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1 d within the first 48 h of development (late gastrula).
2 ic endodermal expression in the blastula and gastrula.
3 for both D/V and A/P patterning of the early gastrula.
4 nd signaling mechanisms patterning the human gastrula.
5 eron-inducible transmembrane proteins in the gastrula.
6 naling centers that pattern the blastula and gastrula.
7 stributed mesodermal fields within the early gastrula.
8 ed out by redundant enzymes in the zebrafish gastrula.
9 mesodermal extension exists in the zebrafish gastrula.
10 anging from the mid-blastula through the mid-gastrula.
11 convergent extension movements in zebrafish gastrula.
12 ein activity specifies cell fates within the gastrula.
13 ed in a loss of Sox17alpha expression in the gastrula.
14 sue and regulates somite size in the Xenopus gastrula.
15 he prospective notochord region of the early gastrula.
16 osteriorization of neuroectoderm in the late gastrula.
17 sed in the presumptive mesoderm of the early gastrula.
18 rostral to the primitive streak in the early gastrula.
19 astula, and to the posterior mesoderm by mid-gastrula.
20 ed throughout the nonaxial region of the spt gastrula.
21 de variety of posterior tissues of the mouse gastrula.
22 ted by the dorsal and ventral centers of the gastrula.
23 ntributes to defective cell movements in the gastrula.
24 mes exclusively in bottle cells in the early gastrula.
25 albeit incomplete, is already evident in the gastrula.
26 nt in a broad, crescent-shaped region of the gastrula.
27 in patterning the A/P axis of the amphioxus gastrula.
28 m during gut endoderm formation in the mouse gastrula.
29 ifically in the dorsolateral mesoderm of the gastrula, a domain that is established by the interactio
34 us endoderm patterning such that during late gastrula and early somite stages of embryogenesis, Wnt a
37 ongest in the presumptive neural ectoderm at gastrula and neural plate stages, but there is minor par
39 Loss of NRH1 function is followed, during gastrula and neurula stages, by a dramatic increase in a
45 -catenin is present in endoderm cells of the gastrula, and depletion of beta-catenin from embryos res
46 extent of mesoderm formation in the Xenopus gastrula, and point to related roles for Xenopus HNF3bet
47 a BMP antagonist in the context of the frog gastrula, and that it acts cooperatively with chordin to
49 evel the observation that cells of the early gastrula are less committed to one germ layer than are c
50 lino concentrations specifically cause a pre-gastrula arrest of cell division and morphogenesis, and
51 x is expressed in the foregut region of late gastrula avian and mammalian embryos in a pattern that o
52 h dorsal and ventral mesoderm across the pre-gastrula axis historically called the dorsal-ventral axi
53 ses, STELLA was immunolocalized to the mouse gastrula between Early Streak (ES) and 12-somite pair (-
56 are essential in generating the presumptive gastrula BMP activity gradient that patterns the dorsal-
57 nction, we find that larvae with reduced mid-gastrula Bmp signaling cannot properly excrete waste.
59 in and zic2, weakly represses sox11 at early gastrula but later (st12) induces it; weakly represses s
60 ed early in development, in the blastula and gastrula, but not at later stages when a putative chemos
62 s a cross-species functional screen of mouse gastrula cDNA libraries for components of endoderm and m
65 he ventral and dorsal tail bud, whereas post-gastrula Chordin activity patterns the derivatives of th
67 ue territories are specified, early and late gastrula, during which important morphogenetic events oc
68 , FGF, and other signaling molecules in late gastrula-early neurula stage embryos generate the border
69 teral blastoderm isolates (LBIs) at the late gastrula/early neurula stage (i.e., stage 3d/4) that lac
70 tero-posterior and dorso-ventral axis in the gastrula ectoderm and also has trunk- and tail-promoting
75 ellular levels of Sizzled and Chordin in the gastrula embryo and enzyme reaction constants were all i
77 lusively within the organizer of the Xenopus gastrula embryo and therefore are predicted to act as bo
79 st steps in germ layer patterning of the pre-gastrula embryo to tissue healing, regeneration and home
80 ly restricted to the ventral mesoderm of the gastrula embryo under the signaling control of bone morp
85 c dorsal/ventral (back-to-belly) axis in pre-gastrula embryos and allowed the assignment of the rostr
86 ted by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity
88 an4 (a Wnt co-receptor) and frizzled7 mutant gastrula embryos with disrupted non-canonical Wnt signal
89 r lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and h
90 derm in individual cells from early and late gastrula embryos, by both in situ hybridization and sing
97 ntified over 300 transcripts enriched in the gastrula endoderm, including most of the known endoderm
98 t originate from specific regions of the pre-gastrula epiblast, but the plasticity of cells within th
103 ntire antero-posterior axis of the zebrafish gastrula including prechordal plate and ventral dienceph
104 mammalian cells, and cells of the Drosophila gastrula inhibit Cdk1 to delay the entry into mitosis.
