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1 iologist as service provider, consultant, or gatekeeper.
2 kinases known to have an endogenous cysteine gatekeeper.
3 cule FliK interacts with FlhB, the secretion gatekeeper.
4 and the AMA protein, function as proteasomal gatekeepers.
5 contain and release cargos with mediation by gatekeepers.
6 blic institutions are children's nutritional gatekeepers.
9 hese two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produce
10 from NSAID-induced damages by initiating the gatekeeper action of cell membranes, subsequent to anti-
12 r microenvironment likely serve as important gatekeepers against cancer progression and metastasis.
13 analogue inhibitor reveals that a glutamate gatekeeper and a sterically constricted active site conf
14 light a dual role for WEE1 as both a mitotic gatekeeper and a surveyor of chromatin synthesis, provid
15 he structure to demonstrate that BioH is the gatekeeper and its physiological substrate is pimeloyl-A
16 ukemia, where miR-150 functions as a pivotal gatekeeper and its repression is required for leukemogen
19 cancer resistance protein (BCRP) are 2 major gatekeepers at the blood-brain barrier (BBB) that restri
20 ription factor of Borrelia burgdorferi is a 'gatekeeper' because it activates genes required for spir
21 functionality of Asp-168, which acts like a gatekeeper by altering the width of the heme cavity acce
22 transcription factors function as metabolic gatekeepers by limiting the amount of cellular ATP to le
23 dify water conductance and gradients at key "gatekeeper" cell layers that impact on whole plant water
25 ensity to aggregate, including enrichment of gatekeeper charged residues at the flanks of hydrophobic
27 These findings suggest that two separate gatekeepers control neuronal conversion and maturation a
28 These results identify a role for Erg as a gatekeeper controlling vascular inflammation, thus provi
30 valent complementarity between an engineered gatekeeper cysteine and an electrophilic inhibitor was d
31 ce networks demonstrates that the removal of gatekeepers disproportionately contributed to network fr
32 bition and activation, CBD-B functions as a "gatekeeper" domain that modulates the control exerted by
33 ent of type II hybrid inhibitors to overcome gatekeeper drug-resistant mutations in cSrc-T338M, as we
35 aturation and consecutively overcoming these gatekeepers enables deterministic reprogramming of HAFs
36 and suggest that this enzyme functions as a gatekeeper enzyme to prevent the vast majority of O-mann
40 n neocortical development as a translational gatekeeper for functionally related mRNA subgroups and p
42 suggest that during WNV infection, Ccr7 is a gatekeeper for nonspecific viral transference to the bra
43 circadian clock has emerged as an important gatekeeper for reducing immunity-associated costs, which
45 irement to suppress ROCK, which may act as a gatekeeper for the transition to anchorage independence.
46 t the nuclear pore complex (NPC) is the sole gatekeeper for transit of cellular material in and out o
47 e use of micro- and nanometre-sized pores as gatekeepers for controlling the movement of fluids, vapo
49 mbranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathol
52 e role of plasmodesmata as both conduits and gatekeepers for the propagation of rapid cell-to-cell si
53 te that intestinal epithelial cells serve as gatekeepers for the supply of AHR ligands to the host an
54 endothelial and epithelial cells as natural gatekeepers for virus-induced sickness behavior, demonst
56 suggested that absence of CAC can act as a "gatekeeper" for further testing among low- and intermedi
59 This is the first evidence for an organelle gatekeeper function at the AIS, which could provide a re
61 arget of P4H1 in O(2) regulation, indicate a gatekeeper function for the beta3-galactosyltransferase
66 al two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenti
68 rboxylic acid cycle metabolites bypassed the gatekeeper function of PAX5 and IKZF1 and readily enable
69 with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be pron
70 of SOD2 activity and ROS by SIRT1 provides a gatekeeper function to reduce PARK2-mediated mitophagy a
73 ieved by epigenetic regulation of a critical gatekeeper gene, the transcription factor Elf5, that rei
74 e for a pivotal role of Rassf1a as an early 'gatekeeper' gene, whose loss of function deteriorates ce
76 MYD88 expressing WM cells with a mutated HCK gatekeeper greatly increased the half maximal effective
79 ognized element in its C-terminal region, a 'gatekeeper' helix, which extends over the adjacent subun
80 , decreased phosphorylation of the NF-kappaB gatekeeper IkappaBalpha and survival occurred in MYD88 L
82 Conclusion: When PSMA PET is used as the gatekeeper in addition to bone scanning, radionuclide th
83 show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) wher
87 (PP) inhibitors due to the presence of a Gly gatekeeper in the essential calcium dependent protein ki
89 ferase 1 (UGT1) is a central quality control gatekeeper in the mammalian endoplasmic reticulum (ER).
