ライフサイエンスコーパス: gatekeeper

1 iologist as service provider, consultant, or gatekeeper.

2 kinases known to have an endogenous cysteine gatekeeper.

3 cule FliK interacts with FlhB, the secretion gatekeeper.

4 and the AMA protein, function as proteasomal gatekeepers.

5 contain and release cargos with mediation by gatekeepers.

6 blic institutions are children's nutritional gatekeepers.

7 kinases, while methionine is the predominant gatekeeper (39%).

8 We propose GateKeeper, a new hardware accelerator that functions as

9 hese two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produce

10 from NSAID-induced damages by initiating the gatekeeper action of cell membranes, subsequent to anti-

11 ranscription factors, is emerging as a major gatekeeper against oxidative stress.

12 r microenvironment likely serve as important gatekeepers against cancer progression and metastasis.

13 analogue inhibitor reveals that a glutamate gatekeeper and a sterically constricted active site conf

14 light a dual role for WEE1 as both a mitotic gatekeeper and a surveyor of chromatin synthesis, provid

15 he structure to demonstrate that BioH is the gatekeeper and its physiological substrate is pimeloyl-A

16 ukemia, where miR-150 functions as a pivotal gatekeeper and its repression is required for leukemogen

17 n Fim1 has diverse roles as both a filament "gatekeeper" and as a filament cross-linker.

18 The addition of GateKeeper as a pre-alignment step can reduce the verifi

19 cancer resistance protein (BCRP) are 2 major gatekeepers at the blood-brain barrier (BBB) that restri

20 ription factor of Borrelia burgdorferi is a 'gatekeeper' because it activates genes required for spir

21 functionality of Asp-168, which acts like a gatekeeper by altering the width of the heme cavity acce

22 transcription factors function as metabolic gatekeepers by limiting the amount of cellular ATP to le

23 dify water conductance and gradients at key "gatekeeper" cell layers that impact on whole plant water

24 ting T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.

25 ensity to aggregate, including enrichment of gatekeeper charged residues at the flanks of hydrophobic

26 Removal of gatekeeper control in the E292A mutant resulted in a sel

27 These findings suggest that two separate gatekeepers control neuronal conversion and maturation a

28 These results identify a role for Erg as a gatekeeper controlling vascular inflammation, thus provi

29 Thus, Aquarius and HRDE-1 act as gatekeepers coordinating gene expression and genome defe

30 valent complementarity between an engineered gatekeeper cysteine and an electrophilic inhibitor was d

31 ce networks demonstrates that the removal of gatekeepers disproportionately contributed to network fr

32 bition and activation, CBD-B functions as a "gatekeeper" domain that modulates the control exerted by

33 ent of type II hybrid inhibitors to overcome gatekeeper drug-resistant mutations in cSrc-T338M, as we

34 mesopores of MSN, which is regulated by the gatekeeper effect of FITC-G-Ins.

35 aturation and consecutively overcoming these gatekeepers enables deterministic reprogramming of HAFs

36 and suggest that this enzyme functions as a gatekeeper enzyme to prevent the vast majority of O-mann

37 Due to its function as an inflammatory gatekeeper, expression and activation of NLRP3 need to b

38 The gatekeeper feature is conserved across membrane-associat

39 APC is considered a gatekeeper for colorectal cancer (CRC).

40 n neocortical development as a translational gatekeeper for functionally related mRNA subgroups and p

41 ant coronary artery disease and can act as a gatekeeper for invasive revascularization.

42 suggest that during WNV infection, Ccr7 is a gatekeeper for nonspecific viral transference to the bra

43 circadian clock has emerged as an important gatekeeper for reducing immunity-associated costs, which

44 teric hindrance, thus serving as a molecular gatekeeper for substrate binding and catalysis.

45 irement to suppress ROCK, which may act as a gatekeeper for the transition to anchorage independence.

