ライフサイエンスコーパス: gap junction

1 h chemical synapses and electrical synapses (gap junctions).

2 the same components making both sides of the gap junction.

3 ood pressure involves connexin 36-containing gap junctions.

4 onized by shared parallel fiber input and by gap junctions.

5 oplasmic reticulum (ER) Ca(2+) channels, and gap junctions.

6 2 neuromuscular junctions, augmented by 1206 gap junctions.

7 an synchronize amongst IS cells via specific gap junctions.

8 ers of fibroblast cells that communicate via gap junctions.

9 zed that VLDL can modulate and reduce atrial gap junctions.

10 nearby GABAergic RME neurons through GLR-RME gap junctions.

11 toreceptors are electrically coupled through gap junctions.

12 late neuronal intracellular pathways through gap junctions.

13 y by "hijacking" neighboring neurons through gap junctions.

14 rinergic responses are conducted to SMCs via gap junctions.

15 dendrites or inside astroglia dye-filled via gap junctions.

16 electrical transmission between FSIs through gap junctions.

17 rization responses are conducted to SMCs via gap junctions.

18 t uninfected cells through contact dependent gap junctions.

19 connexin43, suggesting a role for connexin43 gap junctions.

20 xternal receptors or intracellularly through GAP junctions.

21 duced Ca(2+) release and propagation through gap junctions.

22 Cx40 and Cx43 which may impair stability of gap junctions.

23 exin 43 delocalization at intercardiomyocyte gap junctions, a change not observed in sedentary mice.

24 inals form two independent sets of homotypic gap junctions, a feature which might be important for li

25 nt declines were reversed by pharmacological gap junction activation.

26 itary tissue, direct cell contacts involving gap junctions allowed local spatial coordination of prol

27 rements and pharmacological manipulations of gap junction and dopamine receptor activity provide comp

28 cal synapses are the functional correlate of gap junctions and allow transmission of small molecules

29 plicated intercellular communication through gap junctions and calcium release from intracellular sto

30 In conclusion, MetS-VLDL modulates gap junctions and delays both atrial and ventricular con

31 persists in shaking B mutants that eliminate gap junctions and dye coupling among GF circuit neurons.

32 rces, including active dendritic mechanisms, gap junctions and extracellular signals.

33 ta130-136 transgenic mice with impaired Cx43 gap junctions and hemichannels showed significantly incr

34 signal electrically through dendrodendritic gap junctions and possibly via chemical dendritic GABAer

35 rus into mice leads to the redistribution of gap junctions and promotes ventricular tachycardia, show

36 a network of interactions between cadherins, gap junctions and spontaneous activity governs neuron as

37 ission, persisted during partial blockade of gap junctions and were mediated, in part, by AMPAergic t

38 mapped as a multiplex network with synaptic, gap junction, and neuromodulator layers representing alt

39 beta-cells propagates to the delta-cells via gap junctions, and the consequential stimulation of soma

40 ely 0.1 m/s without synaptic transmission or gap junctions, and this speed is not consistent with axo

41 Gap junctions are cellular contact sites composed of clu

42 calization in non-compact myelin areas where gap junctions are normally formed.

43 tribution of, and protein expression within, gap junctions are still debated.

44 ely accepted that synaptic transmissions and gap junctions are the major governing mechanisms for sig

45 Connexins, the constituent proteins of gap junctions, are transmembrane proteins.

46 We investigated connexin-assembled gap junctions as an alternative route for discharging la

47 ized and differentiated cells, in regulating gap junction assembly.

48 onnexin 30 (Cx30) promoted formation of Cx30 gap junctions at points of contacts between adjacent non

49 Blocking gap junctions attenuated neuronal coupling and mechanica

50 Thus, in a sparsely connected network, gap junctions between a small subset of cells can, throu

51 Gap junctions between AVA and A-MNs only allow antidromi

52 Control of synchronicity by gap junctions between GnRH1 neurons has been proposed bu

53 Intraglomerular gap junctions between MCs at the same glomerulus can gre

54 irect ionic and metabolic coupling occur via gap junctions between neurons.