90 ted substrate flexibility and functions as a gatekeeper in the processing of unnatural substrates.
91 2 of the mitochondrial TIM23 translocon as a gatekeeper in the release of membrane proteins from the
92 findings define PTEN as an essential genomic gatekeeper in the skin through its ability to positively
98 This pseudo-atomic model of the connector-gatekeeper interaction revealed the existence of a commo
101 This finding suggests the presence of a gatekeeper kinase activity that controls latent HIV-1 in
102 We recently demonstrated the presence of a gatekeeper kinase function that controls latent HIV-1 in
103 therapeutic stimuli that do not target this gatekeeper kinase will likely fail to trigger efficient
104 When implemented on a single FPGA chip, GateKeeper maintains high accuracy (on average >96%) whi
105 d causes receptor degradation, suggesting a "gatekeeper" mechanism that ensures targeting of inactive
106 eceptor tyrosine kinases identifiable by the gatekeeper Met-502 and the unique hinge loop conformatio
110 rt in axons and instead suggest an organelle gatekeeper model in which UNC-16 (JIP3/Sunday Driver) se
111 ndings imply a new paradigm for LIN28 - as a gatekeeper molecule that regulates the transition betwee
112 d for renal cancer, as an inhibitor for ABL1 gatekeeper mutant drug-resistant leukaemia patients.
115 L) with BCR-ABL kinase inhibitors, the T315I gatekeeper mutant has emerged as resistant to all curren
116 ks native and mutated BCR-ABL, including the gatekeeper mutant T315I, which is uniformly resistant to
117 the regulatory spine is preassembled in this gatekeeper mutant, rendering phosphorylation on the acti
119 unds effectively inhibit clinically relevant gatekeeper mutants of KIT and Abl in biochemical and cel
120 s are conformationally less flexible, target gatekeeper mutated drug-resistant EGFR-L858R/T790M, and
121 new FGFR inhibitors and identify a secondary gatekeeper mutation as a mechanism of acquired resistanc
122 cquired resistance caused by the EGFR(T790M) gatekeeper mutation can occur either by selection of pre
124 ar, the resistance to imatinib caused by the gatekeeper mutation T315I in Bcr-Abl remains a challenge
129 ant to higher doses (1 muM) also developed a gatekeeper mutation, L1196M, within the kinase domain, r
130 s ineffectual against EML4-ALK harboring the gatekeeper mutation, we observed that two structurally d
134 GIST and the Kit(T669I) (human KIT(T670I)) "gatekeeper" mutation found in imatinib-resistant GIST pa
136 ously sensitive TNBCs, we failed to identify gatekeeper mutations, new driver events or drug pump act
138 Our data point to the importance of such "gatekeeper" mutations in enabling major changes in subst
139 reas high-dose treatment selected for T315I "gatekeeper" mutations resistant to all 3 Food and Drug A
141 cally demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulator
142 g in an E3 complex, and establish Usp37 as a gatekeeper of APC/C-mediated ubiquitination of cyclin A.
