ライフサイエンスコーパス: gating property

1 potassium (Kv1-Kv4) channels in assembly and gating properties.

2 tigated the effects of pH variations on VDAC gating properties.

3 nal A-type K+ channels without any change in gating properties.

4 are known to be regulators of the channels' gating properties.

5 in LCC density with similar conductance and gating properties.

6 vivo generates a protein with unique voltage gating properties.

7 of function because of the modifications in gating properties.

8 el because of its distinct voltage-dependent gating properties.

9 ls but resembled P-type Ca channels in their gating properties.

10 a2+ channel current without altering channel gating properties.

11 an embryonic kidney-293 cells revealed novel gating properties.

12 onents of the expression system modulate its gating properties.

13 n of KATP channels without affecting channel gating properties.

14 d sulfonylurea sensitivity and ATP-dependent gating properties.

15 mal current kinetics with minimal changes in gating properties.

16 tion expressed HERG current but with altered gating properties.

17 eference to the modulation of single-channel gating properties.

18 ng anion-selective channels that lacked GABA-gating properties.

19 allosteric modulator compounds, and controls gating properties.

20 pk1 activation is the result of Ppk1 channel gating properties.

21 urther diversify Nematostella Shaker channel gating properties.

22 ashout was needed to reestablish the initial gating properties.

23 lion-derived cell line, without changing its gating properties.

24 eir current densities without altering their gating properties.

25 ce complexes with diverse ion-conducting and gating properties.

26 hat play a major role in determining channel-gating properties.

27 at have been engineered to exhibit different gating properties.

28 ted channel, substantially influencing their gating properties.

29 has been correlated with changes in channel-gating properties.

30 sue-specific manner, modifying the channel's gating properties.

31 r cell surface expression and single-channel gating properties.

32 of coupling, and exhibited unaltered voltage-gating properties.

33 nt amplitude, without a detectable effect on gating properties.

34 owever, they exert opposing effects on TRPM8 gating properties.

35 regulates its intracellular distribution and gating properties.

36 in the dynamic regulation of Cav3.2 channel gating properties.

37 wed significant changes in voltage-dependent gating properties.

38 events were responsible for variant-specific gating properties.

39 electrical activity derives from its unusual gating properties.

40 rdomain interaction in vitro and altered the gating properties and calmodulin sensitivity of expresse

41 The gating properties and current amplitudes of mammalian vo

42 glutamate receptors (AMPA-Rs) with distinct gating properties and exhibit different transmission dyn

43 ype must be conferred entirely by changes in gating properties and is not remedied by coexpression wi

44 1 channels exhibit altered voltage-dependent gating properties and lack the bulk of the phosphorylati

45 also that families of Ca2+ channels display gating properties and neurotransmitter modulation that d

46 rming CaV alpha1 subunit to modulate channel gating properties and promote cell surface trafficking.

47 alylation, of Kv1.1 affected its macroscopic gating properties and slowed activation and C-type inact

48 ular beta auxiliary subunit, which alter the gating properties and trafficking of the calcium channel

49 opic and single-channel conductance, voltage-gating properties, and kinetics; pH gating sensitivity w

50 region form functional channels with altered gating properties, and we show that NPAS is a general me

51 AMPA receptor surface expression and channel gating properties; and (2) trans-synaptic organizing mol

52 Their ion-gating properties are consistent with those of AChR isot

53 ypes of voltage-gated calcium channel, their gating properties are key for the precise control of neu

54 erefore unnecessary to invoke exotic channel-gating properties as an explanation.

55 tilayer-modified membranes showed reversible gating properties as the pH condition of feed solution w

56 , the molecular basis of their uniquely slow gating properties as well as the stoichiometry and inter

57 cularly terminal sialylation, affected Kv1.1 gating properties both by altering the surface potential

58 cularly terminal sialylation, affected Kv1.l gating properties both by altering the surface potential

59 ypic channels with distinct permeability and gating properties but do not form functional homomeric/h

60 Small alterations in gating properties can lead to severe changes in cellular

61 Here, we show that cAMP effects on the gating properties CNGCs persist when protein synthesis i

62 ls with lower current amplitudes and altered gating properties compared with wild type.

63 channels in native smooth muscle demonstrate gating properties consistent with a role in maintaining

64 ereby phosphorylation-induced changes in LCC gating properties contribute to EAD generation.