106 al4-UAS-mediated fezl overexpression in late gastrula is capable of expanding the prethalamus telence
107 dherens junctions in Drosophila melanogaster gastrula is delayed until mesoderm is internalized, desp
108 We report that FoxD3 function in the Xenopus gastrula is essential for dorsal mesodermal development
109 Dorsoventral specification of the zebrafish gastrula is governed by the functions of the dorsal shie
111 in the yolk cell and hypoblast in the early gastrula, just preceding the appearance of the bib mesod
112 show that BMP signaling is nearly absent in gastrula lacking both maternal and zygotic Laf/Alk8 acti
113 Inhibition of Bmp signaling in the early gastrula leads to increased beta-cell numbers and partia
114 expression domains of Xnr-2 and Xbra in the gastrula marginal zone appear to mark presumptive blood
116 le, and in the embryo it is expressed in the gastrula marginal zone, neural plate, and cranial and tr
118 al (trunk and tail) regions of the zebrafish gastrula, neural specification is initiated at all DV po
122 During vertebrate development the dorsal gastrula or Spemann-Mangold organizer orchestrates axis
124 eta-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarc
125 es for prdm1 in limiting the function of the gastrula organizer and regulating cell fate specificatio
126 boz and Nodal signaling largely cooperate in gastrula organizer formation, they have opposing roles i
131 een shown to be a determinant at the Xenopus gastrula organizer region and a segment-polarity determi
136 lled to the opposite cell edges in zebrafish gastrula parallels their distribution in fly, and sugges
138 se results we conclude that in the amphioxus gastrula RA signaling primarily acts via regulation of H
139 linker region localizes to a ventral vegetal gastrula region that could coordinate DV patterning with
141 ONT1 expression in the organizer of the late gastrula stabilizes the gradient of BMP signaling that i
142 the injected quadrant, while at mid- to late-gastrula stage and beyond, more PMCs are found outside t
143 fic GFP reporter DNA construct were grown to gastrula stage and their fluorescence recorded as a seri
146 ned along the dorsal-ventral axis during the gastrula stage by opposing gradients of Bmps and Bmp inh
148 different steps: first, an induction at the gastrula stage dependent on signals arising from the dor
149 non-axial mesoderm occurs across the classic gastrula stage DV axis while DV patterning aligns along
150 plate precursor cells in the epiblast of the gastrula stage embryo, and does not share a lineage with
151 should be highest on the dorsal side of the gastrula stage embryo, we have found that while Smad2 ph
153 strate that HBX2 specifically interacts with gastrula stage embryonic extracts and that in vitro tran
154 trulation, we manipulated Notch signaling in gastrula stage embryos and examined gene expression in r
155 al mesendoderm (Spemann organizer tissue) of gastrula stage embryos and that its expression is regula
156 However, our analysis of these pathways in gastrula stage embryos indicates that the MAP kinase pat
158 Smurf1 is enriched on the dorsal side of gastrula stage embryos, and blocking Smurf1 disturbs neu
159 vation of the Notch pathway, specifically in gastrula stage embryos, results in a dramatic decrease i
165 ntral halves of axin-depleted embryos at the gastrula stage have dramatically increased levels of cho
166 m, transcripts first being detectable at the gastrula stage in a ring of mesendoderm just inside the
168 ters containing more than 72000 cDNAs from a gastrula stage library were hybridized with differential
170 pts are detected in the visceral endoderm of gastrula stage mouse embryos, suggesting a signaling rol
171 n of the Xenopus ABCE1 arrests growth at the gastrula stage of development, consistent with a block i
177 etal cells of Xenopus embryos from the early gastrula stage onwards, when these cells become committe
179 own that retinoic acid (RA) signaling at the gastrula stage strongly influences anterior-posterior (A
180 gly, we find that Bmp signaling from the mid-gastrula stage through early somitogenesis is important
181 gnaling acts from early cleavage through the gastrula stage to specify and maintain dorsal/anterior d
182 have undertaken a transcriptomic analysis on gastrula stage Xenopus embryos in which MyoD has been kn
183 estricted to lateral and ventral mesoderm in gastrula stage Xenopus embryos, leading us to investigat
184 bra in the presumptive trunk and tail at the gastrula stage, and find that they fate to presumptive s
185 xtends across to the ventral side by the mid-gastrula stage, and is then turned off in the dorsal ect
186 degradation beginning precisely at the early gastrula stage, and represses translation of transcripts
187 ior development while, starting at the early gastrula stage, BMP signaling promotes ventral/posterior
188 in embryos from fertilization to the initial gastrula stage, but that a tremendous increase in retino
189 axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not
190 tral mesoderm of the zebrafish embryo at the gastrula stage, by directly interfering with the binding
191 ssed in the S. purpuratus embryo, up to late gastrula stage, by means of high-resolution custom tilin
192 amming onset was first observed at the early gastrula stage, even if the cells to be replaced were re
195 igate the targets of RA signaling during the gastrula stage, we used the basal chordate amphioxus, in
196 g in the basal chordate amphioxus during the gastrula stage, which is the RA-sensitive period for ant
197 mesoderm and endoderm cells up to the early gastrula stage, while module 24 generates late endoderma
211 lateral edges of the neural plate at the mid-gastrula stage; in contrast to its mouse and chick ortho
213 n patterns of these markers in blastula- and gastrula-stage chick embryos, using whole-mount in situ
215 a critical window of development in the late gastrula-stage embryo when vitamin A is essential for no
216 tides results in normal development of early gastrula-stage embryos but abnormal, asymmetric larvae.
