ライフサイエンスコーパス: gating mechanism

1 ering-length lipid chains using a cleft-like gating mechanism.

2 ter permeability of AqpB, hinting at a novel gating mechanism.

3 s subunit boundaries, suggesting a concerted gating mechanism.

4 n in NMDA receptors-controls this activation gating mechanism.

5 entual identification of the channel and its gating mechanism.

6 role of Ca(2+) and Na(+) ions in the channel gating mechanism.

7 omain is associated with the channel pore or gating mechanism.

8 the nAChR and provide new insights into the gating mechanism.

9 bably activates the channel through a direct gating mechanism.

10 is no consensus kinetic model for the GABAR gating mechanism.

11 rs (IP(3)Rs) may be critical for the channel gating mechanism.

12 regions, suggesting that they share a common gating mechanism.

13 is essential to understanding the Cl(-) ion gating mechanism.

14 basis of ion channel function, including the gating mechanism.

15 cacies of agonists, suggesting a role in the gating mechanism.

16 s an essential component of the ISOC channel gating mechanism.

17 ovide touchstones for an emerging allosteric gating mechanism.

18 and s2 substates), revealing a proportional gating mechanism.

19 tent with a molecular defect in the receptor gating mechanism.

20 five identical pores that have a coordinated gating mechanism.

21 lies on PKC-dependent ClC-1 inhibition via a gating mechanism.

22 ches to come up with a model for the channel gating mechanism.

23 ction pathway and forms a key element of the gating mechanism.

24 anges in symmetry that are important for the gating mechanism.

25 n and most likely lead to disturbance of the gating mechanism.

26 of the channel and vacuolar anion tune this gating mechanism.

27 motions of the channel and to elucidate its gating mechanism.

28 and hampered in silico investigation of the gating mechanism.

29 that act to close Cx26 hemichannels via this gating mechanism.

30 the evolutionary flexibility of the voltage-gating mechanism.

31 sitions characteristic of the intrinsic loop gating mechanism.

32 d share a common calcium/calmodulin-mediated gating mechanism.

33 ealing an agonist-independent, light-induced gating mechanism.

34 ssion could serve a role in a time-dependent gating mechanism.

35 riction at the lower gate, suggesting a dual gating mechanism.

36 conserved structure for ion selectivity and gating mechanisms.

37 cules but less is known about the underlying gating mechanisms.

38 s, and thus offers a novel approach to study gating mechanisms.

39 for understanding ion filtration and channel-gating mechanisms.

40 de chain at position 241 interferes with its gating mechanisms.

41 ed by bistable activation states and dynamic gating mechanisms.

42 sed by T cells have adopted novel regulation/gating mechanisms.

43 e cation channels (SOCs) display multi-modal gating mechanisms.

44 te distinct, there may be analogies in their gating mechanisms.

45 processivity may be controlled by different gating mechanisms.

46 e strength of electrical coupling mostly via gating mechanisms.

47 unction relationships, perm-selectivity, and gating mechanisms.

48 , and outer vestibule play a crucial role in gating mechanisms.

49 ls obeying equilibrium versus nonequilibrium gating mechanisms.

50 (4,5)P(2)) depletion when exploring the TRPL gating mechanism?

51 bserved pore closure by a novel "hydrophobic gating" mechanism: A dewetting transition of the hydroph

52 in REM sleep suggests drastically different gating mechanisms across sleep stages.

53 absence of the activation of this GABAergic gating mechanism, active sleep occurs.

54 hese processes are conditional upon critical gating mechanisms actively enforced by the default state

55 Their gating mechanisms also are speculated to have overlappin

56 suggesting an S4-S5 linker-mediated PtdInsP2 gating mechanism among TRPML channels.

57 structural insight into the general voltage-gating mechanism among voltage-gated channels.