55 red RPE cell integrity and communication via gap junctions between RPE and neural retina during RGC n

56 acilitated by D2-like receptor modulation of gap-junctions between PCB and the hook sensillum.

57 s gap junction genes, and drugs that inhibit gap junctions blocked neural responses in SMCs, but not

58 ing intact adult and embryonic hearts with a gap junction blocker, beta-glycyrrhetinic acid (BGA).

59 ous hyperactivity using meclofenamic acid, a gap junction blocker.

60 e involved in regulating the permeability of gap junctions by regulating their size.

61 ts that some types of chemical modulation of gap junctions can be executed through the underlying mec

62 ng cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resti

63 Disruption of GLR-RME gap junctions causes misaccumulation of axonal markers i

64 ons and the consequences on hemichannels and gap junction channel (GJC) functions remain unknown.

65 pse is based on electrical properties of the gap junction channel encompassing two fast and two slow

66 kin-Huxley equations and a 36-state model of gap junction channel gating to simulate electrical signa

67 ied in the patient displayed no formation of gap junction channel plaques.

68 ssion of Cx26-Asp50Asn and wild-type Cx26 in gap junction channel plaques.

69 e X-ray crystal structures of the human Cx26 gap junction channel with and without bound Ca(2+).

70 rived lipid vesicles that contain functional gap junction channels and encapsulate molecular cargos.

71 evel of connexin43 (Cx43), a protein forming gap junction channels and hemichannels associated with d

72 mily of membrane-spanning proteins that form gap junction channels and hemichannels.

73 KEY POINTS: Gap junction channels are essential for the formation an

74 en adenosine receptors and the regulation of gap junction channels in endothelial cells of the blood-

75 s a multicellular system and for the role of gap junction channels in exacerbating the effects of dec

76 Gap junction channels mediate intercellular signalling t

77 Both failed to form gap junction channels or hemichannels when expressed alo

78 Here we show that these vesicles form gap junction channels with cells, opening a direct and e

79 results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule

80 endently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative e

81 43 showed a transdominant inhibition of Cx43 gap junction channels, without reductions in Cx43 protei

82 pears to be unrelated to its role in forming gap junction channels.

83 ins partake in proposed gating mechanisms of gap junction channels.

84 detail, the modulation of ionic transport in gap-junction channels (GJCs).

85 ness in humans, which are knock-outs for the gap-junction channels connexin 26 and connexin 30 genes,

86 fness in humans, which are knockouts for the gap-junction channels connexin 26 and connexin 30 genes,

87 vide a tool for similar exploration of other gap junction circuits.

88 Activation of Tyk2 led to a decrease in Cx43 gap junction communication by increasing the turnover ra

89 dicate that, like Src, Tyk2 can also inhibit gap junction communication by phosphorylating Cx43.

90 bited only a mild transdominant reduction in gap junction communication when co-expressed with Cx30.

91 pontaneous activity, cadherin expression and gap junction communication.

92 in astrocyte-like glia and in changes in the gap-junction component innexin2 in cortex glia.

93 R1, namely, that it directly regulates major gap junction components, contributing to proper cell-cel

94 promotes the assembly of carcinoma-astrocyte gap junctions composed of connexin 43 (Cx43).

95 lls (DCs) and pillar cells (PCs), coupled by gap-junctions composed of connexin 26 (Cx26) and Cx30.

96 pike-triggered spikelets transmitted through gap junctions conditionally trigger postjunctional spike

97 nism has long been identified as electrical: gap junctions conduct ions between CMs, triggering membr

98 r passive electrical properties and the mean gap junction conductance (0.9 nS).

99 In HF-AS, enhancing gap junction conductance (with rotigaptide) increased co

100 tifying potassium current (IK1) density, and gap junction conductance.

101 Gap junctions confer interconnectivity of the cytoplasm

102 tis elegans The molecular composition of the gap junctions connecting RMG hub neurons with sensory sp

103 also demonstrated lowered expression of the gap junction connexin 43.

