ライフサイエンスコーパス: ganglioside

1 condensation of the layer at small mol % of ganglioside.

2 c acid and sugars within the backbone of the ganglioside.

3 lceramide synthase (GCS) (gene Ugcg)-derived gangliosides.

4 first biosynthetic enzyme of a- and b-series gangliosides.

5 in sialic acid-containing glycolipids termed gangliosides.

6 on of sialic acid moieties in virus membrane gangliosides.

7 h engage LSTc as well as multiple sialylated gangliosides.

8 saccharides of mono-, di-, and trisialylated gangliosides.

9 lycans (GAGs), and secondary accumulation of gangliosides.

10 the ion abundances of labile lipids such as gangliosides.

11 human tumors produce and shed high levels of gangliosides.

12 MS was applied to NDs containing mixtures of gangliosides.

13 late neuronal function by catabolizing brain gangliosides.

14 , thus affording differentiation of isobaric gangliosides.

15 the differentiation of a, b, and c series of gangliosides.

16 d utilized unique mechanisms to bind complex gangliosides.

17 opulation and engagement of CT with suitable gangliosides.

18 nes, glycerophospho-serines, sulfatides, and gangliosides.

19 r lipids such as NeuAc- and NeuGc-containing gangliosides.

20 ion in toxicity in mice deficient in complex gangliosides.

21 y the sialic acid, but not other moieties in gangliosides.

22 ch represents the highest number of reported gangliosides.

23 d class of the cell's plasma membrane called gangliosides.

24 ssive RT112 cells by reducing (p < 0.01) Gb3 ganglioside (-50 +/- 3%) and sphingosine 1-phosphate (S1

25 the synthesis and extracellular shedding of gangliosides, a class of biologically active cell surfac

26 ID MS/MS, applied here for the first time to gangliosides, a novel, tetrasialylated O-GalNAc modified

27 eral studies have implied that specific anti-ganglioside Abs induce neuropathy in patients with axona

28 ies indicate that, in this mouse model, anti-ganglioside Abs induce sequential nodal and axonal injur

29 d inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact ner

30 To study the mechanisms of anti-ganglioside Abs-induced neuropathy, we established a new

31 eptors (FcgammaRs) were involved in the anti-ganglioside Abs-mediated nodal and axonal injury in this

32 s model) and systemic administration of anti-ganglioside Abs.

33 dy, we investigated the possibility that GM2 ganglioside accumulation in a mouse model of Sandhoff di

34 For example, either ganglioside addition or human glucosylceramide synthase

35 rotavirus, VP8* interacts with cell surface gangliosides, allowing engulfment into a membrane vesicl

36 Gangliosides also affect the aggregation of Abeta (Alzhe

37 ng, this work suggests that complex neuronal gangliosides also modulate hypothalamic IR signaling and

38 In contrast to glucosylceramide and gangliosides, alterations in complex neutral GSLs such a

39 PD-MS strategy allowed the elucidation of 27 gangliosides among five different classes.

40 hermal titration calorimetry, a screening of ganglioside analogues together with a detailed character

41 tolysosomes and lowered their content of GM2 ganglioside and Abeta-immunoreactivity without detectabl

42 nockout mice also have reduced levels of GM1 ganglioside and myelin in neuronal axons.

43 Abeta oligomers become sequestered onto GM1 ganglioside and presumably other lipids on neuronal memb

44 m mouse brain, which was found to contain 17 gangliosides and 13 sulfatides.

45 Labile compounds such as gangliosides and cardiolipins are detected in the negati

46 P(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane rafts surroun

47 the group A carbohydrate epitope GlcNAc and gangliosides and dopamine receptors found on the surface

48 Relative contributions of gangliosides and glycoproteins to CTB binding depend on

49 colylated hexosamines were found in cellular gangliosides and incorporated into Chinese hamster ovary

50 erefore likely to cooperate with each other: gangliosides and members of the synaptic vesicle glycopr

51 ure, where an upper aqueous layer containing gangliosides and other polar lipid subclasses is further

52 The identification of gangliosides and other polar lipids is based on accurate

53 ortant roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin

54 ers efficiently into neurons lacking complex gangliosides and shows no reduction in toxicity in mice

55 insights into the functional roles of brain gangliosides and sialoglycoproteins consistent with rela

56 e UGCG-depleted cells show reduced levels of gangliosides and significantly elevated levels of rhEPO

57 enes responsible for terminal sialylation of gangliosides and some glycoproteins.

