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1 odel of primary sudden cardiac death defines gap junctional abnormalities as a key molecular feature
2                                    Decreased gap junctional and phosphorylated Cx43 was also detected
3                      We study the effects of gap-junctional and ephaptic coupling on conduction in th
4 +) alternans that relies on a combination of gap-junctional and voltage-Ca(2+) coupling.
5 ional resistivity such that increased total, gap-junctional, and proportional Cx40 expression increas
6 6 K protein correlates with known changes in gap junctional area in the regenerating weanling rat liv
7 ultures were carried out and correlated with gap-junctional areas per inferface determined by freeze-
8 nductance; (iii) when applied to slices, the gap junctional blocker, 18 alpha-glycyrrhetinic acid, wh
9          The transients are abolished by the gap-junctional blocker octanol.
10  increase in membrane stress, and blocked by gap junctional blockers.
11  cellular physical changes were prevented by gap-junctional blockers, oleamide and beta-glycyrrhetini
12 es in gap junctional channel gating, unitary gap junctional channel conductance, and hemichannel gati
13 ence of astrocytic Cx43 protein and that its gap junctional channel function is not necessary for Cx4
14 homology, they exhibit marked differences in gap junctional channel gating, unitary gap junctional ch
15                                            A gap junctional channel is formed by two hemichannels.
16 actors are required for the decrease in Cx43 gap-junctional channel permeability.
17  mBMSCs formed connexin 43 (Cx43)-containing gap junctional channels (GJCs) with the alveolar epithel
18                 Our results show that Cx45.6 gap junctional channels are three times less permeable t
19             Previous studies have shown that gap junctional channels formed from the lens connexins C
20 rease was due to unregulated accumulation of gap junctional channels from nonjunctional pools, rather
21 e absolute permeabilities calculated for all gap junctional channels in this study are, with one exce
22                                         Hemi-gap junctional channels in Xenopus oocytes are formed fr
23 e action of at-RA, suggesting that gating of gap junctional channels is mediated through an RAR(beta)
24 nes from oocytes, and it is likely that hemi-gap junctional channels provide Ca2+ and metabolism-sens
25                  The data indicate that hemi-gap junctional channels provide the Ca2+-inhibited pathw
26 oocytes injected with D47A cRNA did not form gap junctional channels when paired homotypically.
27 ing many of biophysical properties of Cx45.6 gap junctional channels, including molecular permeabilit
28                                       Unlike gap junctional channels, Panx1 forms single-membrane cha
29 educed the unitary conductance of Cx45.6-43N gap junctional channels.
30 nce, and decreased the conductance of single gap junctional channels.
31 dent on an extensive network of cell-to-cell gap junctional channels.
32                                              Gap-junctional channels (connexin oligomers) are large-d
33  that the permeability of connexin 43 (Cx43) gap-junctional channels (connexons) to small organic mol
34  (Cx43) by PKC abolishes the permeability of gap-junctional channels and hemichannels to large hydrop
35                                              Gap-junctional channels are formed by two connexons or g
36 rmeability, and which cannot form functional gap-junctional channels between neighboring cells.
37 ssed at the plasma membrane and did not form gap-junctional channels but formed hemichannels that beh
38    One of the most striking features of hemi-gap-junctional channels is that they are dramatically mo
39                                The homotypic gap-junctional channels were closed in a voltage-depende
40 e-dependent manner, but failed to affect non-gap-junctional channels, including glutamate receptors.
41                                              Gap-junctional channels, permeable to large hydrophilic
42 s, transient receptor potential channels and gap-junctional channels.
43 ells, preventing the formation of functional gap-junctional channels.
44 the gap junctions (immunostaining), improved gap junctional communication (dye spread), and reduced v
45  molecular and functional characteristics of gap junctional communication (GJC) in the auditory and v
46 v-Src disrupts connexin (Cx)43 intercellular gap junctional communication (GJC) is not clear.
