ライフサイエンスコーパス: gelatinase

1 can inhibit matrix metalloproteinases (MMPs/gelatinases).

2 ion of which is dependent on the presence of gelatinase.

3 hin the relatively large S1' pocket of these gelatinases.

4 se (MMP) activity, in particular that of the gelatinases.

5 ty of vascular endothelial growth factor and gelatinases.

6 e in the levels of matrix metalloproteinases gelatinase A (MMP-2) and gelatinase B (MMP-9) after part

7 NSE) on two matrix metalloproteinases, MMP-2/gelatinase A and MMP-9/gelatinase B, which are known to

8 or both MMP-9 and metalloproteinase-2 (MMP-2/gelatinase A).

9 he expression of metalloproteinase-2 (MMP-2, gelatinase A).

10 ctive over stromelysin 1, collagenase 1, and gelatinases A and B, respectively.

11 used a NIRF substrate for gelatinases (MMP-2/gelatinase-A and MMP-9/gelatinase-B) in apolipoprotein E

12 will bind selectively to stromelysin-1 over gelatinase-A which is gratifying given the high degree o

13 as of apoE-/- mice produced NIRF signals for gelatinase action, whereas aortas of apoE+/+ mice inject

14 junction of the cushion tissue and impaired gelatinase activities in the muscular component of the i

15 reduced collagen accumulation and increased gelatinase activities in the wounds of estrogen-treated

16 c mice resulted in a significant decrease of gelatinase activity 1 week after AA treatment.

17 the fsrB mutant produced very low levels of gelatinase activity after prolonged incubation in vitro

18 (50 mg/kg, i.p.) showed reduced hippocampal gelatinase activity after transient global cerebral isch

19 As suggested by our data, inhibition of gelatinase activity appears to be a mechanism of action

20 n-null Alport mice, suggesting that elevated gelatinase activity exacerbates glomerular disease progr

21 e antibodies also immunoprecipitated the HMW gelatinase activity from OA SF.

22 of TG2 activity using KCC009 decreases MMP-2 gelatinase activity in cancer cells.

23 roteinase (MMP)-9 activity in vivo and lower gelatinase activity in cerebral microvessels.

24 zymography confirmed that SB-3CT suppressed gelatinase activity in HVC, and histological analysis re

25 otein (BSP) has been shown to induce limited gelatinase activity in latent matrix metalloproteinase-2

26 Our findings demonstrate that the HMW gelatinase activity in OA SF represents a complex of NGA

27 ar washings was evaluated by zymography, and gelatinase activity in the cornea and conjunctiva was de

28 hy of the proximal jejunum reveals increased gelatinase activity in the intestinal wall after ischemi

29 hepatic matrixmetalloproteinase (MMP)-9 and gelatinase activity increased significantly after sepsis

30 orescence co-localization suggests that this gelatinase activity is derived from MMP-9 released from

31 icated that MMP-9 and not MMP-2 mediated the gelatinase activity observed in infiltrating cells.

32 CNSE, anacardic acid, markedly inhibited the gelatinase activity of 3T3-L1 cells.

33 Furthermore, PAF stimulated the gelatinase activity of MMP-2 by activating transcription

34 Inhibition of the gelatinase activity of MMP9 decreased the number of meta

35 Gelatine zymography revealed different gelatinase activity patterns that, although not linked t

36 AA treatment results in a decrease in gelatinase activity that correlates with the significant

37 ealed that testosterone-induced perivascular gelatinase activity that was most prominent in HVC.

