ライフサイエンスコーパス: gap junction protein

1 ncreased level of connexin 43, an astroglial gap junction protein.

2 ock-out (KO) mice for connexin36, a neuronal gap junction protein.

3 onnexin 43 (Cx43), the most widely expressed gap junction protein.

4 a molecular crosstalk between desmosomal and gap junction proteins.

5 hrough persistent expression and function of gap junction proteins.

6 nexin1, a vertebrate homolog of invertebrate gap junction proteins.

7 eir mammalian homologues, the pannexins, are gap junction proteins.

8 ny known intercellular adhesion proteins and gap junction proteins.

9 of this regulation, we studied photoreceptor gap junction proteins.

10 or by pannexins, a newly described family of gap junction proteins.

11 tion channels and subsequently internalizing gap junction proteins.

12 on levels or posttranslational processing of gap junction proteins.

13 ression of connexin 43 (Cx43) (also known as gap junction protein alpha 1 [GJA1]).

14 how that de novo missense mutations in GJA1 (gap junction protein alpha 1) cause EKVP.

15 anslated small C terminus isoform, GJA1-20k (Gap Junction Protein Alpha 1- 20 kDa), which is required

16 35, and a candidate gene (GJA4) encoding the gap junction protein alpha-4 (connexin 31, Cx31) was exc

17 oglein (DSG)1, tight junction protein 2, and gap junction protein alpha.

18 ly unidentified proteolytic targeting of the gap junction protein, alpha 1(GJA1); however, surprising

19 + mice carry a mutation in one allele of the gap junction protein alpha1 gene (Gja1), resulting in a

20 pled VBN neurons require Cx36 but that other gap junction proteins also contribute.

21 Fibrosis, cellular dysfunction, and gap junction protein alterations occur in AF and cause c

22 We analyzed the effects of mutating gap junction proteins and blocking neuromuscular transmi

23 Our data demonstrate a novel role for gap junction proteins and suggest gap junction-mediated

24 d expression of connexin 36 (Cx36) (neuronal gap junction protein), and inactivation of group II mGlu

25 Although mutations in ion channels, gap junction proteins, and signaling molecules have been

26 Connexins (Cxs) are the main mammalian gap junction proteins, and the distribution of some Cx s

27 uence homology to innexins, the invertebrate gap junction proteins, and which also shares topological

28 These gap junction proteins are expressed with overlapping cel

29 servations indicate that although astrocytic gap junction proteins are maintained at high levels thro

30 nd expression of connexin 36 (Cx36; neuronal gap junction protein) are regulated by an interplay betw

31 tions in one gene, connexin 26 (encoding the gap junction protein beta 2), may be responsible for hal

32 We report a missense mutation in the gap junction protein beta-3 (encoding Connexin 31), whic

33 yopathy, a 308,769 base pair deletion in the Gap Junction Protein, beta 6 (GJB6) gene that causes Hea

34 Mutations in GJB2 (gap junction protein, beta-2) are the major cause of aut

35 cytes from human articular cartilage express gap junction proteins called connexins (Cxs).

36 of a set of diseases caused by mutations in gap junction proteins called connexins.

37 Functional expression of gap junction proteins can be obtained conveniently with

38 Dynamically regulated expression of the gap junction protein connexin (Cx)43 plays pivotal roles

39 the proper function and distribution of the gap junction protein connexin (Cx)43.

40 Mutations in the gene encoding the cochlear gap junction protein connexin 26 (CX26) cause prelingual

41 The gap junction protein connexin 26 (Cx26) has been detecte

42 including a significant upregulation of the gap junction protein connexin 26 (Cx26).

43 tly, mutations in the GJB6 gene encoding the gap junction protein connexin 30 have been shown to caus

44 ents with mutations in the gene encoding the gap junction protein connexin 32 (Cx32), which is expres

45 ents with mutations in the gene encoding the gap junction protein connexin 32 (Cx32).

