ライフサイエンスコーパス: gamma-herpesvirus

1 e from dealing effectively with a pathogenic gamma-herpesvirus.

2 aintain long-term control of this persistent gamma-herpesvirus.

3 oma-associated herpesvirus (KSHV) is a human gamma-herpesvirus.

4 d NK cell-mediated immune control of a human gamma-herpesvirus.

5 re conserved in the EBNA1 orthologs of other gamma herpesviruses.

6 sequences were distributed more uniformly in gamma-herpesviruses.

7 esviruses but not in members of the beta- or gamma-herpesviruses.

8 activated differently in alpha- compared to gamma-herpesviruses.

9 DNA features differed in alpha- compared to gamma-herpesviruses.

10 the beta-subfamily and absent in alpha- and gamma-herpesviruses.

11 monstrate a novel mechanism where the murine gamma herpesvirus 68 (gammaHV68) latency-associated, ant

12 oma-associated herpesvirus (KSHV) and murine gamma herpesvirus 68 (MHV-68), plays a critical role in

13 pe III ER membrane protein encoded by murine gamma herpesvirus 68.

14 llowing intragastric inoculation with murine gamma-herpesvirus 68 (gamma HV-68), expression of substa

15 after respiratory challenge with the murine gamma-herpesvirus 68 (gammaHV-68), then develop symptoms

16 model of gamma-herpesvirus infection, murine gamma-herpesvirus 68 (gammaHV-68), we were surprised to

17 Infection of medial smooth muscle cells with gamma-herpesvirus 68 (gammaHV68) causes severe chronic v

18 Murine gamma-herpesvirus 68 (gammaHV68) infection is a new mode

19 s are generated and maintained during murine gamma-herpesvirus 68 (gammaHV68) persistent infection de

20 e we demonstrate that infection of mice with gamma-herpesvirus 68 (gammaHV68) provides a novel model

21 of complement factor C3 (C3) and the murine gamma-herpesvirus 68 (gammaHV68) RCA protein in viral pa

22 ins of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is providing insights

23 ths after respiratory exposure to the murine gamma-herpesvirus 68 (gammaHV68), then succumb with symp

24 ct effector mechanisms of CD4 T cells during gamma-herpesvirus 68 (gammaHV68)-persistent infection ar

25 Murine gamma-herpesvirus 68 (MHV-68) infection of mice represen

26 cial for maintenance of latency during mouse gamma-herpesvirus 68 (MHV-68) infection.

27 Murine gamma-herpesvirus 68 (MHV-68) provides an important expe

28 d the differentiation and function of murine gamma-herpesvirus 68 (MHV-68)-specific CD4(+) T cells us

29 /- and wt mice were infected with the murine gamma-herpesvirus 68 (MHV-68).

30 we report that the miRNAs encoded by murine gamma-herpesvirus 68 (MHV68) are also generated via atyp

31 T-I CTL function and the clearance of murine gamma-herpesvirus 68 and lymphocytic choriomeningitis cl

32 However, murine gamma-herpesvirus 68 causes a chronic lytic infection in

33 of a full-length oncogenic viral cyclin from gamma-herpesvirus 68 complexed with cdk2.

34 istinct from host protein synthesis shutoff, gamma-herpesvirus 68 down-regulates surface MHC class I

35 The murine gamma-herpesvirus 68 has many similarities to EBV, and i

36 mmune surveillance, exemplified by the mouse gamma-herpesvirus 68 M3 decoy receptor.

37 The murine gamma-herpesvirus 68 replicates in epithelial sites afte

38 for the generation and maintenance of murine gamma-herpesvirus 68-specific CD8(+) set now have been a

39 ical factors in limiting the level of murine gamma-herpesvirus-68 (gammaHV-68) infection.

40 The murine gamma-herpesvirus-68 (gammaHV68) establishes viral laten

41 Murine gamma-herpesvirus-68 (gammaHV68), a rodent pathogen rela

42 ) T cell population during persistent murine gamma-herpesvirus-68 (MHV-68) infection.

43 The murine gamma-herpesvirus-68 (MHV-68) K3 protein, like that of t

44 k-old apoE-/- mice were infected with murine gamma-herpesvirus-68 (MHV-68).

45 f memory CD8(+) T cells reactive to a murine gamma-herpesvirus-68 Ag.

