ライフサイエンスコーパス: gate

1 amplitude of the clock pulse applied to the gate.

2 rd motion of the M2-M3 loop near the channel gate.

3 d site proximal to the AMPA receptor channel gate.

4 standard method of using only the diastolic gate.

5 lconer first reported a mouse with a reeling gate.

6 M in a left-handed spiral open at the Mcm2-5 gate.

7 speed bumps" or electrostatically switchable gates.

8 ty to ligand analogously to such proteolytic gating.

9 ate that 14-3-3 protein mediates the coupled gating.

10 ur between KCNQ1 and KCNE1 during activation gating.

11 endent structural changes related to channel gating.

12 N terminus is indispensable for Orai channel gating.

13 nt's sensitivity to GPCR-Gq/11-PLC-dependent gating.

14 changes in the membrane environment on MscL gating.

15 e carrier density of graphene via electrical gating.

16 sed topological invariants to explain memory gating.

17 hways that couple agonist binding to channel gating.

18 o antagonize NsVBa without affecting channel gating.

19 n turn implies the existence of magnetically gated accretion, in which disk material builds up around

20 ent, which also explains residual ATPase and gating activity of dephosphorylated CFTR.

21 by surface functional groups in a chemically gated-all-around configuration.

22 uppressed channel binding and its effects on gating, also altered the conformational displacement bet

23 gs confirmed this prediction and also showed gating alterations, a reduced glutamate affinity associa

24 tes that the lipid bilayer modulates channel gating, although it is not clear how.

25 l for SB-FETs with the phenomenon of contact gating - an effect that significantly affects the carrie

26 dual-gate device consisting of a planar back gate and a point-like top gate made by decorating a scan

27 The interplay between the intracellular gate and the selectivity filter underlies the structural

28 mportant for communications between the pore gate and the voltage sensor during deactivation.

29 of interest in the design of chemical logic gates and signal amplification schemes.

30 We create logic gates and signal transmission lines by spatially arrangi

31 s results in both faster rates of activation gating and an elimination of the fast component of gatin

32 understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotide-gated chan

33 membrane patches and showed altered channel gating and current flow through open channels.

34 fined, which impedes detailed study of their gating and ion permeation properties.

35 ven by stochastic Ca2+ release channel (RyR) gating and is used to study mechanisms of DAD variabilit

36 ling to identify residues that contribute to gating and selectivity in discrete open states.

37 position; however, the mechanisms of ciliary gating and the dynamics of the gating components are lar

38 2Cu3O7-X (YBCO) by simultaneous ionic liquid gating and X-ray absorption experiments.

39 ARPs) critically influence the distribution, gating, and pharmacology of AMPARs, but the contribution

40 ransitions, independently coupled to channel gating, and that (2) TRPV1 and Ca(2+)-bound CaM but not

41 halt C-inactivation, prevented mode-shift of gating; and (iii) that, in the total absence of C-type i

42 The aqueous cavity and lateral gate are reminiscent of features of protein-conducting c

43 e of efficiency, we use a field programmable gate array for strictly hardware-based computation and a

44 came more polar with opening of the external gates as the protein transitioned from the inward to out

45 xtension of the calculation methods (soliton gates) as they become possible in the cubic non-linear S

46 ude for the full-length wild-type KcsA, a pH-gated bacterial channel, in membrane bilayers.

47 on of this interaction appears to be sensory gating, because inactivating the central, basolateral, a

48 within 2 nm of the interface under negative gate-bias.

49 ust sequence of even-denominator FQH in dual-gated BLG devices.

50 The precise control of an ion channel gate by environmental stimuli is crucial for the fulfilm

51 t single-photon linear deterministic quantum gate by exploiting polarization along with spatial-parit

52 Gated by the neurotransmitter glutamate, AMPA receptors

53 sory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting ster

54 g to gating by dilation, gating by tilt, and gating by a combination of both dilation and tilt.

55 signatures" are calculated, corresponding to gating by dilation, gating by tilt, and gating by a comb

56 ulated, corresponding to gating by dilation, gating by tilt, and gating by a combination of both dila

57 hat is not conserved in CaV2 or CaV3 voltage-gated Ca(2+) channel subunits.