65 In contrast, TipE did not alter these gating properties except for a hyperpolarizing shift in

66 I(Ks) caused by loss of function or altered gating properties explains the prolonged QT interval and

67 n bilayers, this channel has conductance and gating properties identical to the in situ channel, pass

68 We characterized the kinetics of these novel gating properties in a series of additional voltage-step

69 ay permit evolutionary changes that tune the gating properties in different species.

70 e channels in liposomes and exhibits voltage-gating properties in planar phospholipid bilayers.

71 Pyr-R channels also exhibit altered gating properties, including a approximately 13 mV posit

72 GluR-A with alanines produced channels with gating properties indistinguishable from wild type.

73 nction as unapposed hemichannels to identify gating properties intrinsic to hemichannels and how they

74 These changes in permeation and gating properties mimic the changes induced by mutations

75 xperiments showed typical pressure-dependent gating properties of a stretch-activated channel with a

76 receptor current amplitudes and altered the gating properties of alpha1beta2 receptor channels by re

77 t alternative splicing did not influence the gating properties of alpha1C and alpha1E subunits.

78 units that regulate both the trafficking and gating properties of AMPA receptors, and different TARP

79 t, we consider the impact of crowding on the gating properties of bacterial mechanosensitive membrane

80 The gating properties of BK(Ca) channels are Ca(2+)-, voltag

81 the beta subunit family can finely tune the gating properties of Ca(2+)- and voltage-dependent BK ch

82 ximal capsaicin concentrations, and that the gating properties of capsaicin activation differ from th

83 concentration of permeant ions modulate the gating properties of cardiac L-type Ca(2+) channels.

84 n addition to controlling the expression and gating properties of Cav1.3 channels, the largely extrac

85 in chicken cone photoreceptors regulate the gating properties of cGMP-gated cationic channels (CNGCs

86 ken retinal cone photoreceptors modulate the gating properties of cGMP-gated channels (CNGCs) such th

87 roup of mutations also conferring changes in gating properties of Cx32 channels.

88 nding on the state, unitary conductances and gating properties of each hemichannel.

89 rovides a template to further understand the gating properties of Eag1 and related channels.

90 osine phosphorylation is correlated with the gating properties of expressed wild-type and mutant Kv c

91 The gating properties of GIRK channels (Kir3.1/Kir3.2a) acti

92 We examined formation and gating properties of heterotypic gap junction (GJ) chann

93 and two slow gates in series to describe the gating properties of homotypic and heterotypic GJ channe

94 ped a stochastic four-state model describing gating properties of homotypic and heterotypic GJ channe

95 The voltage-dependent gating properties of I(to,fast) were, however, not alter

96 membrane and/or by perturbing the intricate gating properties of Kv11.1 channels.

97 Abstract beta1-Subunits enhance the gating properties of large-conductance Ca(2+)-activated

98 We report the first characterization of the gating properties of M34T, which had previously been rep

99 xiliary subunits differentially regulate the gating properties of Na(v)1.7 channels.

100 Little is known of the gating properties of native SK channels in CNS neurons.

101 fect of S241A and S241L substitutions on the gating properties of Nav1.7.

102 effects on trafficking and voltage-dependent gating properties of recombinant Ca(v)2.1 Ca2+ channel c

103 new methodology to study the permeation and gating properties of recombinant mammalian InsP(3)Rs in

104 on of the localization and voltage-dependent gating properties of the abundant neuronal Kv2.1 channel

105 ssed in Xenopus oocytes, beta1 modulates the gating properties of the channel-forming type IIA alpha

106 arly in the C terminus, drastically modifies gating properties of the channel.

107 ensity that is not accompanied by changes in gating properties of the channel.

108 erpolarizing shifts in the voltage-dependent gating properties of the channel.

109 ace and brings about profound changes in the gating properties of the channel.

110 2.1 monomer did not significantly affect the gating properties of the channel.

111 he binding of IP(3) to the LBD regulates the gating properties of the channel.

112 shear stress activates ENaC by modifying the gating properties of the channel.

113 to connexons, docking with adjacent cells or gating properties of the gap junction.

114 expression of Kv4.2 or Kv4.3 alone, and the gating properties of the heteromeric Kv4.2/Kv4.3 channel

115 ta subunit involved in the modulation of the gating properties of the high voltage-activated calcium

116 We have studied the gating properties of the hSkM1-R669H mutant Na channel e

117 Single-channel recordings reveal improved gating properties of the I507-ATC compared to I507-ATT D

118 we determined macroscopic and single-channel gating properties of the intercellular channels formed.