47                                              Gap junctional communication (GJC) modulates the express
48 en ECs, established Cx43-based intercellular gap junctional communication (GJC) with ECs, and increas
49 ng pathway responsible for the disruption of gap junctional communication (GJC), wild-type PDGF recep
50  several gap junction proteins suggests that gap junctional communication among motor neurons may be
51                                              Gap junctional communication and channel assembly can be
52 ynamic localization in frog embryos requires gap junctional communication and H,K-ATPase function.
53 ssion of connexin43 and connexin45 modulates gap junctional communication and production of bone matr
54 modulates coupling mediated by Cx50 and that gap junctional communication and signal transduction pat
55   Taken together, these results suggest that gap junctional communication and the Cx expression profi
56 involved in this developmental regulation of gap junctional communication are largely unknown.
57  neurons may maintain or even increase their gap junctional communication as they mature.
58 y guarding pHi, NHE1 preferentially protects gap junctional communication at intercalated discs, whil
59 the osteocalcin CxRE, and that disruption of gap junctional communication attenuates the ability of c
60          Src can phosphorylate Cx43 to block gap junctional communication between transformed cells.
61 18beta-glycyrrhetinic acid, blocked not only gap junctional communication but also intercellular calc
62                   Importantly, disruption of gap junctional communication by overexpression of connex
63        This observation may help explain how gap junctional communication can be suppressed between m
64                                              Gap junctional communication had no apparent influence o
65                       Thus, the reduction in gap junctional communication in Cx43 KO astrocytes leads
66 compatible with current models for a role of gap junctional communication in dorso-ventral patterning
67 lling mediated by protein kinase C (PKC) and gap junctional communication in TE differentiation and b
68                                   Therefore, gap junctional communication in the POA and hypothalamus
69         These data suggest the potential for gap junctional communication in the pre-BotC of both neo
70  connexins has underscored the importance of gap junctional communication in the skin and its appenda
71                   In C. elegans, the role of gap junctional communication in touch sensitivity has be
72 ngs suggest that unique biochemical modes of gap junctional communication influence lens clarity and
73 estigate whether growth factor signaling and gap junctional communication interact during the develop
74                          In the ocular lens, gap junctional communication is a key component of homeo
75 , there has been little evidence that direct gap junctional communication is a requirement for endocy
76                                              Gap junctional communication is essential for proper dev
77                                   Astrocytic gap junctional communication is important in steroid hor
78                                              Gap junctional communication is often lower between aggr
79 1 by the inhibitory Sp3 on the promoter when gap junctional communication is perturbed.
80                    Functional studies showed gap junctional communication is reduced and cell motilit
81                     Here we evaluate whether gap junctional communication is required for the LR asym
82                                              Gap junctional communication is therefore both necessary
83            Thus, Src utilizes Cas to inhibit gap junctional communication mediated by Cx43.
84                      We find that perturbing gap junctional communication not only slows the INM of p
85 +i cross gap junctions, so we tested whether gap junctional communication plays a role in changes in
86 nse alleles exhibiting high or low levels of gap junctional communication reveal a correlation betwee
87 matergic and glycinergic transmission and of gap junctional communication suppress spontaneous activi
88 PKCgamma mediated IGF-I-induced decreases in gap junctional communication through interaction with an
89  serine368 (S368) has been shown to decrease gap junctional communication via a reduction in unitary
90         Dye-coupling analysis indicated that gap junctional communication was inhibited in the cardia
91                         However, significant gap junctional communication was not required, indicatin
92                                  Blockade of gap junctional communication with carbenoxolone did not
93 de responses being abolished by interrupting gap junctional communication with the connexin-mimetic p
94 ile flow in a manner that depends in part on gap junctional communication, even though the two hormon
95 chick embryos with lindane, which diminishes gap junctional communication, frequently unbiased normal
96                                Inhibition of gap junctional communication, in contrast, had no influe
97 ompounds traditionally used as inhibitors of gap junctional communication, like heptanol and 18beta-g
98 32 form the neuroanatomic substrate for this gap junctional communication, which may be important in
99 l with respect to PKC-mediated signaling and gap junctional communication.
100 ill the scratch required early (within <6 h) gap junctional communication.
101  signaling cascade leading to enhancement of gap junctional communication.
102  separate pathways for neuronal versus glial gap junctional communication.