217 mal mouse development when transplanted into gastrula-stage embryos, providing in vivo functional val
218 have identified a molecular pathway linking gastrula-stage endoderm patterning to organ specificatio
220 xpression of the homeobox gene Pitx2 links a gastrula-stage intercellular signalling cascade to the l
222 animal cap explants, although expression of gastrula-stage mesodermal markers was very weak and subs
223 orting from disaggregated late blastula- and gastrula-stage sea urchin embryos according to the regul
224 l of neural transformation in which a planar gastrula-stage Wnt8 signal, promoted by Nodal signaling
226 h control is exerted during the early to mid-gastrula stages (i.e., stages 2-3a), prior to formation
227 at is expressed ubiquitously at blastula and gastrula stages and is enriched in neural tissues and th
228 with nlz1 in a broad posterior domain during gastrula stages as well as at the midbrain-hindbrain bou
229 ion of plakoglobin protein during the egg to gastrula stages caused collapse of embryonic architectur
230 ly asymmetric cell divisions at blastula and gastrula stages give rise to the superficial (apical) an
231 urprise, levels of Xbra are elevated at late gastrula stages in such embryos, and over-expression of
233 ors ectopically accumulate in the PS at late gastrula stages in Wnt5a(-/-); Wnt11(-/-) embryos and th
234 th, while cell death during the blastula and gastrula stages is random and predominantly caspase-medi
237 d dynamic pattern in the nervous system from gastrula stages onward, with lesser expression in mesode
239 on of Smad2 signaling in the neural plate at gastrula stages results in inhibition of neural markers,
240 ct in the regulation of Cdx genes and during gastrula stages the normal expression of the Cdx genes r
241 lation, but becomes insensitive during early gastrula stages when Hairy2a/Dlx5 requires an inhibition
243 rmal and non-neural ectodermal fates even at gastrula stages, after the conventionally assigned end o
244 sumptive rhombomere (r) 3/r4 boundary during gastrula stages, and its expression progressively expand
245 erm expresses lvnumb during the blastula and gastrula stages, and that the protein is localized to th
246 opus ALDH1 was not expressed at blastula and gastrula stages, but was expressed at the neurula stage.
250 h the NP is sensitive to BMP levels at early gastrula stages, Hairy2a/Dlx5 expression is unaffected.
253 ucts of an FGF induction at the blastula and gastrula stages, initially express neural plate-specific
254 signaling plays an essential role during the gastrula stages, it has not been possible with mutants o
256 al skeleton first occurs around mid- to late-gastrula stages, when some PMCs from an aboral quadrant
257 pus embryos are large, and during the egg to gastrula stages, when there is little extracellular matr
278 expressed as early as 30% epiboly and during gastrula stages: in the germ ring, shield, prechordal pl
279 of the blastoderm and for rare cells of the gastrula that involute into the hypoblast, motility appe
280 the entire vegetal half was removed at early gastrula, the animal caps reprogrammed and replaced the
281 le many of these proteins are expressed post-gastrula, their later roles have typically remained uncl
282 last of pre-streak embryos, and in the early gastrula they are located in the mid-primitive streak, f
284 ange in BMP necessity from BMP inhibition at gastrula to BMP activation at neurula stages is further
291 ling molecules are found in the blastula and gastrula vegetal pole and induce both endoderm and mesod
295 fate maps of the zebrafish late blastula and gastrula, we demonstrate that individual cells can give
296 be expressed in the mesoendoderm of Xenopus gastrula were characterized according to their modes of
297 The dorsal/anterior endoderm of the Xenopus gastrula, which expresses Hex and the putative head-indu
298 -cripto, which begins in the epiblast of the gastrula, with a pattern similar to EGF-CFC genes of oth
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