58 ls are thought to have two primary conserved gating mechanisms: an inactivation (or C-type) gate at t

59 PPI reflects a nonlearned sensorimotor gating mechanism and also shows a robust gender differen

60 This study proposes a unique channel gating mechanism and delivers detailed molecular insight

61 Here, we study the gating mechanism and energy coupling of OpuA reconstitut

62 ) is a foundation for understanding the AChR gating mechanism and for engineering both the ligand and

63 he Cx43 carboxyl-terminal domain in the fast gating mechanism and in the establishment of residual co

64 mportant implications for both the channel's gating mechanism and its regulatory adaptation mechanism

65 targets for SAR studies to shed light on the gating mechanism and locus of bastadin-5 binding on thes

66 To explore the connection between the gating mechanism and the influx and efflux of water mole

67 hin-gender differences in basic sensorimotor gating mechanisms and implicate the known neural substra

68 Our results offer additional insights into gating mechanisms and suggest revisions to prevailing mo

69 nd much remains to be understood about NMDAR gating mechanisms and the molecular events that shape th

70 2+) binding sites involved in gating and the gating mechanism are not fully known.

71 p ligand-gated ion receptors that govern the gating mechanism are still not well understood.

72 to determine channel opening and that these gating mechanisms are allosterically coupled.

73 e entrance to active sites and let alone the gating mechanisms are not always obvious from X-ray crys

74 of MSNA through increased sensitivity of a 'gating' mechanism, as indicated by an increase in the sl

75 cytosolic components is tightly regulated by gating mechanisms at the cilium base; however, the mecha

76 and implicates selective attention as a main gating mechanism between sensory and memory systems.

77 t on gating, illustrating differences in the gating mechanisms between connexin isoforms.

78 cations not only on our understanding of the gating mechanism but also on the general experimental de

79 We infer details of this gating mechanism by studying the free energetics of Cl(-

80 xchange/MS and functional studies, suggest a gating mechanism by which NP opens to accept RNA.

81 g subunit have been recently identified, the gating mechanism by which Orai1 channels conduct Ca(2+)

82 he channel domain, thereby being part of the gating mechanisms by which the IP(3)-induced conformatio

83 plasma-membrane Ca(2+) currents with dynamic gating mechanisms, Ca(2+)-buffering reactions with diffu

84 mitter receptors with similar structures and gating mechanisms can exhibit strikingly different funct

85 The SDSL-EPR based structure reveals a gating mechanism consistent with a scissoring-type motio

86 he sensory gating hypothesis posits that the gating mechanism continues to be necessary for retrieval

87 quantitatively characterized an alternative gating mechanism controlled by a cluster of hydrophobic

88 oteasome activity occurs, in part, through a gating mechanism controlling the sizes of pores at the t

89 results suggest that a phosphorylation-based gating mechanism controls cargo selection by yeast retro

90 These results suggest that a loop-gating mechanism controls the catalytic reaction.

91 The prevailing view is that different BK gating mechanisms converge to determine channel opening

92 A gating mechanism dependent on polo-like kinase-1 (PLK1)

93 odulation is a functionally relevant sensory gating mechanism deployed by attention.

94 icated that activation by menthol involves a gating mechanism distinct and separable from gating by c

95 bition of CEm cells is mediated by an active gating mechanism downstream of the BLA.

96 esults provide evidence of a 'conformational gating' mechanism driven by the interactions between the

97 This "super-float-gating" mechanism enables very high sensitivity photodet

98 may underlie the conserved rectification or gating mechanisms exhibited by these channels.

99 gentamicin binding, supporting a stochastic gating mechanism for antibiotic binding, rather than an

100 as been implicated in this brain region as a gating mechanism for behavioral responses to emotional s

101 enerating preceding inhibition may provide a gating mechanism for conditional corticothalamic feedbac

102 and these results also support a hydrophobic gating mechanism for control of ion permeation.

103 The crystal structure also suggests a gating mechanism for GlpG that controls substrate access

104 The structure reveals an alternative gating mechanism for K(v) channels and provides a templa

105 and provide evidence for a Brownian affinity gating mechanism for nucleocytoplasmic transport.