103 orly invasive, possibly due to their loss of gap junctional communication.
104  shown to exert dominant negative effects on gap junctional communication.
105 d/or Ser282 initiates the down-regulation of gap junctional communication.
106 steonectin, was less sensitive to changes in gap junctional communication.
107 f Cx43 to the plasma membrane, and inhibited gap junctional communication.
108                Following the hypothesis that gap-junctional communication (GJC) may underlie this sig
109 ccurrence in the hippocampus is dependent on gap-junctional communication and it has been suggested t
110 a oscillations has been suggested to involve gap-junctional communication between axons of principal
111 d meiotic maturation in part by antagonizing gap-junctional communication between sheath cells and oo
112 gap junctions, and that neurons can regulate gap-junctional communication by glia.
113                               Suppression of gap-junctional communication by various protein kinases,
114                    Therefore, the absence of gap-junctional communication caused by R75W expression i
115 Furthermore, we show for the first time that gap-junctional communication is an important requirement
116    This study demonstrates that heterologous gap-junctional communication is required for the complet
117                                   Changes in gap-junctional communication were asymmetrical, indicati
118 tic G alpha(o/i) and G alpha(s) pathways and gap-junctional communication with somatic cells of the g
119 art by antagonizing inhibitory sheath/oocyte gap-junctional communication.
120 iated by voltage-gated calcium signaling and gap-junctional communication.
121 ylate cyclase signaling and soma-to-germline gap-junctional communication.
122  sites of cell-cell contact, adjacent to the gap junctional complex.
123 alization of pH(i) from 7.2 to 7.8 increased gap junctional conductance (g(j)) of approximately 100-f
124                                              Gap junctional conductance (G(j)), and membrane conducta
125        It remains unknown whether changes in gap junctional conductance (Gj) accompany the increased
126  of the study was to determine the effect of gap junctional conductance (Gj) remodeling and Cx43 redi
127                                              Gap junctional conductance (Gj) was measured using a dua
128 er connexin43 (Cx43) overexpression enhanced gap junctional conductance (Gj).
129 mp recording techniques, we investigated the gap junctional conductance and the coupling coefficient
130 sibly including a role of ZO-1 in regulating gap junctional conductance at these highly modifiable el
131                         At-RA did not act on gap junctional conductance by lowering [pH](i) or by inc
132 entrant circuits may result from a decreased gap junctional conductance consequent to an increase in
133  (at-RA) reversibly reduced the amplitude of gap junctional conductance in a dose-dependent manner, b
134                                 We evaluated gap junctional conductance in CKO ventricular pairs usin
135 l mechanisms for maintained propagation when gap junctional conductance is severely reduced.
136                                     Enhanced gap junctional conductance may be useful to promote the
137    Transjunctional voltage regulates cardiac gap junctional conductance, but the kinetics of inactiva
138 lated by conduction velocity restitution and gap junctional conductance.
139 nexons may contribute to the modification of gap junctional conductance.
140 ellular pathways resulting in an increase in gap junctional conductance.
141 cells expressing wild-type CX50 showed large gap junctional conductances and extensive transfer of ne
142 irs or N2A cells, and examined the resulting gap junctional conductances.
143 eeks, but there were offsetting increases in gap junctional conductances.
144           They also demonstrate that, at low gap-junctional conductivities, the accuracy of fully mac
145 upling increases propagation velocity at low gap junctional conductivity while it decreases propagati
146  the onset of locomotion promote the loss of gap junctional connections between developing motoneuron
147                   These interactions include gap-junctional connections between inhibitory cells and
148 nic coupling of neurons, most likely through gap-junctional connections.
149     These changes were preceded by a loss of gap junctional connexin43 labeling and astrocytic prolif
150 t unexpected findings involving targeting of gap junctional connexins.