58 validates the use of ESI-MS for cell-derived gangliosides and supports the further development of lip

59 accumulation of glycolipids like GM2 and GM3 gangliosides and unesterified cholesterol in surviving P

60 Abeta oligomers bound strongly to GM1 ganglioside, and blocking the sialic acid residue on GM1

61 o proteolytic degradation and unable to bind gangliosides, and even in the presence of admixed B subu

62 imaging of acidic lipids such as sulfatides, gangliosides, and phosphatidylinositols in the negative

63 ion of the transporter variant away from GM1 ganglioside- and flotillin1-enriched membranes, and is a

64 ostinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated wit

65 xonal forms of Guillain-Barre syndrome, anti-ganglioside antibodies bind gangliosides on nerve surfac

66 stigated whether endocytic clearance of anti-ganglioside antibodies by nerve terminals might also be

67 itter recycling, are able to endocytose anti-ganglioside antibodies from the cell surface so rapidly

68 The typical AMAN-associated anti-ganglioside antibodies were rarely present.

69 unexpected pathway by which pathogenic anti-ganglioside antibodies, and potentially other gangliosid

70 oblems, they were exposed to anti-disialosyl ganglioside antibodies, including those derived from a p

71 uch signalling and the pathogenic effects of ganglioside antibodies.awx012media15372351982001.

72 Remarkably, systemically delivered anti-ganglioside antibody in mice was so avidly cleared from

73 of neuromuscular junctions, from where anti-ganglioside antibody was retrogradely transported to the

74 Gangliosides are a family of glycosphingolipids characte

75 Within the intracellular milieu, gangliosides are constituents of the autophagosome membr

76 For digestion, gangliosides are endocytosed and reach intra-endosomal v

77 Gangliosides are extracted by chloroform-methanol-water

78 Gangliosides are important cellular membrane components

79 Gangliosides are major cell-surface determinants on all

80 or engagement, while the more weakly binding gangliosides are not required for productive infection.

81 leaflet, distinct nanodomains consisting of gangliosides are observed.

82 Gangliosides are the main glycolipids of neuronal plasma

83 t sialic acid-containing glycosphingolipids (gangliosides) are also ligands for human NoVs.

84 including flotillin-1, cholesterol, and GM1 ganglioside, are altered.

85 membranes, and their sialylated derivatives, gangliosides, are the major class of glycoconjugates exp

86 erotypes of BoNTs (BoNT/A-G) require complex gangliosides as co-receptors.

87 ng domain (HCR), BoNT/C was shown to utilize gangliosides as dual host receptors.

88 BoNT/C utilizes dual gangliosides as host cell receptors.

89 membrane with their glycans facing outward, gangliosides associate laterally with each other, sphing

90 h an association between the accumulation of gangliosides, autophagic vacuoles, and the intraneuronal

91 deteriorates as the physiological profile of gangliosides becomes progressively and distinctively abn

92 This showed that ganglioside binding at the Sia-1 site was accessible on

93 the mobile fraction of the raft marker, GM1 ganglioside binding cholera toxin B subunit Ctb, at cell

94 Release of ganglioside binding may enhance GluR2-containing AMPAR a

95 ntained the point mutation W1266A within the ganglioside binding pocket was designed.

96 l-cell recognition by trans interaction with ganglioside binding proteins on apposing cells.

97 anglioside antibodies, and potentially other ganglioside binding proteins, are cleared from the syste

98 and biochemical studies showed that the two ganglioside binding sites, termed GBP2 and Sia-1, were i

99 into Neuro-2A cells required both functional ganglioside binding sites.

100 able ATP (ATPgammaS) significantly disrupted ganglioside binding, whereas it enhanced AMPAR associati

101 of ganglioside functions, affinity-captured ganglioside-binding proteins from rat cerebellar granule

102 ase, because of defects in the first step of ganglioside biosynthesis (GM3 synthase), results in a se

103 Inherited defects in ganglioside biosynthesis causing fatal neurodegenerative

104 Human congenital disorders of ganglioside biosynthesis invariably result in intellectu

105 n inherited disease arising from a defect in ganglioside biosynthesis is known.

106 Disrupting ganglioside biosynthesis may result in reduced synaptic

107 Human congenital disorders of ganglioside biosynthesis result in paraplegia, epilepsy,

108 me that catalyzes the second step in complex ganglioside biosynthesis, as the cause of this neurodege

109 L5, which codes for an enzyme early in brain ganglioside biosynthesis, result in an early-onset seizu

110 efects in two sequentially acting enzymes in ganglioside biosynthesis, there is the real possibility

111 stem are revealed by congenital mutations in ganglioside biosynthetic genes.