106 Here we report that a gating mechanism for Pi release controlled by the inter-

107 The results suggest a possible gating mechanism for proton movement that includes key r

108 uctive olfactory cues that may function as a gating mechanism for sensory activation of defensive res

109 perception threshold and may thus serve as a gating mechanism for the access to conscious experience.

110 ical data, the structure suggests a possible gating mechanism for the SK channel.

111 mechanism is unlikely to represent a final, gating mechanism for these channels.

112 have provided important clues regarding the gating mechanism for this family of proteins.

113 asis of K(+) selectivity and suggest a novel gating mechanism for this large and important family of

114 t the plasma membrane and suggesting similar gating mechanisms for both TRPML channels.

115 rotons, supporting the existence of multiple gating mechanisms for different stimuli.

116 Here, we discuss possible gating mechanisms for electron transfer across the endos

117 ionary in TRPV1, highlighting differences in gating mechanisms for these structurally related channel

118 sidues), inactivation (one residue), or both gating mechanisms (four residues).

119 mportant role in Ca(2+) homeostasis, but its gating mechanisms, functions, and regulation are still u

120 Overall, this ion-flux gating mechanism generates a one-way "check valve" withi

121 This hydrophobic gating mechanism has implications for CRAC channel funct

122 effect of the TS mutation on other L-channel gating mechanisms has yet to be investigated.

123 Although fast and slow gating mechanisms have been described in gap junctions (

124 Potential gating mechanisms have been investigated using the tempe

125 thermal sensation and nociception, but their gating mechanisms have remained elusive.

126 selectivity, the transport pathway, and the gating mechanism-have remained unanswered for this prote

127 This gating mechanism in a neural circuit is further demonstr

128 ls by selective disruption of the binding or gating mechanism in certain subunits.

129 bute to our understanding of the electrolyte gating mechanism in complex oxides and may be relevant f

130 Implications for the gating mechanism in light of these and experimental resu

131 The suppression of this gating mechanism in mature animals represents a new form

132 rotation of M2 segments is probably a common gating mechanism in other ligand-gated ion channels.

133 These results suggest that the gating mechanism in PIP1;4 may be more sensitive to prol

134 PV4 contains an additional voltage-dependent gating mechanism in series with the main intracellular g

135 loop itself, possibly by serving as a mobile gating mechanism in shielding critical intermediates (in

136 We propose that (i) G272R disrupts a gating mechanism in the core chamber that regulates subs

137 e we probe the central features of the STIM1 gating mechanism in the human CRAC channel protein, ORAI

138 -ray structures of the two end-points of the gating mechanism in the same pentameric ligand-gated ion

139 mechanical coupling and coordination of the gating mechanism in transporters, which might be expecte

140 ative spliced isoforms may represent a major gating mechanism in vivo, therefore conferring important

141 his finding is consistent with an allosteric gating mechanism in which ligand shifts the equilibrium

142 for our understanding of voltage-sensing and gating mechanisms in channels.

143 ombined results of the ion translocation and gating mechanisms in KR2 may provide a basis for the rat

144 odel that will enable the study of potential gating mechanisms in more detail.

145 t, our results suggest drastically different gating mechanisms in NREM and REM sleep.

146 Joint disruptions of the binding and gating mechanisms in the same or alternate subunits of a

147 tep toward understanding the fundamentals of gating mechanisms in this class of channels.

148 e observations provide support for kinesin-1 gating mechanisms in which one head stimulates the rate

149 hed experimental data and points to a simple gating mechanism: in the closed state, the His-37 and Tr

150 Moreover it is apparent that several gating mechanisms including calmodulin, protein kinase C

151 d that within the seven-state single-channel gating mechanism, inhibition of TRPM8 by short sM8-6 iso

152 dentified, and it has been hypothesized that gating mechanisms involve conformational changes in the

153 mic deactivation, which may reflect a limbic gating mechanism involved in modifying interactions betw

154 The structural basis for this unique gating mechanism involves an insert near the nucleotide

155 Based on these findings, we propose a unique gating mechanism involving a helical turn upon the bindi

156 binding and a potential oxidation triggered gating mechanism involving access to the hydrophobic tun

157 for TRPC1 channel opening through a similar gating mechanism involving PKC and PI(4,5)P2.

