ライフサイエンスコーパス: gamma-synuclein

1 d increased expression of beta-synuclein and gamma synuclein.

2 ng the MTZ, which contain protease resistant gamma-synuclein.

3 closely related members, alpha-, beta-, and gamma-synuclein.

4 disease, and the highly homologous beta and gamma-synuclein.

5 hibition of the 20 S proteasome by monomeric gamma-synuclein.

6 close homologues, termed beta-synuclein and gamma-synuclein.

7 shares high sequence identity with beta- and gamma-synuclein.

8 e protofibrils comprising alpha-synuclein or gamma-synuclein.

9 ne-activated apoptosis pathway is blocked by gamma-synuclein.

10 bodies, but these do not stain for beta- or gamma-synuclein.

11 described in the homologous genes beta- and gamma-synuclein.

12 ducted with antibodies to alpha-, beta-, and gamma-synuclein.

13 as observed at 4:1 molar excess of beta- and gamma-synucleins.

14 s, we investigated the effect of ziram on ZF gamma-synuclein 1 (gamma1).

15 most abundant message (75-80%), followed by gamma-synuclein (10-15%) and alpha-synuclein (8-10%).

16 We demonstrate here that beta- and gamma-synuclein (a third homologue that is expressed pri

17 alpha-, beta-, and gamma-Synuclein, a novel family of neuronal proteins, ha

18 s, none of which contained beta-synuclein or gamma-synuclein abnormalities.

19 opathological changes include aggregation of gamma-synuclein, accumulation of various inclusions in n

20 stent with alphaS and its homologs beta- and gamma-synuclein all forming tetramers while sharing only

21 No genetic link between beta and gamma-synuclein, and any neurodegenerative disease has b

22 -1, microtubule associated protein-2 (MAP2), gamma-synuclein, and NeuN, whereas Brn3 transcription fa

23 s were detected with alpha- but not beta- or gamma-synuclein antibodies in 22% of FAD brains, and alp

24 These results indicate that beta- and gamma-synuclein are intrinsically less fibrillogenic tha

25 In addition, beta and gamma-synuclein are reported to aggregate less readily t

26 curring synuclein isoforms (alpha, beta, and gamma-synuclein) are similarly effective inhibitors of P

27 Two homologous proteins, beta- and gamma-synucleins, are also abundant in the brain.

28 Our data reveal gamma-synuclein as a regulator of lipid handling in adip

29 cytes during glaucoma likely depends on this gamma-synuclein, as mice lacking gamma-synuclein fail to

30 beta- and gamma-synucleins, as well as the Parkinson's disease-ass

31 These findings demonstrate that gamma-synuclein can be involved in neuropathophysiologic

32 ons that drastically accelerate aggregation, gamma-synuclein can form fibrils with a lag phase roughl

33 Importantly, oxidized gamma-synuclein can initiate alpha-synuclein aggregation

34 e we show that another member of the family, gamma-synuclein, can be easily oxidized and form annular

35 We find that gamma-synuclein closely resembles alpha-synuclein in its

36 r data indicate that oncogenic activation of gamma-synuclein contributes to the development of breast

37 In breast cancer, increased expression of gamma-synuclein correlates with disease progression.

38 Most importantly, beta- and gamma-synuclein could not be cross-seeded with alpha-syn

39 gamma-Synuclein-deficient adipocytes also contain fewer

40 ains, using antibodies to alpha-, beta-, and gamma-synuclein, demonstrated many alpha-synuclein-posit

41 Consequently, overexpression of gamma-synuclein did not have any noticeable effect on th

42 We have found that gamma-synuclein-expressing cells are significantly more

43 nblastine is significantly down-regulated in gamma-synuclein-expressing cells, indicating that the pa

44 reason, we characterized alpha-, beta-, and gamma-synuclein expression in primary hippocampal neuron

45 nds on this gamma-synuclein, as mice lacking gamma-synuclein fail to up-regulate Mac-2 at the MTZ aft

46 The IC(50) of monomeric gamma-synuclein for the 20 S proteolysis was 400 nm.

47 er's disease, but beta-synuclein (betaS) and gamma-synuclein (gammaS) have not yet been implicated in

48 Further, beta-synuclein (betaS) and gamma-synuclein (gammaS) immunoreactivity was detected i

49 S)], as well as in various types of cancers [gamma-synuclein (gammaS)].

50 Co-incubating beta-synuclein with gamma-synuclein had no effect on the inhibition of the 2

51 arkably, another member of this gene family, gamma-synuclein, has been shown to be overexpressed in b

52 Knockdown of gamma-synuclein in adipocytes causes redistribution of t

53 ata suggest that the functions of alpha- and gamma-synucleins in presynaptic terminals are not fully

