ライフサイエンスコーパス: gap gene

1 his screen identified a mutation in the rab3-GAP gene.

2 he clade that contained all other eukaryotic gap genes.

3 dominal expression of the Kruppel and knirps gap genes.

4 the transcriptional regulation of posterior gap genes.

5 f Capicua (Cic), a repressor of the terminal gap genes.

6 stal (PD) axis into broad domains by the leg gap genes.

7 for pre-gastrulation expression of posterior gap genes.

8 ressive feedback loops between complementary gap genes.

9 xpression patterns of homologs of Drosophila gap genes.

10 he glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene.

11 ody plan is initiated with the activation of gap genes, a set of transcription-factor-encoding genes

12 The leg gap genes act combinatorially to initiate the expression

13 g on the comprehensive knowledge of maternal gap gene activation in Drosophila, we used loss- and gai

14 ions, transcription factors encoded by other gap genes appear to function as dedicated repressors.

15 At the anterior, terminal gap genes are also activated by the Tor pathway but Bcd

16 First, prior to the expression of pb, the gap genes are required to specify the domains where pb m

17 Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is con

18 ed by the overlapping expression of the head gap gene buttonhead (btd) and the primary pair-rule gene

19 sion is not detectably regulated by the head gap genes buttonhead or orthodenticle, by the proneural

20 Taken together, four gap genes carry enough information to define a cell's lo

21 Regulatory interactions found in gap gene circuits provide consistent and sufficient mech

22 ons involved in gap gene regulation based on gap gene circuits, which are mathematical gene network m

23 Here we present evidence that every gap gene contains multiple enhancers with overlapping ac

24 he opposing expression landscapes of the leg gap gene dachshund (dac) and the tarsal PD genes, bric-a

25 tion of orthodenticle, whereas all posterior gap gene domains of knirps, giant, hunchback, tailless a

26 set through negative regulation by the same gap gene domains that regulate stripes 3 and 7, but at d

27 nteractions among transcription factors, the gap genes, driven by maternal inputs.

28 f this gradient is transmitted to downstream gap genes, each occupying a well defined spatial domain.

29 in a combinatorial fashion with the cephalic gap genes empty spiracles (ems) and buttonhead (btd) to

30 Gap genes encode transcription factors involved in the p

31 e question of how the maternal regulation of gap genes evolved.

32 Our models reproduce gap gene expression at high accuracy and temporal resolu

33 show that torso signalling permits terminal gap gene expression by antagonising Gro-mediated repress

34 Initiation and dynamics of gap gene expression differ markedly between M. abdita an

35 The spatial pattern of gap gene expression domains along the AP axis is general

36 of the embryo, the relative positions of the gap gene expression domains in relation to one another,

37 Maternal and gap gene expression in Nasonia suggest long germ embryog

38 t can have long-range and dynamic effects on gap gene expression in the posterior.

39 ty correlates with high reliance of anterior gap gene expression on Bicoid.

40 show that Nasonia caudal is an activator of gap gene expression that acts far towards the anterior o

41 sor acts in this process to confine terminal gap gene expression to the embryonic termini.

42 e initial position of boundaries for zygotic gap gene expression, which in turn convey positional inf

43 ide consistent and sufficient mechanisms for gap gene expression, which largely agree with mechanisms

44 e induction of sequential kinematic waves of gap gene expression.

45 dal, leading to a lack of dramatic action on gap gene expression: caudal instead plays a limited role

46 th the establishment of spatially restricted gap gene-expression patterns in response to broad gradie

47 posterior region depends on combinations of gap gene factors that differ from those utilised for the

48 Over 90% of the open reading frame of gap genes for glycolytic glyceraldehyde-3-phosphate dehy

49 d orthologues of all of the Drosophila trunk gap genes from Clogmia, and determined their domains of

50 pattern suggests that hb may have acquired a gap gene function in arthropods or insects after their p

51 promoter fragment from a well characterized GAP gene, GAP-43, is sufficient to activate expression i

52 a melanogaster, hypomorphic mutations in the gap gene giant (gt) have long been known to affect ecdys

53 pression approach to examine the role of the gap gene giant (gt) in patterning anterior regions of th

54 The gap gene giant (gt) is involved in a repression mechanis

55 identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhance

56 habditis elegans homologue of the Drosophila gap gene hunchback (hb) and have designated it hbl-1 (hu

57 Activation of the gap gene hunchback (hb) by the maternal Bicoid gradient

58 In Drosophila, the gap gene hunchback (hb) is expressed in a dynamic patter

59 re shown to be orthologues to the Drosophila gap gene hunchback (hb).

60 aspects of the expression of the Drosophila gap gene hunchback are shared with its orthologs in the

61 nd function of the homolog of the Drosophila gap gene hunchback in an intermediate germ insect, the m

62 full activation of the enhancer, whereas the gap genes hunchback (hb) and knirps (kni) are required f

63 The gap genes hunchback and giant display inverted patterns

64 oad domain is required for activation of the gap genes hunchback and Kruppel.

65 Many of these genes, including the gap-gene hunchback, are initially activated in a broad d

66 ruppel, even-skipped seems to act as an uber-gap gene in Oncopeltus, indicating that it may have both

67 blastoderm requires even-skipped, which is a gap gene in Oncopeltus.

