ライフサイエンスコーパス: gating

1 invaders in a time-of-day-dependent manner (gating).

2 sed topological invariants to explain memory gating.

3 e direct evidence for K2P selectivity filter gating.

4 allosteric mechanisms regulating its channel gating.

5 and during agonist-dependent and spontaneous gating.

6 near pore constrictions and regulate channel gating.

7 ance, attentional bias, and impaired sensory gating.

8 g bilayer, were actively involved in channel gating.

9 major functional states associated with K(+) gating.

10 ory, anxiety-like behaviour and sensorimotor gating.

11 vity, anxiety, depression, and somatosensory gating.

12 with postsynaptic NMDARs to modify receptor gating.

13 ositively shifting the voltage dependency of gating.

14 ts of mutations on channel voltage-dependent gating.

15 lpha2delta1-mediated shift in the activation gating.

16 ate structural basis of channel assembly and gating.

17 rgo significant relative displacement during gating.

18 icity on VAMP721 binding without influencing gating.

19 -based sensors that undergo analyte-specific gating.

20 accessible site on the channel to alter its gating.

21 ions that couple activation and inactivation gating.

22 ll subsets that may be missed by traditional gating.

23 ganized as a tether that can trigger channel gating.

24 ites reveals their distinct roles in channel gating.

25 ing that the mutation impairs agonist-evoked gating.

26 rs require the presence of external ions for gating.

27 that ATP-binding site 1 modulates intraburst gating.

28 ls and dendritic excitability underlies this gating.

29 o antagonize NsVBa without affecting channel gating.

30 N terminus is indispensable for Orai channel gating.

31 ty to ligand analogously to such proteolytic gating.

32 ate that 14-3-3 protein mediates the coupled gating.

33 ur between KCNQ1 and KCNE1 during activation gating.

34 endent structural changes related to channel gating.

35 e carrier density of graphene via electrical gating.

36 nt's sensitivity to GPCR-Gq/11-PLC-dependent gating.

37 changes in the membrane environment on MscL gating.

38 hways that couple agonist binding to channel gating.

39 We discuss their gating according to the force-from-lipids principle and

40 ndings provide a framework for understanding gating across the family of ionotropic glutamate recepto

41 ent, which also explains residual ATPase and gating activity of dephosphorylated CFTR.

42 peats to the pore, and are poised to control gating allosterically.

43 uppressed channel binding and its effects on gating, also altered the conformational displacement bet

44 gs confirmed this prediction and also showed gating alterations, a reduced glutamate affinity associa

45 tes that the lipid bilayer modulates channel gating, although it is not clear how.

46 l for SB-FETs with the phenomenon of contact gating - an effect that significantly affects the carrie

47 s results in both faster rates of activation gating and an elimination of the fast component of gatin

48 understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotide-gated chan

49 screte open states, each with unique channel gating and conductance properties that reflect contribut

50 ctivation is a complex aspect of Nav channel gating and consists of fast and slow components, each of

51 membrane patches and showed altered channel gating and current flow through open channels.

52 nits is varied, we address the energetics of gating and establish whether gating is a cooperative pro

53 fined, which impedes detailed study of their gating and ion permeation properties.

54 ns the dynamic coupling between CRAC channel gating and ion selectivity.

55 ven by stochastic Ca2+ release channel (RyR) gating and is used to study mechanisms of DAD variabilit

56 s a result, multiple functions such as ionic gating and molecular filtering can be implemented into o

57 conserved transmembrane cavity impacts both gating and permeation properties.

58 coefficient that is capable of tunable water gating and precise small molecule separation.

59 ighbours is an essential ingredient for both gating and readout.

60 xtracellular collar plays a distinct role in gating and represents a hub for powerful allosteric modu

61 3A (or Q4863A in RyR2) critical for both the gating and Ryd binding not only has significantly less i

62 ling to identify residues that contribute to gating and selectivity in discrete open states.