158 A cleft-like conformational gating mechanism, involving two interhelical loops and o

159 The ITDP gating mechanism is based on recent experimental finding

160 Previous studies suggested that this gating mechanism is controlled by a beta-hairpin and an

161 Our study indicates that the loop-gating mechanism is likely to be a source of the substra

162 of chronic itch, including alloknesis, this gating mechanism is lost.

163 Its gating mechanism is poorly understood due to the tiny vo

164 One important gating mechanism is produced by intra- or extracellular

165 Thus, a channel-gating mechanism is suggested through enhancing the NBD-

166 and lipid composition that is determined by gating mechanisms localized at the base of the cilium.

167 A similar pore architecture and gating mechanism may apply to other channels in the same

168 ZI innervates all higher-order nuclei, this gating mechanism may exert similar regulation of thalami

169 amine affinity, we conjectured that the fast gating mechanism might affect the kinetics of polyamine

170 trant FAAH inhibitors, which strengthen this gating mechanism, might offer a new approach to pain the

171 A CFTR gating mechanism model based on adenylate kinase activit

172 We propose that a regulatory "gating" mechanism normally blocks multiple rounds of str

173 These data suggest that a common gating mechanism occurs, coupling neurotransmitter bindi

174 Here the gating mechanism of a P2X receptor was studied by normal

175 methods can be used to identify not only the gating mechanism of a protein, but also associated physi

176 The gating mechanism of an enzyme is therefore very importan

177 ch could be interpreted as the postulated pH-gating mechanism of AQP0-mediated water transport at pH

178 of RCK2 likely underlie the Ca(2+)-dependent gating mechanism of BK(Ca) channels.

179 h is frequently invoked as a hallmark of the gating mechanism of Cys-loop receptors, is minimal, if a

180 which suggests that an additional molecular gating mechanism of high Q10 - which is not present in t

181 I and type III IP(3)Rs and propose that the gating mechanism of IP(3)R Ca(2+) channels involves the

182 The gating mechanism of K(v) channels is not known.

183 Understanding the gating mechanism of mechanosensitive channels is challen

184 ubstituted residues suggest that the overall gating mechanism of MscK is comparable to that of MscS,

185 L6 loop is not the primary voltage-dependent gating mechanism of MspA.

186 The detailed assembly process and the gating mechanism of Mtb proteasome have remained unknown

187 imilarity to slow inactivation, an intrinsic gating mechanism of Na+ channels.

188 These results provide new insight into the gating mechanism of P2X receptors and establish a versat

189 ns for the role of subunit interfaces in the gating mechanism of P2X receptors and points to a role o

190 This study illuminates the gating mechanism of PapC ushers and its importance in ma

191 We assessed the gating mechanism of PS modulation of GluN1/GluN2A recept

192 structure, allow us to elucidate the ligand gating mechanism of RCK-regulated K(+) channels.

193 The molecular identity and the gating mechanism of SOC and CRAC channels have remained

194 llectively, these results support a stepwise gating mechanism of STIM1-operated Orai1 channels; the i

195 The gating mechanism of the acetylcholine receptor channel (

196 These results shed light on the gating mechanism of the AChR and present a complementary

197 sms, however, do not completely override the gating mechanism of the alpha-channel.

198 imental data, and by comparison to the known gating mechanism of the bacterial KirBac channel.

199 Ca(2+) influx, a direct demonstration of the gating mechanism of the Cch1 channel remains elusive.

200 re of a Kir3.1 chimera revealed the possible gating mechanism of the G loop gate.

201 Here, we investigate the gating mechanism of the human CRAC channel Orai1 by its

202 odels of the structure and voltage-dependent gating mechanism of the KvAP bacterial K+ channel that a

203 rting the involvement of the Cys loop in the gating mechanism of the LGICs.