58 o activated by Ca(2+) influx through voltage-gated Ca(2+) channels and synaptically activated NMDA re

59 depolarization increases to activate voltage-gated Ca(2+) channels in the adjacent vascular smooth mu

60 It is generally accepted that voltage-gated Ca(2+) channels, CaV, regulate Ca(2+) homeostasis

61 demyelinated brain and suggest that voltage-gated Ca(2+) influx in OPCs is critical for remyelinatio

62 coding exon (exon 47) of the Cav2.1 voltage-gated calcium channel (VGCC) gene produces two major iso

63 he ryanodine receptor but not in the voltage-gated calcium channel, indicating that these phenotypes

64 udes oscillatory calcium signals via voltage-gated calcium channels as a key component.

65 their implications, with a focus on voltage-gated calcium channels as part of the disease process an

66 -channel current amplitude of native voltage-gated calcium channels can be resolved accurately despit

67 alcium-dependent manner and binds to voltage-gated calcium channels.

68 The AND gate can be controlled orthogonally by light and protona

69 Cngb1 locus-encoded beta-subunit of rod cGMP-gated cation channel and associated glutamic acid rich p

70 ier that operates downstream from cyclic GMP-gated cation channels and distal guanylate cyclases.

71 Spontaneous gating caused by the introduction of the beta2(L285R) mu

72 Voltage-gated CaV2.1 channels comprise a pore-forming alpha1A su

73 Cyclic nucleotide-gated channel (CNGC) family members mediate Ca(2+) influ

74 -microscopy structure of a cyclic-nucleotide-gated channel from Caenorhabditis elegans in the cyclic

75 Whereas NMDA receptors gate channels with slow kinetics, responsible primarily

76 cAMP opens cyclic nucleotide-gated channels allowing a Ca(2+) influx that opens Ca(2+

77 ating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide modulation of relat

78 Cyclic-nucleotide-gated channels are essential for vision and olfaction.

79 ocalizing chimeras are also functional light-gated channels.

80 and an elimination of the fast component of gating charge movement and of fluorescence.

81 sion via the allosteric modulation of ligand-gated chloride channels, such as hetero-oligomeric alpha

82 n the CLCNKB gene encoding the human voltage-gated chloride ClC-Kb (hClC-Kb) channel cause classic Ba

83 onse through the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolarizing chlori

84 found that cAMP activates cyclic nucleotide-gated (CNG) channels and thereby induces a Ca(2+) influx

85 The classical explanation for the gating compliance is that the conformational rearrangeme

86 ms of ciliary gating and the dynamics of the gating components are largely unknown.

87 widespread, however, energy efficient logic gates comprising as few devices as possible are required

88 proof of principle experiments of an optical gating concept for free electrons via direct time-domain

89 lustrate how membrane properties and voltage-gated conductances can extract distinct stimulus feature

90 Such gate-controlled spin-polarizations in the quantum Hall r

91 In a hitherto unobserved state (s4), the gate controlling access to the CP is open.

92 eurons in the anterior hypothalamus that may gate corticotropin-releasing factor output from the amyg

93 p (A305V) that form the GABA binding/channel gating coupling junction and the channel pore (T288N), w

94 CF and the action of drugs that repair CFTR gating defects.

95 e responses and elicits TS-like sensorimotor gating deficits in the D1CT-7 mouse, one of the best-val

96 coherence times reported to date in Si/SiGe gate-defined quantum dots.

97 Moreover, our gate design can be readily multiplexed as demonstrated b

98 The junction size is controlled with a dual-gate device consisting of a planar back gate and a point

99 rostructure, and chemical composition of the gate dielectric and CuPc films are analyzed by atomic fo

100 e, low-cost UV-ozone (UVO)-treated polymeric gate dielectric is reported here.

101 te was incorporated into InGaZnO TFTs as the gate dielectric.

102 activation of RhoA using the CRY2/CIBN light-gated dimerizer system.

