ライフサイエンスコーパス: gap gene

1 his screen identified a mutation in the rab3-GAP gene.

2 he clade that contained all other eukaryotic gap genes.

3 dominal expression of the Kruppel and knirps gap genes.

4 the transcriptional regulation of posterior gap genes.

5 Drosophila eve locus, which is controlled by gap genes.

6 ormed by localized repressors encoded by the gap genes.

7 f Capicua (Cic), a repressor of the terminal gap genes.

8 stal (PD) axis into broad domains by the leg gap genes.

9 for pre-gastrulation expression of posterior gap genes.

10 ressive feedback loops between complementary gap genes.

11 xpression patterns of homologs of Drosophila gap genes.

12 he glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene.

13 ody plan is initiated with the activation of gap genes, a set of transcription-factor-encoding genes

14 The leg gap genes act combinatorially to initiate the expression

15 g on the comprehensive knowledge of maternal gap gene activation in Drosophila, we used loss- and gai

16 ions, transcription factors encoded by other gap genes appear to function as dedicated repressors.

17 At the anterior, terminal gap genes are also activated by the Tor pathway but Bcd

18 First, prior to the expression of pb, the gap genes are required to specify the domains where pb m

19 Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is con

20 ed by the overlapping expression of the head gap gene buttonhead (btd) and the primary pair-rule gene

21 sion is not detectably regulated by the head gap genes buttonhead or orthodenticle, by the proneural

22 le to show how expression levels of the four gap genes can be jointly decoded into an optimal specifi

23 Taken together, four gap genes carry enough information to define a cell's lo

24 Regulatory interactions found in gap gene circuits provide consistent and sufficient mech

25 ons involved in gap gene regulation based on gap gene circuits, which are mathematical gene network m

26 of neighboring gap domains when knocking out gap genes, consistent with previous observations.

27 Here we present evidence that every gap gene contains multiple enhancers with overlapping ac

28 he opposing expression landscapes of the leg gap gene dachshund (dac) and the tarsal PD genes, bric-a

29 tion of orthodenticle, whereas all posterior gap gene domains of knirps, giant, hunchback, tailless a

30 set through negative regulation by the same gap gene domains that regulate stripes 3 and 7, but at d

31 nteractions among transcription factors, the gap genes, driven by maternal inputs.

32 stripe 3 and 4 dynamics by modulating other gap gene dynamics.

33 f this gradient is transmitted to downstream gap genes, each occupying a well defined spatial domain.

34 in a combinatorial fashion with the cephalic gap genes empty spiracles (ems) and buttonhead (btd) to

35 Gap genes encode transcription factors involved in the p

36 e question of how the maternal regulation of gap genes evolved.

37 Our models reproduce gap gene expression at high accuracy and temporal resolu

38 tes the eve stripes by establishing specific gap gene expression boundaries, which provides the embry

39 show that torso signalling permits terminal gap gene expression by antagonising Gro-mediated repress

40 Initiation and dynamics of gap gene expression differ markedly between M. abdita an

41 The spatial pattern of gap gene expression domains along the AP axis is general

42 of the embryo, the relative positions of the gap gene expression domains in relation to one another,

43 Although changes in gap gene expression extend beyond the manipulated gene,

44 Maternal and gap gene expression in Nasonia suggest long germ embryog

45 t can have long-range and dynamic effects on gap gene expression in the posterior.

46 oencoder compressing the dynamics of spatial gap gene expression into a two-dimensional (2D) latent m

47 ty correlates with high reliance of anterior gap gene expression on Bicoid.

48 show that Nasonia caudal is an activator of gap gene expression that acts far towards the anterior o

49 sor acts in this process to confine terminal gap gene expression to the embryonic termini.

50 e initial position of boundaries for zygotic gap gene expression, which in turn convey positional inf

51 ance can be traced back to variations in the gap gene expression, which is rendered sensitive to the

52 ide consistent and sufficient mechanisms for gap gene expression, which largely agree with mechanisms

53 nated spatiotemporal differences in terminal gap gene expression.

54 e induction of sequential kinematic waves of gap gene expression.