63 position; however, the mechanisms of ciliary gating and the dynamics of the gating components are lar

64 a pi-helix, which is required for stringent gating and tight coupling of ion and substrate fluxes in

65 2Cu3O7-X (YBCO) by simultaneous ionic liquid gating and X-ray absorption experiments.

66 and collapse of the inner pore (hydrophobic gating) and (2) constriction of the inner pore by tight

67 anding of ion selectivity, reversed polarity gating, and cAMP regulation in HCN channels.

68 ers, regulates KCNQ channel ion selectivity, gating, and pharmacology by direct physical interaction

69 ARPs) critically influence the distribution, gating, and pharmacology of AMPARs, but the contribution

70 ransitions, independently coupled to channel gating, and that (2) TRPV1 and Ca(2+)-bound CaM but not

71 halt C-inactivation, prevented mode-shift of gating; and (iii) that, in the total absence of C-type i

72 although their mechanisms of ion permeation gating are not well understood.

73 a reveal that the effect of alcohols on MscL gating arises not through specific binding sites but thr

74 ce DeepCyTOF, a standardization approach for gating, based on deep learning techniques.

75 on of this interaction appears to be sensory gating, because inactivating the central, basolateral, a

76 Consistent with an effect on CFTR gating behavior, we found that altering gating kinetics

77 ells in tumor-bearing mice, which eliminates gating biases and identifies immune cell subsets that ma

78 inity binding sites for CaM at its universal gating brake and its unique form of regulation via the t

79 We show that the gating brake assumes a helical conformation upon binding

80 fically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels.

81 ct Ca(2+)-binding sites on CaM and an intact gating brake sequence (first 39 amino acids of the I-II

82 myocardium of 13% +/- 5%, similar to cardiac gating but with a 90% +/- 57% higher contrast-to-noise r

83 g to gating by dilation, gating by tilt, and gating by a combination of both dilation and tilt.

84 sibility of protein-only mediated mechanical gating by demonstrating that the interaction between Ton

85 signatures" are calculated, corresponding to gating by dilation, gating by tilt, and gating by a comb

86 ay provide a mechanism for the inhibition of gating by inverse agonists such as bicuculline.

87 ulated, corresponding to gating by dilation, gating by tilt, and gating by a combination of both dila

88 Our results demonstrate that, in addition to gating calcium release from intracellular stores, mAChR

89 amics of the holo-form at sites critical for gating cAMP binding.

90 DIV through which modulation of inactivation gating can inhibit or facilitate Nav1.1 function.

91 Spontaneous gating caused by the beta2(L285R) mutation was also redu

92 Spontaneous gating caused by the introduction of the beta2(L285R) mu

93 ves very high accuracy on the semi-automated gating challenge of the FlowCAP-I competition as well as

94 Ion conductivity and the gating characteristics of tetrameric glutamate receptor

95 ural basis and role of the fast component of gating charge (Qfast) is unclear, and its relationship t

96 We then use the gating charge analysis to study how the T1 domain modifi

97 and an elimination of the fast component of gating charge movement and of fluorescence.

98 kinetics, and an unusual underlying biphasic gating charge movement with fast and slow components tha

99 ique to investigate the relationship of fast gating charge movement-to-residue interactions between D

100 inhibition (PPI), a measure of sensorimotor gating commonly deficient in individuals with SCZ and ot

101 The classical explanation for the gating compliance is that the conformational rearrangeme

102 tein interactions that occur between ciliary gating components and transiting cargoes during ciliary

103 ms of ciliary gating and the dynamics of the gating components are largely unknown.

104 proof of principle experiments of an optical gating concept for free electrons via direct time-domain

105 in, only one of which contributes to channel-gating control.

