ライフサイエンスコーパス: gelsolin

1 ruption (latrunculin or pipette perfusion of gelsolin).

2 calcium-dependent manner similar to that of gelsolin.

3 eolytic fragments of mutant (D187N/Y) plasma gelsolin.

4 equivalent to fourth and fifth G domains of gelsolin.

5 to LTA inhibits F-actin depolymerization by gelsolin.

6 aortic endothelial cells was compromised by gelsolin.

7 ish corneal crystallin previously called C/L-gelsolin.

8 th x-ray crystallography data for vertebrate gelsolin.

9 vivo may be mediated or inhibited by plasma gelsolin.

10 otoreceptors via the actin-severing protein, gelsolin.

11 ation in astrocytes appears to be blocked by gelsolin.

12 re all consistent with PrABP80 being a plant gelsolin.

13 alpha-actin and decreased the expression of gelsolin.

14 s ability to down-regulate the expression of gelsolin.

15 , aminopeptidase N, CXCL9, endothelin-1, and gelsolin.

16 mplement 3, collagen II, thymosin beta4, and gelsolin.

17 structural similarities and differences with gelsolin.

18 we made several truncated versions of plasma gelsolin.

19 -H1 abrogated the actin-severing activity of Gelsolin.

20 ation of phagosomes enriched with NMMIIA and gelsolin.

21 binding sequence in the cytoskeletal protein gelsolin.

22 tes the cytoskeleton via an interaction with gelsolin.

23 A peptide based on the PPI binding site of gelsolin (160-169) binds purified LTA at the same molecu

24 We document the depletion of plasma gelsolin (25-50% of normal) in murine models of sepsis a

25 ify a physical interaction between N-RAS and gelsolin, a factor that has been shown to promote surviv

26 Here we report that plasma gelsolin, a highly conserved human protein, binds LPS fr

27 Lowering the activity of Gelsolin, a known calcium-activated actin filament-sever

28 Gelsolin, a known target of Atf3 transcriptional activit

29 Gelsolin, a multifunctional actin-binding protein, media

30 We hypothesize that plasma concentrations of gelsolin, a protein that responds to injured tissue, mig

31 s interferes with 5-FU-induced expression of gelsolin, a protein with known antiapoptotic activity.

32 ated genes (P<0.0001) were in the domains of gelsolin (actin cytoskeleton), matrix metallopeptidases

33 wed filament elongation, whereas gelsolin or gelsolin-actin complex strongly capped and inhibited elo

34 However, gelsolin, gelsolin-actin complex, or cytochalasin D did not enhanc

35 eterodimeric capping protein (CP), CapG, and gelsolin-actin complex.

36 sing the NMR structure of villin 14T and the gelsolin-actin/Ca2+ crystal structure, six putative site

37 this RPGR-gelsolin interaction, compromising gelsolin activation.

38 ity was negatively affected in parallel with Gelsolin activity, suggesting that Nm23-H1 binding inact

39 Here, we used gelsolin affinity chromatography to purify actin from fi

40 Gelsolin also competes with LPS-binding protein (LBP), a

41 In this study we investigate whether gelsolin also interacts with bacterial wall molecules of

42 rin efficiently accelerates the formation of gelsolin amyloid by enabling intermolecular beta-sheet f

43 issue-selective deposition observed there in gelsolin amyloid disease.

44 , such as those found in Alzheimer's and the gelsolin amyloid diseases, result from the misassembly o

45 ergy nucleus, accelerating 8 and 5 kDa D187N gelsolin amyloidogenesis.

46 ated that heparin is capable of accelerating gelsolin amyloidogenesis.

47 t ECM components are capable of accelerating gelsolin amyloidogenesis.