204 Understanding the gating mechanism of the nicotinic acetylcholine receptor

205 icroscopy to obtain deeper insights into the gating mechanism of the NPC as the basis of a new transp

206 The gating mechanism of the potassium channel KcsA was studi

207 Here we have characterized the gating mechanism of the rat TRPM8 reconstituted in plana

208 y developing new models of the structure and gating mechanism of the transmembrane and extracellular

209 interface is a key structural element in the gating mechanism of these glutamate receptor families.

210 The gating mechanism of this pathway is still unclear.

211 he high-resolution pore architecture and the gating mechanism of this superfamily, however, remain un

212 A fundamental question about the gating mechanism of voltage-activated K+ (Kv) channels i

213 Atomic-scale models on the gating mechanism of voltage-gated potassium channels (Kv

214 Furthermore, both fast and slow gating mechanisms of Cx40 exhibit a negative gating pola

215 In Part II of this study, the detailed gating mechanisms of E. coli-MscL under various types of

216 eparate connexin domains partake in proposed gating mechanisms of gap junction channels.

217 ational dynamics, and water molecules in the gating mechanisms of K(+) channels.

218 cular framework for understanding the ligand gating mechanisms of K+ channels.

219 This study aims to explore gating mechanisms of mechanosensitive channels in terms

220 1 will serve as a paradigm for understanding gating mechanisms of other channels.

221 The general folding pattern and gating mechanisms of our current models are similar to s

222 ides represent novel tools for exploring the gating mechanisms of several Na(V) and Ca(V) channels.

223 view we summarize the diverse properties and gating mechanisms of SOCs in smooth muscle.

224 between the substrate translocation and the gating mechanisms of the EAAT-associated anion channel.

225 EM) approach is used to explore the detailed gating mechanisms of the MscL in Escherichia coli embedd

226 ovides the structural bases for assembly and gating mechanisms of the Mtb proteasome.

227 The gating mechanisms of the related TRPV2 channel are poorl

228 the CTDs of N1, 2A, or 2B and determined the gating mechanisms of these receptors.

229 l starting point for elucidating the complex gating mechanisms of TRPM4 and reveal the molecular arch

230 uide further work designed to understand the gating mechanisms of TRPV1 channels based on comparisons

231 vided a powerful tool to establish the basic gating mechanisms of voltage-dependent K(+) channels, im

232 Our findings have implications for the gating mechanisms of voltage-gated ion channels, suggest

233 er column in the entry channel as the likely gating mechanism on the luminal side.

234 The unique gating mechanism overcomes the drawback of charge screen

235 Existing models for the gating mechanism propose a role for the microtubule latt

236 ed on similar structural principles, and the gating mechanism recently emerging for the transporters,

237 ibition for the BIS; the attention/emotional gating mechanism regulating cortical sensory input for t

238 te depicted by its crystal structure and its gating mechanism remain unclear.

239 roton backflow, but the number and nature of gating mechanisms remain elusive, as does the mechanism

240 ailed structural basis for voltage-dependent gating mechanisms remain obscure.

241 recently are insensitive to ADPR, and their gating mechanisms remain unclear.

242 tructure of the closed state is unknown, the gating mechanism remains controversial.

243 and vital role in many cell functions, their gating mechanism remains to be elucidated.

244 bolism to cellular excitability, whereas the gating mechanism remains unclear.

245 re-function studies on these proteins, their gating mechanism remains unclear.

246 +) ions to determine the ionic-dependence of gating mechanisms responsible for channel inactivation a

247 The proposed gating mechanism reveals critical spatial relationships

248 of peripheral release suggests a cooperative gating mechanism(s) for central release.

249 ting and slow V(j) gating suggests that both gating mechanisms share common structural elements.

250 Our results define a unique gating mechanism shared by K(2P) family members and sugg

251 ut in certain CF mutants constitute the only gating mechanism, stimulated by ivacaftor, a clinically

252 TrkH resembles a K(+) channel and may have a gating mechanism substantially different from K(+) chann

253 nct from other ion channels, similarities in gating mechanisms suggest common structural elements.