46 t the nuclear pore complex (NPC) is the sole gatekeeper for transit of cellular material in and out o

47 e use of micro- and nanometre-sized pores as gatekeepers for controlling the movement of fluids, vapo

48 onstrating that cadherins-6, -9, and -10 are gatekeepers for high-magnitude LTP.

49 mbranes that envelop the brain, as potential gatekeepers for modulating brain inflammation and pathol

50 phase ranges of cortical oscillations act as gatekeepers for perception.

51 Microorganisms have a role as gatekeepers for terrestrial carbon fluxes, either causin

52 e role of plasmodesmata as both conduits and gatekeepers for the propagation of rapid cell-to-cell si

53 te that intestinal epithelial cells serve as gatekeepers for the supply of AHR ligands to the host an

54 endothelial and epithelial cells as natural gatekeepers for virus-induced sickness behavior, demonst

55 As dietary gatekeepers for young children, parents are often the pr

56 suggested that absence of CAC can act as a "gatekeeper" for further testing among low- and intermedi

57 These data support the role of LpL as the "gatekeeper" for tissue lipid distribution.

58 hypothesise that W68 may act as a molecular'gatekeeper' for Kir channels.

59 This is the first evidence for an organelle gatekeeper function at the AIS, which could provide a re

60 Thus, EEPD1 performs a gatekeeper function for replication fork repair by media

61 arget of P4H1 in O(2) regulation, indicate a gatekeeper function for the beta3-galactosyltransferase

62 CsfB thus appears to serve a gatekeeper function in blocking the action of two sigma

63 Targeting this gatekeeper function may provide new pharmacotherapeutic

64 In summary, our data suggest that the gatekeeper function of Apc consists of two roles, clonal

65 pansion (crypt fission), consistent with the gatekeeper function of Apc.

66 al two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenti

67 Our study indicates that the gatekeeper function of omega-3 PUFAs improves GI safety

68 rboxylic acid cycle metabolites bypassed the gatekeeper function of PAX5 and IKZF1 and readily enable

69 with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be pron

70 of SOD2 activity and ROS by SIRT1 provides a gatekeeper function to reduce PARK2-mediated mitophagy a

71 sts that CBD-B dynamics are critical for its gatekeeper function.

72 ect on actin binding but could determine its gatekeeper function.

73 ieved by epigenetic regulation of a critical gatekeeper gene, the transcription factor Elf5, that rei

74 e for a pivotal role of Rassf1a as an early 'gatekeeper' gene, whose loss of function deteriorates ce

75 suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth.

76 MYD88 expressing WM cells with a mutated HCK gatekeeper greatly increased the half maximal effective

77 cell lines, mutant BRAF bound the ER stress gatekeeper GRP78, which rapidly expanded the ER.

78 Activity assays demonstrate that the gatekeeper helix is important for directing the substrat

79 ognized element in its C-terminal region, a 'gatekeeper' helix, which extends over the adjacent subun

80 , decreased phosphorylation of the NF-kappaB gatekeeper IkappaBalpha and survival occurred in MYD88 L

81 When PSMA PET is used as the gatekeeper in addition to bone scanning, radionuclide th

82 Conclusion: When PSMA PET is used as the gatekeeper in addition to bone scanning, radionuclide th

83 show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) wher

84 or proline isomerization as a conformational gatekeeper in domain swapping and oligomerization.

85 Our data indicate that NOTCH1 acts as a gatekeeper in human cSCC.

86 a hormone receptor that acts as a molecular gatekeeper in reproductive decisions.

87 (PP) inhibitors due to the presence of a Gly gatekeeper in the essential calcium dependent protein ki

88 SIK pathway functions as a key gluconeogenic gatekeeper in the liver.

89 ferase 1 (UGT1) is a central quality control gatekeeper in the mammalian endoplasmic reticulum (ER).

90 ted substrate flexibility and functions as a gatekeeper in the processing of unnatural substrates.