104 More than 70 mutations in the gap junction connexin43 (Cx43) gene, GJA1, are associate

105 tive high-frequency hearing, suggesting that gap junctions contribute to passive cochlear mechanics a

106 ub-and-spoke circuit of neurons connected by gap junctions controls aggregation behavior and related

107 Connexin36 gap junctions coordinate glucose-induced calcium oscilla

108 ells via cyclic nucleotide diffusion through gap junctions could provide a general mechanism for dive

109 In the thalamocortical system, gap junctions couple inhibitory neurons that are similar

110 ly and in the islet model that reductions in gap junction coupling allow progressively greater glucos

111 Ca(2+) and Na(+) signalling, K(+) buffering, gap junction coupling and metabolism.

112 vity compared to WT mice, indicating reduced gap junction coupling between neurons.

113 Here we examined the mechanisms by which gap junction coupling contributes to islet dysfunction i

114 Loss of gap junction coupling disrupts these dynamics, similar t

115 2-PAA stimulated cAMP synthesis and enhanced gap junction coupling in a concentration-dependent manne

116 ors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures f

117 cal link between adenosine receptors and the gap junction coupling in endothelial cells of the blood-

118 in HF but not CTL hearts, suggesting weaker gap junction coupling in HF-AS versus CTL-AS myocytes.

119 adenosine receptor subtype A2B increases the gap junction coupling in the human blood-brain barrier e

120 ound in NDM suppress [Ca2+], and the role of gap junction coupling in this suppression.

121 nels as a physiological link that integrates gap junction coupling into the adenosine receptor-depend

122 Although the increased gap junction coupling is cAMP-dependent, neither the pro

123 eral mechanisms underlying the disruption to gap junction coupling under conditions associated with t

124 Interestingly, we found that gap junction coupling was modulated by spontaneous retin

125 Decreases in gap junction coupling were dependent on NO-regulated PKC

126 ne in the coordination of [Ca(2+)] dynamics, gap junction coupling, and insulin secretion dynamics wi

127 It is shown how reduced IK1 density and gap junction coupling, as observed in heart failure, inc

128 ent disrupted calcium dynamics and decreased gap junction coupling, in the absence of disruptions to

129 dicted for many mutations upon reductions in gap junction coupling, where stochastic noise played a s

130 ompletely devoid of bona fide astrocytes and gap junction coupling, whereas coupled astrocytes were a

131 s and a consecutive sustained enhancement of gap junction coupling.

132 gonist 2-phenylaminoadenosine (2-PAA) on the gap junction coupling.

133 a(2+) influx, which leads to the increase in gap junction coupling.

134 tive KATP channels under different levels of gap junction coupling.

135 s the overall islet response, as a result of gap junction coupling.

136 nsider the neuroprotective role of astrocyte gap junction coupling.

137 ta in modulating cytokine-induced changes in gap junction coupling.

138 termine their respective roles in modulating gap junction coupling.

139 by insulin secretion, calcium dynamics, and gap junction coupling.

140 by which pro-inflammatory cytokines mediate gap junction coupling.

141 suppressed the 2-PAA-related enhancement of gap junction coupling.

142 not affect the 2-PAA-related enhancement of gap junction coupling.

143 In lenses in which gap-junction coupling is increased, the central pressure

144 d, the central pressure is lower, whereas if gap-junction coupling is reduced, the central pressure i

145 We demonstrated that when gap junction-deficient HeLa cells expressed the N14K and

146 red a suppression of alpha-cell activity via gap junction-dependent activation of delta-cells.

147 agon secretion is mediated by beta-cells via gap junction-dependent activation of delta-cells/somatos

148 We show that increased CO2 elicits a gap junction-dependent release of PGE2.

149 beled putative MC dendrites further revealed gap junctions distributed uniformly along the apical den

150 Gap junctions dynamically remodel to adapt to sympatheti

151 ns are disrupted by manipulating cadherin or gap junction expression.

152 Vertebrates have 2 gap junction families: pannexins (Panxs) and connexins (

153 -out, indicated that lactate anions permeate gap junctions faster than highly-buffered H(+) ions.

154 release whereas electrical synapses utilize gap junctions for direct ionic and metabolic coupling.