46 cobacterium tuberculosis), and viral (murine gamma-herpesvirus-68 and Sendai) infections.

47 a murine MHC class II-restricted epitope in gamma-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that eli

48 The murine gamma-herpesvirus-68 has biological and structural simil

49 role of Abs in control of persistent murine gamma-herpesvirus-68 infection.

50 ma-herpesvirus experimental infection model, gamma-herpesvirus-68.

51 The gamma-herpesviruses additionally evade T cells during th

52 Two other T-lymphotropic gamma-herpesviruses, AlHV-1 and OvHV-2, do not produce a

53 mune evasion strategy shared by at least two gamma-herpesviruses allows continued lytic infection in

54 Gamma herpesviruses also encode homologs of the Bcl-2 fa

55 of infection and protective immunity for the gamma-herpesviruses and demonstrate the utility of repli

56 cal and structural similarities to the human gamma-herpesviruses, and provides an important in vivo e

57 The gamma-herpesviruses are characterized by their ability t

58 Gamma-herpesviruses are efficacious pathogens which are

59 Because the gamma-herpesviruses are highly species-specific and mice

60 The gamma-herpesviruses are oncogenic B cell lymphotrophic v

61 r pathology induced by gammaHV68 and suggest gamma-herpesviruses as candidate etiologic agents for hu

62 oma-associated herpesvirus (KSHV) is a human gamma-herpesvirus associated with several human malignan

63 ic vaccination strategies must target latent gamma-herpesvirus at the site of infection.

64 P receptors in mice results in an increased gamma-herpesvirus burden and an altered host response.

65 These data demonstrate that a gamma-herpesvirus can accelerate atherosclerosis in the

66 Rhesus lymphocryptovirus (rhLCV) is a gamma-herpesvirus closely related to EBV, which establis

67 ng latent infection with gammaHV68, a murine gamma-herpesvirus closely related to human gamma-herpesv

68 HHV-8 is a B-lymphotropic gamma-herpesvirus closely related to the Epstein-Barr vi

69 We have identified a major gamma-herpesvirus-divergent locus (DL-B) in HHV-8 DNA en

70 The gL proteins of alpha herpesviruses and gamma herpesviruses do not have a significant percentage

71 with B cell lines transformed by the related gamma-herpesvirus EBV.

72 The oncogenic gamma-herpesviruses EBV and Kaposi sarcoma-associated he

73 The human gamma-herpesviruses EBV and Kaposi's sarcoma-associated

74 The gamma-herpesvirus, EBV, is reliably found in a latent st

75 The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated

76 The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated

77 The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated

78 Gamma-herpesviruses encode a cytoplasmic mRNA-targeting

79 Many gamma-herpesviruses encode candidate oncogenes including

80 Several gamma-herpesviruses encode homologs of host regulators o

81 Several gamma-herpesviruses encode proteins related to the mamma

82 alpha-, beta-, and gamma-Herpesviruses encode putative viral protein kinase

83 ble tegument components included the EBV and gamma-herpesvirus-encoded BLRF2, BRRF2, BDLF2 and BKRF4

84 Here, we discuss gamma-herpesvirus-encoded miRNAs and focus on recent fin

85 This gamma-herpesvirus encodes for several unique proteins th

86 us nuclear antigen 1 (EBNA-1) of the related gamma-herpesvirus Epstein-Barr virus, specific DNA recog

87 are homology with two lymphotropic oncogenic gamma-herpesviruses, Epstein-Barr virus and Herpesvirus

88 d herpesvirus, we have used a natural rodent gamma-herpesvirus experimental infection model, gamma-he

89 Together, these observations suggested that gamma-herpesviruses exploit the B cell life cycle in the

90 gamma-Herpesviruses express proteins that modulate B lym

91 A new member of the gamma-herpesvirus family, HHV-8 (also known as Kaposi's

92 mediate early transcription activator of the gamma-herpesvirus family.