112 se brains, and intraneuronal accumulation of ganglioside-bound Abeta (GAbeta) immunoreactivity in a b

113 Furthermore, in the plasma membrane, CD81-ganglioside bridges arising from preformed glycolipid pa

114 y reconstitution studies indicated that GD1a ganglioside, but not other gangliosides, could restore P

115 rted to interact with sialic acid-containing gangliosides, but the role of these glycans in JCPyV inf

116 rtant roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues i

117 rted to sphingomyelins and glucosylceramides/gangliosides by the addition of polar head groups.

118 9/Siglec-1, an I-type lectin that recognizes gangliosides, captures the virus.

119 engineered to express a CAR against the GD2 ganglioside (CAR.GD2), which is highly expressed by neur

120 erties of SAPs, and the strong regulation of ganglioside catabolism by membrane lipids.

121 n mouse models, whereas inherited defects in ganglioside catabolism causing various clinical forms of

122 n (heavy chain receptor binding domain) with ganglioside co-receptors orients the translocation domai

123 by tethering of TeNT to the membrane through ganglioside co-receptors prior to acidification.

124 Gangliosides consist of a backbone of sphingoid base and

125 We found that GPR37(tGFP) partitioned in GM1 ganglioside-containing lipid rafts in the plasma membran

126 ut CNS resulted in a 36-76% reduction in GM1-ganglioside content in the brain and 75-86% in the spina

127 ilencing in RCC cells increased the membrane ganglioside content, in particular the GD1a content, and

128 Ganglioside conversion by Neu3 sialidase further activat

129 al sialic acid (SA) on the cell surface GD1a ganglioside could be used for PSV binding and infection

130 dicated that GD1a ganglioside, but not other gangliosides, could restore PSV binding and infection, f

131 Here, we report the overexpression of ganglioside D3 (GD3) in LAM.

132 gangliosides on various cells, we show that ganglioside D3 (GD3) is overexpressed on eight neurosphe

133 ity that a previously unidentified family of ganglioside deficiency diseases exist.

134 provide convincing evidence linking b-series gangliosides deficiency and neurogenesis defects to beha

135 we report that tumor cells engineered to be ganglioside deficient exhibit impaired tumorigenicity, s

136 g myeloid-derived suppressor cells (MDSC) in ganglioside-deficient tumors, in contrast with the large

137 ences from the alpha subunit that confer GM2 ganglioside-degrading activity and protease resistance.

138 The initial step was ganglioside dependent, while the subsequent step involve

139 tained the interchain disulfide bond, showed ganglioside-dependent binding to neurons, required acidi

140 ed tumorigenicity, supporting a link between ganglioside-dependent immune escape and tumor outgrowth.

141 precursor analogs to modulate the sialylated ganglioside-dependent interaction of MLV particles with

142 We exposed primary mouse CD8(+) CTL to gangliosides derived from three sources (tumors and norm

143 al sclerosis, conduritol B epoxide preserved ganglioside distribution at the neuromuscular junction,

144 evaluate the temporal expression profiles of gangliosides during the course of neurodegeneration in r

145 Moreover, we observed that the presence of ganglioside enhances both the initial pore formation and

146 racts with alpha2-3-sialyllactose-containing gangliosides enriched in lipid rafts to inhibit raft-dep

147 Our results identify ganglioside-enriched lipid rafts to be receptors that me

148 d a second, localized to cholesterol and GM1 ganglioside-enriched microdomains, that displays restric

149 Our study demonstrates that the b-series gangliosides, especially GD3, play a crucial role in the

150 eared from the circulation by endocytosis at ganglioside-expressing plasma membranes that it was rapi

151 of the CaR-ESI-MS assay using NDs containing gangliosides extracted from porcine brain led to the dis

152 a(1-40) is weakly observed in the absence of gangliosides, fiber-dependent membrane fragmentation can

153 To probe the mechanisms of ganglioside functions, affinity-captured ganglioside-bin

154 Dutch mutant APP(E693Q)) form complexes with gangliosides (GAbeta).

155 For example, the complex ganglioside GD1a interacts dynamically with the IRs on a

156 nce of fibronectin aggregates in MS lesions, ganglioside GD1a might act as a potential novel therapeu

157 re we demonstrate that exogenous addition of ganglioside GD1a overcomes the inhibiting effect of aggr

158 Recently, we identified the ganglioside GD2 as a novel breast cancer stem cell marke

159 directed against the melanoma target antigen ganglioside GD2 in addition to murine CD3.