91 2 of the mitochondrial TIM23 translocon as a gatekeeper in the release of membrane proteins from the

92 findings define PTEN as an essential genomic gatekeeper in the skin through its ability to positively

93 A gatekeeper in this process is activation of beta(2) inte

94 ion, which recognizes CX3CR1 as an essential gatekeeper in this scenario.

95 enin signaling components, which are crucial gatekeepers in common forms of intestinal cancer.

96 This reveals that STRA6 functions as a "gatekeeper" in retinol (vitamin A)-mediated differentiat

97 arch did not become centralized around a few gatekeeper institutions.

98 This pseudo-atomic model of the connector-gatekeeper interaction revealed the existence of a commo

99 designed to assess the role of the putative gatekeeper interactions.

100 GateKeeper is the first design to accelerate pre-alignme

101 This finding suggests the presence of a gatekeeper kinase activity that controls latent HIV-1 in

102 We recently demonstrated the presence of a gatekeeper kinase function that controls latent HIV-1 in

103 therapeutic stimuli that do not target this gatekeeper kinase will likely fail to trigger efficient

104 When implemented on a single FPGA chip, GateKeeper maintains high accuracy (on average >96%) whi

105 d causes receptor degradation, suggesting a "gatekeeper" mechanism that ensures targeting of inactive

106 eceptor tyrosine kinases identifiable by the gatekeeper Met-502 and the unique hinge loop conformatio

107 We target the gatekeeper MET146 of c-Jun N-terminal kinase 3 (JNK3) to

108 Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1).

109 Our Emotional Gatekeeper model demonstrates how this circuit enables f

110 rt in axons and instead suggest an organelle gatekeeper model in which UNC-16 (JIP3/Sunday Driver) se

111 ndings imply a new paradigm for LIN28 - as a gatekeeper molecule that regulates the transition betwee

112 d for renal cancer, as an inhibitor for ABL1 gatekeeper mutant drug-resistant leukaemia patients.

113 The T790M gatekeeper mutant favors activation by stabilizing a hyd

114 What is more the T315I gatekeeper mutant has a significant impact on the bindin

115 L) with BCR-ABL kinase inhibitors, the T315I gatekeeper mutant has emerged as resistant to all curren

116 ks native and mutated BCR-ABL, including the gatekeeper mutant T315I, which is uniformly resistant to

117 the regulatory spine is preassembled in this gatekeeper mutant, rendering phosphorylation on the acti

118 In addition, the same gatekeeper mutants failed to restore proper symbiotic fe

119 unds effectively inhibit clinically relevant gatekeeper mutants of KIT and Abl in biochemical and cel

120 s are conformationally less flexible, target gatekeeper mutated drug-resistant EGFR-L858R/T790M, and

121 new FGFR inhibitors and identify a secondary gatekeeper mutation as a mechanism of acquired resistanc

122 cquired resistance caused by the EGFR(T790M) gatekeeper mutation can occur either by selection of pre

123 As such, the design of gatekeeper mutation resistant kinase inhibitors is a cru

124 ar, the resistance to imatinib caused by the gatekeeper mutation T315I in Bcr-Abl remains a challenge

125 ever, resistance mutations, particularly the gatekeeper mutation T790M, limit this efficacy.

126 This gatekeeper mutation therefore identifies a key missing s

127 The BCR-ABL1 kinase domain gatekeeper mutation Thr315Ile (T315I) confers resistance

128 This gatekeeper mutation was readily detected using a unique

129 ant to higher doses (1 muM) also developed a gatekeeper mutation, L1196M, within the kinase domain, r

130 s ineffectual against EML4-ALK harboring the gatekeeper mutation, we observed that two structurally d

131 y ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation.

132 esistance to other TKIs, including the F691L gatekeeper mutation.

133 e kinase domain of ALK, including the L1196M gatekeeper mutation.