103 lations, believed to exert active inhibitory gating, downmodulate the temporal width of LRD in slower

104 Cases reclassified as Cpc-PH based on QRS-gated DPD demonstrated higher pulmonary arterial pressur

105 Within PH-LHD, the QRS-gated DPD yielded higher calculated DPD values (3 [-1 to

106 ateral somatosensory cortex (iS1) to sensory gating during index finger voluntary activity.

107 on teniposide (VM26), can interfere with DNA gate dynamics and shorten the dwell time in the closed s

108 in lower impact levels compared to cradle-to-gate ecotoxicity from production for those products.

109 osensory processing is subserved by a robust gating effect in the oscillatory domain, as well as a dy

110 Two gating effects, the electrostatic doping and electrochem

111 cal sensor platforms is the requirement of a gate electrode, which imposes restrictions on sensor dev

112 stablish that the intrinsic probability of a gate entering the lumen favors the in state by close to

113 a recognition unit with a sensitive extended-gate field-effect transistor (EG-FET) transducer leads t

114 injection from the source electrode in back-gated field effect transistors.

115 Top-gated field-effect transistors based on Bi2O2Se crystals

116 The GaTe flakes display multiple sharp photoluminescence emi

117 onstrate an efficient resonantly driven CNOT gate for electron spins in silicon.

118 the bilayer normal, includes the W41 primary gate for proton conductance and may prevent the gate fro

119 ssistance and grants from the Bill & Melinda Gates Foundation (collectively termed ODA+) to reproduct

120 te roles the USA, UK, and the Bill & Melinda Gates Foundation have had in financing three of these fo

121 e for proton conductance and may prevent the gate from opening, representing an alternative view for

122 s the full range of motion of the activation gate, from closed with its orifice fully occluded to ope

123 We present iTango, a light- and ligand-gated gene expression system based on a light-inducible

124 a range of poorly understood experiments in gated graphene structures at low doping.Two-dimensional

125 neously exploits the pH dependency of liquid-gated graphene-based transistors and the change in the l

126 yperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate excitability in neurons, a

127 yperpolarization-activated cyclic nucleotide-gated (HCN) channels, and contributes to depolarizing th

128 iac troponin I using electrical double layer gated high field AlGaN/GaN HEMT biosensor.

129 e with quantitative microperfusion data from gated human foot microvasculature.

130 cule by calculating distributions of logical gates implemented by the molecule via propagating patter

131 a persistently closed form of the activation gate in which the intracellular ends of the four S6 segm

132 ty filter underlies the structural basis for gating in potassium ion channels.

133 can account for highly sensitive mechanical gating in the setting of a narrow, cation-selective pore

134 eptors, confirming that alpha1(T47R) impairs gating independently of activation by any agonist.

135 Functional assessment of gated individual dermal microvessels is therefore of out

136 are therefore ascribed an important role in gating information transmission across cortex.

137 e monolayers expressing a depolarizing light-gated ion channel (Ca(2+)-translocating channelrhodopsin

138 py Torpedo model; the only pentameric ligand-gated ion channel imaged in a native lipid membrane.

139 t Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammatory mecha

140 ow that G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via activatio

141 This study provides an example of a ligand-gated ion channel whose deactivation is sensitive to ago

142 s display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channel

143 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signal

144 ceptors (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the excitatory neurotran

145 Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the

146 assigned 2378 models of voltage- and calcium-gated ion channels coded in NEURON to 211 clusters.

147 Modulators of transmitter-gated ion channels have a wide range of maximal effects

148 ntly, major principles of function for light-gated ion channels have been elucidated by creating chan

149 Desensitization in pentameric ligand-gated ion channels plays an important role in regulating

150 Channelrhodopsins (ChRs) are light-gated ion channels widely used for activating selected c

151 us studies have focused on pentameric ligand-gated ion channels, the details of anesthetic binding an

152 naptic transmission by functioning as ligand-gated ion channels.

153 ntrast, SMIT1 had no effect on Kv1.1 (KCNA1) gating, ion selectivity, or pharmacology.