46 ganglion cells in mice lacking the neuronal gap junction protein connexin 36 (Cx36) have nearly norm

47 Utilizing islets from a gap junction protein connexin 36 knockout mouse model to

48 signaling, and required the presence of the gap junction protein connexin 36.

49 s homeodomain-only protein and GATA4 and the gap junction protein connexin 40.

50 A recent study showed that gap junction protein connexin 43 (Cx43) and desmosome pr

51 s indicate that the expression levels of the gap junction protein connexin 43 (cx43) are profoundly d

52 ession and distribution of the intercellular gap junction protein connexin 43 (Cx43) in dogs.

53 The gap junction protein connexin 43 (Cx43) is absent in the

54 Lateralization of the ventricular gap junction protein connexin 43 (Cx43) occurs in epicar

55 Recent studies indicate that the gap junction protein connexin 43 (Cx43) renders GBM cell

56 Astrocytic tumors express the gap junction protein connexin 43 (Cx43), and we show her

57 estricted to intercalated discs and binds to gap junction protein connexin 43 (Cx43).

58 blast growth factor (bFGF), NPCs express the gap junction protein connexin 43 and are dye-coupled.

59 e comparison of Kit immunoreactive cells and gap junction protein connexin 43 in both small intestine

60 sion of several contractile proteins and the gap junction protein connexin 43 through cAMP/PKA signal

61 sion of several contractile proteins and the gap junction protein connexin 43 through cAMP/PKA signal

62 in and beta1D integrin were reduced, and the gap junction protein connexin 43 was mislocalized to the

63 the localization pattern and function of the gap junction protein connexin 43 were examined in vivo i

64 src produces tyrosine phosphorylation of the gap junction protein connexin 43, decreases gap junction

65 utations in the gene GJA1, which encodes the gap junction protein connexin 43, underlie oculodentodig

66 mined whether dysregulated expression of the gap junction protein connexin 43, which has been observe

67 UMR 106-01 cells predominantly express the gap junction protein connexin 45 (Cx45), are poorly dye

68 reflected decreased expression levels of the gap junction protein connexin 46 (Cx46).

69 nant mutations in the GJB2 gene encoding the gap junction protein connexin-26, suggesting an etiologi

70 from mutations in the gene GJB3 encoding the gap junction protein connexin-31 (Cx31).

71 rm running on the expression of the neuronal gap junction protein connexin-36 among inhibitory intern

72 ative IIF, and even cell strains lacking the gap junction protein connexin-36 exhibited nonnegligible

73 tion, other signaling molecules, such as the gap junction protein connexin-43 (Cx43), also influence

74 ocity correlated with a 53% reduction in the gap junction protein connexin-43.

75 Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30

76 Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30

77 s, the transcription factor Hf1b/Sp4 and the gap junction proteins connexin 40 and connexin 43 were m

78 entified a mutation in the gene encoding the gap-junction protein connexin 26 (Cx26) that segregates

79 ated desmosomal protein plakoglobin, and the gap-junction protein connexin-43.

80 To define further the mechanisms of gap junction protein (connexin (Cx)) oligomerization wit

81 mapped previously to 6q25-26, human cardiac gap junction protein (connexin 43) mapped previously to

82 s cells without detectably increasing either gap junction protein (connexin) synthesis or assembly.

83 y understood but probably involve changes in gap junction protein (connexin) synthesis, assembly into

84 audin 1, 14, 16, and zona occludens 2), nine gap junction proteins (connexin 26, 30, 30.3, 31, 32, 40

85 Previously, we showed that expression of the gap junction protein, connexin (Cx) 43, is increased by

86 synapses) and the expression of the neuronal gap junction protein, connexin 36 (Cx36), transiently in

87 The astrocytic gap junction protein, connexin 43 (Cx43), was identified

88 companied by tyrosine phosphorylation of the gap junction protein, connexin 43 (Cx43).

