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1 odel of primary sudden cardiac death defines gap junctional abnormalities as a key molecular feature
5 ional resistivity such that increased total, gap-junctional, and proportional Cx40 expression increas
6 6 K protein correlates with known changes in gap junctional area in the regenerating weanling rat liv
7 ultures were carried out and correlated with gap-junctional areas per inferface determined by freeze-
8 nductance; (iii) when applied to slices, the gap junctional blocker, 18 alpha-glycyrrhetinic acid, wh
11 cellular physical changes were prevented by gap-junctional blockers, oleamide and beta-glycyrrhetini
12 es in gap junctional channel gating, unitary gap junctional channel conductance, and hemichannel gati
13 ence of astrocytic Cx43 protein and that its gap junctional channel function is not necessary for Cx4
14 homology, they exhibit marked differences in gap junctional channel gating, unitary gap junctional ch
17 mBMSCs formed connexin 43 (Cx43)-containing gap junctional channels (GJCs) with the alveolar epithel
20 rease was due to unregulated accumulation of gap junctional channels from nonjunctional pools, rather
21 e absolute permeabilities calculated for all gap junctional channels in this study are, with one exce
23 e action of at-RA, suggesting that gating of gap junctional channels is mediated through an RAR(beta)
24 nes from oocytes, and it is likely that hemi-gap junctional channels provide Ca2+ and metabolism-sens
27 ing many of biophysical properties of Cx45.6 gap junctional channels, including molecular permeabilit
33 that the permeability of connexin 43 (Cx43) gap-junctional channels (connexons) to small organic mol
34 (Cx43) by PKC abolishes the permeability of gap-junctional channels and hemichannels to large hydrop
37 ssed at the plasma membrane and did not form gap-junctional channels but formed hemichannels that beh
38 One of the most striking features of hemi-gap-junctional channels is that they are dramatically mo
40 e-dependent manner, but failed to affect non-gap-junctional channels, including glutamate receptors.
44 the gap junctions (immunostaining), improved gap junctional communication (dye spread), and reduced v
45 molecular and functional characteristics of gap junctional communication (GJC) in the auditory and v
48 en ECs, established Cx43-based intercellular gap junctional communication (GJC) with ECs, and increas
49 ng pathway responsible for the disruption of gap junctional communication (GJC), wild-type PDGF recep
50 several gap junction proteins suggests that gap junctional communication among motor neurons may be
52 ynamic localization in frog embryos requires gap junctional communication and H,K-ATPase function.
53 ssion of connexin43 and connexin45 modulates gap junctional communication and production of bone matr
54 modulates coupling mediated by Cx50 and that gap junctional communication and signal transduction pat
55 Taken together, these results suggest that gap junctional communication and the Cx expression profi
58 y guarding pHi, NHE1 preferentially protects gap junctional communication at intercalated discs, whil
59 the osteocalcin CxRE, and that disruption of gap junctional communication attenuates the ability of c
61 18beta-glycyrrhetinic acid, blocked not only gap junctional communication but also intercellular calc
66 compatible with current models for a role of gap junctional communication in dorso-ventral patterning
67 lling mediated by protein kinase C (PKC) and gap junctional communication in TE differentiation and b
70 connexins has underscored the importance of gap junctional communication in the skin and its appenda
72 ngs suggest that unique biochemical modes of gap junctional communication influence lens clarity and
73 estigate whether growth factor signaling and gap junctional communication interact during the develop
75 , there has been little evidence that direct gap junctional communication is a requirement for endocy
85 +i cross gap junctions, so we tested whether gap junctional communication plays a role in changes in
86 nse alleles exhibiting high or low levels of gap junctional communication reveal a correlation betwee
87 matergic and glycinergic transmission and of gap junctional communication suppress spontaneous activi
88 PKCgamma mediated IGF-I-induced decreases in gap junctional communication through interaction with an
89 serine368 (S368) has been shown to decrease gap junctional communication via a reduction in unitary
93 de responses being abolished by interrupting gap junctional communication with the connexin-mimetic p
94 ile flow in a manner that depends in part on gap junctional communication, even though the two hormon