143 tigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin
144 d previously unrecognized role of BRCA2 as a gatekeeper of DOX-induced cardiomyocyte apoptosis and su
147 drogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced
149 thin a lipophilic pocket past the methionine gatekeeper of group II PAKs approached by these type I 1
153 ed OTX2 as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in m
154 vations define a specific role for Akt2 as a gatekeeper of osteogenic differentiation through regulat
155 ntly been identified as a key neuroendocrine gatekeeper of reproduction and is essential for the init
156 ry metabolite regulator), serves as a global gatekeeper of secondary metabolism and a repressor of nu
157 of PLN's inhibitory activity and a critical gatekeeper of SR calcium cycling and contractility in th
158 his issue of Neuron now identifies BDNF as a gatekeeper of synaptic and behavioral plasticity in coca
159 assign functional significance to Tcf-1 as a gatekeeper of T-cell fate and show that Tcf-1 is directl
160 ing epithelial markers such as E-cadherin, a gatekeeper of the epithelial phenotype and a suppressor
161 role of innate leukotriene B4 signaling as a gatekeeper of the hematopoietic niche transition.Hematop
163 Mechanistically, miR-23a targeted PPIF, gatekeeper of the mitochondria permeability transition p
166 lytic pathway, revealing how CD44 could be a gatekeeper of the Warburg effect (aerobic glycolysis) in
169 sient receptor potential vanilloid 5) is the gatekeeper of transcellular Ca(2+) reabsorption in the d
170 aled, for the first time, that Nrf2 is a key gatekeeper of Txnip transcription, suppressing both its
171 ophils, in cooperation with serum, are vital gatekeepers of a host's microbiome and frontline defende
172 of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new tre
174 repression and highlight Ovol1 and Ovol2 as gatekeepers of epithelial adhesion and differentiation b
175 we identified bone lining cells as important gatekeepers of estrogen-controlled bone resorption.
176 r results further indicate that ET cells are gatekeepers of glomerular output and prime determinants
181 ough taxonomists have traditionally acted as gatekeepers of order, the numbers of, and speed at which
184 ber of tropomyosin (Tm) isoforms function as gatekeepers of the actin filament, controlling the spati
186 mily proteins BAX and BAK serve as essential gatekeepers of the intrinsic apoptotic pathway and, when
187 hemostatic plug but also act individually as gatekeepers of the vascular wall to help preserve vascul
189 ls, pointing to the endothelial cells as the gatekeepers of this hyperaggressive host immune response
192 ctokinase-1 (PFK1), which is considered the "gatekeeper" of glycolysis because it catalyzes the step
193 eterochromatin protein 1 (HP1) proteins are "gatekeepers" of epigenetic gene silencing that is mediat
194 at tumor-reactive CD4(+) T cells act as the "gatekeepers" of the host antitumor immunity in the postc
197 ved pathways represent central oncogenic or 'gatekeeper' pathways that are pivotal to understanding t
198 vel findings demonstrate that the glycolysis gatekeeper PDK1 has a critical role in BCSC reprogrammin
199 e that several univariate methods provide a "gatekeeper" performance threshold that should be applied
204 Mutations in the catalytic domain at the gatekeeper position represent the most prominent drug-re
206 a lead us to propose that the SAC is a major gatekeeper preventing the progression of oocytes harbour
208 e protein classes is mediated by a conserved gatekeeper protein, MxiC, in Shigella As its molecular m
209 threaded models of gp8 (connector) and gp11 (gatekeeper) proteins, which were docked into the corresp
211 e mutants of ALK in the phosphate anchor and gatekeeper regions were generated and their kinase activ
212 be employed in multivalent systems to act as gatekeepers regulating post-translational modification.
213 may allow proline to act as a conformational gatekeeper, regulating interconversion between monomer a
214 ge exploits a large-to-small mutation of the gatekeeper residue (a conserved hydrophobic amino acid)
215 from both parasites contains a rare glycine gatekeeper residue adjacent to the ATP-binding pocket.
216 e, the BAZ1A bromodomain has a non-canonical gatekeeper residue and binds relatively weakly to acetyl
217 ce through a secondary T790M mutation at the gatekeeper residue and dose-limiting toxicities from wil
218 identifies a phenyl ring that traverses the gatekeeper residue and positions the thiazole in the bac
221 an kinases by capitalizing on a small serine gatekeeper residue in the active site of the Plasmodium
222 Remarkably, CDPK1 contains a small glycine gatekeeper residue in the ATP binding pocket making it s
223 We demonstrate here that Lys-35 acts as a gatekeeper residue in TTR, strongly decreasing its amylo
226 succeed in being effective against the T338M gatekeeper residue mutation in the kinase binding site.