154 e to provide reconfigurability, the proposed gate is 'electrically' reconfigurable at run-time simply

155 We show that highly reliable special swap gate is achievable by different detuning.

156 tate by close to 20-fold, that entry of each gate is noncooperative, with the number of gates that ca

157 This inverted operation of Boolean gates is particularly striking: They provide inputs cons

158 at the energetic strength of coupling of the gates is strongly altered when this residue is mutated t

159 ggest that the regulation of CFTR intraburst gating is distinct from the ATP-dependent mechanism that

160 or transition induced in VO2 by ionic liquid gating is due to oxygen vacancy formation rather than to

161 ain of the AMPAR for their function, but the gating is influenced by this surface in opposing directi

162 reported voltage-dependence of Panx1 channel gating is not directly mediated by the membrane potentia

163 by measuring the pH response of an extended gate ISFET pH sensor.

164 unction or a gain-of-function of the voltage-gated K+ channel Kv1.2, were described to cause a new mo

165 citability through the activation of voltage-gated KCNQ2-5 potassium channels.

166 SMIT1 also altered the gating kinetics and/or voltage dependence of KCNQ2, KCNQ

167 ar dynamics simulations to characterize MscL gating kinetics in different bilayer environments under

168 s), yielding a receptor complex with altered gating kinetics, pharmacology, and pore properties.

169 cated in E-T coupling, activation of voltage-gated L-type Ca(2+) channels (LTCCs) in the plasma membr

170 ePYR1 recognizes and binds ABA by the common gate-latch-lock mechanism resembling the Arabidopsis ABA

171 ential role of these residues in hydrophobic gating, Leu267 and Leu270 in human Slo2.1 were each repl

172 Here, a cradle-to-gate life cycle assessment for the production of 15 diff

173 lex with the hook motif of hGW182 reveals a "gate"-like interaction that is critical for GW182 dockin

174 g of a planar back gate and a point-like top gate made by decorating a scanning tunnelling microscope

175 Mechanical gating may be mediated by the membrane or by protein(s)

176 inhibition to regulate sensory thresholds by gating mechanical inputs in the dorsal horn.

177 Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its

178 Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hin

179 n and most likely lead to disturbance of the gating mechanism.

180 ombined results of the ion translocation and gating mechanisms in KR2 may provide a basis for the rat

181 and lipid composition that is determined by gating mechanisms localized at the base of the cilium.

182 LIP protein tags to create a family of light-gated metabotropic glutamate receptors (mGluRs).

183 the TMD elements contribute independently to gating modulation.

184 tg complex, with overall loss of function in gating modulation.

185 The nucleus accumbens (NAc) gates motivated behaviors through the functional output

186 1178S), three of which are homologous to the gating mutations of cystic fibrosis transmembrane conduc

187 Voltage-gated Na(+) (NaV) channels are key regulators of myocard

188 Voltage-gated Na(+) channels (Nav ) modulate neuronal excitabili

189 ends on the gating rates of the fast voltage-gated Na(+) current.

190 is that the regulatory cues conformationally gate NADPH-binding, implicitly providing a handle for ac

191 multimolecular complexes composed of voltage-gated Nav and Kv7 channels associated with cell adhesion

192 otransmission in the spinal cord dorsal horn gates nociceptive signaling, is essential in maintaining

193 ites and a helix controlling the cytoplasmic gate of KdpA is linked to the phosphorylation domain of

194 the sensitivity to GPCR-Gq/11-PLC-dependent gating of a receptor-operated channel.

195 s especially noteworthy when considering the gating of ascending signal streams for auditory processi

196 hes using the same catalyst to achieve logic gating of controlled polymerization reactions.

197 s ingested, suggesting pre-systemic feedback gating of drinking.

198 a similar mechanism could also occur in the gating of other ion channels.

199 itivity," and those that alter the selective gating of sensory information or "choice bias." Model-ba

200 number of biological phenomena, notably the gating of stretch activated ion channels.

201 aser switching is performed by electrostatic gating of the metamaterial/graphene device, demonstratin

202 uggests a mechanism of temperature-dependent gating of thermal TRP channels involving an intracellula

203 Ionic-liquid gating on a functional thin film with a low voltage has

204 hannel heterologous expressed in oocytes was gated open by extracellular sulfate.