89 In cultured corneal fibroblasts, the gap junction protein, connexin 43, was highly expressed

90 A significant decrease in the gap junction protein, connexin 43, was observed in the N

91 in tissue culture that expressed a specific gap junction protein, connexin 43.

92 A significant decrease in the gap junction proteins, connexin-43 and connexin-40, was

93 The lens gap-junction protein, connexin 56, is modified by phosph

94 They also express cardiac gap-junction protein, connexin-43, similar to CMs and sy

95 o contiguous genes respectively encoding the gap junction protein connexin26 (Cx26) and connexin 30 (

96 Mutations in the gene GJB2, encoding the gap junction protein Connexin26 (Cx26), are the most pre

97 The isoelectric points of the gap junction proteins connexin26 (Cx26) and connexin32 (

98 l (A88V) mutation in the gene coding for the gap-junction protein connexin30 (Cx30) protects the coch

99 )-mediated degradation of the wild-type (WT) gap junction protein connexin32 (Cx32) is inhibited by m

100 Junction beta1 (GJB1), the gene encoding the gap junction protein connexin32 (Cx32), cause the X-link

101 Mutations in GJB1, the gene encoding the gap junction protein connexin32 (Cx32), cause the X-link

102 d by mutations in the GJB1 gene encoding the gap junction protein connexin32 (Cx32).

103 Here, we show for the first time that a gap junction protein, connexin32 (Cx32), acts as a lung

104 aranodes; these regions contain at least one gap junction protein, connexin32 (Cx32).

105 The major neuronal gap junction protein connexin36 (Cx36) exhibits the rema

106 All these synapses require the gap junction protein connexin36 (Cx36) for robust electr

107 , Christie et al. use mice deficient for the gap junction protein connexin36 (Cx36) to demonstrate th

108 ctrical synapses that depend strongly on the gap junction protein connexin36 (Cx36).

109 ectrical synapses, most of which require the gap junction protein connexin36 (Cx36).

110 ermal N-cadherin, Zonula Occludens-1 and the gap junction protein Connexin43 (Cx43) compared to intac

111 The gap junction protein connexin43 (Cx43) forms intercellul

112 ytes might release ATP; however, whether the gap junction protein connexin43 (Cx43) forms these "hemi

113 NNB1), showed increased association with the gap junction protein connexin43 (Cx43) in PG CKO hearts.

114 and epithelial responses at the level of the gap junction protein connexin43 (Cx43) in polarized huma

115 trate a previously unrecognized role for the gap junction protein connexin43 (Cx43) in the regulation

116 To characterize the role of the gap junction protein connexin43 (Cx43) in ventricular co

117 The gap junction protein connexin43 (Cx43) is a tumor suppre

118 dification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as

119 that in cultured myocytes, rapid loss of the gap junction protein connexin43 (Cx43) occurs in conjunc

120 erize in the endoplasmic reticulum (ER), the gap junction protein connexin43 (Cx43) oligomerizes in a

121 We targeted the gap junction protein connexin43 (Cx43) responsible for m

122 Hemodynamic regulation of the endothelial gap junction protein connexin43 (Cx43) was studied in a

123 ROS 17/2.8 cells, which express the gap junction protein connexin43 (Cx43), are well dye cou

124 fic mutations in GJA1, the gene encoding the gap junction protein connexin43 (Cx43), cause an autosom

125 accompanied by overt mislocalization of the gap junction protein connexin43 (Cx43).

126 Regulation of cell-cell communication by the gap junction protein connexin43 can be modulated by a va

127 tic modification of myoblasts to express the gap junction protein connexin43 decreased arrhythmogenic

128 The gap junction protein connexin43 followed a similar but d

129 Fusions of the gap junction protein connexin43 to mRFP1 formed fully fu

130 in phospholamban, and a 60% reduction in the gap junction protein connexin43, relative to neighboring

131 o express individual P2 receptors and/or the gap junction protein connexin43.