227 We find that Dasatinib's impotency against gatekeeper residue mutations arises from a loss of ligan
229 dole derivatives reveal the influence of the gatekeeper residue on the orientation of small-molecule
230 cts the N- and C-lobes and, in most cases, a gatekeeper residue that is thought to exert allosteric c
231 ase domain, specifically substitution of the gatekeeper residue threonine-790 with methionine (T790M)
232 e presence of a heterozygous mutation at the gatekeeper residue, encoding FGFR3(V555M); consistent wi
233 Although this mutation does not lie at the gatekeeper residue, it confers resistance to ROS1 kinase
234 istance, through a secondary mutation of the gatekeeper residue, means that clinical responses only l
238 3.28) act either as molecular switches or as gatekeeper residues that introduce constraints limiting
239 en properly occupied concomitantly opens the gatekeeper residues within the active site and realigns
243 cases, introduction of a glycine or alanine gatekeeper results in diminished kinase activity and ATP
244 4 and 2 regained catalytic activity, the G1 gatekeeper retinoblastoma protein was phosphorylated and
245 e for selection by thymic MHC2, suggesting a gatekeeper role for ITK in ensuring that only Tregs sele
246 ing hepatocarcinogenesis and establish a new gatekeeper role for p53 in repressing c-MYC-induced CSC
248 well known that the small intestine plays a gatekeeper role in the maintenance of cholesterol balanc
249 ed MAN1B1 can play a mannosidase-independent gatekeeper role in the proteostasis network of higher eu
250 stroke, we found that the cerebellum plays a gatekeeper role, as lesions of the tonsil, the lobus sem
253 inically are the acquisition of a secondary "gatekeeper" T790M EGFR mutation that increases the affin
254 nally, we identify the retromer complex as a gatekeeper, terminating beta-arrestin 1-mediated ERK pho
255 ntrinsic rheostat of BMP signalling: it is a gatekeeper that governs the transition between stem cell
262 protease an additional histidine acts as a "gatekeeper" that fine-tunes the sensitivity of the PC1/3
264 ) and magnetic resonance CA as a noninvasive gatekeeper to CA in determining the etiology of heart fa
265 ically effective, and potentially economical gatekeeper to CA in patients presenting with heart failu
268 nment makes the gold nanoparticles work as a gatekeeper to control the release of guest molecules fro
269 between beta-CD and diazo-linker works as a gatekeeper to control the release of trapped molecules f
274 e potential of CCTA to serve as an effective gatekeeper to invasive coronary angiography will depend,
275 bit either role of Ded1, positioning it as a gatekeeper to optimize Ded1 activity to the appropriate
276 Trial integration could serve as an early gatekeeper to plasticity, helping to ensure that longer-
279 sociation of KIR and that His-36 serves as a gatekeeper to prevent unregulated signaling through KIR2
280 f how kinase-substrate recognition acts as a gatekeeper to regulate actin cytoskeletal dynamics.
281 cell body and the cilium and functions as a gatekeeper to regulate trafficking of ciliary proteins.
282 er, our study identifies TRAF6 as a critical gatekeeper to restrict p53 mitochondrial translocation,
283 A-based lesion-specific ischemia will be the gatekeeper to the cardiac catheterization laboratory and
286 e data suggest that SHIP2 and A34 may act as gatekeepers to regulate dissemination of poxviruses when
287 results identify SCS macrophages as crucial gatekeepers to the CNS that prevent fatal viral invasion
288 suggests that it may serve as an effective "gatekeeper" to invasive testing in patients needing adju
291 : (1) Question, Persuade, and Refer (QPR), a gatekeeper training module targeting teachers and other
292 ceted suicide prevention programs, including gatekeeper training, education and mental health awarene
293 ches that need further investigation include gatekeeper training, education of physicians, and intern
295 , we reported SYMRK to be phosphorylated on "gatekeeper" Tyr both in vitro as well as in planta.
296 cases been found to function as "structural gatekeepers," which avoid unwanted interactions by negat
297 gene (RB1; encoding RB) is often cited as a gatekeeper, whose inactivation - direct or indirect - is
299 invite and schedule speakers serve as gender gatekeepers with the power to create or reduce gender di
300 hemistry shows that the FRB domain acts as a gatekeeper, with its rapamycin-binding site interacting
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