205 By directly measuring KcsA's activation gate opening and closing in conditions that promote or h

206 also demonstrate that the mechanisms of pore gate-opening-induced and relaxation-induced voltage-sens

207 Our findings could prove useful for quantum gate operations, but also for classical charge and infor

208 unclear how store depletion stimulates this gating pathway.

209 is stress response and impaired sensorimotor gating, phenotypic effects that were associated with dys

210 died on the surface of the soma: the voltage-gated potassium and sodium channels Kv1.4 and Nav1.6 and

211 The voltage-gated potassium channel subfamily A member 3 (Kv1.3) dom

212 I1-IgG-positive specimens had higher voltage-gated potassium channel-IgG immunoprecipitation values (

213 ecific subclasses of voltage- and/or calcium-gated potassium channels may provide an important approa

214 Voltage-gated potassium channels of the KCNQ (Kv7) subfamily are

215 igen-antibody binding interactions induced a gate potential, thereby changing the drain-source curren

216 great insight into the mechanism of voltage-gated processes but has been challenging to study experi

217 ns in previously unreported HVCN1, a voltage-gated proton channel-encoding gene and B-cell receptor s

218 nstantaneous frequency, which depends on the gating rates of the fast voltage-gated Na(+) current.

219 S3, has a unique action, suppressing channel gating rather than blocking the pore of heterologously e

220 ation of interactions in the vicinity of the gating region of the pore, namely between residues E90,

221 However, how TARPs modulate AMPA receptor gating remains poorly understood.

222 el opening, the precise mechanism underlying gating remains poorly understood.

223 tent with their combined role in hydrophobic gating, replacement of both Leu residues with the isoste

224 1) The central gate residue Glu(130) (Glu(90) in Chlamydomonas reinhard

225 g residues (132 to 140), and Leu-122, a pore-gating residue.

226 ate entry pore size and the bulkiness of the gating residues.

227 permeation pathway lies between the core and gate ring of helices, distinct from the transporter path

228 ithfully reproduced by an allosteric channel gating scheme.

229 further demonstrate that these interneurons gate sensory inputs and control pain through temporally

230 ong been known that the somatosensory cortex gates sensory inputs from the contralateral side of the

231 Here we use gate set tomography to completely characterize operation

232 ction, and the need to compile into discrete gate sets, the necessary computations can be performed i

233 we here theoretically show that well-defined gate shape, sensitive response to pH and salt concentrat

234 The AND gate shows high conductivity when treated with UV light

235 CNE1 and KCNE3 subunits modify KCNQ1 channel gating so differently is largely unknown.

236 This voltage-gated sodium (Nav) channel subtype also plays an importa

237 ing genotyping and sequencing of the voltage gated sodium channel (VGSC) gene did not detect the comm

238 However, expression analysis of voltage-gated sodium channel alpha subunits revealed NaV 1.7 mRN

239 ted conformational cycle in a single voltage-gated sodium channel and give insight into the structura

240 ve been associated with mutations in voltage-gated sodium channel genes.

241 The Nav1.1 voltage-gated sodium channel is a critical contributor to excita

242 ABSTRACT: Voltage-gated sodium channel NaV 1.7 is required for acute and i

243 ations in SCN2A, a gene encoding the voltage-gated sodium channel Nav1.2, have been associated with a

244 t the expression and function of the voltage-gated sodium channel Nav1.7 are increased in a preclinic

245 Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sen

246 other vertebrates, target conserved voltage-gated sodium channels (NaV) of nerve and muscle, causing

247 Voltage-gated sodium channels (Navs) play crucial roles in excit

248 nd propagated by a single isoform of voltage gated sodium channels - SCN5A.

249 ing Schwann cells, such as clustered voltage-gated sodium channels at the node of Ranvier and Shaker-

250 from entry through NMDA receptors or voltage-gated sodium channels.