38 Blockade of gelatinase activity using a small molecule inhibitor (BA

39 Sites of gelatinase activity visualized by NIRF colocalized with

40 ring short-term rhRLX administration (24 h), gelatinase activity was found to be essential for renal

41 The gelatinase activity was localized in the external granul

42 In situ zymography showed that gelatinase activity was mostly co-localized with neurons

43 In situ zymography showed that gelatinase activity was mostly colocalized with neuron-s

44 13 expression and matrix metalloproteinase 2 gelatinase activity were significantly impaired in Adam1

45 fter prolonged incubation in vitro versus no gelatinase activity with TX5128 and did not show the ext

46 which showed a similar level of aortic valve gelatinase activity, and inflammation between the two gr

47 with markedly reduced tumor uPA expression, gelatinase activity, and prolonged tumor basement membra

48 podosomes in mouse DC are foci of pronounced gelatinase activity, dependent on the enzyme membrane ty

49 GM6001 (100 mg/kg) ameliorated dysregulated gelatinase activity, neutrophil infiltration, production

50 unction was insensitive to the inhibition of gelatinase activity, suggesting that collagen degradatio

51 prase), which exhibited a 7-fold increase in gelatinase activity, whereas levels of dipeptidyl peptid

52 tinoblastoma (RB) tumor burden by modulating gelatinase activity.

53 rix metalloproteinase-2 and -9 and decreased gelatinase activity.

54 EGF substantially increased endothelial MMP2 gelatinase activity.

55 tivities: dipeptidyl peptidase and a 170-kDa gelatinase activity.

56 ar resistance as a result of upregulation of gelatinase activity.

57 UDCA regulates the expression of TIMP-1 and gelatinases activity in PMA stimulated cells.

58 rococcus faecalis controls the expression of gelatinase and a serine protease via a quorum-sensing me

59 However, coproduction of gelatinase and cytolysin did not increase virulence addi

60 ment of known virulence traits revealed that gelatinase and cytolysin production accounted for 40.8%

61 tant rendered defective in the expression of gelatinase and serine protease as the result of a polar

62 Rather, ADAM9 protein is stored in the gelatinase and specific granules and the secretory vesic

63 mulated exocytosis of secretory vesicles and gelatinase and specific granules but not azurophil granu

64 sma membrane/secretory vesicle fractions and gelatinase and specific granules, but not in azurophil g

65 h the gelE gene (pTEX5438) in trans restored gelatinase and translocation, demonstrating that gelatin

66 ree fsr genes also resulted in production of gelatinase and translocation.

67 nt results were found for the expressions of gelatinases and EMMPRIN among the groups demonstrating t

68 ts of CsA on ligature-induced expressions of gelatinases and EMMPRIN in gingival tissues were examine

69 ficantly less gingival protein expression of gelatinases and EMMPRIN than the Lig group.

70 f all legume seeds analyzed, inhibiting both gelatinases and HT29 migration and growth, while pea see

71 sed inhibitors that show high selectivity to gelatinases and MMP-14 (inhibitor 3) and to only MMP-2 (

72 trix metalloproteinases (i.e., collagenases, gelatinases) and neutrophil elastase activities.

73 member of stromelysins), MMP-9 (considered a gelatinase), and MMP-14 (considered a member of the coll

74 t in the human genome through Western blots, gelatinase, and promoter-reporter assays and incorporate

75 ficant synergistic reduction of collagenase, gelatinase, and serpinolytic (alpha1-PI degrading) activ

76 The phage03 gene cluster was also present in gelatinase-and-cytolysin-negative strain E. faecalis JH2

77 Both gelatinases are synthesized predominantly by stromal cel

78 Human neutrophil gelatinase associated lipocalin (NGAL) was found to be i

79 To test if activation of gelatinases associated with seprase could be involved in

80 here was no difference in urinary neutrophil gelatinase-associated liopcalin to creatinine ratios aft

81 ted whether cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) can predict devel

82 MMP-9/neutrophil gelatinase-associated lipocalin (NGAL) complex is also s

83 electrochemical immunosensor for neutrophil gelatinase-associated lipocalin (NGAL) detection has bee

84 Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an ea

85 nvestigate the prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) in a large popula

86 Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa secre

87 Previous research suggests that neutrophil gelatinase-associated lipocalin (NGAL) is a high-quality

88 Neutrophil gelatinase-associated lipocalin (NGAL) is a novel renal

89 Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted gly

90 We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early bioma

91 Neutrophil gelatinase-associated lipocalin (NGAL) is an early marke

92 immunosensor for the detection of neutrophil gelatinase-associated lipocalin (NGAL) is developed by t