48 e-selective deposition characteristic of the gelsolin amyloidoses is likely influenced by the extrace

49 milial amyloidosis of Finnish type (FAF), or gelsolin amyloidosis, is a systemic amyloid disease caus

50 The gene for gelsolin (an actin-binding, cytoskeletal regulatory prot

51 ulation by the activating k-ras mutation was gelsolin, an actin-binding protein whose expression is f

52 k of Atf3 induction suppresses expression of gelsolin, an actin-severing protein, and rescues spine d

53 te the unique and complementary functions of gelsolin and ADF/cofilin in the recycling of actin filam

54 oll-like receptors (TLRs) are neutralized by gelsolin and by a peptide based on gelsolin residues 160

55 ments, shortened to physiological lengths by gelsolin and cross-linked with recombinant human filamin

56 effects of YopO-mediated phosphorylation on gelsolin and identified its phosphorylation sites by mas

57 n, despite the presence of full-length D187N gelsolin and its 68-kDa cleavage product in blood-demons

58 oflourescence to monitor complexes formed by Gelsolin and Nm23-H1 in living cells, we observed their

59 ease of [Ca(2+)]i, minimal colocalization of gelsolin and NMMIIA in focal adhesions, and minimal intr

60 The Ca(2+) -dependent interaction of gelsolin and NMMIIA in turn enables actin remodeling and

61 ized the F-actin much faster than the native gelsolin and other truncates at the same molar ratios.

62 dysregulation of the actin-severing protein gelsolin and Pctaire1 (Cdk16) kinase, which cooperates w

63 parison of sequence alignments between human gelsolin and plant villins with x-ray crystallography da

64 These residues are conserved in GSNL-1 and gelsolin and previously implicated in actin-severing act

65 However, the YopO phosphorylation sites on gelsolin and the consequences of YopO-mediated phosphory

66 his is the first direct evidence for a plant gelsolin and the first example of efficient severing by

67 trometry revealed that PrABP80 is related to gelsolin and villin.

68 scinderin (adseverin) gene, and scinla (C/L-gelsolin) and scinlb are novel scinderin-like genes.

69 akage of cell breakdown products (low plasma gelsolin), and possibly altered vitamin K usage or gluco

70 ctin-remodeling complex that includes actin, gelsolin, and EPLIN.

71 n breast cancer such as STAT2, CD24 antigen, gelsolin, and lipocalin2.

72 ith and activates the actin-severing protein gelsolin, and that gelsolin regulates actin disassembly

73 from bovine cardiac skinned muscle fibres by gelsolin, and the actin filament was reconstituted from

74 g proteins, such as alpha-actinin, vinculin, gelsolin, and tropomyosins (TMs), is considered to contr

75 The presence of misfolding-prone D187N gelsolin appears to exacerbate the age-associated declin

76 Circulating levels of Gc-globulin and gelsolin are reduced shortly after severe trauma, and ad

77 Mutations in gelsolin are responsible for a systemic amyloidosis firs

78 ctin-depolymerizing factor (ADF)/cofilin and gelsolin are the two major factors to enhance actin fila

79 High amounts of exogenous gelsolin are, however, required to treat animal models o

80 The related villins and gelsolins are conserved proteins that are constructed fr

81 y, the actin regulatory factors, cofilin and gelsolin, are recruited to BCR clusters in both mAg- and

82 ch, we identified the actin-severing protein Gelsolin as binding partner for Nm23-H1, verifying their

83 , hepatoma-derived growth factor (HDGF), and gelsolin as factors potentially contributing to this act

84 inhibition of the actin binding activity of gelsolin as well as the actin depolymerizing activity of

85 usly identified a gelsolin-like protein (C/L-gelsolin) as a corneal crystallin in zebrafish.

86 nd Ca(2+)-dependent enrichment of NMMIIA and gelsolin at collagen adhesions, and abundant intracellul

87 were collected for full-length human plasma gelsolin at nanomolar to millimolar concentrations of fr

88 long, with a knob-like mass attributable to gelsolin at one end.

89 ys of actin depolymerizing effects show that gelsolin binds more tightly to LPS than it does to its o

90 [Ca2+]i also blocks the severing activity of gelsolin, but not actin-depolymerizing factor (ADF)/cofi

91 Immunodepletion of gelsolin, but not Xenopus ADF/cofilin, eliminates calciu

92 phosphorylates the actin-remodeling protein gelsolin, but the functional importance of this gelsolin

93 was used to overcome the severing action of gelsolin by polymerizing actin, complete inhibition of t

94 at of the crystal structures solved for Ca2+/gelsolin C-terminal and N-terminal halves+/-monomeric G-

95 f either gelsolin or CapG and does not uncap gelsolin-capped filaments.