155 To utilize gap junctions for molecular delivery we have developed C

156 d-type (WT) levels and significantly reduced gap junction formation and function in osteoblasts and o

157 connexin family of membrane proteins enable gap junction formation and homeostasis, supporting commu

158 e affected tissues show remarkable disrupted gap junction formation and significant upregulation of c

159 A deficiency in LRP6 disrupts Cx43 gap junction formation and thereby impairs the cell-to-c

160 , we report the scaffold function of LRP6 in gap junction formation of cardiomyocytes.

161 fibroblasts and fibroblasts are connected by gap junctions formed by proteins such as connexin-43, wh

162 Astrocytes are extensively connected by gap junctions formed of connexins, which also exist as f

163 e-cell imaging data further demonstrate that gap junctions formed of the tail-deleted Cx32 are highly

164 merging as complex structures, consisting of gap junction-forming connexin proteins and also multiple

165 apses in zebrafish, Danio rerio, require two gap-junction-forming Connexins for formation and functio

166 causes only hearing loss, exhibited impaired gap junction function and showed no transdominant intera

167 d with human pathologies and how they affect gap junction function.

168 PDGFRalpha(+) cells express gap junction genes, and drugs that inhibit gap junctions

169 Electrical synapses are created by gap junction (GJ) channels that provide direct ionic com

170 is coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently described t

171 ctrical interactions with cardiomyocytes via gap junction (GJ) channels.

172 role of zonula occludens-1 protein (ZO-1) in gap junction (GJ) function, we generated and analyzed a

173 ury associated with a down-regulation of the gap junction (GJ) protein connexin43 (Cx43).

174 Gap-junction (GJ) channels formed from connexin (Cx) pro

175 Gap junctions (GJs) are important for maintenance of CNS

176 Gap junctions (GJs) exhibit a complex modus of assembly

177 ells, and presents as hemichannels (HCs) and gap junctions (GJs) on the cell membrane.

178 Gap junctions (GJs), intercellular channels composed of

179 gap junctional protein innexin shaking-B to gap junctions (GJs).

180 synchronization of myometrial cells through gap junctions (GJs).

181 Delivering drugs through gap junctions has the potential to boost the effectivene

182 the significance of connexin 43 (Cx43)-based gap junction in maintaining the homeostasis of BTB in th

183 These results reveal roles of gap junctions in a complex behavior at cellular resoluti

184 We investigated the properties of gap junctions in cerebellar interneurons by combining pa

185 ediated by an injury-induced upregulation of gap junctions in glial cells surrounding DRG neurons.

186 ur study reveals the function of glia-neuron gap junctions in neuronal axon specification and shows t

187 ic mice with functional hemichannels but not gap junctions in osteocytes did not display a significan

188 Notably, it is abolished by a mutation in gap junctions in projection neurons and is found to be m

189 pillary diameter by pericytes and a role for gap junctions in vascular network interactions.

190 ncreased vascular monolayer permeability and gap junctions, increased NCAM expression and produced ha

191 Conversely, in CTL hearts, gap junction inhibition (carbenoxolone) decreased coupli

192 The gap junction inhibitor carbenoxolone increases the spont

193 e delta-cells was rapid and sensitive to the gap junction inhibitor carbenoxolone, whereas the effect

194 expressed by astrocytes in the CNS and forms gap junction intercellular communications between astroc

195 tractile signal apparently spreading through gap junctions into neighboring muscle cells.

196 ated in the granulosa cells diffuses through gap junctions into the oocyte, maintaining meiotic proph

197 szlay et al. (2016) shows that the number of gap junctions is the dominant factor underlying the stre

198 isolated a missense mutation in the UNC-7(L) gap-junction isoform, which perturbs DOP-2 signaling in

199 t the tissue level, we modeled the increased gap junction lateralization and lower conduction velocit

200 ogical data, makes general predictions about gap junctions: locations close to the soma; relatively s

201 , long-range activation of astroglia through gap junctions may promote recurrent seizures on the mode

202 These results demonstrate that gap junctions may serve as an amplifier of chemical tran

203 The orally bioavailable modulators of gap junctions meclofenamate and tonabersat break this pa

204 behaviors, indicating that UNC-9-containing gap junctions mediate RMG signaling.