95 chick embryos with lindane, which diminishes gap junctional communication, frequently unbiased normal
97 ompounds traditionally used as inhibitors of gap junctional communication, like heptanol and 18beta-g
98 32 form the neuroanatomic substrate for this gap junctional communication, which may be important in
109 ccurrence in the hippocampus is dependent on gap-junctional communication and it has been suggested t
110 a oscillations has been suggested to involve gap-junctional communication between axons of principal
111 d meiotic maturation in part by antagonizing gap-junctional communication between sheath cells and oo
115 Furthermore, we show for the first time that gap-junctional communication is an important requirement
116 This study demonstrates that heterologous gap-junctional communication is required for the complet
118 tic G alpha(o/i) and G alpha(s) pathways and gap-junctional communication with somatic cells of the g
123 alization of pH(i) from 7.2 to 7.8 increased gap junctional conductance (g(j)) of approximately 100-f
126 of the study was to determine the effect of gap junctional conductance (Gj) remodeling and Cx43 redi
129 mp recording techniques, we investigated the gap junctional conductance and the coupling coefficient
130 sibly including a role of ZO-1 in regulating gap junctional conductance at these highly modifiable el
132 entrant circuits may result from a decreased gap junctional conductance consequent to an increase in
133 (at-RA) reversibly reduced the amplitude of gap junctional conductance in a dose-dependent manner, b
137 Transjunctional voltage regulates cardiac gap junctional conductance, but the kinetics of inactiva
141 cells expressing wild-type CX50 showed large gap junctional conductances and extensive transfer of ne
145 upling increases propagation velocity at low gap junctional conductivity while it decreases propagati
146 the onset of locomotion promote the loss of gap junctional connections between developing motoneuron
149 These changes were preceded by a loss of gap junctional connexin43 labeling and astrocytic prolif
151 increased resting calcium levels and reduced gap junctional coupling among astrocytes, at concentrati
152 results suggest that the reestablishment of gap junctional coupling among axotomized adult motor neu
155 both synaptic mechanisms and maintenance of gap junctional coupling among neurons within the spinal
156 These observations demonstrate that H1 cell gap junctional coupling and thus D1 receptor activity ar
157 ling are dynamic and that cell-type-specific gap junctional coupling arises gradually during spinal c
159 oblasts by approximately 20 mV and increased gap junctional coupling between myofibroblasts and cardi
160 ents provided the first direct evidence that gap junctional coupling between neurons, specifically me
161 by a factor of 4 by physiological levels of gap junctional coupling between sister MCs at the same g
162 st the hypothesis that reduced spinal neuron gap junctional coupling decreases temporally correlated
163 cifer yellow dye spread demonstrated reduced gap junctional coupling in areas with Connexin 43 isofor
164 nnel activity, synaptic vesicle release, and gap junctional coupling in the neuromasts of living fish
167 intercellular geometry of connexin43 (Cx43) gap junctional coupling is key to coordinated spread of
172 amined the effect of light adaptation on the gap junctional coupling of alpha-ganglion cells (alpha-G
173 continuous subthreshold oscillations require gap junctional coupling of IO neuron somata within 40 mi
174 ugh the ERK pathway lead to the asymmetry in gap junctional coupling required for proper lens functio
175 ion, they suggest a novel mitogenic role for gap junctional coupling that is connexin specific and in
180 uction velocity is relatively insensitive to gap junctional coupling when sodium ion channels are loc
181 n activity, which, in part, is controlled by gap junctional coupling within the spinal cord, appears
182 ffects of changes in extracellular geometry, gap junctional coupling, and sodium ion channel distribu
183 erneurons was not related to the strength of gap junctional coupling, and was still prevalent in conn
184 slet cells, are believed to arise in part by gap junctional coupling, but the mechanisms through whic
185 t mechanisms, particularly those mediated by gap junctional coupling, regulate synapse formation with
187 e potentials and cardiomyocyte-cardiomyocyte gap junctional coupling, TGF-beta1 depolarized cardiomyo
188 measurements revealed normal levels of ionic gap junctional coupling, whereas the passage of fluoresc
204 by its equivalent action on whole-cell hemi-gap-junctional currents and on cell-free excised patch h