93 Neutrophil gelatinase-associated lipocalin (NGAL) is expressed and

94 determine the association between neutrophil gelatinase-associated lipocalin (NGAL) levels and cardio

95 einase (MMP)-3, MMP-8, MMP-9, and neutrophil gelatinase-associated lipocalin (NGAL) were found in dis

96 interleukin-8 (IL-8), biotin, and neutrophil gelatinase-associated lipocalin (NGAL) were the most rob

97 creted protein 24p3 (lipocalin-2, neutrophil gelatinase-associated lipocalin (NGAL)), which is expres

98 e results with those obtained for neutrophil gelatinase-associated lipocalin (NGAL), a comparator "AK

99 We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubu

100 lates epithelial cells to express neutrophil gelatinase-associated lipocalin (Ngal), a member of the

101 ss the prognostic value of plasma neutrophil gelatinase-associated lipocalin (NGAL), a novel marker o

102 Neutrophil gelatinase-associated lipocalin (Ngal), also known as si

103 bodies induced high expression of neutrophil gelatinase-associated lipocalin (NGAL), an iron-binding

104 sferrin (TF), ceruloplasmin (CP), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte che

105 lant patients to evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL), IL-18, and kidne

106 Median values for neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (

107 e novel AKI biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), kidney injury mo

108 Urine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury mo

109 y concentrations of microalbumin, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury mo

110 with urinary interleukin (IL)-18, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury mo

111 This study measured levels of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury mo

112 ve measures of urine IL-18, urine neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL c

113 ve measures of urine IL-18, urine neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL c

114 ased immunoassay for detection of neutrophil gelatinase-associated lipocalin (NGAL), which is a new d

115 pecific for human MMP-9 and human neutrophil gelatinase-associated lipocalin (NGAL).

116 from human neutrophils and termed neutrophil gelatinase-associated lipocalin (NGAL).

117 tio (ACR), and urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL); each measurement

118 The neutrophil gelatinase-associated lipocalin (NGAL, also known as LCN

119 uating the cut-off level of urine neutrophil gelatinase-associated lipocalin (uNGAL) for diagnosing A

120 Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been identif

121 Urine neutrophil gelatinase-associated lipocalin (uNGAL) has shown promis

122 0.0004), and was noninferior for neutrophil gelatinase-associated lipocalin [14.7 mug/L (interquarti

123 (Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin [N-GAL] Evaluation of Sy

124 Lipocalin 2 (Lcn2; 24p3; neutrophil gelatinase-associated lipocalin [NGAL]) is an antimicrob

125 ination) of 4 urinary biomarkers (neutrophil gelatinase-associated lipocalin [NGAL], interleukin [IL]

126 a tubular damage biomarker (urine neutrophil gelatinase-associated lipocalin [uNGAL]), forming a comp

127 ie2 receptor and in urinary MMP-9/neutrophil gelatinase-associated lipocalin activity after cediranib

128 ence in concentrations of urinary neutrophil gelatinase-associated lipocalin after the 2 infusions (P

129 ermined the prognostic utility of neutrophil gelatinase-associated lipocalin and creatinine, alone an

130 These include a plasma panel (neutrophil gelatinase-associated lipocalin and cystatin C) and a ur

131 ciated with AKI severity, and for neutrophil gelatinase-associated lipocalin and cystatin C, with poo

132 Neutrophil gelatinase-associated lipocalin and liver fatty acid-bin

133 Serum neutrophil gelatinase-associated lipocalin and serum interleukin-18

134 Urinary neutrophil gelatinase-associated lipocalin and urinary kidney injur

135 rognostic utility of both urinary neutrophil gelatinase-associated lipocalin and varying creatinine-b

136 Serum neutrophil gelatinase-associated lipocalin at day 3 was lower in th

137 The upper quartile of urinary neutrophil gelatinase-associated lipocalin best predicted the prima

138 um creatinine, interleukin-6, and neutrophil gelatinase-associated lipocalin concentrations.

