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1 irect binding of the drug to the pore of the gap junction channel.
2 at contribute to the ion selectivity of this gap junction channel.
3 th that generated by IP(3) diffusing through gap junction channels.
4 uted to a direct effect on the properties of gap junction channels.
5 r partners, thus modifying the regulation of gap junction channels.
6 connexin selectivity, or gating polarity of gap junction channels.
7 modulated by the connexin composition of the gap junction channels.
8 directly on, or intimately associated with, gap junction channels.
9 ustering may be a requirement for opening of gap junction channels.
10 ins partake in proposed gating mechanisms of gap junction channels.
11 ing of LR determinants through intercellular gap junction channels.
12 gre proteins may join in forming heteromeric gap junction channels.
13 gene v-src appears to cause acute closure of gap junction channels.
14 ce states are a commonly observed feature of gap junction channels.
15 astrocytes by direct signaling via homotypic gap junction channels.
16 cortex are coupled together into clusters by gap junction channels.
17 ake exhibited properties similar to those of gap junction channels.
18 of the astrocyte-to-astrocyte couplings via gap junction channels.
19 g cells, a process thought to be mediated by gap junction channels.
20 : Connexins are the pore forming subunits of gap junction channels.
21 d stability, and unitary conductance of Cx50 gap junction channels.
22 le mutants of Ala-40 did not form functional gap junction channels.
23 Connexin proteins are the subunits of gap junction channels.
24 st in part, by fast (in minutes) turnover of gap junction channels.
25 by two adjacent hemichannels, which can form gap junction channels.
26 llular electrical signaling independent from gap junction channels.
27 nnexins is an important mechanism regulating gap junction channels.
28 (Cx43) is a transmembrane protein that forms gap junction channels.
29 ercellular communication that occurs through gap junction channels.
30 pears to be unrelated to its role in forming gap junction channels.
31 requires the expression of connexin43 (Cx43) gap junction channels.
32 up fluorescent tracer molecules permeant to gap junction channels.
33 use (19), revealing significant diversity in gap junction channels.
34 ty ratios were unchanged from wild-type Cx40 gap junction channels.
35 ns during embryogenesis, can form oligomeric gap-junction channels.
37 namics of intercellular dye transfer through gap junction channels, a technique we named Trojan-local
42 ell communication through connexin 43 (Cx43) gap junction channels also plays a major role in the wou
43 odels for a symmetrical (homotypic) connexin gap junction channel and were described by either a one-
44 rived lipid vesicles that contain functional gap junction channels and encapsulate molecular cargos.
46 evel of connexin43 (Cx43), a protein forming gap junction channels and hemichannels associated with d
47 ichannels is important to assess the role of gap junction channels and hemichannels in health and dis
52 duces intercellular communication by closing gap junction channels and subsequently internalizing gap
53 ceptor" model for pH gating of Cx40 and Cx43 gap junction channels and suggest that interactions betw
55 , no information exists on the prevalence of gap junction channels and their function in the aging br
56 s, that have permeability similar to that of gap junction channels and thus can be utilized in studie
57 gomerize with each other to form heteromeric gap junction channels and to determine the functional an
66 unds antagonize the inhibition suggests that gap junction channels are regulated by a complex interpl
68 dependence and single-channel conductance of gap junction channels as well as for studies of chemical
71 Our data suggest that the selectivity of gap junction channels at intercalated disks is increased
74 HCs) are hexamers of connexins that can form gap-junction channels at points of cell contacts or "fre
75 member of the family of proteins that forms gap junction channels between cells, was immunoaffinity-
76 l gating characteristics of connexin (Cx) 50 gap junction channels between pairs of N2A neuroblastoma
77 Addition of carbenoxolone (200 microM), a gap junction channel blocker, to the media stopped spont
79 and dental pain and if pannexin or pannexin/gap junction channel blockers reduce stimulation-depende
80 re inhibited by three structurally different gap-junction channel blockers, but not by the P2X(7) blo
83 a8 connexin (Cx50 or Gja8), subunits of lens gap junction channels, cause a variety of cataracts via
84 gests that the path of communication through gap junction channels circumvents the node and streak.
87 increases the chemical gating sensitivity of gap junction channels composed of connexin 32 and decrea
90 ness in humans, which are knock-outs for the gap-junction channels connexin 26 and connexin 30 genes,
91 fness in humans, which are knockouts for the gap-junction channels connexin 26 and connexin 30 genes,
94 enamic acid (FFA) and related derivatives on gap junction channel currents, applying the dual whole-c
95 results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule
96 The authors conclude that the roles of lens gap junction channels depend not only on the primary seq
97 hat chemical regulation of connexin43 (Cx43) gap junction channels depends on the integrity of the ca
98 e-channel conductance of the hCx37 homotypic gap junction channel does not saturate with transjunctio
99 pse is based on electrical properties of the gap junction channel encompassing two fast and two slow
100 mice showed marked perturbations of cardiac gap junction channel expression and localization, includ
102 (Cx32) can oligomerize to form intracellular gap junction channels facilitating a shorter pathway for
105 ontrast, quinine did not substantially block gap junction channels formed by Cx26, Cx32, Cx40, and Cx
110 y of critical importance because loss of the gap junction channel-forming proteins, connexins Cx32 an
112 eptides as regulators of Cx43 expression and gap junction channel function in dissociated myocytes an
113 vity of connexin proteins was independent of gap junction channel function, because physical isolatio
115 kin-Huxley equations and a 36-state model of gap junction channel gating to simulate electrical signa
117 reduces junctional conductance by modifying gap junction channel gating, while maintaining cells in
119 ssociated with germline inactivation of this gap junction channel gene and uncovered an essential rol
120 d characterization of smedinx-11--an innexin gap junction channel gene expressed in the adult stem ce
122 ons and the consequences on hemichannels and gap junction channel (GJC) functions remain unknown.