106 p (A305V) that form the GABA binding/channel gating coupling junction and the channel pore (T288N), w

107 teraction between Kv1.3 and NavBeta1 through gating current measurements using the Cut-open Oocyte Vo

108 stal N-terminus (Delta2-135) accelerated off-gating current, but did not influence the relative contr

109 Interestingly, the "true" mode-shift of gating currents was approximately 40 mV, much greater th

110 CF and the action of drugs that repair CFTR gating defects.

111 lly, mice lacking IgSF21 show a sensorimotor gating deficit.

112 e responses and elicits TS-like sensorimotor gating deficits in the D1CT-7 mouse, one of the best-val

113 sensitivity toward divalent cation-mediated gating differed between small atomic ions (current) and

114 lations, believed to exert active inhibitory gating, downmodulate the temporal width of LRD in slower

115 de pore, which accounts for mechanosensitive gating due to in-plane area expansion.

116 ateral somatosensory cortex (iS1) to sensory gating during index finger voluntary activity.

117 This optical gating effect allows us to write and erase p-n junctions

118 osensory processing is subserved by a robust gating effect in the oscillatory domain, as well as a dy

119 develop a quantitative understanding of the gating effect of charged biomolecules in ionic solution

120 via PIP2, and thereby influences the unique gating effects of retigabine.

121 Two gating effects, the electrostatic doping and electrochem

122 of the open state by propofol, i.e., reduced gating efficacy.

123 Quantitatively, membrane tension will alter gating energetics in proportion to the change in project

124 c and thermodynamic remodeling of the mutant gating energetics toward its wild-type counterpart.

125 kinetic and thermodynamic remodelling of the gating energetics towards that of wild-type CTFR.

126 can be used to replicate CD expression-based gating, even in the presence of significant imaging nois

127 ping is impaired, thus revealing key kinetic gating features in CcO.

128 N139 thus assumes a gating function by which proton passage through the D-ch

129 model is used to investigate how random RyR gating gives rise to probabilistic triggered activity in

130 Although gating has been demonstrated in multiple sensory systems

131 loop, a region that is critical for channel gating in all pentameric ligand-gated ion channels.

132 re must capture mechanical forces to control gating in another way.

133 f the confined copolymer that allows logical gating in biosensors and nanofluidic devices.

134 y expressed in neonatal DRG and modifies KAR gating in DRG neurons in a developmentally regulated fas

135 the possible implications of such circadian gating in immune reactions against pathogenic infections

136 ty filter underlies the structural basis for gating in potassium ion channels.

137 f CcO mutants, but also explains how kinetic gating in the D-channel is imperative to achieving high

138 Gating in the human somatosensory cortices is a critical

139 sory and motor cortex, contribute to sensory gating in the iS1 during voluntary activity in humans.

140 mic functional connectivity of somatosensory gating in the lower extremities of healthy human partici

141 esence of a second head generates strain and gating in the myosin-5B dimer that alters the kinetic si

142 can account for highly sensitive mechanical gating in the setting of a narrow, cation-selective pore

143 eptors, confirming that alpha1(T47R) impairs gating independently of activation by any agonist.

144 eptors, confirming that alpha1(T47R) impairs gating independently of agonist activation.

145 are therefore ascribed an important role in gating information transmission across cortex.

146 critical for CFTR function, because channel gating involves NBD1/NBD2 dimerization, and NBD2 contain

147 al cells into discrete groups of cell types (gating) involves time-consuming sequential manual steps,

148 ntrast, SMIT1 had no effect on Kv1.1 (KCNA1) gating, ion selectivity, or pharmacology.

149 e energetics of gating and establish whether gating is a cooperative process involving the concerted

150 ggest that the regulation of CFTR intraburst gating is distinct from the ATP-dependent mechanism that

151 or transition induced in VO2 by ionic liquid gating is due to oxygen vacancy formation rather than to

152 ain of the AMPAR for their function, but the gating is influenced by this surface in opposing directi

153 reported voltage-dependence of Panx1 channel gating is not directly mediated by the membrane potentia

154 CFTR channel gating is strictly coupled to phosphorylation and ATP hy

155 SMIT1 also altered the gating kinetics and/or voltage dependence of KCNQ2, KCNQ

156 ar dynamics simulations to characterize MscL gating kinetics in different bilayer environments under

157 CFTR gating behavior, we found that altering gating kinetics influenced the sensitivity to inhibition

158 s), yielding a receptor complex with altered gating kinetics, pharmacology, and pore properties.