54 d detected alpha-synuclein, but not beta- or gamma-synuclein, in glial cytoplasmic inclusions (GCIs)

55 of the synuclein family, beta-synuclein and gamma-synuclein, in the development and progression of n

56 ividually expressing mouse alpha-, beta-, or gamma-synuclein, indicating they are functionally redund

57 cal properties to alpha-synuclein, beta- And gamma-synucleins inhibit alpha-synuclein fibril formatio

58 In the current study, we have found that gamma-synuclein is associated with two major mitogen-act

59 Recently we and others have found that gamma-synuclein is dramatically up-regulated in the vast

60 gamma-Synuclein is highly expressed in human white adipo

61 Here we show that gamma-synuclein is nutritionally regulated in white adip

62 ted brain mitochondria of alpha-, beta-, and gamma-synuclein knock-out mice and monomeric alpha-synuc

63 hat brain mitochondria of alpha-, beta-, and gamma-synuclein knock-out mice are uncoupled, as charact

64 NK1), and have shown that over-expression of gamma-synuclein leads to constitutive activation of ERK1

65 a these independent but complementary roles, gamma-synuclein may coordinately modulate lipid storage

66 We hypothesize that gamma-synuclein may deliver SNAP-23 to the SNARE complex

67 Two amino acid residues in gamma-synuclein, methionine and tyrosine located in neig

68 determine if levels of alpha-, beta- and/or gamma-synuclein mRNAs are differentially affected in bra

69 Compared with HFD-fed WT mice, HFD-fed gamma-synuclein-null mutant mice display increased lipol

70 We also tested the effects of gamma-synuclein on apoptosis and activation of JNK and E

71 xcess expression of the third family member, gamma-synuclein, on the nervous system we generated tran

72 te-stage breast and ovarian cancers and that gamma-synuclein over-expression can enhance tumorigenici

73 astine, etoposide does not activate JNK, and gamma-synuclein over-expression has no apparent effect o

74 a suggest that post-translationally modified gamma-synuclein possesses prion-like properties and may

75 ein for nigral dopaminergic neurons, whereas gamma-synuclein proved to be nontoxic and had very low a

76 ese data, we hypothesize that the alpha- and gamma-synucleins regulate proteasomal function and that

77 rative effects induced by alpha-, beta-, and gamma-synuclein revealed that beta-synuclein was eventua

78 gamma-Synuclein secreted from neuronal cells into condit

79 Here, we assessed whether gamma-synuclein shares the ability of alpha-synuclein to

80 w that fresh solutions of alpha-, beta-, and gamma- synuclein show the same natively unfolded structu

81 Both beta and gamma-synuclein show less extensive transient long-range

82 However, gamma Synuclein (SNCG) is also highly associated with br

83 gamma synuclein (SNCG), previously identified as a breas

84 Taking advantage of the fact that gamma-synuclein (Sncg) mRNA is expressed specifically an

85 ms, Brn3b (Pou4f2), Brn3c (Pou4f3), Thy1 and gamma-synuclein (Sncg), and some other markers of neuron

86 asomal activities only weakly, but monomeric gamma-synuclein strongly inhibited ubiquitin-independent

87 rolase L1, rat ortholog of human DJ-1/Park7, gamma-synuclein, superoxide dismutase 1), anti-oxidant p

88 gamma-Synuclein (Syn G) is highly expressed in retinal g

89 oxidation plays a key role in the ability of gamma-synuclein to aggregate and seed the aggregation of

90 synuclein family members beta-synuclein and gamma-synuclein to DAT trafficking is not known.

91 -casein, recombinant human alpha-, beta- and gamma-synuclein, together with the A30P and A53T mutants

92 nsgenic mice expressing high levels of mouse gamma-synuclein under control of Thy-1 promoter.

93 , no fibrils could be detected for beta- and gamma-synuclein under the same conditions.

94 gamma-Synuclein, unlike its homologs, formed a soluble o

95 in the presynaptic terminal, whereas little gamma-synuclein was expressed at all.

96 n was of intermediate toxicity to yeast, and gamma-synuclein was non-toxic.

97 synaptic vesicles, the C-terminal domain of gamma-synuclein was not able to interact with synaptobre

98 ng brains of mice lacking alpha-, beta-, and gamma-synuclein, we report that extracellular monomeric

99 tion-related proteins, including Abeta42 and gamma-synuclein, we sought to determine whether latrepir

100 aggregation properties of alpha-, beta-, and gamma-synuclein were comparatively elucidated in the rat

101 were decreased in AD and DLBD, and levels of gamma-synuclein were increased in AD cases.

102 perties of a random coil, whereas alpha- and gamma-synucleins were slightly more compact and structur