254 We suggest that this gating mechanism synchronizes the binding of the two sub

255 nnels exhibit two distinct voltage-dependent gating mechanisms termed slow and fast gating.

256 Our results support a unique gating mechanism that allows the repertoire of Lon subst

257 The Aqy1 case reveals a gating mechanism that connects the inner channel gating

258 ong support for a proposed strain-controlled gating mechanism that enhances processivity.

259 Here, we characterize a gating mechanism that involves regulation of spike propa

260 To solve this dilemma, we propose a gating mechanism that leads to a hundredfold enhancement

261 o control ammonium flux, potentially using a gating mechanism that limits flux to protect against amm

262 ants likely allow Mn(2+) entry via loss of a gating mechanism that normally holds the transporter in

263 nput to the DRN controls a serotonergic self-gating mechanism that regulates innate defensive respons

264 this conformational change is coupled to the gating mechanism that regulates ion conduction.

265 ssue injury, and may be part of a peripheral gating mechanism that regulates the access of nociceptiv

266 Here we introduce a gating mechanism that uses a capillary-stabilized liquid

267 oduce fluent speech by providing an external gating mechanism that yokes a ventral language network t

268 etric, which precludes a direct extension of gating mechanisms that close canonical fourfold symmetri

269 cough, and an almost binary output suggests gating mechanisms that encode and modulate this defensiv

270 6 and Cx50 hemichannels contain two distinct gating mechanisms that generate reductions in conductanc

271 lose synaptic plasticity but rather acquire gating mechanisms that prevent the induction of synaptic

272 expected to affect both front and rear head gating, mechanisms that underlie processive walking.

273 alpha, -beta and -gamma are determined by a gating mechanism through which amino acid differences in

274 a allow a molecular movie of the ferroxidase gating mechanism to be developed and provide further ins

275 Acquisition of a physical gating mechanism to control catalytic function through g

276 activity of PV+ neurons may thus serve as a gating mechanism to enhance feedforward, but not lateral

277 However, the contribution of each gating mechanism to oxidative stress-induced TRPM2 activ

278 This processive motility requires gating mechanisms to coordinate the mechanochemical cycl

279 beta subunits that appear to target specific gating mechanisms to regulate the channel activity.

280 gand-gated channel that obeys an equilibrium gating mechanism uncoupled from its enzymatic activity.

281 ndent inactivation, which suggests different gating mechanisms underlie these two types of voltage-de

282 SKOR, indicating that a voltage-independent gating mechanism underlies the K+ sensing process.

283 al Na+ channel NaV1.1 to explore and explain gating mechanisms underlying cellular excitability and p

284 However, very little is known about the gating mechanisms underlying KCNQ1 channel activation.

285 zing >40 engineered variants to identify the gating mechanism used by rhomboid proteases.

286 Using this gating mechanism, we now investigate TRPM8 inhibition in

287 To investigate ciliary gating mechanisms, we developed a system to clog the por

288 To elucidate potential cooperation of these gating mechanisms, we replaced the Cx43NT with the Cx37N

289 tion could, for instance, act as the primary gating mechanism when stimuli are still visible.

290 Moreover, we observed a remarkably potent gating mechanism when the animal was standing on its hin

291 c has an intrinsic phosphorylation-dependent gating mechanism where the SH2 domain adopts an open con

292 s coupled to protein translation by a simple gating mechanism whereby a nascent protein blocks the po

293 results suggest that Rad4/XPC uses a kinetic gating mechanism whereby lesion selectivity arises from

294 These findings substantiate a gating mechanism whereby the TRP domain acts as a coupli

295 es proposed signal transduction pathways and gating mechanisms which link physiological stimuli to op

296 these channels are known to exhibit a unique gating mechanism, which appears to be triggered by the p

297 This gating mechanism, which defines the constitutive activit

298 gs indicate that Ser-354 of Bcr is part of a gating mechanism, which, after its phosphorylation, allo

299 s are maintained out of phase by a series of gating mechanisms, which lead to processive runs averagi

300 of the selectivity filter may be a universal gating mechanism within K(+) channels.