160 Ganglioside GD2 is highly expressed on neuroectodermal t

161 We previously demonstrated that ganglioside GD3 is a major species in embryonic mouse br

162 We previously showed that ganglioside GD3 plays a crucial role in the maintenance

163 In this study, we identify ganglioside GD3, which was isolated from the polar lipid

164 icity caused by anti-GD3 antibody binding to ganglioside GD3.

165 f a striped phase of condensed DPPC and DPPC/ganglioside geometrically packed complexes at low concen

166 study, IMS MS was introduced in human brain ganglioside (GG) research.

167 GCases and was able to efficiently hydrolyze gangliosides, globosides, (n)Lc-type GSLs, and cerebrosi

168 The ganglioside (glycolipid) GM1 is thought to be the sole C

169 Gangliosides GM(3) and GD(3) are located in the apical a

170 LBs) containing increasing concentrations of ganglioside (GM(1)).

171 The effect of the main gangliosides (GM(1), GM(3), GD(3)) and free sialic acid

172 he spatial localization of the most abundant gangliosides, GM(3) and GD(3), in Caco-2 cells has been

173 ney were positive for the lipid raft markers ganglioside GM1 and Caveolin-1.

174 preferential localization of sphingomyelin, ganglioside GM1 and cholesterol in the monolayer region

175 virus simian virus 40 (SV40), which uses the ganglioside GM1 as a receptor that mediates cell binding

176 We report that intraventricular infusion of ganglioside GM1 induces phosphorylation of mutant huntin

177 l-dependent cohesive phase separation of the ganglioside GM1 into nano- and microscale assemblies in

178 ra toxin causes diarrheal disease by binding ganglioside GM1 on the apical membrane of polarized inte

179 Finally, nuclear membrane-associated ganglioside GM1 plays a pivotal role in Ca(2+) homeostas

180 In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE)

181 toxin, with their natural GSL receptors, the ganglioside GM1, and the globotriaosylceramide Gb3, resp

182 of the cholera toxin B subunit, which binds ganglioside GM1, to the Golgi apparatus.

183 ycero-3-phospho-l-serine (sodium salt)), and ganglioside GM1.

184 iation constant for cholera toxin binding to ganglioside GM1.

185 particles, we demonstrate that both alpha2-3 gangliosides GM1 and GM3 are capable of mediating this i

186 Cross-linking of raft gangliosides GM1 with cholera toxin (CTxB) was shown to

187 sults revealed that CTB5 binds to six of the gangliosides (GM1, GM2, GM3, GD1a, GD1b, and GT1b), whil

188 nstrate the reliability of the method, seven gangliosides (GM1, GM2, GM3, GD1a, GD1b, GD2, and GT1b)

189 bind GT1b, but bound specifically to another ganglioside, GM1.

190 beta-hexosaminidase deficiency in which the ganglioside GM2 and other glycolipids accumulate intrace

191 lethanolamine, phosphatidylinositol, and the gangliosides GM2 and GM3.

192 Ganglioside GM3 mediates adipocyte insulin resistance, b

193 The ST3GAL5 enzyme synthesizes ganglioside GM3, a glycosophingolipid enriched in neural

194 Ganglioside GM3, a host-derived glycosphingolipid incorp

195 lysobisphosphatidic acid, sphingomyelin, the ganglioside GM3, and cholesterol esters, all of which su

196 s including several sphingolipids (ceramide, ganglioside GM3, GM2, GM1, GD3 and GD1a), cardiolipin, c

197 ids, such as ceramide, glucosylceramide, and ganglioside GM3, have been implicated in various aspects

198 yed milder PKD, revealing a pivotal role for ganglioside GM3.

199 osylceramide, globotriaosylceramide, and the gangliosides GM3 and GM1 were significantly elevated in

200 ns that bound selectively to the major brain ganglioside GT1b (GT1b:GM1 > 4; p < 10(-4)), three regul

201 The binding involved gangliosides GT1b and GD1a and a few membrane lipids.

202 The brain-abundant gangliosides GT1b and GQ1b were specifically recognized

203 -deficient) mice expressing only GM3 and GD3 gangliosides had normal auditory structure and function.