151 increased resting calcium levels and reduced gap junctional coupling among astrocytes, at concentrati
152  results suggest that the reestablishment of gap junctional coupling among axotomized adult motor neu
153      In rodent lumbar spinal cord, extensive gap junctional coupling among motor neurons innervating
154  NMDA antagonist, has been shown to maintain gap junctional coupling among motor neurons.
155  both synaptic mechanisms and maintenance of gap junctional coupling among neurons within the spinal
156  These observations demonstrate that H1 cell gap junctional coupling and thus D1 receptor activity ar
157 ling are dynamic and that cell-type-specific gap junctional coupling arises gradually during spinal c
158            Mefloquine, at 25 microM, blocked gap junctional coupling between interneurons in neocorti
159 oblasts by approximately 20 mV and increased gap junctional coupling between myofibroblasts and cardi
160 ents provided the first direct evidence that gap junctional coupling between neurons, specifically me
161  by a factor of 4 by physiological levels of gap junctional coupling between sister MCs at the same g
162 st the hypothesis that reduced spinal neuron gap junctional coupling decreases temporally correlated
163 cifer yellow dye spread demonstrated reduced gap junctional coupling in areas with Connexin 43 isofor
164 nnel activity, synaptic vesicle release, and gap junctional coupling in the neuromasts of living fish
165  from both bipolar and amacrine cells and by gap junctional coupling involving ganglion cells.
166                                Interneuronal gap junctional coupling is a hallmark of neural developm
167  intercellular geometry of connexin43 (Cx43) gap junctional coupling is key to coordinated spread of
168 d motor neurons suggested that, after birth, gap junctional coupling is spatially restricted.
169                  After injury, interneuronal gap junctional coupling may mediate signaling that maint
170                          Our work shows that gap junctional coupling modulates neuronal activity patt
171       In the lens, Cx46 and Cx50 provide the gap junctional coupling needed for homeostasis and growt
172 amined the effect of light adaptation on the gap junctional coupling of alpha-ganglion cells (alpha-G
173 continuous subthreshold oscillations require gap junctional coupling of IO neuron somata within 40 mi
174 ugh the ERK pathway lead to the asymmetry in gap junctional coupling required for proper lens functio
175 ion, they suggest a novel mitogenic role for gap junctional coupling that is connexin specific and in
176       In testing the possible involvement of gap junctional coupling the following experimental obser
177                                              Gap junctional coupling was demonstrated by the presence
178              The relevance of heterocellular gap junctional coupling was evaluated by the use of fibr
179                                              Gap junctional coupling was stronger between astrocytes
180 uction velocity is relatively insensitive to gap junctional coupling when sodium ion channels are loc
181 n activity, which, in part, is controlled by gap junctional coupling within the spinal cord, appears
182 ffects of changes in extracellular geometry, gap junctional coupling, and sodium ion channel distribu
183 erneurons was not related to the strength of gap junctional coupling, and was still prevalent in conn
184 slet cells, are believed to arise in part by gap junctional coupling, but the mechanisms through whic
185 t mechanisms, particularly those mediated by gap junctional coupling, regulate synapse formation with
186                                The effect of gap junctional coupling, sodium ion channel distribution
187 e potentials and cardiomyocyte-cardiomyocyte gap junctional coupling, TGF-beta1 depolarized cardiomyo
188 measurements revealed normal levels of ionic gap junctional coupling, whereas the passage of fluoresc
189 afficking of wild-type connexin36 and blocks gap junctional coupling.
190 f six of the chimeras induced high levels of gap junctional coupling.
191 urones were identified as potential sites of gap junctional coupling.
192 n event necessary and sufficient to increase gap junctional coupling.
193  by ephaptic effects, even in the absence of gap junctional coupling.
194 embrane potential oscillations suggestive of gap junctional coupling.
195  at earlier stages, though without involving gap junctional coupling.
196 in an electrically coupled network depend on gap junctional coupling?
197                            Furthermore, both gap-junctional coupling and changes in [Ca(2+)](i) have
198                                              Gap-junctional coupling and gap junction-dependent Ca(2+
199           In addition to the often-described gap-junctional coupling between astrocytes, coupling als
200                  We show further that strong gap-junctional coupling of both membrane potential and c
201                              We investigated gap-junctional coupling of rods and cones in macaque ret
202 al mice, and that patterning is modulated by gap-junctional coupling.
