that is also shared by members of the IL-2 f

278 RNAs, including the T cell-receptor beta and gamma chains, the T cell and natural killer (NK) cell-su

279 mice deficient in both apolipoprotein E and gamma-chain, the common subunit of activating Fcgamma re

280 Independently of the FcepsilonRI gamma-chain, this single-chain FcepsilonRI was internali

281 ombin binds to the highly anionic fibrinogen gamma' chain through anion-binding exosite II.

282 In addition, the binding of the gamma' chain to thrombin was weakened in a dose-dependen

283 isease and associates with either the common gamma-chain to form the type I IL-4R or with the IL-13R

284 igen-induced FcepsilonRI-Lyn association and gamma-chain tyrosine phosphorylation were both impaired

285 mic profile analysis identified ATP synthase gamma chain, ubiquinol-cyt-C reductase, heat shock prote

286 une deficiency in HIV-infected patients, and gamma -chain-utilizing cytokines may play an important r

287 Other common gamma-chain-utilizing cytokines were unable to induce Fo

288 signal correlative microscopy, we found that gamma-chain variable region 5 (V(gamma)5) TCRs expressed

289 T cells expressing the TCR containing the gamma-chain variable region 9 and the delta-chain variab

290 actor XIIIa-catalyzed dimerization of fibrin gamma chains was selected to represent the D-dimer antig

291 Second, cross-linking of fibrin gamma chains was virtually the same for both types of fi

292 gnaling through the common cytokine receptor gamma-chain was critical for the optimal expression of b

293 s behind clearance of the aberrant Aguadilla gamma-chain, we expressed the mutant gammaD domain in ye

294 ased activation motif receptors: Fc receptor gamma chain, which is noncovalently associated with the

295 IL2RG encodes the common gamma chain, which is part of several interleukin recept

296 e mimicking the C-terminus of the fibrinogen gamma' chain, which binds thrombin and inhibits its acti

297 bulin (Ig) receptor GPVI and the Fc receptor gamma-chain, which has an immunoreceptor tyrosine-based

298 d with the shared IL-2/IL-15Rbeta and common gamma-chains, which activate signaling pathways on NK ce

299 press IL-7 receptors, which share the common gamma chain with IL-2 receptors, IL-7 cannot initiate li

300 enitors lacking the cytokine receptor common gamma-chain yields leukemogenic pre-B cells that exhibit