204 iosides were used to determine the effect of ganglioside headgroup charge and geometry on its interac

205 We postulate that gangliosides, highly expressed on tumor cell membranes,

206 Various inherited defects of ganglioside hydrolases, e.g., of beta-galactosidase and

207 aim at elucidating whether exogenously added gangliosides (i.e., cell surface lipids with a potential

208 ncreasing the ratio of GM1/GD1a and GM1/GT1b gangliosides immediately after injury in vitro and in vi

209 nd colocalize with the lipid raft marker GM1 ganglioside in cell-cell junctions of mammary epithelial

210 id analysis confirmed a complete lack of GM3 ganglioside in patient fibroblasts, while microarray ana

211 agal deficiency leads to accumulation of GM1-ganglioside in the central nervous system (CNS).

212 important for understanding the role of this ganglioside in the flexibility of neuronal membranes.

213 ed for the identification of a wide range of gangliosides in biological samples.

214 lyses revealed up to 60% decreased levels of gangliosides in cerebellum and forebrain.

215 ctures of amphiphilic glycosphingolipids and gangliosides in comparison to collision induced dissocia

216 rgets lipid rafts we show that clustering of gangliosides in lipid rafts is important.

217 rane interactions mediate the recognition of gangliosides in membranes by BoNT/DC.

218 lysosomes, thereby impairing the turnover of gangliosides in myelin.

219 of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help

220 of BoNT HCRs as probes to study the role of gangliosides in neurotransmission.

221 ass signals from intact cardiolipin (CL) and gangliosides in normal brain and the effect of a control

222 l alterations in response to loss of complex gangliosides in patient fibroblasts and in zebrafish emb

223 d GT1b-represent the vast majority (>90%) of gangliosides in the brains of all mammals and birds.

224 We report here altered levels of gangliosides in the cerebrospinal fluid of amyotrophic l

225 The functions of gangliosides in the human nervous system are revealed by

226 oral deficits, and support a crucial role of gangliosides in the long-term maintenance of NSCs in adu

227 The molecular functions of brain gangliosides include regulation of receptors in the same

228 Mutations in the ganglioside-induced differentiation associated protein 1

229 opy micrographs further support the model of ganglioside-induced DPPC condensation with condensed dom

230 engaged by the sialated glycosphingolipids (gangliosides) integrated in the rigid structures of astr

231 provided additional confirmation of the NoV-ganglioside interactions.

232 Since the GM1 ganglioside is a major constituent of mammalian lipid ra

233 The GM2 ganglioside is an antigen expressed in the majority of m

234 raminidase 3 and 4 double-knockout mice, GM3 ganglioside is stored in microglia, vascular pericytes,

235 c myelin-associated glycoprotein by neuronal gangliosides is due to the C18 acyl membrane anchor of C

236 , causing conversion of GD1a and GT1b to GM1 ganglioside, is an essential step in regeneration occurr

237 d sensitive method can be applied to monitor ganglioside levels in plasma from normal people and neur

238 n addition to studies suggesting that simple gangliosides like GM3 regulate peripheral IR signaling,

239 hereas transient nanodomain incorporation of ganglioside lipid GM1 is apparent in both the live-cell

240 As a striking exception, vesicles containing ganglioside lipids GM1 or GM3 accelerate the process.

241 of densely packed autofluorescent material, gangliosides, lysozyme, phosphorylated tau, and amyloid-

242 Systemic delivery of an anti-ganglioside mAb was used for selective intraneuronal/axo

243 emic injection of fluorescently labeled anti-ganglioside mAb.

244 tudy are that fluorescent conjugates of anti-ganglioside mAbs are valuable delivery vectors to visual

245 these changes may be due to dysregulation of ganglioside-mediated oligodendroglial precursor cell pro

246 NEU3 sialidase, a key enzyme in ganglioside metabolism, is activated under hypoxic condi

247 A by >65 and >17%, respectively, and for the ganglioside mixture by 0 and 40%, respectively.

248 ents because less DPPC is needed to condense ganglioside molecules with larger cross-sectional areas.

249 We examine the use of an anti-ganglioside monoclonal antibody (mAb) as selective neuro

250 ganglioside-monosialic acid 3 synthase (GM3S) is a known

251 binding specificities of these proteins for ganglioside oligosaccharides.

252 s and were recovered in part as bound to GM1 ganglioside on membranes.