134 GIST and the Kit(T669I) (human KIT(T670I)) "gatekeeper" mutation found in imatinib-resistant GIST pa

135 resistance are not active against the T315I "gatekeeper" mutation.

136 ously sensitive TNBCs, we failed to identify gatekeeper mutations, new driver events or drug pump act

137 zotinib-resistant tumors harboring secondary gatekeeper mutations.

138 Our data point to the importance of such "gatekeeper" mutations in enabling major changes in subst

139 reas high-dose treatment selected for T315I "gatekeeper" mutations resistant to all 3 Food and Drug A

140 evaluations across the different nutritional gatekeepers need to be integrated.

141 cally demanding process in which mTORC1, the gatekeeper of anabolism, occupies a privileged regulator

142 g in an E3 complex, and establish Usp37 as a gatekeeper of APC/C-mediated ubiquitination of cyclin A.

143 tigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin

144 d previously unrecognized role of BRCA2 as a gatekeeper of DOX-induced cardiomyocyte apoptosis and su

145 lial Tie2 receptor, has been identified as a gatekeeper of endothelial activation.

146 We find that FOXO1 acts as a gatekeeper of endothelial quiescence, which decelerates

147 drogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced

148 stem regulates DA release and is a canonical gatekeeper of goal-directed behavior.

149 thin a lipophilic pocket past the methionine gatekeeper of group II PAKs approached by these type I 1

150 signals on eIF4F positions this factor as a gatekeeper of malignant fate.

151 Thus, MICU1 is a gatekeeper of MCU-mediated Ca(2+)(m) uptake that is esse

152 Here, we demonstrate that the gatekeeper of mitochondrial Ca(2+) uptake, Mitochondrial

153 ed OTX2 as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in m

154 vations define a specific role for Akt2 as a gatekeeper of osteogenic differentiation through regulat

155 ntly been identified as a key neuroendocrine gatekeeper of reproduction and is essential for the init

156 ry metabolite regulator), serves as a global gatekeeper of secondary metabolism and a repressor of nu

157 of PLN's inhibitory activity and a critical gatekeeper of SR calcium cycling and contractility in th

158 his issue of Neuron now identifies BDNF as a gatekeeper of synaptic and behavioral plasticity in coca

159 assign functional significance to Tcf-1 as a gatekeeper of T-cell fate and show that Tcf-1 is directl

160 ing epithelial markers such as E-cadherin, a gatekeeper of the epithelial phenotype and a suppressor

161 role of innate leukotriene B4 signaling as a gatekeeper of the hematopoietic niche transition.Hematop

162 as mitochondrial carotenoid scavenger and a gatekeeper of the intrinsic apoptotic pathway.

163 Mechanistically, miR-23a targeted PPIF, gatekeeper of the mitochondria permeability transition p

164 The nuclear pore complex (NPC) is the gatekeeper of the nucleus, capable of actively discrimin

165 Our study identifies CD2AP as the gatekeeper of the podocyte TGF-beta response through its

166 lytic pathway, revealing how CD44 could be a gatekeeper of the Warburg effect (aerobic glycolysis) in

167 Functioning as a gatekeeper of this developmental signaling transition, t

168 chizosaccharomyces pombe Dcp2 is a conserved gatekeeper of this open-to-closed transition.

169 sient receptor potential vanilloid 5) is the gatekeeper of transcellular Ca(2+) reabsorption in the d

170 aled, for the first time, that Nrf2 is a key gatekeeper of Txnip transcription, suppressing both its

171 ophils, in cooperation with serum, are vital gatekeepers of a host's microbiome and frontline defende

172 of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new tre

173 IAPs are therefore, not only gatekeepers of cell death, but are probably also involve

174 repression and highlight Ovol1 and Ovol2 as gatekeepers of epithelial adhesion and differentiation b

175 we identified bone lining cells as important gatekeepers of estrogen-controlled bone resorption.