203               Both CX50 and CX50G46V induced gap junctional currents in pairs of Xenopus oocytes.
204  by its equivalent action on whole-cell hemi-gap-junctional currents and on cell-free excised patch h
205 on macroscopic human connexin46 (hCx46) hemi-gap-junctional currents using the two-electrode voltage-
206  is more stable and contains a high level of gap-junctional Cx43 whereas that formed with hypoxic cel
207  hypoxic melanoma cells selectively degrades gap-junctional Cx43, leading to the destabilization of t
208 le and contains a significant lower level of gap-junctional Cx43.
209 found hearing loss, but the mechanism of the gap-junctional defect is unknown.
210                      Following disruption of gap junctional dye coupling by treatment with 1 mM octan
211 eticular nucleus (TRN), a brain area rich in gap junctional (electrical) synapses, regulates cortical
212 eticular nucleus (TRN), a brain area rich in gap-junctional (electrical) synapses, regulates cortical
213  The synaptic connections, both chemical and gap junctional, form a neural network with four striking
214 sing SNARF as a proton carrier, suggest that gap junctional H+ transmission may be accomplished physi
215 Cx46 hemichannel opening, then dye influx by gap junctional/hemichannel permeable dyes should be meas
216               We propose that Zpg-containing gap junctional hemichannels in the germ cell plasma memb
217                                              Gap junctional hemichannels mediate cell-extracellular c
218 utamate release was not affected by blocking gap junctional hemichannels with 18alpha-glycyrrhetinic
219                                     Neuronal gap junctional hemichannels, composed of pannexin-1 subu
220 onal channels are formed by two connexons or gap-junctional hemichannels in series, with each connexo
221           Here, we show that Cx26 R75W forms gap-junctional hemichannels that display altered voltage
222 cium-dependent gating properties of two lens gap-junctional hemichannels were compared at the macrosc
223 es formed by head-to-head association of two gap-junctional hemichannels, one from each of the adjace
224  heterogeneous cells might be facilitated by gap junctional intercellular channels which are permeabl
225           Adenosine and NECA also stimulated gap junctional intercellular communication (as assessed
226                                Disruption of gap junctional intercellular communication (GJIC) and/or
227                                              Gap junctional intercellular communication (GJIC) betwee
228                                      Loss of gap junctional intercellular communication (GJIC) betwee
229                                              Gap junctional intercellular communication (GJIC) has be
230                                              Gap junctional intercellular communication (GJIC) plays
231 K)/ganciclovir (GCV) gene therapy depends on gap junctional intercellular communication (GJIC) to pro
232 the mixture of DMSO and PMA, an inhibitor of gap junctional intercellular communication (GJIC).
233  initial repair process that is dependent on gap junctional intercellular communication (GJIC).
234             We hypothesize that the level of gap junctional intercellular communication among dividin
235 elieved to be critical for the regulation of gap junctional intercellular communication and for the f
236 atinocytes, despite a lack of heterocellular gap junctional intercellular communication between the t
237  A rigorous and unambiguous demonstration of gap junctional intercellular communication demands both
238 y was used to quantitatively investigate the gap junctional intercellular communication in several ho
239              These data suggest that altered gap junctional intercellular communication may underlie
240                                              Gap junctional intercellular communication via these cha
241 ifferences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phospho
242  the number of neighboring cells coupled via gap junctional intercellular communication, providing a
243 sible mechanism for bilateral communication, gap junctional intercellular communication, was also inv
244 asal levels of Cx26 and Cx43, rendering them gap junctional intercellular communication-deficient as
245 ons dock between adjacent cells to allow for gap junctional intercellular communication.
246  rat osteocalcin promoter for sensitivity to gap junctional intercellular communication.
247 Ser279/Ser282 sites is sufficient to disrupt gap junctional intercellular communication.
248 valent number of MSCs was down-regulated via gap junctional intercellular communication.