96 program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine m

97 s accompanied by upregulation of cytoplasmic gelsolin (cGSN), an abundant actin-severing protein invo

98 y labelled thin filament was attached to the gelsolin-coated surface of a polystyrene bead.

99 to promote survival and show that the N-RAS:gelsolin complex is modulated differently in wild-type a

100 The Ca2+-sensitive actin-severing protein gelsolin concentrates in the Listeria rocket tails at no

101 Plasma gelsolin concentrations were assessed serially on day 0

102 tin, nectin, zyxin, vinculin, laminingamma3, gelsolin, connection43, and N-cadherin.

103 utants suggested that the N-terminal half of gelsolin contained sequences which were responsible for

104 uh7 cells transfected with plasmids encoding gelsolin deletion mutants suggested that the N-terminal

105 shRNA, but not by another barbed-end capper, gelsolin, demonstrating that the phenotype was specific

106 Gelsolin-dependent removal of thin filament proteins als

107 ved only in tissues synthesizing human D187N gelsolin, despite the presence of full-length D187N gels

108 Because the 68 kDa fragment of gelsolin does not form amyloid fibrils in vitro or in a

109 for D6 in D6-HP as in the highly homologous gelsolin domain 6.

110 beit at a lower efficiency than observed for gelsolin domains G1-G3.

111 Gelsolin domains G4-G6 selectively require Ca(2+) to int

112 coding gelsolin-like proteins based on their gelsolin domains in zebrafish: gsna and gsnb group with

113 re constructed from a core of six homologous gelsolin domains.

114 that is related to the actin binding protein gelsolin enhanced estrogen receptor activity, and mutati

115 Gelsolin exhibits tight, Ca(2+)-dependent binding to ful

116 ctin-remodeling protein gelsolin, increasing gelsolin expression and leading to faster glucose-induce

117 We demonstrated that silencing of gelsolin expression by small interfering RNA sensitized

118 lpha-actin; on the other hand, knocking down gelsolin expression enhanced the assembly of alpha-actin

119 apoptosis by demonstrating that silencing of gelsolin expression through RNAi sensitized cells to 5-F

120 t in part through the negative regulation of gelsolin expression.

121 tin cytoskeleton in a depolymerized state by gelsolin facilitates calcium-dependent apical accumulati

122 echanisms that could explain how this unique gelsolin family member might regulate both stable kerati

123 ndicate that GSNL-1 is a novel member of the gelsolin family of actin regulatory proteins and provide

124 The gelsolin family of actin regulatory proteins is activate

125 ke protein-1 (GSNL-1) is a new member of the gelsolin family of actin regulatory proteins.

126 The gelsolin family of proteins is a major class of actin re

127 CapG is the only member of the gelsolin family unable to sever actin filaments.

128 Jak3 and cytoskeletal proteins of the villin/gelsolin family.

129 may maintain an inactive conformation of the gelsolin family.

130 implicated in actin-severing activity of the gelsolin family.

131 seeded with preformed 8 kDa fragment plasma gelsolin fibrils.

132 ains between C. elegans GSNL-1 and mammalian gelsolin for actin regulatory functions.

133 ntaining gelsolin fragments or an N-terminal gelsolin fragment (amino acid residues 1-70) in the pres

134 siRNA reduced the effects of the N-terminal gelsolin fragment and TRAIL.

135 ther, our study suggests that the N-terminal gelsolin fragment enhances TRAIL-induced loss of cell vi

136 e N-terminal region of gelsolin identified a gelsolin fragment in IHH CM.