205 on macroscopic human connexin46 (hCx46) hemi-gap-junctional currents using the two-electrode voltage-
206 is more stable and contains a high level of gap-junctional Cx43 whereas that formed with hypoxic cel
207 hypoxic melanoma cells selectively degrades gap-junctional Cx43, leading to the destabilization of t
211 eticular nucleus (TRN), a brain area rich in gap junctional (electrical) synapses, regulates cortical
212 eticular nucleus (TRN), a brain area rich in gap-junctional (electrical) synapses, regulates cortical
213 The synaptic connections, both chemical and gap junctional, form a neural network with four striking
214 sing SNARF as a proton carrier, suggest that gap junctional H+ transmission may be accomplished physi
215 Cx46 hemichannel opening, then dye influx by gap junctional/hemichannel permeable dyes should be meas
218 utamate release was not affected by blocking gap junctional hemichannels with 18alpha-glycyrrhetinic
220 onal channels are formed by two connexons or gap-junctional hemichannels in series, with each connexo
222 cium-dependent gating properties of two lens gap-junctional hemichannels were compared at the macrosc
223 es formed by head-to-head association of two gap-junctional hemichannels, one from each of the adjace
224 heterogeneous cells might be facilitated by gap junctional intercellular channels which are permeabl
231 K)/ganciclovir (GCV) gene therapy depends on gap junctional intercellular communication (GJIC) to pro
235 elieved to be critical for the regulation of gap junctional intercellular communication and for the f
236 atinocytes, despite a lack of heterocellular gap junctional intercellular communication between the t
237 A rigorous and unambiguous demonstration of gap junctional intercellular communication demands both
238 y was used to quantitatively investigate the gap junctional intercellular communication in several ho
241 ifferences in gap junction plaque formation, gap junctional intercellular communication, Cx43 phospho
242 the number of neighboring cells coupled via gap junctional intercellular communication, providing a
243 sible mechanism for bilateral communication, gap junctional intercellular communication, was also inv
244 asal levels of Cx26 and Cx43, rendering them gap junctional intercellular communication-deficient as
249 t fibroblast growth factor (FGF) upregulates gap junctional intercellular dye transfer in primary cul
251 rovide a valuable model to study the role of gap-junctional intercellular communication in epidermal
252 ay and Western blot analyses reveal that the gap junctional intracellular communication molecule conn
255 xin47 (Cx47) and astrocytic Cx30 to panglial gap junctional networks as well as myelin maintenance an
257 mulations of these models revealed that this gap junctional/paracrine mechanism accounts for up to 23
258 but are consistent with the hypothesis that gap-junctional particles contain central hydrophilic cha
259 ermits a determination of absolute values of gap junctional permeability as a function of dye size an
263 ly different from hemichannels in the docked gap junctional plaques examined after their exposure by
265 vere reductions in function and formation of gap junctional plaques were transferred to other connexi
266 lian cells, the mutant CX46 was not found at gap junctional plaques, but it showed extensive co-local
270 r intercellular transport and communication, gap junctional pores have been the subject of numerous i
276 onal circuit, by increasing targeting of the gap junctional protein innexin shaking-B to gap junction
277 iol and progesterone on the abundance of the gap junctional protein, connexin 43 (CX43), which is hig
278 d disruption of GJC and phosphorylation of a gap junctional protein, connexin-43 (Cx43), which requir
279 ed knockout of Connexin43, the major cardiac gap junctional protein, uniformly develop sudden cardiac
282 ndertaken to examine the hypothesis that the gap junctional proteins connexin 32 (Cx32; expressed by
283 constructed a series of chimeric Cx46-Cx45.6 gap junctional proteins in which a single transmembrane
285 o re-entry) that could arise from changes in gap junctional proteins, especially connexin43 (Cx43).
289 ocity (theta) and anisotropic ratio, and how gap junctional remodeling is modulated by the extracellu
290 el that exhibits ventricular arrhythmias and gap junctional remodeling, beta-catenin and Cx43 express
292 nvestigated by direct ex vivo measurement of gap-junctional resistivity and quantitative connexin imm
293 Cx40 is associated with human right atrial gap-junctional resistivity such that increased total, ga
299 ted a slight increase in total Cx43, whereas gap junctional (Triton-insoluble) Cx43 decreased, and no
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