159 ng shift in voltage sensitivities and faster gating kinetics.

160 ential role of these residues in hydrophobic gating, Leu267 and Leu270 in human Slo2.1 were each repl

161 conformational rearrangements to the common gating ligand, phosphatidylinositol bisphosphate (PIP2),

162 Mechanical gating may be mediated by the membrane or by protein(s)

163 inhibition to regulate sensory thresholds by gating mechanical inputs in the dorsal horn.

164 suggesting an S4-S5 linker-mediated PtdInsP2 gating mechanism among TRPML channels.

165 This study proposes a unique channel gating mechanism and delivers detailed molecular insight

166 and implicates selective attention as a main gating mechanism between sensory and memory systems.

167 results suggest that a phosphorylation-based gating mechanism controls cargo selection by yeast retro

168 and these results also support a hydrophobic gating mechanism for control of ion permeation.

169 This hydrophobic gating mechanism has implications for CRAC channel funct

170 Our study indicates that the loop-gating mechanism is likely to be a source of the substra

171 methods can be used to identify not only the gating mechanism of a protein, but also associated physi

172 Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its

173 nput to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive respons

174 tion could, for instance, act as the primary gating mechanism when stimuli are still visible.

175 Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hin

176 n and most likely lead to disturbance of the gating mechanism.

177 ombined results of the ion translocation and gating mechanisms in KR2 may provide a basis for the rat

178 and lipid composition that is determined by gating mechanisms localized at the base of the cilium.

179 ailed structural basis for voltage-dependent gating mechanisms remain obscure.

180 cules but less is known about the underlying gating mechanisms.

181 This nano-gating membrane expands the scope of temperature-respons

182 vely high temperature, here we report a nano-gating membrane with a negative temperature-response coe

183 ions of the diffusion model over the urgency-gating model, and therefore, the notion that evidence ac

184 educed current density, and insensitivity to gating modulation by Ca(2+)-CaM.

185 F-Stg complex was stable, but had diminished gating modulation.

186 the TMD elements contribute independently to gating modulation.

187 tg complex, with overall loss of function in gating modulation.

188 We show that Hm1a inhibits the gating movement of the domain IV voltage sensor (VSDIV),

189 Moreover, the activity of several gating mutants was also partially rescued upon deletion

190 1178S), three of which are homologous to the gating mutations of cystic fibrosis transmembrane conduc

191 o reveal the molecular mechanisms underlying gating, numerous structures for glutamate receptors have

192 mine whether the effects of cross-linking on gating observed are the result of switching of the chann

193 Here we exploit equilibrium gating of a hydrolysis-deficient mutant and apply Phi va

194 the sensitivity to GPCR-Gq/11-PLC-dependent gating of a receptor-operated channel.

195 circuit-based mechanism showing differential gating of afferent control of D1 and D2 MSN activity by

196 s especially noteworthy when considering the gating of ascending signal streams for auditory processi

197 ains over whether this deficit in inhibitory gating of auditory sensory processes has relevance for p

198 sity and modulation of the voltage-dependent gating of CaV1.2.

199 hes using the same catalyst to achieve logic gating of controlled polymerization reactions.

200 ht the utility of Gel-PTH, we achieved "AND" gating of controlled radical polymerization wherein vari

201 s ingested, suggesting pre-systemic feedback gating of drinking.