249 t fibroblast growth factor (FGF) upregulates gap junctional intercellular dye transfer in primary cul
250                                              Gap-junctional intercellular communication in endothelia
251 rovide a valuable model to study the role of gap-junctional intercellular communication in epidermal
252 ay and Western blot analyses reveal that the gap junctional intracellular communication molecule conn
253                                              Gap junctional mechanisms require further consideration
254              Once engaged with the astrocyte gap-junctional network, brain metastatic cancer cells us
255 xin47 (Cx47) and astrocytic Cx30 to panglial gap junctional networks as well as myelin maintenance an
256 may have emerged via restoration of previous gap-junctional networks.
257 mulations of these models revealed that this gap junctional/paracrine mechanism accounts for up to 23
258  but are consistent with the hypothesis that gap-junctional particles contain central hydrophilic cha
259 ermits a determination of absolute values of gap junctional permeability as a function of dye size an
260                               Thus, altering gap junctional permeability by manipulating the expressi
261 ctation, H(+) ions can induce an increase of gap-junctional permeability.
262   Cx26 and Cx30 were also coexpressed in the gap junctional plaques between Claudius cells.
263 ly different from hemichannels in the docked gap junctional plaques examined after their exposure by
264 e was reduced and incorporation of Cx43 into gap junctional plaques was markedly diminished.
265 vere reductions in function and formation of gap junctional plaques were transferred to other connexi
266 lian cells, the mutant CX46 was not found at gap junctional plaques, but it showed extensive co-local
267 ression or relocation to the cell surface or gap junctional plaques.
268 ible promoter, both CX50 and CX50G46V formed gap junctional plaques.
269                Our results further show that gap-junctional plaques formed of a sorting motif-deficie
270 r intercellular transport and communication, gap junctional pores have been the subject of numerous i
271                                          The gap junctional protein connexin (Cx) 45 is strongly expr
272                      The contribution of the gap junctional protein connexin 36 (Cx36) to the regulat
273                             The pore-forming gap junctional protein connexin 43 (Cx43) has a short (1
274 5, integrin alpha3beta1, E-cadherin, and the gap junctional protein connexin 43.
275            Expression of the redox-sensitive gap junctional protein Cx43 (Connexin 43) was reduced in
276 onal circuit, by increasing targeting of the gap junctional protein innexin shaking-B to gap junction
277 iol and progesterone on the abundance of the gap junctional protein, connexin 43 (CX43), which is hig
278 d disruption of GJC and phosphorylation of a gap junctional protein, connexin-43 (Cx43), which requir
279 ed knockout of Connexin43, the major cardiac gap junctional protein, uniformly develop sudden cardiac
280                                      Because gap junctional proteins are widely expressed in the mamm
281 dentified in vertebrates and found to encode gap junctional proteins as well.
282 ndertaken to examine the hypothesis that the gap junctional proteins connexin 32 (Cx32; expressed by
283 constructed a series of chimeric Cx46-Cx45.6 gap junctional proteins in which a single transmembrane
284                                          Two gap junctional proteins, connexin43 and connexin45, were
285 o re-entry) that could arise from changes in gap junctional proteins, especially connexin43 (Cx43).
286  the surface expression of unique subsets of gap junctional proteins.
287 e increase in the volume of cells expressing gap-junctional proteins (connexins).
288                    The relative roles of the gap-junctional proteins connexin40 (Cx40) and connexin43
289 ocity (theta) and anisotropic ratio, and how gap junctional remodeling is modulated by the extracellu
290 el that exhibits ventricular arrhythmias and gap junctional remodeling, beta-catenin and Cx43 express
291                                     Specific gap-junctional resistivity (Rj) correlated not only with
292 nvestigated by direct ex vivo measurement of gap-junctional resistivity and quantitative connexin imm
293   Cx40 is associated with human right atrial gap-junctional resistivity such that increased total, ga
294 0 expression and a corresponding increase in gap-junctional resistivity.
295 , and proportional Cx40 expression increases gap-junctional resistivity.
296                                     As such, gap junctional signalling appears to be a substantial co
297                         Global modulation of gap junctional states in Xenopus embryos by pharmacologi
298  Cx43 within the plasma membrane at apparent gap junctional structures.
299 ted a slight increase in total Cx43, whereas gap junctional (Triton-insoluble) Cx43 decreased, and no
300 led to myofibroblasts during pharmacological gap junctional uncoupling.

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