132 s in primary ovine lens cultures express the gap junction proteins connexin43 (Cx43) and connexin49 (

133 ed that the total amounts of the ventricular gap junction proteins connexin43 and connexin45 (Cx43 an

134 The gap junction protein, connexin43 (Cx43), has critical ro

135 In this study, we examine the role of the gap junction protein, connexin43 (Cx43), in the transcri

136 Although the major cardiac gap junction protein, connexin43 (Cx43), is expressed ab

137 The half-life of the principal cardiac gap junction protein, connexin43 (Cx43), is only 1.5 to

138 nges in phosphorylation of the major cardiac gap junction protein, connexin43 (Cx43).

139 and immunoconfocal analysis showed that the gap junction protein, connexin43, was widely and persist

140 Odontoblasts expressed the gap junction protein, connexin43, which can form transme

141 Wnt signaling, followed by the expression of gap junction protein, connexin43.

142 Two gap junction proteins, connexin43 (Cx43) and connexin45

143 ons in GJA12/GJC2, the gene that encodes the gap junction protein connexin47 (Cx47), cause Pelizaeus-

144 The lens fiber cell-specific gap junction protein connexin49 is a substrate for a mem

145 onstrated TPA-induced phosphorylation of the gap junction protein connexin56 (Cx56).

146 Gap junction proteins (connexins) facilitate intercellul

147 derstanding the functional roles of specific gap junction proteins (connexins) in brain, lens, retina

148 tion studies in mice have revealed roles for gap junction proteins (connexins) in heart development.

149 So far all gap junction proteins (connexins), with the exception of

150 e have revealed some unexpected roles of the gap junction proteins (connexins).

151 how that in valved veins of the mouse, three gap junction proteins (Connexins, Cxs), Cx37, Cx43, and

152 Ectopic expression of gap junction proteins, connexins (Cxs), leads to an incr

153 Lens gap junction proteins, connexins [1], are known to be ph

154 Forced expression of gap junction proteins, connexins, enables gap junction-d

155 Phosphorylation of gap junction proteins, connexins, plays a role in global

156 Loss-of-function mutations of gap junction proteins, connexins, represent a mechanism

157 ding for ion channel proteins, including the gap junction proteins, connexins.

158 genetically engineering cells to overexpress gap junction proteins, could enhance cell differentiatio

159 fy motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transme

160 atal and adult rats, and we propose that the gap junction proteins Cx26 and Cx32 form the neuroanatom

161 ectrical synapses composed of the vertebrate gap junction protein Cx36 between Caenorhabditis elegans

162 or example, such studies have implicated the gap junction protein Cx36 in synchronizing rhythmic acti

163 sing histochemical reporters in place of the gap junction protein Cx36.

164 ibronectin EIIIA, Foxc2, calcineurin and the gap junction protein Cx37 are required for lymphatic val

165 monstrated that the carboxyl terminus of the gap junction protein Cx43 (Cx43CT) can act as an indepen

166 binds to a specific region of the ubiquitous gap junction protein Cx43 in a Ca(2+)-dependent manner,

167 al protein plakoglobin and the major cardiac gap junction protein Cx43 were markedly diminished in bu

168 increased the expression and distribution of gap junction protein Cx43, which became reduced in ablat

169 ciates with intercalated discs, and integral gap junction proteins Cx43 (connexin 43), Cx45 (connexin

170 The gap junction protein, Cx43, plays a pivotal role in coup

171 The gap junction protein, Cx43, was expressed intensively ar

172 Changes in expression of the cardiac gap junction protein, Cx43, were measured by confocal mi

173 ycle (assembly, gating, and turnover) of the gap junction protein, Cx43.

174 rial osteoblastic cells also express another gap junction protein, Cx46.