123 amily of vertebrate proteins constituents of gap junction channels (GJCs) that connect the cytoplasm
127 contrast, anandamide, a blocker of connexin gap junction channels, had no effect of cell-to-cell com
132 mbrane and forms functional hemichannels and gap junction channels; however, it causes cell death eve
133 effects of VVAA mutants on hemichannels and gap junction channels imply that inter-TM interactions c
136 en adenosine receptors and the regulation of gap junction channels in endothelial cells of the blood-
137 s a multicellular system and for the role of gap junction channels in exacerbating the effects of dec
138 but electrophysiological characterization of gap junction channels in freshly isolated vascular smoot
140 unidirectionally throughout the epiblast by gap junction channels in order to pattern left-sided Shh
142 (Cx26) and Cx30 are predominant isoforms of gap junction channels in the cochlea and play a critical
143 ible for acidification-induced uncoupling of gap junction channels in the heart and in other Cx43-exp
145 NSY-5 forms hemichannels and intercellular gap-junction channels in Xenopus oocytes, consistent wit
146 the phosphorylation state can regulate Cx32 gap junction channels, in addition to the direct interac
147 ally useful method to block certain types of gap junction channels, including those between neurons t
150 Intercellular coupling via connexin40 (Cx40) gap junction channels is an important determinant of imp
152 egarding the regulation of connexin43 (Cx43) gap junction channels is that, upon intracellular acidif
153 fferent combinations of Cx46 and Cx50 within gap junction channels lead to unique biophysical propert
154 oposed that intercellular signalling through gap junction channels may influence aspects of follicula
155 oleamide- induced inactivation of glial cell gap junction channels may serve to regulate communicatio
158 hether intercellular coupling via connexin43 gap junction channels modulates hormonal responsiveness
159 d the unitary conductance of hCx37 homotypic gap junction channels more than predicted by screening a
160 of junctional resistance (or conductance) of gap junction channels or connexin hemichannels in the du
162 second messengers, including Ca(2+), through gap junction channels, or by a paracrine pathway that in
166 e the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric
167 s appears to interfere with formation of new gap junction channels, presumably by reducing insertion
168 ferent protein families, including the human gap junction channel protein connexin 26, the ATP bindin
172 e-specific patterns of expression of diverse gap junction channel proteins (connexins), and regulator
173 cytes can rapidly adjust their expression of gap junction channel proteins in response to changes in
174 Atrial myocytes express three different gap junction channel proteins-connexin43 (Cx43), connexi
176 endently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative e
179 tran (to 0.22) and heptanol, an uncoupler of gap junction channels, significantly decreased it (to 0.
182 e integral membrane proteins forming aqueous gap junction channels that allow the diffusional exchang
183 Connexins (Cx) are protein components of gap junction channels that permit the passage of small m
184 omeric, there exists a multitude of possible gap-junction channels that could underlie the homotypic
185 Contrary to previous conceptions of the gap junction channel, the residues lining the pore are l
187 ouring progenitors through connexin43 (Cx43) gap junction channels, thereby coordinating the migratio
188 Thus, the data indicate that halothane gates gap junction channels to the closed state in a dose-depe
191 d rats showed that the density of fiber cell gap junction channels was approximately the same, intrac
193 g current observed for Cx26/Cx32 heterotypic gap junction channels were determined in transfected mou
195 sticated cell-cell communication network via gap junction channels, which are made up of at least thr
196 e X-ray crystal structures of the human Cx26 gap junction channel with and without bound Ca(2+).
197 extent to which malignant glioma cells form gap junction channels with astrocytes from either adult
199 clamp revealed that endothelial cells formed gap junction channels with Cx43+/+ but not Cx43-/- proge
200 pressing glioma cells established functional gap junction channels with host astrocytes and dispersed
201 further demonstrated that blocking pannexin/gap junction channels with probenecid or carbenoxolone s
202 ge as second messenger molecules endows Cx36 gap junction channels with properties well suited for me
204 olecule being sufficient to occlude the Cx40 gap junction channel within the KCl permeation pathway.
205 43 showed a transdominant inhibition of Cx43 gap junction channels, without reductions in Cx43 protei
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