55 dal, leading to a lack of dramatic action on gap gene expression: caudal instead plays a limited role

56 th the establishment of spatially restricted gap gene-expression patterns in response to broad gradie

57 posterior region depends on combinations of gap gene factors that differ from those utilised for the

58 Over 90% of the open reading frame of gap genes for glycolytic glyceraldehyde-3-phosphate dehy

59 d orthologues of all of the Drosophila trunk gap genes from Clogmia, and determined their domains of

60 pattern suggests that hb may have acquired a gap gene function in arthropods or insects after their p

61 promoter fragment from a well characterized GAP gene, GAP-43, is sufficient to activate expression i

62 a melanogaster, hypomorphic mutations in the gap gene giant (gt) have long been known to affect ecdys

63 pression approach to examine the role of the gap gene giant (gt) in patterning anterior regions of th

64 The gap gene giant (gt) is involved in a repression mechanis

65 identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhance

66 habditis elegans homologue of the Drosophila gap gene hunchback (hb) and have designated it hbl-1 (hu

67 Activation of the gap gene hunchback (hb) by the maternal Bicoid gradient

68 In Drosophila, the gap gene hunchback (hb) is expressed in a dynamic patter

69 re shown to be orthologues to the Drosophila gap gene hunchback (hb).

70 aspects of the expression of the Drosophila gap gene hunchback are shared with its orthologs in the

71 nd function of the homolog of the Drosophila gap gene hunchback in an intermediate germ insect, the m

72 full activation of the enhancer, whereas the gap genes hunchback (hb) and knirps (kni) are required f

73 The gap genes hunchback and giant display inverted patterns

74 oad domain is required for activation of the gap genes hunchback and Kruppel.

75 Many of these genes, including the gap-gene hunchback, are initially activated in a broad d

76 As canonical gap genes, hunchback and Kruppel play a crucial role in

77 ruppel, even-skipped seems to act as an uber-gap gene in Oncopeltus, indicating that it may have both

78 blastoderm requires even-skipped, which is a gap gene in Oncopeltus.

79 he possibility that giant might not act as a gap gene in short and intermediate germ insects.

80 r results suggest that giant was a bona fide gap gene in the ancestor of these insects with this role

81 We find that Oncopeltus giant is a canonical gap gene in the maxillary and labial segments and also p

82 is gene network, we are studying the role of gap genes in a representative of a basally diverging dip

83 adient that prevents expression of posterior gap genes in anterior regions.

84 a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ

85 ule system that is directly regulated by the gap genes in Drosophila.

86 By contrast, activation of gap genes in flies relies on redundant functions of Bico

87 We measure spatiotemporal levels of four gap genes in heterozygous and homozygous gap mutant embr

88 measure this information, in bits, using the gap genes in the Drosophila embryo as an example.

89 ssically assumed intricate set of repressive gap gene interactions.

90 ts of regional information from maternal and gap genes into the segmental expression of segment polar

91 y is the first demonstration that a cephalic gap gene is directly regulated by Bcd.

92 t the posterior pole, expression of terminal gap genes is mediated by the local activation of the Tor

93 findings indicate that point mutation of Rho-GAP genes is unexpectedly frequent in several cancer typ

94 The asymmetric distribution of the gap gene knirps (kni) in discrete expression domains is

95 ryos, we analyzed how changing levels of the gap gene Kruppel (Kr) affects transcriptional dynamics o

96 In Drosophila, the gap gene Kruppel is required for proper formation of the

97 subfamily of genes related to the Drosophila gap gene kruppel.

98 ally, we ask whether spatial localization of gap genes Kruppel (Kr) and giant (gt) and the pair-rule

99 in the repression of three target genes, the gap genes Kruppel (Kr) and hunchback (hb), and the pair-

100 tions of several target genes, including the gap genes Kruppel (Kr), knirps (kni), and giant (gt), an

101 ds to visualize the temporal dynamics of the gap genes Kruppel and knirps, which are essential for th

102 at reproducible positions, even with varying gap gene levels.

103 ppy-paired 1 (Slp1), which is expressed in a gap gene-like anterior domain.

104 ese results suggest that Slp1 functions as a gap gene-like repressor, in addition to its roles at the

105 sue of Cell, Savard et al. identify a beetle gap gene, mille-pattes, that encodes an unusual polycist

106 Expression analysis in gap gene mutants showed that stripe 5 is restricted ante

107 DLC1 was the Rho-GAP gene mutated most frequently, with 5%-8% of tumors i

108 accompanied by reduced expression levels of gap genes near the middle of large embryos.