175 ine also blocked channels formed by the lens gap junction protein, Cx50 (IC(50) approximately 1.1 mic

176 Lens fiber cells contain two gap junction proteins (Cx56 and Cx45.6 in the chicken).

177 y mutations in GJB1, which codes for Cx32, a gap junction protein expressed by Schwann cells and olig

178 Connexin (Cx) 26, a major gap junction protein expressed in mammary epithelial cel

179 nexin 40 (Cx40), a developmentally regulated gap junction protein expressed in motor and other spinal

180 Connexin43 (Cx43) is a major gap junction protein expressed in the mammalian heart an

181 We provide evidence that gap junction proteins, expressed during development, are

182 Analyses of gap junction protein expression in cat and rat showed th

183 al coupling and dye coupling and patterns of gap junction protein expression in lumbar spinal motor n

184 Gap junction proteins form the substrate for electrical

185 3 and Cx43 are the most abundantly expressed gap junction proteins from each family.

186 Deficiencies in the gap junction protein gene connexin 40 (Cx40), a downstre

187 ood vessels, and decreased expression of the gap junction protein Gjb2 (Cx26).

188 anscription factors Foxc2 and Nfatc1 and the gap junction proteins Gjc2, Gja1, and Gja4 were temporos

189 However, no specific gap junction protein has yet been functionally linked to

190 ylation of members of the connexin family of gap junction proteins has been correlated with gap junct

191 Macrophages that lack connexin43 (Cx43), a gap junction protein, have been reported to exhibit dram

192 regulating factors is Connexin 43 (Cx43), a gap junction protein highly expressed by astrocytes at t

193 increased strong expressions of connexin 43 gap junction protein in heart and lung specimens by immu

194 Connexin43 (Cx43) is the most abundant gap junction protein in higher vertebrate organisms and

195 in serine phosphorylation on the connexin-43 gap junction protein in T51B rat liver epithelial cells.

196 The primary gap junction protein in the working myocardium, connexin

197 transgenic mouse models that implicate glial gap junction proteins in demyelinating diseases and the

198 led that connexin43 (Cx43), one of the major gap junction proteins in human vascular endothelial cell

199 This study examined whether innexins, gap junction proteins in insects, are involved in anti-P

200 r in addition to their conventional roles as gap junction proteins in lens cells.

201 pression of the two most abundant astrocytic gap junction proteins in young and senescent brains and

202 ique to chordates; innexins/pannexins encode gap-junction proteins in prechordates and chordates.

203 us of Drosophila encodes a germline-specific gap junction protein, Innexin 4, that is required for su

204 Connexin-43 (Cx43), a gap junction protein involved in control of cell prolife

205 n and increased expression of connexin 43, a gap junction protein involved with labor.

206 In addition, messenger RNA for gap junction proteins is expressed in motoneurons of the

207 +-dependent inhibition of the alpha-class of gap junction proteins is mediated by the direct associat

208 Connexin 43 (gap junction protein) is expressed in pigmented and albi

209 lular communication (GJIC) and/or connexins (gap junction proteins) is frequently reported in maligna

210 trate that connexin 32 (Cx32), a key hepatic gap junction protein, is an essential mediator of DILI b

211 nnexin43 (Cx43), the predominant ventricular gap junction protein, is critical for maintaining normal

212 Connexin 32 (Cx32), a gap junction protein, is found within the para-nodal reg

213 he expression of connexin 43 (Cx43), a major gap junction protein, is markedly enhanced in response t

214 ion of Cx43 (connexin 43), the major cardiac gap junction protein, is often associated with arrhythmi

215 e regulation of expression of connexin 43, a gap junction protein, is part of the transduction mechan

216 ealed the presence of Cx43, the main cardiac gap junction protein, localized to cell-cell borders.

217 vious studies suggested that the connexin-43 gap junction protein may be a target of activated MAP ki

218 Gap junction proteins mediate signaling communication by

219 determine whether the pre-BotC contains the gap junction proteins necessary for electrotonic communi

220 ning, we found that dco encodes Gja3/Cx46, a gap junction protein not previously implicated in heart

221 at a transient network formed by the innexin gap-junction protein NSY-5 coordinates left-right asymme

222 The principal gap junction protein of intercellular communication, con

223 -cadherin and connexin43, major adhesion and gap junction proteins of the intercalated disk, yet both

224 the PKCgamma phosphorylated the connexin 43 gap junction proteins on Ser-368.