176 r results further indicate that ET cells are gatekeepers of glomerular output and prime determinants

177 Thus, our results point to ECs as gatekeepers of HSPC trafficking and identify a CD26-medi

178 "Master" transcription factors are the gatekeepers of lineage identity.

179 ts were enriched at promoters and may act as gatekeepers of monoallelic mRNA expression.

180 ying potassium (GIRK) channels are important gatekeepers of neuronal excitability.

181 ough taxonomists have traditionally acted as gatekeepers of order, the numbers of, and speed at which

182 w that stimulatory peptides are the ultimate gatekeepers of puberty.

183 l occupancy, suggesting that nucleosomes are gatekeepers of TF binding sites.

184 ber of tropomyosin (Tm) isoforms function as gatekeepers of the actin filament, controlling the spati

185 We identify macrophages as gatekeepers of the cancer-host cell interaction: deprivi

186 mily proteins BAX and BAK serve as essential gatekeepers of the intrinsic apoptotic pathway and, when

187 hemostatic plug but also act individually as gatekeepers of the vascular wall to help preserve vascul

188 re increasingly recognized as organ-specific gatekeepers of their microenvironment.

189 ls, pointing to the endothelial cells as the gatekeepers of this hyperaggressive host immune response

190 These studies identify DCs as metabolic gatekeepers of thymic egress.

191 f the downstream effector ERK is a critical "gatekeeper" of behavioral sensitivity to ethanol.

192 ctokinase-1 (PFK1), which is considered the "gatekeeper" of glycolysis because it catalyzes the step

193 eterochromatin protein 1 (HP1) proteins are "gatekeepers" of epigenetic gene silencing that is mediat

194 at tumor-reactive CD4(+) T cells act as the "gatekeepers" of the host antitumor immunity in the postc

195 Phosphofructokinase-1 (PFK1), the 'gatekeeper' of glycolysis, catalyses the committed step

196 As one of the primary 'gatekeepers' of the cell, p53 has a major role in sensin

197 ved pathways represent central oncogenic or 'gatekeeper' pathways that are pivotal to understanding t

198 vel findings demonstrate that the glycolysis gatekeeper PDK1 has a critical role in BCSC reprogrammin

199 e that several univariate methods provide a "gatekeeper" performance threshold that should be applied

200 Substitution of the FLT3 "gatekeeper" phenylalanine with leucine (F691L) conferred

201 Thus, gatekeeper phosphorylation is critical for synchronizing

202 Since gatekeeper phosphorylation was not necessary for activit

203 n especially prevalent T315I mutation at the gatekeeper position of the kinase domain.

204 Mutations in the catalytic domain at the gatekeeper position represent the most prominent drug-re

205 ic regulator of male germ cell fate and as a gatekeeper preventing initiation of TGCTs.

206 a lead us to propose that the SAC is a major gatekeeper preventing the progression of oocytes harbour

207 paB, the needle itself and the intracellular gatekeeper protein MxiC.

208 e protein classes is mediated by a conserved gatekeeper protein, MxiC, in Shigella As its molecular m

209 threaded models of gp8 (connector) and gp11 (gatekeeper) proteins, which were docked into the corresp

210 We found that Src with a cysteine gatekeeper recapitulates wild type activity and can be i

211 e mutants of ALK in the phosphate anchor and gatekeeper regions were generated and their kinase activ

212 be employed in multivalent systems to act as gatekeepers regulating post-translational modification.

213 may allow proline to act as a conformational gatekeeper, regulating interconversion between monomer a

214 ge exploits a large-to-small mutation of the gatekeeper residue (a conserved hydrophobic amino acid)

215 from both parasites contains a rare glycine gatekeeper residue adjacent to the ATP-binding pocket.