109 o identify the optimal sensor for the entire gap gene network and to argue that the physical limitati

110 explore a detailed mechanistic model of the gap gene network in the Drosophila embryo, optimizing it

111 We use the gap gene network in the early fly embryo as an example o

112 We use the gap gene network in the early fly embryo as an example t

113 enon through a systems-level analysis of the gap gene network in the scuttle fly Megaselia abdita (Ph

114 Although the qualitative structure of the gap gene network is conserved, there are differences in

115 tanding of the evolution and function of the gap gene network outside of Drosophila.

116 Analysis of recent experiments on the gap gene network shows that all these signatures are obs

117 duced 10 of the 11 links in the well-studied gap gene network.

118 rimary morphogen inputs to the output of the gap gene network.

119 Thus, mutation of Rho-GAP genes occurs frequently in some cancer types and the

120 Here, we report the regulatory effects of gap genes on the spatial expression of disco, disco-r, a

121 Of the dorso-medially expressed head gap genes, only tailless (tll) is required for the speci

122 l regulatory region upstream of the cephalic gap gene orthodenticle (otd) is sufficient to recapitula

123 Here, we focused on the cephalic gap gene orthodenticle (otd), which establishes a specif

124 audal and activates the anterior and central gap genes orthodenticle, hunchback and Kruppel.

125 patterns of 27 genes; these include several gap genes, pair-rule genes, and anterior, posterior, tru

126 network in the early Drosophila embryo, the gap gene patterning system.

127 d by the preceding non-periodic maternal and gap gene patterns, whereas 'secondary' pair-rule genes a

128 Maternally defined spatial modes control gap genes positioning, without the classically assumed i

129 two sets of transcriptional repressors: the gap gene products and the Polycomb group proteins.

130 body, apparently due to repression by other gap gene products.

131 lysis of regulatory interactions involved in gap gene regulation based on gap gene circuits, which ar

132 ific effects on transcription: expression of gap genes remains wild-type, but striped patterning of t

133 modulates the speed of a genetic cascade of gap genes, resulting in the induction of sequential kine

134 Activated Ras or disruption of a Ras GAP gene results in reduced ERK2 activation whereas disr

135 Loss of function of a given head gap gene results in the absence of l'sc expression in it

136 at repressive interactions among overlapping gap genes show anteroposterior asymmetry with posterior

137 t represses anterior expression of the trunk gap genes so that head and thorax can properly form.

138 The cephalic gap genes specify anterior head development in the Droso

139 ion factors, including repressors encoded by gap genes such as Kruppel, knirps, giant and the mesoder

140 Since several other anteriorly expressed gap genes such as tailless and orthodenticle have previo

141 The gap gene system constitutes the most upstream zygotic la

142 xt-nearest neighbor domains, inspired by the gap gene system in the Drosophila embryo.

143 erimentally tractable regulatory network-the gap gene system of dipteran insects-using an alternative

144 tail and the hindgut depends on the terminal gap gene tailless, but beyond this the regulation of the

145 riggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb).

146 halic neurectoderm is controlled by the head gap genes tailless (tll), orthodenticle (otd), buttonhea

147 r activity elicits the transcription of two 'gap' genes, tailless (tll) and huckebein (hkb), in overl

148 of bowl mutations on the expression of leg 'gap' genes that confer regional identity on the developi

149 ring early embryogenesis, kni functions as a gap gene to control expression of segmentation genes wit

150 en LOAD and a compound genotype of the three GAPD genes was observed in all three sample sets.

151 h findings in Drosophila melanogaster, where gap genes were found to be regulated by two nonredundant

152 pposing influence of more centrally deployed gap genes which repress the response to Ras.

153 sed that Bcd directly activates the cephalic gap genes, which are the first zygotic genes to be expre

154 The earliest zygotic control is by gap genes, which determine regions of several contiguous

155 rphogens control the patterned activation of gap genes, which encode transcriptional regulators that

156 der the control of maternal-effect genes and gap genes, while late stripes are expressed by a single