93 tion of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is

94 By using a gamma-herpesvirus (gammaHV) infection model, we demonstr

95 The M3 gene of the gamma-herpesvirus gammaHV68 encodes an abundant secreted

96 effective, long-term control of a persistent gamma-herpesvirus (gammaHV68) in Ig(-/-) microMT mice, s

97 The experimental mouse gamma-herpesvirus, gammaHV68 (or MHV-68), has provided a

98 gamma-herpesviruses (gammaHVs) are common human pathogen

99 Gamma-herpesviruses (gammaHVs) are widespread oncogenic

100 Gamma herpesviruses (GHVs) are responsible for a substan

101 ck of relevant small animal models for human gamma-herpesviruses has impeded progress in understandin

102 Investigations into a murine gamma-herpesvirus have now provided evidence that vaccin

103 against gamma-herpesvirus infection and that gamma-herpesviruses have evolved an immune evasion strat

104 Thus, oncogenic gamma-herpesviruses have evolved diverse strategies to c

105 Tumor-causing gamma-herpesviruses have evolved elaborate mechanisms to

106 us recrudescence can be modeled using murine gamma-herpesvirus in CD4 T cell-depleted mice.

107 ided valuable new information on the role of gamma-herpesviruses in the pathogenesis of AIDS-associat

108 The gamma-herpesviruses, in contrast to the alpha- and beta-

109 gammaHV68 shares latency programs with human gamma-herpesviruses - including the loci for gene 73, v-

110 ection with either influenza virus or murine gamma-herpesvirus induced the expected expression of GrB

111 as been unclear whether lytic infection with gamma herpesviruses induces a similar effect.

112 ically alcelaphine herpesvirus 1 (AlHV-1), a gamma-herpesvirus inducing malignant catarrhal fever (MC

113 Disease associated with persistent gamma-herpesvirus infection (EBV, HHV-8) is a significan

114 Disease associated with persistent gamma-herpesvirus infection (EBV, human herpesvirus 8) i

115 hat complement is a key host defense against gamma-herpesvirus infection and that gamma-herpesviruses

116 important roles during latent and persistent gamma-herpesvirus infection and that herpesviruses encod

117 ation of immune surveillance against chronic gamma-herpesvirus infection in immunosuppressed individu

118 ockade of IFNgamma reactivated latent murine gamma-herpesvirus infection in vivo, suggesting a "two-s

119 anscription factor Stat6, reactivated murine gamma-herpesvirus infection in vivo.

120 l for understanding how immunity and chronic gamma-herpesvirus infection inter-relate.

121 prominent during the replicative phase of a gamma-herpesvirus infection protects against subsequent

122 in the generation of protective memory to a gamma-herpesvirus infection remains unknown.

123 Using the murine model of gamma-herpesvirus infection, murine gamma-herpesvirus 68

124 r expression makes toward immunity against a gamma-herpesvirus infection.

125 erstanding of the CD4 T cell response during gamma-herpesvirus infection.

126 in the establishment and control of chronic gamma-herpesvirus infection.

127 s are critical for the control of persistent gamma-herpesvirus infection.

128 nce of CD8 T cell memory during a persistent gamma-herpesvirus infection.

129 important for immune control of EBV-related gamma-herpesvirus infection.

130 y that the defective control of intercurrent gamma-herpesvirus infections in patients with AIDS not o

131 ic persistent viral infections, particularly gamma-herpesvirus infections.

132 butor to alterations in gene expression, and gamma-herpesviruses interface with the host RNA targetin

133 ated members of the rhadinovirus subgroup of gamma herpesviruses, K1 and STP exhibit no similarity in

134 The tumorigenic human gamma-herpesvirus Kaposi's sarcoma-associated herpesviru

135 The human gamma herpesviruses, Kaposi sarcoma-associated virus (KS

136 A newly recognized gamma herpesvirus known as Kaposi sarcoma-associated her

137 ssecting mechanisms of CD4 immune control of gamma-herpesvirus latency and the development of therape

138 largely protect against subsequent wild-type gamma-herpesvirus latency establishment.

139 ice represents a unique system for analyzing gamma-herpesvirus latency in splenic B cells at differen

140 c viral replication is not a requirement for gamma-herpesvirus latency in vivo and suggest that viral

141 ntribution of humoral immunity to control of gamma-herpesvirus latency, and have significant implicat

142 T cells are essential for immune control of gamma-herpesvirus latency.

143 ls are critical effectors for the control of gamma-herpesvirus latent infection, and they mediate thi

144 n important experimental model for analyzing gamma-herpesvirus latent infection.

145 n excellent animal model system to study the gamma herpesvirus life cycle both in vitro and in vivo.