225 Here, we report that gap junction proteins, or connexins (Cxs), are required

226 ormed this study to test the hypothesis that gap junction protein overexpression would improve conduc

227 iological data that erythrocytes express the gap junction protein pannexin 1.

228 0 quantity (rs=0.54, P=0.01, n=20), and Cx40 gap-junction protein per unit area of en face disk (rs=0

229 Connexin(Cx)43 is the major gap junction protein present in osteoblasts.

230 ngly, we investigated whether connexin 43, a gap junction protein present in the basal layer of norma

231 (Cx37) or connexin40 (Cx40), the predominant gap junction proteins present in vascular endothelium, a

232 d early increases in connexin 26, a cochlear gap junction protein previously shown to interact with F

233 The gene for the connexin 26 gap junction protein, recently shown to be mutant in bot

234 interaction between glutamate receptors and gap junction proteins represents a novel mechanism for r

235 2, also known as Gjd3) gene, which encodes a gap junction protein required for normal atrioventricula

236 decreased expression of Cx43, the principal gap junction protein responsible for propagating current

237 a cells transfected with the lens fiber cell gap junction protein sheep Cx44 also results in the inhi

238 ether the presence and distribution of these gap junction proteins show a developmental change in exp

239 Pannexin 1 (Panx1) is a novel gap junction protein shown to have tumor-suppressive pro

240 Our data shows that connexin 36, a gap junction protein specific to neurons, is most densel

241 ously described in psoriasis--connexin 26, a gap junction protein; squamous cell carcinoma antigen-1

242 despite the persistent expression of several gap junction proteins suggests that gap junctional commu

243 al uncoupling, but the preservation of other gap junction proteins supports slow action potential pro

244 Connexin43 (Cx43) is a gap junction protein that forms multimeric channels that

245 Connexin40 (Cx40) is an abundant gap junction protein that is expressed in atrial myocyte

246 Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkin

247 Connexin26 (Cx26) is a gap junction protein that oligomerizes in the cell to fo

248 Connexin26 is a ubiquitous gap junction protein that serves critical homeostatic fu

249 neurons may occur by modulation of existing gap junction proteins that are constitutively expressed

250 Connexins are gap junction proteins that form aqueous channels to inte

251 f related connexin genes encodes the subunit gap junction proteins that form intercellular channels i

252 expression gradients of calcium handling and gap junction proteins that may worsen chamber function a

253 etween AMPA-type glutamate receptors and the gap junction proteins that mediate electrical synaptic t

254 tion of nerve signaling results in a loss of gap junction protein, the reentry of the cells into the

255 res topological similarities with vertebrate gap junction proteins, the connexins.

256 romes have been linked to mutations in glial gap junction proteins, the connexins.

257 t osteosarcoma cell lines that differ in the gap junction proteins they express, in their ability to

258 eduction in the abundance of a major cardiac gap junction protein through targeted deletion of a Cx43

259 nd chemicals require connexin (Cx) 32, a key gap junction protein, to induce hepatotoxicity.

260 Immunostaining for gap junction proteins was performed on SIDS-associated p

261 Connexin 43, a cardiac gap junction protein, was expressed between grafted cell

262 Recently, connexin35/36 (Cx35/36) gap junction proteins were found to be highly expressed

263 GJB2 encodes connexin 26, a gap junction protein, which permits intercellular ion an

264 he colocalization of connexin43 (Cx43alpha1) gap junction protein with N-cadherin, p120, and other N-

265 nsmembrane/first extracellular domain of the gap junction protein with the mutation replacing a negat

266 cardiac growth factor that leads to loss of gap junction proteins within a spatially confined microe

267 Here we show that the gap junction protein Zero population growth (Zpg) is req

268 the downregulated genes were connexin-31, a gap junction protein; ZO1 and occludin, tight junction p