253 e syndrome, anti-ganglioside antibodies bind gangliosides on nerve surfaces, thereby causing injury t

254 In current models, BoNTs initially bind gangliosides on resting neurons and upon SV exocytosis a

255 BoNT/C accesses gangliosides on the plasma membrane.

256 By analysis of gangliosides on various cells, we show that ganglioside

257 N-glycosylation or the synthesis of specific gangliosides or displaying Neu5Gc-terminated, as opposed

258 tococcus, and with sialoglycans presented as gangliosides or in the form of sialoglycan microarrays,

259 lated by different facilitator lipids (e.g., gangliosides or phosphoinositols), revealing a plausible

260 rat oligodendrocytes to GD1a, but not other gangliosides, overcomes aggregated fibronectin-induced i

261 way for a greater understanding of the role gangliosides play in neuronal structure and function and

262 n TgCRND8 mice where abnormally abundant GM2 ganglioside-positive granules are detected in neuronal l

263 onize insulin signaling in myotubes, whereas ganglioside precursors do not.

264 able to remove sialic acid residues from the gangliosides present on adjacent cells, thus creating ce

265 tion, supporting a direct connection between ganglioside production by tumor cells and the recruitmen

266 ical, and genetic tools advance, research on gangliosides promises to reveal mechanisms of molecular

267 ture, and block its interaction with the GM1 ganglioside receptor in the outer leaflet of the plasma

268 B subunit homopentamer (CTB5) and its native ganglioside receptor, beta-D-Gal-(1 --> 3)-beta-D-GalNAc

269 e virus, apparently by utilizing a different ganglioside receptor.

270 We here propose that the glycan part of the ganglioside receptors mainly provides abundance and spec

271 n of cholesterol-rich domains and associated ganglioside receptors prefer to occur in the monolayer a

272 E: Plasma membrane accessibility of the dual ganglioside receptors suggests synaptic vesicle exocytos

273 Transient ganglioside reconstitution of the tumor cell inoculum wa

274 bolic blocks in processing and catabolism of gangliosides result in the development of severe neurolo

275 de on the basis of the correlation among the ganglioside retention, the number of saccharide units, a

276 IL-2Ralpha/IL-15Ralpha colocalized with GM1 ganglioside-rich lipid rafts, but MHC I clusters retract

277 rast with the large MDSC infiltrates seen in ganglioside-rich littermate control tumors.

278 The glycan motifs of gangliosides serve as initial coreceptors for these prot

279 Mounting evidence supports the notion that gangliosides serve regulatory roles in neurogenesis; lit

280 eficiency in GD3 and the downstream b-series gangliosides showed a progressive loss of NSCs both at t

281 eral novel acid glycosphingolipids, like the gangliosides sialyl-lactotetraosylceramide and sialyl-gl

282 Gangliosides (sialylated glycolipids) play an essential

283 Gangliosides, sialylated glycosphingolipids, found on al

284 species, and ESI-MS was used to quantify the ganglioside species expressed within these injured neuro

285 sulting in unambiguous identification of 145 ganglioside species from 19 subclasses, which represents

286 there is no treatment available for neuronal ganglioside storage diseases.

287 Thus, tumor-shed gangliosides suppress lytic activity of CD8(+) T cells b

288 GM3, a lipid raft ganglioside synthesized by GM3 synthase (GM3S), regulate

289 The GBP2 binding site recognized gangliosides that contained a sia5 sialic acid, whereas

290 d, whereas the Sia-1 binding site recognized gangliosides that contained a sia7 sialic acid and sugar

291 Utilizing gangliosides that uniquely recognized the GBP2 and Sia-1

292 Externally applied sialidase converted GD1a ganglioside to GM1 and rescued axon regeneration in CNS

293 e the signals from the low-abundance CLs and gangliosides to allow their GCIB-SIMS detection at 8 and

294 tion-resistant saturated and monounsaturated gangliosides) to regions including the CA1 and CA3 of th

295 Gangliosides were altered and enriched within an expande

296 Otherwise, phospholipids and gangliosides were pointed as healthy volunteers' skin li

297 lo-(GA1), disialo-(GD1b) and trisialo-(GT1b) gangliosides were used to determine the effect of gangli

298 gCTB retained nanomolar affinity to GM1-ganglioside with only marginal reduction of physicochemi

299 HCR (HCR/T) and TeNT(RY) were found to bind gangliosides with similar affinities and specificities,

300 m that uses virion-incorporated host-derived gangliosides with terminal alpha2-3-linked sialic acid l