139 /kg/h for >/=12 hours) and plasma neutrophil gelatinase-associated lipocalin level higher than 150 ng

140 n our adjusted models, enrollment neutrophil gelatinase-associated lipocalin level was independently

141 iscriminatory power of enrollment neutrophil gelatinase-associated lipocalin level was the greatest (

142 Serum neutrophil gelatinase-associated lipocalin levels are strongly pred

143 mbining both DeltaSCr-initial and neutrophil gelatinase-associated lipocalin measured 3 hours after c

144 come was noninferiority for urine neutrophil gelatinase-associated lipocalin on the day after surgery

145 Urine neutrophil gelatinase-associated lipocalin remained independently a

146 ylcarnitine linked with levels of neutrophil gelatinase-associated lipocalin representing acute tubul

147 ve iron, interleukin (IL)-18, and neutrophil gelatinase-associated lipocalin to predict PNF and DGF i

148 in, redox-active iron, IL-18, and neutrophil gelatinase-associated lipocalin to predict viability of

149 otic pathways, and no increase in neutrophil gelatinase-associated lipocalin to suggest tubular injur

150 Urinary neutrophil gelatinase-associated lipocalin was measured at baseline

151 ted in intrinsic AKI, but urinary neutrophil gelatinase-associated lipocalin was most useful (81% spe

152 Urine neutrophil gelatinase-associated lipocalin was the most sensitive m

153 Combining urinary neutrophil gelatinase-associated lipocalin with a novel creatinine-

154 f novel urinary biomarkers (e.g., neutrophil gelatinase-associated lipocalin) in this patient group.

155 ycoproteins (e.g., cadherin 5 and neutrophil gelatinase-associated lipocalin) typically circulate in

156 h as kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin).

157 tion between the concentration of neutrophil gelatinase-associated lipocalin, an established AKI biom

158 kers kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin, and doses>/=0.005 mg/kg

159 role of serum cystatin C (Scyc), neutrophil gelatinase-associated lipocalin, and interleukin-18 in p

160 T components (elastase, histones, neutrophil gelatinase-associated lipocalin, and proteinase-3) were

161 f high-mobility group protein B1, neutrophil gelatinase-associated lipocalin, and S100B were higher i

162 arkers of renal injury, including neutrophil gelatinase-associated lipocalin, CXCL1, and CXCL2.

163 jury proteins (osteopontin [OPN], neutrophil gelatinase-associated lipocalin, cystatin C, trefoil fac

164 els of the iron acceptor proteins neutrophil gelatinase-associated lipocalin, hemopexin, and transfer

165 ls of novel biomarkers, including neutrophil gelatinase-associated lipocalin, high-mobility group pro

166 Kidney injury biomarker levels (neutrophil gelatinase-associated lipocalin, IL-18, and kidney injur

167 ollowing five urinary biomarkers: neutrophil gelatinase-associated lipocalin, IL-18, kidney injury mo

168 highest tertiles of peak urinary neutrophil gelatinase-associated lipocalin, IL-18, KIM-1, liver fat

169 nd cystatin C) and a urine panel (neutrophil gelatinase-associated lipocalin, interleukin 18, and kid

170 A biomarker panel of neutrophil gelatinase-associated lipocalin, interleukin-1ra, and Pr

171 er surgery) urine interleukin 18, neutrophil gelatinase-associated lipocalin, kidney injury molecule

172 dy, 5 urinary biomarkers (urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-

173 tamyl transpeptidase, cystatin C, neutrophil gelatinase-associated lipocalin, kidney injury molecule-

174 ge markers of renal injury (urine neutrophil gelatinase-associated lipocalin, kidney injury molecule-

175 n and blood flow, whereas GFR and neutrophil gelatinase-associated lipocalin, monocyte chemoattractan

176 we measured renal vein levels of neutrophil gelatinase-associated lipocalin, monocyte chemoattractan

177 Neutrophil gelatinase-associated lipocalin, myeloperoxidase, and in

178 dney injury molecule-1, KIM-1 and neutrophil gelatinase-associated lipocalin, NGAL), kidney growth, a

179 gen activator receptor, suPAR and neutrophil gelatinase-associated lipocalin, NGAL.