146 Unique to gamma-herpesviruses, like Kaposi's sarcoma-associated he

147 Recently, the DNA sequences of a novel human gamma-herpesvirus-like (HHV-8) agent have been detected

148 MP1 signaling.IMPORTANCE EBV is a ubiquitous gamma herpesvirus linked to malignancies such as nasopha

149 It has been proposed that the gamma-herpesviruses maintain lifelong latency in B cells

150 Intranasal infection of mice with the murine gamma-herpesvirus MHV-68 results in an acute lytic infec

151 us recrudescence can be modeled using murine gamma-herpesvirus (MHV)-68 in mice lacking CD4(+) T cell

152 We infected mice with a murine gamma-herpesvirus (MHV-68).

153 w chimera mice after infection with a murine gamma-herpesvirus, MHV-68.

154 matically in mice infected with a persistent gamma-herpesvirus, MHV-68.

155 In this study, using a murine gamma-herpesvirus model, we demonstrate an early dominan

156 e pre-eminent animal model for understanding gamma-herpesvirus pathogenesis and immunity.

157 ctions for studies of this valuable model of gamma-herpesvirus pathogenesis.

158 CD8 T cell memory that is maintained during gamma-herpesvirus persistence has the capacity to surviv

159 As gamma-herpesviruses primarily cause human disease during

160 The mouse gamma-herpesvirus protein mK3 is a viral RING-CH-type E3

161 response, Tarakanova et al. characterized a gamma-herpesvirus protein, which phosphorylates histone

162 Immune surveillance failure followed by gamma-herpesvirus recrudescence can be modeled using mur

163 Immune surveillance failure followed by gamma-herpesvirus recrudescence can be modeled using mur

164 ine lymphotropic herpesvirus-1 (PLHV-1) is a gamma-herpesvirus related to Epstein-Barr virus (EBV) an

165 svirus (KSHV) is a recently discovered human gamma herpesvirus strongly implicated in AIDS-related ne

166 e gamma-herpesvirus closely related to human gamma-herpesviruses such as EBV and Kaposi's sarcoma-ass

167 uired for malignant transformation caused by gamma-herpesviruses, such as Kaposi's sarcoma virus.

168 are encoded by Herpesvirus saimiri (HVS), a gamma Herpesvirus that causes aggressive T cell leukemia

169 Murine herpesvirus-68 (MHV-68) is a type 2 gamma herpesvirus that productively infects alveolar epi

170 HHV-8 is an oncogenic gamma-herpesvirus that causes Kaposi's sarcoma, Castlema

171 Herpesvirus saimiri, a gamma-herpesvirus that establishes latency in the T cell

172 Herpesvirus saimiri (HVS) is a gamma-herpesvirus that expresses Sm class U RNAs (HSURs)

173 Epstein-Barr virus (EBV) is a lymphotropic gamma-herpesvirus that has co-evolved with human species

174 The Epstein-Barr virus (EBV) is a gamma-herpesvirus that infects B cells and epithelial ce

175 (KSHV), or human herpervirus 8 (HHV-8), is a gamma-herpesvirus that infects human lymphocytes and is

176 EBV is a B lymphotrophic gamma-herpesvirus that is associated with multiple human

177 Herpesvirus saimiri (HVS) is an oncogenic gamma-herpesvirus that produces microRNAs (miRNAs) by co

178 saimiri (HVS) is an oncogenic, lymphotropic, gamma-herpesvirus that transforms human and simian T cel

179 svirus (also named human herpesvirus 8) is a gamma-herpesvirus that undergoes both lytic and latent i

180 Unlike other gamma-herpesviruses, that encode transmembrane proteins

181 The DNA sequences of a novel human gamma-herpesvirus type 8 (HHV-8) have recently been dete

182 NA decay rates impact transcription and that gamma-herpesviruses use this feedback mechanism to facil

183 A gamma-herpesvirus v-bcl-2 was essential for efficient ex

184 A previously undescribed gamma-herpesvirus was cultured from acute JME white matt

185 repeats predominated in alpha-herpesviruses, gamma-herpesviruses were enriched in short, GC-rich init

186 KSHV is a gamma herpesvirus with homology to herpesvirus Saimiri a

187 uman and primate lymphotropic herpesviruses (gamma-herpesviruses) with the development of lymphomas,