119 We have investigated the gating properties of the inward rectifier chloride chann

120 Thus the gating properties of the L-type Ca(2+) channels expresse

121 Exploiting the unique charge movement and gating properties of the L382V mutant of Shaker, we show

122 ing/deswelling properties of multilayers and gating properties of the multilayer-modified TEPC membra

123 The gating properties of the Na(+) current through H1 and th

124 -M1 or S2-M4, was dependent on the intrinsic gating properties of the NMDA receptors, being more effe

125 channel and thus providing the transport and gating properties of the NPC.

126 crucial role in the membrane expression and gating properties of the pore-forming alpha(1) subunit.

127 uggest that Ca(v)beta subunits determine the gating properties of the presynaptic Ca(2+) channels wit

128 in II, angiotensin receptors type 1 modulate gating properties of the remaining Kv4.3 channels on the

129 1239H and R1239G have similar effects on the gating properties of the skeletal muscle L-type Ca2+ cha

130 pus oocytes, the beta1 subunit modulates the gating properties of the type IIA alpha subunit, resulti

131 the effect of these three key lipids on the gating properties of the voltage-dependent anion channel

132 so forms an 8-pS chloride channel with mixed gating properties of the wild type and mutant CFTR chann

133 combination of Cx43 and Cx45 on the voltage-gating properties of their channels, we transfected DNA

134 Mimicking the gating properties of these biological structures would b

135 This is due, in large part, to the unique gating properties of these channels, which are character

136 nate (MTS) reagents for their effects on the gating properties of these cysteine mutants in intact Xe

137 of Na(v)1.6 and Na(v)1.8 by pp38, regulates gating properties of this channel but not its current de

138 V(j)-dependent gating properties of this mutant channel were characteri

139 The voltage- and calcium-dependent gating properties of two lens gap-junctional hemichannel

140 proposed model can also be used to simulate gating properties of unapposed hemichannels.

141 The purpose of this study was to compare the gating properties of various alpha1 subunit complexes co

142 pable of modulating both the conductance and gating properties of voltage-gated ion channels in hippo

143 The gating properties of voltage-gated potassium channels ar

144 ly that polypeptide toxins that modulate the gating properties of voltage-sensitive cation channels a

145 In mdx mouse cells the intrinsic gating property of fast voltage-sensitive inactivation i

146 gate, the R state results from an intrinsic gating property of the channel filter region.

147 d of the pore, R is most likely an intrinsic gating property of the K(+) filter.

148 The hysteretic gating property of the multilayer-modified TEPC membrane

149 lectrophysiologically and were found to have gating properties only slightly altered from wild-type.

150 ns, which potentially regulate the channel's gating properties over a spectrum of different tissues o

151 ulted in voltage dependence and inactivation-gating properties, respectively, of the T(in) channel th

152 residual conductance state (G(min)) and V(j) gating properties, respectively.

153 Examination of desensitization and gating properties revealed these to be similar in VB and

154 ess constructs generated in this study shows gating properties similar to wild-type BK channel but wi

155 s) were reduced by 30-40%, respectively, and gating properties, such as the voltage of half-maximum a

156 These gating properties suggest a physiological mechanism by w

157 bits substantial time- and voltage-dependent gating properties that may have significance for the phy

158 ondition, resulted in current amplitudes and gating properties that were intermediate between wild-ty

159 hanol results from a modification of channel gating properties: the contribution of long openings to

160 r permeability characteristics but different gating properties: the probability of the wild-type chan

161 channel beta subunits modify alpha1 subunit gating properties through direct interactions with intra

162 Based on its brain distribution and novel gating properties, we suggest that alpha1I plays importa

163 Gating properties were altered modestly in most mutant c

164 formed intercellular channels, although the gating properties were altered.

165 Observed gating properties were consistent with a second gating m

166 The biomimetic ion-gating properties were demonstrated by measuring the pH-

167 l networking, pH-tuning, and electrochemical gating properties were identified between the network fi

168 .1), involved in voltage- and time-dependent gating properties were investigated by heterologous expr

169 ectifying K(+) (GIRK) channels have distinct gating properties when activated by receptors coupled sp

170 nits formed functional channels with altered gating properties when expressed alone in oocytes.

171 ptophan (W) and examined their corresponding gating properties when expressed in Hek293t cells along

172 d robust sodium currents, but with different gating properties, whereas the splicing variant with the

173 s findings of the creation of biomimetic ion-gating properties with core-shell nanoparticle network a

174 se-dependent curve, altered Ca(2+)-dependent gating properties with decreased maximal open probabilit