180 (SCN; also known as lipocalin-2, neutrophil gelatinase-associated lipocalin, or 24p3) into the urina

181 d, the optimal 3-marker panel was neutrophil gelatinase-associated lipocalin, protein C, and interleu

182 nd human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional d

183 Renal vein neutrophil gelatinase-associated lipocalin, tumor necrosis factor-a

184 of recombinant wild-type sequence neutrophil gelatinase-associated lipocalin, wild-type cys(98)-24p3/

185 n of kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin.

186 ted induction of c-fos, junb, and neutrophil gelatinase-associated lipocalin.

187 ated the expression of NGAL/LCN2 (neutrophil gelatinase-associated lipocalin/lipocalin 2), a secreted

188 (SCN; also known as lipocalin 2, neutrophil gelatinase-associated lipocalin/NGAL, or 24p3).

189 adhesion molecule, periostin, and neutrophil gelatinase-associated lipocalin; and a two-fold decrease

190 By introducing chicken gelatinase B (chMMP-9) as a specific marker for heteroph

191 e elastase (matrix metalloproteinase-12) and gelatinase B (matrix metalloproteinase-9).

192 metalloproteinases gelatinase A (MMP-2) and gelatinase B (MMP-9) after partial hepatectomy.

193 The effect of Brij-35 on human gelatinase B (MMP-9), matrilysin (MMP-7), and membrane-t

194 ate that a Plg cascade synergizes with MMP-9/gelatinase B in vivo during dermal-epidermal separation

195 urvival can be improved by inhibiting MMP-9 (gelatinase B) activity.

196 nd activation of metalloproteinase-9 (MMP-9, gelatinase B) in a well-established steatotic rat liver

197 gated the role of metalloproteinase-9 (MMP-9/gelatinase B) in liver ischemia/reperfusion (I/R) injury

198 d cord and matrix metalloproteinase-9 (MMP-9/gelatinase B), expressed by infiltrating monocytes.

199 lloproteinases, MMP-2/gelatinase A and MMP-9/gelatinase B, which are known to have critical roles in

200 of the extracellular matrix-degrading enzyme gelatinase B/matrix metalloproteinase-9 (Mmp-9) on islet

201 kage within 30-60 min, likely independent of gelatinase B/MMP-9 activities.

202 Although MMP-9/gelatinase-B is an important component of these TGF-beta

203 or gelatinases (MMP-2/gelatinase-A and MMP-9/gelatinase-B) in apolipoprotein E-deficient (apoE-/-) mi

204 expression of matrix metalloproteinase MMP-9/gelatinase-B.

205 If the plasmid-containing host also produces gelatinase, bacteriocin cannot be detected.

206 opment of a sensor platform for detection of gelatinases based on porous silicon photonic films.

207 Gelatinase belongs to the M4 family of bacterial zinc me

208 sor histidine kinase, upon activation by the gelatinase biosynthesis-activating pheromone (GBAP) pept

209 GFP reporter assays confirmed that GBAP (gelatinase biosynthesis-activating pheromone) quorum non

210 -MMP-9 complex was reconstituted in vitro in gelatinase buffer.

211 biofilm formation through the production of gelatinase, but the mechanism has been hitherto unknown.