202 This provides a template to investigate the gating of eukaryotic neurotransmitter receptors, for whi

203 lecular modeling suggest that Rg3 alters the gating of hERG1 channels by interacting with and stabili

204 transformed into electrical signals via the gating of mechanically activated ion channels at sensory

205 Gating of memory encoding was dictated by inter-regional

206 e-delayed cross-frequency connectivity serve gating of memory encoding.

207 Therefore, the gating of memory functions rests on the reciprocally rei

208 -transcriptional regulation for the rhythmic gating of metabolic enzymes remains elusive.

209 a similar mechanism could also occur in the gating of other ion channels.

210 itivity," and those that alter the selective gating of sensory information or "choice bias." Model-ba

211 number of biological phenomena, notably the gating of stretch activated ion channels.

212 We conclude that astrocytes tune the gating of synaptic NMDARs to the vigilance state and dem

213 ne (DMPC) liposomes, suggesting that lateral gating of the BamA barrel and/or hybrid barrel formation

214 aser switching is performed by electrostatic gating of the metamaterial/graphene device, demonstratin

215 ed by an h-current, both of which affect the gating of the Na(+) current.

216 es, which allow membrane voltage to regulate gating of the pore by influencing the Ca(2+) sensors.

217 uggests a mechanism of temperature-dependent gating of thermal TRP channels involving an intracellula

218 urce software is available for the automatic gating of two channel ddPCR experiments in the case wher

219 Ionic-liquid gating on a functional thin film with a low voltage has

220 the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5.

221 e cell firing and (3) transient and coherent gating oscillations.

222 unclear how store depletion stimulates this gating pathway.

223 method to solve for the minimum free-energy gating pathways of the proton-activated bacterial GLIC c

224 niques compared with phase-based respiratory gating (PBRG).

225 ed in Cav3.2 channels to prevent the runaway gating phenotype, a hyperpolarizing shift in voltage sen

226 is stress response and impaired sensorimotor gating, phenotypic effects that were associated with dys

227 nose, thus demonstrating a change in sensory gating potentially mediated by local inhibition of olfac

228 Partial desolvation introduces a gating pressure associated with CO2 adsorption, which sh

229 ritical role for the cholinergic Ipc in this gating process.

230 potassium (Kv1-Kv4) channels in assembly and gating properties.

231 ioral responses to experience by dynamically gating PV+ interneuron function.

232 nstantaneous frequency, which depends on the gating rates of the fast voltage-gated Na(+) current.

233 S3, has a unique action, suppressing channel gating rather than blocking the pore of heterologously e

234 ation of interactions in the vicinity of the gating region of the pore, namely between residues E90,

235 et the mechanisms for temperature and proton gating remain largely unknown.

236 el opening, the precise mechanism underlying gating remains poorly understood.

237 However, how TARPs modulate AMPA receptor gating remains poorly understood.

238 However, the mechanism of gating remains unclear.

239 tent with their combined role in hydrophobic gating, replacement of both Leu residues with the isoste

240 g residues (132 to 140), and Leu-122, a pore-gating residue.

241 The process is, in part, controlled via gating residues localized to the ends of the heptameric

242 ate entry pore size and the bulkiness of the gating residues.

243 he effectiveness of transduction between the gating ring and the pore domain appears to be enhanced.

244 The gating ring and the voltage sensors are directly connect

245 hrough protein interfaces formed between the gating ring and the voltage sensors.

246 Because the gating ring contains sensors to intracellular factors su

247 intramembrane-gated pore and the cytoplasmic gating ring of the channel.

248 r-like domain and the pore domain, forming a gating ring that couples conformational changes triggere

249 nformational changes are propagated from the gating ring to the pore through covalent linkers and thr

250 w how TARPs sculpt the ligand-binding domain gating ring, enhancing kainate potency and diminishing t

251 ithfully reproduced by an allosteric channel gating scheme where the channel is able to open from all

252 ithfully reproduced by an allosteric channel gating scheme.