205 pply metabolic substrates to neurons through gap junction-mediated astroglial networks.

206 ma occurs secondary to RGC death through the gap junction-mediated bystander effect.

207 Gap junction-mediated electrical coupling between beta-c

208 cells (MTCs) by GABA release from SACs: (2) gap junction-mediated electrical coupling is strong for

209 hat both intact pericyte function as well as gap junction-mediated signaling across the vascular netw

210 ganglion cells (RGCs) was strongly shaped by gap-junction-mediated electrical coupling within the bip

211 Our results demonstrate that ipRGCs form gap junction microcircuits during development that are m

212 Electrical synapses, formed by gap junctions, modulate sensory circuits.

213 results suggest that lateral excitation via gap junctions modulates odor tuning in the antennal lobe

214 Here we show that ipRGCs form an extensive gap junction network with other retinal neurons, includi

215 We determined that this modulation of ipRGC gap junction networks occurs via dopamine released by wa

216 periments to show that ipRGCs form extensive gap junction networks that strongly contribute to the ov

217 nal waves mediate dopaminergic modulation of gap junction networks to regulate pre-vision light respo

218 hotoreceptors, increased the extent of ipRGC gap junction networks, thus increasing the number of lig

219 ox balance using a reducing agent-indicating gap junction nexus stability is modifiable.

220 dwork for exploration of mechanisms by which gap junction nexus stability modulates intercellular com

221 nd as structural adhesion complexes known as gap junction nexuses.

222 taneous conductance-voltage rectification of gap junctions on an asymmetry of cell-to-cell signaling.

223 The facilitating effect of intraglomerular gap junctions on interglomerular synchrony is through tr

224 is determined due to the inaccessibility of gap junctions on the dendritic tree.

225 We observe that with weak gap junction or excitatory synaptic coupling, network he

226 Moreover, we find that blockade of gap junctions or ablation of Cx36 significantly reduces

227 ia electrical or chemical connections (i.e., gap junctions or excitatory/inhibitory synapses).

228 Pharmacological blockade of gap junctions or genetic ablation of connexin 36 (Cx36)

229 Drugs that block K(+) channels and gap junctions or that activate Ca(++) channels significa

230 Many cells in the CNS communicate via gap junctions, or electrical synapses, the regulation of

231 ent stem cells (hiPSCs) contained functional gap junctions partially contributed by Connexin 45 (CX45

232 Our results establish that the number of gap junctions per connection is the main determinant of

233 and perifusion insulin secretion assays, and gap junction permeability measurements.

234 lly connect the cytoplasm of adjacent cells, gap junctions permit transport of a diverse range of mol

235 ell surface, there were stark differences in gap junction plaque formation, gap junctional intercellu

236 arkedly increases endogenous myocardial Cx43 gap junction plaque size at the intercalated discs.

237 within the connexin proteins that determine gap junction plaque stability.

238 nnexin isoform, the cluster of channels (the gap junction plaque) can be stably or fluidly arranged.

239 Ca(2+) in turn induces the formation of new gap junction plaques and a consecutive sustained enhance

240 tations (Y151C, V181M, R183C and L239I) form gap junction plaques and produce levels of junctional co

241 ressed expression results in accumulation of gap junction plaques at the plasma membrane.

242 The S183F mutant formed some gap junction plaques but was largely retained within the

243 nhancement was accompanied by an increase in gap junction plaques formed by Cx43.

244 164Q and C168Y) either form no morphological gap junction plaques or, if they do, produce little or n

245 consistently exhibit overt reduction of Cx43 gap junction plaques without any abnormality in Wnt sign

246 n potential firing in MCs through changes in gap junction properties.

247 anslated small C terminus isoform, GJA1-20k (Gap Junction Protein Alpha 1- 20 kDa), which is required

248 oglein (DSG)1, tight junction protein 2, and gap junction protein alpha.

249 + mice carry a mutation in one allele of the gap junction protein alpha1 gene (Gja1), resulting in a

250 Recent studies indicate that the gap junction protein connexin 43 (Cx43) renders GBM cell

251 estricted to intercalated discs and binds to gap junction protein connexin 43 (Cx43).