216 e, the BAZ1A bromodomain has a non-canonical gatekeeper residue and binds relatively weakly to acetyl

217 ce through a secondary T790M mutation at the gatekeeper residue and dose-limiting toxicities from wil

218 identifies a phenyl ring that traverses the gatekeeper residue and positions the thiazole in the bac

219 We further show that mutation of the gatekeeper residue at the edge of the regulatory spine s

220 The presence of a unique glycine gatekeeper residue in TgCDPK1 permits selective inhibiti

221 an kinases by capitalizing on a small serine gatekeeper residue in the active site of the Plasmodium

222 Remarkably, CDPK1 contains a small glycine gatekeeper residue in the ATP binding pocket making it s

223 We demonstrate here that Lys-35 acts as a gatekeeper residue in TTR, strongly decreasing its amylo

224 Instead, mutation of the gatekeeper residue into leucine, alanine, or threonine r

225 We generated an analog-sensitive gatekeeper residue mutant of PKG Ialpha (M438G) that eff

226 succeed in being effective against the T338M gatekeeper residue mutation in the kinase binding site.

227 We find that Dasatinib's impotency against gatekeeper residue mutations arises from a loss of ligan

228 Mutations in the gatekeeper residue of kinases have emerged as a key way

229 dole derivatives reveal the influence of the gatekeeper residue on the orientation of small-molecule

230 cts the N- and C-lobes and, in most cases, a gatekeeper residue that is thought to exert allosteric c

231 ase domain, specifically substitution of the gatekeeper residue threonine-790 with methionine (T790M)

232 e presence of a heterozygous mutation at the gatekeeper residue, encoding FGFR3(V555M); consistent wi

233 Although this mutation does not lie at the gatekeeper residue, it confers resistance to ROS1 kinase

234 istance, through a secondary mutation of the gatekeeper residue, means that clinical responses only l

235 Mutation of a gatekeeper residue, tryptophan 37, in E. coli lipoic aci

236 ses the catalytic dyad, with Y31 acting as a gatekeeper residue.

237 of a secondary EGFR mutation, T790M, at the gatekeeper residue.

238 3.28) act either as molecular switches or as gatekeeper residues that introduce constraints limiting

239 en properly occupied concomitantly opens the gatekeeper residues within the active site and realigns

240 n specifying the subdomain fold by acting as gatekeeper residues.

241 ng a leukemia with the most common, pan-TKI, gatekeeper resistance mutation, T315I.

242 ecific residue, Ile-145, that might act as a gatekeeper restricting access to the binding site.

243 cases, introduction of a glycine or alanine gatekeeper results in diminished kinase activity and ATP

244 4 and 2 regained catalytic activity, the G1 gatekeeper retinoblastoma protein was phosphorylated and

245 e for selection by thymic MHC2, suggesting a gatekeeper role for ITK in ensuring that only Tregs sele

246 ing hepatocarcinogenesis and establish a new gatekeeper role for p53 in repressing c-MYC-induced CSC

247 istent with epigenetic alterations playing a gatekeeper role in cancer.

248 well known that the small intestine plays a gatekeeper role in the maintenance of cholesterol balanc

249 ed MAN1B1 can play a mannosidase-independent gatekeeper role in the proteostasis network of higher eu

250 stroke, we found that the cerebellum plays a gatekeeper role, as lesions of the tonsil, the lobus sem

251 tes that express a drug-resistant methionine gatekeeper (S147 M) CDPK4 mutant.

252 The gatekeeper system opens for viral genome exit at the beg

253 inically are the acquisition of a secondary "gatekeeper" T790M EGFR mutation that increases the affin

254 nally, we identify the retromer complex as a gatekeeper, terminating beta-arrestin 1-mediated ERK pho

255 ntrinsic rheostat of BMP signalling: it is a gatekeeper that governs the transition between stem cell

256 Thus, IL-10 is an essential gatekeeper that maintains immune homeostasis at distal s

257 We propose that N17 and C38 act as gatekeepers that control the intrinsic heterogeneities o

258 Biological ion channels are molecular gatekeepers that control transport across cell membranes

259 Thus, basophils are gatekeepers that link adaptive immunity with innate effe

260 RAS proteins are signal transduction gatekeepers that mediate cell growth, survival, and diff

261 We found evidence of structural gatekeepers that, when mutated, alleviated native strain

262 protease an additional histidine acts as a "gatekeeper" that fine-tunes the sensitivity of the PC1/3

263 ogen and (2) from the sulfonamide N-H to the gatekeeper threonine.