251 printing of programed cells, including logic gates, spatiotemporally responsive patterning, and weara

252 ques because the application of conventional gating strategies currently used in polychromatic flow c

253 Here we sought to develop a flow cytometric gating strategy to reliably identify blood IgG4(+) B cel

254 Comparing top- and strain-gated structures, we find a 58% increase in electron mob

255 iments where the temperature is modulated in gated structures.

256 hat expected from conventional electrostatic gating, suggesting the possible role of a current-gain i

257 This oxidation potential-gated technology is amenable to endogenous peptides and

258 nd, to enhance specificity, an RNA-based AND gate that generates combinatorial immunomodulatory outpu

259 representation of the controlled NOT (CNOT) gate that is considerably simpler than earlier work, and

260 h gate is noncooperative, with the number of gates that can be accommodated inside the lumen a functi

261 olar amino acids produce channels with leaky gates that conduct ions in the resting state.

262 fluorophore, we constructed AND and OR logic gates that respond to synthetic microRNA (miRNA) inputs.

263 diverse stimuli that directly or indirectly gate the channel selectivity filter (SF).

264 model: force is transmitted via a tether to gate the channel.

265 tude motions within contact F-Q pairs, which gate the electronic coupling, are suggested to be the li

266 TIM1, as it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC channel acti

267 lable formation of the 2DEG via ionic liquid gating, thereby forming a nonvolatile switch.

268 hrough graphene nanoribbons, cascading logic gates through incoherent spintronic switching.

269 s, revealing that these substitutions impair gating through a mechanism independent of orthosteric bi

270 aims to uncover novel insights into channel gating through in-depth structure-function analysis.

271 rs of magnitude longer than typical exchange gate times, and exceeding the longest coherence times re

272 tride (TiN) film, which is incorporated in a gated TiN/SiO2/Ag plasmonic heterostructure.

273 a2 linker, a region that typically acts as a gate to direct RNA or antitoxin binding.

274 h and inhibitory populations that serve as a gate to prevent innocuous stimuli from activating the no

275 gic require extra devices in each individual gate to provide reconfigurability, the proposed gate is

276 is decoded by both dynamic filters and logic gates to shape target gene responses in a context-specif

277 Consistent with the Mlp1/2 role in gene gating to nuclear pores, artificial tethering to the nuc

278 These tri-gate transistors act as enhancement-mode transistors wit

279 owth and their parallel integration into tri-gate transistors and photodetectors at wafer scale (cm(2

280 .1 inhibitor, accelerates a subsequent VSDIV gating transition to accelerate entry into the slow inac

281 lobes across successive junctions creates a gate-tunable transport gap without significantly comprom

282 icles, aimed at assessing the quality of the gates used for the engineering of their state.

283 g provides a framework for engineering AMPAR gating using auxiliary subunits.

284 minor immune cell populations by traditional gating using biaxial plots, or identification of populat

285 explanation the dependence of MPR on the ICa gating variable time constants.

286 automata implement OR, AND, XOR and AND-NOT gates via interacting patterns of excitation.

287 ) of eukaryotic Kir channels control channel gating via stability of a novel inactivated closed state

288 By applying an electrochemical (EC) gate voltage to the molecule, we switch the redox group

289 ng strength (Rabi splitting) via the applied gate voltage, and a tenfold enhancement of polaritonic o

290 mical reaction, are distinguished at various gating voltage regions, as confirmed by X-ray photoelect

291 uctivity changes in response to induced back-gate voltages.

292 Na(+) ion from the Na2 site to intracellular gating, we applied a combination of the thermodynamic co

293 of TMHs within them responsible for channel gating, we perform cross-linking by bifunctional reagent

294 found (i) that KcsA undergoes mode-shift of gating when having K(+) as the permeant ion; (ii) that C

295 al the underlying mechanism of force-induced gating, which could serve as a paradigm of the tether mo

296 al data suggest that TRPV1 channels have two gates within their permeation pathway: one formed by a '

297 Several protein complexes localize to the gating zone and may regulate ciliary protein composition

298 hensive map of the molecular orientations of gating zone components along the inner-to-outer axis of

299 ially map to the inner region of the ciliary gating zone.

300 along the inner-to-outer axis of the ciliary gating zone.