253 ABSTRACT: Sensory gating (SG) is a phenomenon in which neuronal responses

254 e MATRICS Attention-Vigilance Domain and P50 gating), showed no significant effect.

255 CNE1 and KCNE3 subunits modify KCNQ1 channel gating so differently is largely unknown.

256 advantages, paving the way toward ion-liquid-gating spintronic/electronic devices.

257 This enabled us to probe all four major gating states in native-like membranes by combining elec

258 ques because the application of conventional gating strategies currently used in polychromatic flow c

259 Here we sought to develop a flow cytometric gating strategy to reliably identify blood IgG4(+) B cel

260 hat expected from conventional electrostatic gating, suggesting the possible role of a current-gain i

261 ial segment utilizes a "waterfall" mechanism gating synaptic vesicle transport polarity by promoting

262 This work shows a unique ionic-liquid-gating system for strong interfacial magnetoelectric cou

263 nd has great potential applications in smart gating systems and molecular separation.

264 The defective RyR1 gating that we describe probably contributes significant

265 gdala as the brain region important more for gating the entrance into rather than the exit from catap

266 sites are coherent, they provide a means of gating the flow of neural signals between different cort

267 cdhr15, that form the hair bundle tip links gating the mechanoelectrical transduction channels.

268 ment of the cAMP-protein kinase A pathway in gating the recovery.

269 nformational changes associated with channel gating, the fluorescent non-canonical amino acid coumari

270 TIM1, as it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC channel acti

271 lable formation of the 2DEG via ionic liquid gating, thereby forming a nonvolatile switch.

272 s, revealing that these substitutions impair gating through a mechanism independent of orthosteric bi

273 aims to uncover novel insights into channel gating through in-depth structure-function analysis.

274 ighlight the power of describing ion channel gating through the lens of allosteric coupling.

275 that contribute to O1 or O2 selectivity and gating to minimize undesirable effects.

276 Consistent with the Mlp1/2 role in gene gating to nuclear pores, artificial tethering to the nuc

277 and a 36-state model of gap junction channel gating to simulate electrical signal transfer through el

278 thmia yet the mechanistic basis for the slow gating transition is unclear.

279 .1 inhibitor, accelerates a subsequent VSDIV gating transition to accelerate entry into the slow inac

280 rbations to both protein expression and most gating transitions.

281 in that forms a reverse WXXXH motif with the gating tryptophan.

282 g provides a framework for engineering AMPAR gating using auxiliary subunits.

283 minor immune cell populations by traditional gating using biaxial plots, or identification of populat

284 neurons with channel noise (i.e., stochastic gating variable dynamics), and the network connectivity

285 explanation the dependence of MPR on the ICa gating variable time constants.

286 ) of eukaryotic Kir channels control channel gating via stability of a novel inactivated closed state

287 agnetic anisotropy change as response to the gating voltage is precisely detected by in situ electron

288 mical reaction, are distinguished at various gating voltage regions, as confirmed by X-ray photoelect

289 Na(+) ion from the Na2 site to intracellular gating, we applied a combination of the thermodynamic co

290 uctural basis of CD-I control of Kir channel gating, we examined the effect of the R165A mutation on

291 better the kinetic basis of CFTR intraburst gating, we investigated the single-channel activity of h

292 of TMHs within them responsible for channel gating, we perform cross-linking by bifunctional reagent

293 found (i) that KcsA undergoes mode-shift of gating when having K(+) as the permeant ion; (ii) that C

294 al the underlying mechanism of force-induced gating, which could serve as a paradigm of the tether mo

295 Several protein complexes localize to the gating zone and may regulate ciliary protein composition

296 hensive map of the molecular orientations of gating zone components along the inner-to-outer axis of

297 our understanding of the functional roles of gating zone components in regulating ciliary protein com

298 along the inner-to-outer axis of the ciliary gating zone.

299 ially map to the outer region of the ciliary gating zone.

300 ially map to the inner region of the ciliary gating zone.