252 mined whether dysregulated expression of the gap junction protein connexin 43, which has been observe

253 d by mutations in the GJB1 gene encoding the gap junction protein connexin32 (Cx32).

254 ctrical synapses that depend strongly on the gap junction protein connexin36 (Cx36).

255 ectrical synapses, most of which require the gap junction protein connexin36 (Cx36).

256 We targeted the gap junction protein connexin43 (Cx43) responsible for m

257 accompanied by overt mislocalization of the gap junction protein connexin43 (Cx43).

258 al protein plakoglobin and the major cardiac gap junction protein Cx43 were markedly diminished in bu

259 y mutations in GJB1, which codes for Cx32, a gap junction protein expressed by Schwann cells and olig

260 n and increased expression of connexin 43, a gap junction protein involved with labor.

261 Connexin26 (Cx26) is a gap junction protein that oligomerizes in the cell to fo

262 Connexin 43 (gap junction protein) is expressed in pigmented and albi

263 The gap junction protein, connexin43 (Cx43), has critical ro

264 Wnt signaling, followed by the expression of gap junction protein, connexin43.

265 ion of Cx43 (connexin 43), the major cardiac gap junction protein, is often associated with arrhythmi

266 ealed the presence of Cx43, the main cardiac gap junction protein, localized to cell-cell borders.

267 onnexin 43 (Cx43), the most widely expressed gap junction protein.

268 l (A88V) mutation in the gene coding for the gap-junction protein connexin30 (Cx30) protects the coch

269 Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30

270 Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30

271 ciates with intercalated discs, and integral gap junction proteins Cx43 (connexin 43), Cx45 (connexin

272 3 and Cx43 are the most abundantly expressed gap junction proteins from each family.

273 anscription factors Foxc2 and Nfatc1 and the gap junction proteins Gjc2, Gja1, and Gja4 were temporos

274 Gap junction proteins mediate signaling communication by

275 In contrast, gap junctions provide a direct route to the cytoplasm th

276 posed of desmosomes, adherens junctions, and gap junctions provide the structural backbone for coordi

277 Here we describe a RGC that relies on gap junctions, rather than chemical synapses, to convey

278 We further uncover that GLR-RME gap junctions regulate RME axon specification through ac

279 raction with a molecular partner involved in gap junction regulation.

280 ays a central role in angiotensin II-induced gap junction remodeling and arrhythmogenesis.

281 To identify the mechanisms regulating gap junction remodeling in cardiac disease, we sought to

282 Gap junction remodeling is well established as a consist

283 The mechanisms responsible for gap junction remodeling that include alterations in the

284 nt role in disease progression by regulating gap junction remodeling.

285 The defect in Cx43 gap junction resulting from LRP6 reduction is attributab

286 a(2+) channel, only via the hemichannels and gap junction routes.

287 Indeed, selective block of gap junctions significantly reduced propagation but not

288 old labeling revealed a large variability in gap junction size and that only 18% of the 340 channels

289 racteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix pro

290 system in mice, we show that knockout of the gap junction subunit connexin 43 in astrocytes throughou

291 ctions between the NALCN, K(+) channels, and gap junctions that mediate regulation of locomotion in C

292 ound that it was the ACs coupled to RGCs via gap junctions that were lost in glaucoma, whereas uncoup

293 The use of antidromic-rectifying gap junctions to amplify chemical transmission is potent

294 Specifically, we demonstrate that using gap junctions to deliver the chemotherapeutic doxorubici

295 ower expression of connexin43, a major known gap junction unit in vascular cells.

296 The potent role of gap junctions was confirmed in patch-clamp recordings in

297 the tail-deleted Cx32, increases the size of gap junctions, whereas the expression of the tail-delete

298 we developed methods to inhibit unc-9-based gap junctions with dominant-negative unc-1 transgenes.

299 localized at appositional membranes forming gap junctions with enormous cytoplasmic protein accumula

300 ere is remodeling of the plicate domains and gap junctions with vacuole formation around and between