68 he possibility that giant might not act as a gap gene in short and intermediate germ insects.

69 r results suggest that giant was a bona fide gap gene in the ancestor of these insects with this role

70 We find that Oncopeltus giant is a canonical gap gene in the maxillary and labial segments and also p

71 is gene network, we are studying the role of gap genes in a representative of a basally diverging dip

72 adient that prevents expression of posterior gap genes in anterior regions.

73 a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ

74 ule system that is directly regulated by the gap genes in Drosophila.

75 By contrast, activation of gap genes in flies relies on redundant functions of Bico

76 measure this information, in bits, using the gap genes in the Drosophila embryo as an example.

77 ts of regional information from maternal and gap genes into the segmental expression of segment polar

78 y is the first demonstration that a cephalic gap gene is directly regulated by Bcd.

79 t the posterior pole, expression of terminal gap genes is mediated by the local activation of the Tor

80 The asymmetric distribution of the gap gene knirps (kni) in discrete expression domains is

81 In Drosophila, the gap gene Kruppel is required for proper formation of the

82 subfamily of genes related to the Drosophila gap gene kruppel.

83 ally, we ask whether spatial localization of gap genes Kruppel (Kr) and giant (gt) and the pair-rule

84 in the repression of three target genes, the gap genes Kruppel (Kr) and hunchback (hb), and the pair-

85 tions of several target genes, including the gap genes Kruppel (Kr), knirps (kni), and giant (gt), an

86 ds to visualize the temporal dynamics of the gap genes Kruppel and knirps, which are essential for th

87 ppy-paired 1 (Slp1), which is expressed in a gap gene-like anterior domain.

88 ese results suggest that Slp1 functions as a gap gene-like repressor, in addition to its roles at the

89 sue of Cell, Savard et al. identify a beetle gap gene, mille-pattes, that encodes an unusual polycist

90 Expression analysis in gap gene mutants showed that stripe 5 is restricted ante

91 accompanied by reduced expression levels of gap genes near the middle of large embryos.

92 enon through a systems-level analysis of the gap gene network in the scuttle fly Megaselia abdita (Ph

93 Although the qualitative structure of the gap gene network is conserved, there are differences in

94 Analysis of recent experiments on the gap gene network shows that all these signatures are obs

95 rimary morphogen inputs to the output of the gap gene network.

96 duced 10 of the 11 links in the well-studied gap gene network.

97 Here, we report the regulatory effects of gap genes on the spatial expression of disco, disco-r, a

98 Of the dorso-medially expressed head gap genes, only tailless (tll) is required for the speci

99 l regulatory region upstream of the cephalic gap gene orthodenticle (otd) is sufficient to recapitula

100 Here, we focused on the cephalic gap gene orthodenticle (otd), which establishes a specif

101 audal and activates the anterior and central gap genes orthodenticle, hunchback and Kruppel.

102 patterns of 27 genes; these include several gap genes, pair-rule genes, and anterior, posterior, tru

103 d by the preceding non-periodic maternal and gap gene patterns, whereas 'secondary' pair-rule genes a

104 two sets of transcriptional repressors: the gap gene products and the Polycomb group proteins.

105 body, apparently due to repression by other gap gene products.

106 lysis of regulatory interactions involved in gap gene regulation based on gap gene circuits, which ar

107 ific effects on transcription: expression of gap genes remains wild-type, but striped patterning of t

108 modulates the speed of a genetic cascade of gap genes, resulting in the induction of sequential kine

109 Activated Ras or disruption of a Ras GAP gene results in reduced ERK2 activation whereas disr

110 Loss of function of a given head gap gene results in the absence of l'sc expression in it

111 at repressive interactions among overlapping gap genes show anteroposterior asymmetry with posterior

112 t represses anterior expression of the trunk gap genes so that head and thorax can properly form.

113 The cephalic gap genes specify anterior head development in the Droso

114 ion factors, including repressors encoded by gap genes such as Kruppel, knirps, giant and the mesoder

115 Since several other anteriorly expressed gap genes such as tailless and orthodenticle have previo

116 The gap gene system constitutes the most upstream zygotic la

117 riggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb).

118 halic neurectoderm is controlled by the head gap genes tailless (tll), orthodenticle (otd), buttonhea

119 r activity elicits the transcription of two 'gap' genes, tailless (tll) and huckebein (hkb), in overl

120 of bowl mutations on the expression of leg 'gap' genes that confer regional identity on the developi

121 ring early embryogenesis, kni functions as a gap gene to control expression of segmentation genes wit

122 en LOAD and a compound genotype of the three GAPD genes was observed in all three sample sets.

123 h findings in Drosophila melanogaster, where gap genes were found to be regulated by two nonredundant

124 pposing influence of more centrally deployed gap genes which repress the response to Ras.

125 sed that Bcd directly activates the cephalic gap genes, which are the first zygotic genes to be expre

126 The earliest zygotic control is by gap genes, which determine regions of several contiguous

127 rphogens control the patterned activation of gap genes, which encode transcriptional regulators that

128 der the control of maternal-effect genes and gap genes, while late stripes are expressed by a single