212 ce of the initial, transient upregulation of gelatinase by AA injection is unknown, and further studi

213 teinase (MMP)-2 and MMP-9, are extracellular gelatinases capable of degrading another amyloidogenic p

214 provide the first evidence for inhibition of gelatinase catalytic activity by anacardic acid, providi

215 rix metalloproteinase-2 (MMP-2)-an important gelatinase closely associated with tumor aggressiveness

216 ival tissue of the untreated arthritic rats, gelatinase, collagenase, TNF-alpha, and IL-1beta were al

217 little or no translocation and no detectable gelatinase, confirming the importance of both fsr and ge

218 lated targets include other factors, besides gelatinase, described as important for biofilms (BopD),

219 gest that a critical balance between the two gelatinases determines the outcome of inflammatory respo

220 gradients established through the action of gelatinases (eg, matrix metalloproteinase 9), which degr

221 Eyes were evaluated for gelatinase expression and activity by gel and in situ zy

222 u zymography of retinal tumors showed strong gelatinase expression and activity within transgenic RB

223 rat thermal injury model is associated with gelatinase expression and activity.

224 Here we show that glomerular gelatinase expression, specifically matrix metalloprotei

225 x metalloproteinase (MMP)-9, a member of the gelatinase family of MMPs, mediates leukocyte migration

226 e, confirming the importance of both fsr and gelatinase for E. faecalis translocation.

227 Here we show that both gelatinase (GelE) and serine protease (SprE) contribute

228 ion by E. faecalis OG1RF; these mutants lost gelatinase (GelE) and serine protease (SprE) production

229 tion mutant (TX5128), which produces neither gelatinase (GelE) nor the cotranscribed (in the wild typ

230 Gelatinase (GelE) purified from E. faecalis V583 was use

231 The endocarditis antigen (efaA), gelatinase (gelE), collagen-binding protein (ace), and a

232 fratricide as the governing principle behind gelatinase (GelE)-mediated cell death and eDNA release.

233 duction of an extracellular metalloprotease, gelatinase (GelE).

234 E. faecalis V583 and E. faecalis lacking the gelatinase gene (gelE).

235 d with plasma membrane/secretory vesicle and gelatinase granule fractions increased after fMLP stimul

236 eriodontal bone loss with the expressions of gelatinases (i.e., matrix metalloproteinase [MMP]-2 and

237 Zymographic analysis showed that the HMW gelatinase in OA SF comigrated with a purified NGAL-MMP-

238 We therefore investigated the role of the gelatinases in neuronal addition to the HVC of adult fem

239 s study, we first examined the expression of gelatinases in vivo using a collagenase-induced mouse mo

240 ed by a compartmental redistribution of this gelatinase, in which intracellular retention resulted in

241 Moreover, gelatinase inhibition resulted in a significant increase

242 Carbamate 5b was metabolized to the potent gelatinase inhibitor 2, which was present at therapeutic

243 -MMP-9 neutralizing antibody or with a broad gelatinase inhibitor for both MMP-9 and metalloproteinas

244 tudy was to identify and develop a selective gelatinase inhibitor for imaging active MMP2/MMP9 in viv

245 determined that the highly specific thiirane gelatinase inhibitor SB-3CT blocks MMP-9 activity, inclu

246 ated testosterone-implanted females with the gelatinase inhibitor SB-3CT.

247 In contrast, mice treated with a broad gelatinase inhibitor showed rather inferior protection a

248 Gelatinase inhibitor treatment abolished NIRF signals in

249 erivatives of SB-3CT, a selective and potent gelatinase inhibitor, were synthesized and evaluated.

250 tinase and translocation, demonstrating that gelatinase is important for E. faecalis translocation.

251 These results indicate that gelatinase is important for the successful in vitro tran

252 Gelatinase is synthesized as a preproenzyme consisting o

253 gest that of the two enterococcal proteases, gelatinase is the principal mediator of pathogenesis in

254 ve also been described for elastase, MMP-13, gelatinases, mast cell proteases and proteases derived f

255 studies suggested a detrimental role for the gelatinase matrix metalloproteinase (MMP)-9 in ICH, the

256 an also modulate the extracellular levels of gelatinases (matrix metalloproteases, MMPs) and potentia

257 Gelatinases, matrix metalloproteinase (MMP)-2, and MMP-9

258 have demonstrated detrimental roles for the gelatinase MMP-9 in focal cerebral ischemia, how dysregu

259 veral MMPs, including collagenase MMP-13 and gelatinase MMP-9.