264 ) and magnetic resonance CA as a noninvasive gatekeeper to CA in determining the etiology of heart fa

265 ically effective, and potentially economical gatekeeper to CA in patients presenting with heart failu

266 As a gatekeeper to CA, LGE-CMR was also found to be a cheaper

267 reatic tumorigenesis, and it appears to be a gatekeeper to cancer progression.

268 nment makes the gold nanoparticles work as a gatekeeper to control the release of guest molecules fro

269 between beta-CD and diazo-linker works as a gatekeeper to control the release of trapped molecules f

270 lso has chaperone-like properties, acts as a gatekeeper to direct the outcome of this reaction.

271 vate dehydrogenase, the key Ca(2+)-sensitive gatekeeper to glucose oxidation.

272 ncept that CCTA may be used effectively as a gatekeeper to ICA.

273 Consistent with the role of ASPP2 as a gatekeeper to inflammation, ASPP2-deficient brains posse

274 e potential of CCTA to serve as an effective gatekeeper to invasive coronary angiography will depend,

275 bit either role of Ded1, positioning it as a gatekeeper to optimize Ded1 activity to the appropriate

276 Trial integration could serve as an early gatekeeper to plasticity, helping to ensure that longer-

277 As such, GAT3 acts as a gatekeeper to prevent diffusion of GABA away from synaps

278 eins in central hepatocytes and may act as a gatekeeper to prevent hepatic bile salt overload.

279 sociation of KIR and that His-36 serves as a gatekeeper to prevent unregulated signaling through KIR2

280 f how kinase-substrate recognition acts as a gatekeeper to regulate actin cytoskeletal dynamics.

281 cell body and the cilium and functions as a gatekeeper to regulate trafficking of ciliary proteins.

282 er, our study identifies TRAF6 as a critical gatekeeper to restrict p53 mitochondrial translocation,

283 A-based lesion-specific ischemia will be the gatekeeper to the cardiac catheterization laboratory and

284 Peer review acts as the gatekeeper to these mechanisms.

285 Reviewers thereby act as critical gatekeepers to high-quality research.

286 e data suggest that SHIP2 and A34 may act as gatekeepers to regulate dissemination of poxviruses when

287 results identify SCS macrophages as crucial gatekeepers to the CNS that prevent fatal viral invasion

288 suggests that it may serve as an effective "gatekeeper" to invasive testing in patients needing adju

289 RNAP channel and that region 1.1 acts as a "gatekeeper" to monitor channel entry.

290 These residues function as "gatekeepers" to modulate CsgA polymerization efficiency

291 : (1) Question, Persuade, and Refer (QPR), a gatekeeper training module targeting teachers and other

292 ceted suicide prevention programs, including gatekeeper training, education and mental health awarene

293 ches that need further investigation include gatekeeper training, education of physicians, and intern

294 Mutation of the gatekeeper tryptophan abolishes the dynamic behavior of

295 , we reported SYMRK to be phosphorylated on "gatekeeper" Tyr both in vitro as well as in planta.

296 cases been found to function as "structural gatekeepers," which avoid unwanted interactions by negat

297 gene (RB1; encoding RB) is often cited as a gatekeeper, whose inactivation - direct or indirect - is

298 Herein, we show that substituting gatekeeper with nonphosphorylatable residues like Phe or

299 invite and schedule speakers serve as gender gatekeepers with the power to create or reduce gender di

300 hemistry shows that the FRB domain acts as a gatekeeper, with its rapamycin-binding site interacting