260 uraged us to investigate the activity of the gelatinases MMP-2 and MMP-9 in both cell lines.

261 Gel zymography showed elevations in gelatinase (MMP-2 and MMP-9) activity.

262 ROS, nitrotyrosine, and gelatinase (MMP-2 and MMP-9) zymogen activity markedly i

263 The 92-kDa gelatinase (MMP-9) expression is prerequisite for tissue

264 Because the 92-kDa gelatinase (MMP-9) is a known mediator of tumor cell inv

265 Both gelatinases (MMP-2 and -9) and membrane-type 1 MMP (MMP-

266 Gelatinases (MMP-2 and MMP-9(Delta444-707)) appear incap

267 D-336, a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14, accelerates di

268 ue has high affinity and selectivity for the gelatinases (MMP-2 and MMP-9) and represents a new class

269 erotic plaques, we used a NIRF substrate for gelatinases (MMP-2/gelatinase-A and MMP-9/gelatinase-B)

270 iovascular remodeling, and MMPs, such as the gelatinases (MMP-9 and MMP-2), have been identified in t

271 The other gelatinase, MMP-2, is not involved in morphine dependenc

272 Here, we expand our study toward another gelatinase, MMP-2, using molecular dynamics simulations.

273 e interstitial collagenase MMP-1 and the two gelatinases, MMP-2 and MMP-9, but not the membrane-tethe

274 The gelatinases, MMP-2 and MMP-9, digest the endothelial bas

275 Gelatinases MMP2 and MMP9 are of particular interest bec

276 w that nCol is a true collagenase, MMP9 is a gelatinase, MMP3/10a is a stromelysin, and MMP3/10b has

277 CsA inhibited the expressions of gelatinase MMPs and EMMPRIN and partially prevented the

278 d@C82(OH)22 is distinguished between the two gelatinase MMPs with atomic details, but also shed light

279 To assess the possible gelatinase modulation after AA treatment, a single subco

280 of which have gelE but not fsrA or fsrB, are gelatinase negative, and do not translocate), resulted i

281 The majority of gelatinase-negative isolates, including 14 endocarditis

282 isolates but little to no translocation for gelatinase nonproducers.

283 spin-coating gelatin, a substrate protein to gelatinases, onto the porous silicon, which forms a thin

284 isolates), which showed translocation by all gelatinase-positive isolates but little to no translocat

285 digestion products of gelatin by the active gelatinase present in the sample are able to enter the p

286 tin zymography studies on these two secreted gelatinases, present in the conditioned media from 3T3-L

287 proteinases (TIMPs) and did not activate pro-gelatinases (pro-MMP-2 and pro-MMP-9) even in the presen

288 more, introduction of fsr genes into two non-gelatinase-producing E. faecalis isolates, the well-char

289 gative, and do not translocate), resulted in gelatinase production by these strains and restored tran

290 The importance of gelatinase production was also corroborated among 20 E.

291 ontact allergen-induced cytokine production, gelatinase release, and reactive oxygen species producti

292 The results suggest that the E. faecalis gelatinase requires C-terminal processing for full activ

293 metalloelastase) efficiently hydrolyzed the gelatinase-selective alpha1(V)436-447 fluorescent triple

294 , adherence (Epb pili), virulence (cps loci, gelatinase, SprE) and antibiotic resistances (IsaA, tetM

295 e of metalloproteinase 9 (MMP-9), a secreted gelatinase that is consistently up-regulated in both ani

296 f Western immunoblotting showed that the HMW gelatinase was also recognized by antibodies specific fo

297 gene gelE encoding the zinc-metalloprotease gelatinase was found to prevent biofilm formation, sugge

298 lis is a secreted bacterial protease, termed gelatinase, which has been shown to contribute to the pr

299 -130-kd band for high molecular weight (HMW) gelatinase, which has not been characterized.

300 In addition, our gelatinase zymography and fluorescence data confirmed th