137 in that promote the 8 kDa disease-associated gelsolin fragments (residues 173-243) generated at the c

138 Gelsolin fragments encompassing N-terminal regions in po

139 Herein, we show that the 8 and 5 kDa gelsolin fragments form amyloid fibrils by a nucleated p

140 autoantibodies generated against N-terminal gelsolin fragments in patients with chronic liver diseas

141 hown that conditioned medium (CM) containing gelsolin fragments or an N-terminal gelsolin fragment (a

142 The apoptotic activity of N-terminal gelsolin fragments was restricted to activated but not q

143 Villins belong to the villin/gelsolin/fragmin superfamily and comprise at least five

144 ently release the actin-capping protein (CP) gelsolin from barbed actin ends in vitro, allowing for e

145 Structural reconstruction of gelsolin from these data provided a striking visual trac

146 esults show a strong effect of LPS on plasma gelsolin function and suggest that some effects of endot

147 itical insight into how YopO disrupts normal gelsolin function to alter host actin dynamics and thus

148 However, gelsolin, gelsolin-actin complex, or cytochalasin D did

149 ish: gsna and gsnb group with the vertebrate gelsolin gene, scina and scinb group with the scinderin

150 e for PCR amplification of a fragment of the gelsolin gene.

151 toxemic mice (survival rates were 88% in the gelsolin group vs. 0% in the saline group, p < .001) and

152 llenged mice (survival rates were 30% in the gelsolin group vs. 0% in the saline group, p = .001).

153 ukin-10 levels were 205 +/- 108 pg/mL in the gelsolin group vs. 39 +/- 29 pg/mL in the saline group,

154 e actin-binding proteins villin 1 (VIL1) and gelsolin (GSN) in intestinal epithelial cells (IECs) to

155 Here, we report higher gelsolin (GSN) levels in chemoresistant gynecological ca

156 lpha1-antitrypsin (AAT), hemopexin (HX), and gelsolin (GSN), and tested against catabolic stimulation

157 However, unlike gelsolin, GSNL-1 remained bound to the side of F-actin w

158 for sepsis-induced cell injury, that plasma gelsolin has a crucial protective role in sepsis, and th

159 lity to rapidly depolymerize F-actin, plasma gelsolin has emerged as a therapeutic molecule in differ

160 Gelsolin has six homologous gelsolin-like domains (G1-G6

161 ylated gelsolin in the linker region between gelsolin homology domains G3 and G4, which, in the absen

162 r B-cell epitope in the N-terminal region of gelsolin identified a gelsolin fragment in IHH CM.

163 We ascertained the role of gelsolin in 5-FU-induced apoptosis by demonstrating that

164 We examined the role of plasma gelsolin in animal models of sepsis.

165 -induced apoptosis and that re-expression of gelsolin in cells harboring mutant Ras protected cells f

166 The various functions of gelsolin in extracellular compartments are not yet clear

167 that ADF/cofilin and AIP1 are distinct from gelsolin in modulating filament elongation.

168 Depletion of plasma gelsolin in systemic inflammation may contribute to adve

169 SNL-1 has properties different from those of gelsolin in that it remains bound to F-actin and does no

170 , low pH has also been suggested to activate gelsolin in the absence of Ca(2+) ions, although no stru

171 eptides derived from mutant (D187Y/N) plasma gelsolin in the extracellular matrix (ECM).

172 YopO phosphorylated gelsolin in the linker region between gelsolin homology

173 the splicing of the actin-remodeling protein gelsolin, increasing gelsolin expression and leading to

174 show that clear cells express high levels of gelsolin, indicating a potential role in the functional

175 Overexpression of gelsolin inhibited TGF-beta-induced assembly of smooth m

176 ase-causing RPGR mutations perturb this RPGR-gelsolin interaction, compromising gelsolin activation.

177 Gelsolin is a calcium-regulated actin filament severing,

178 Plasma gelsolin is a circulating actin-binding protein that ser

179 Gelsolin is a key actin cytoskeleton-modulating protein

180 Plasma gelsolin is a potential prognostic biomarker for critica

181 Gelsolin is a six-domain (G1-G6) protein activated by ca

182 These data suggest that extracellular gelsolin is involved in the host immune recognition of L

183 Gelsolin is present in other cell types that express the

184 ng in vivo, and the actin disassembly factor gelsolin is required for normal wrapping.

185 We conclude that gelsolin is the primary Ca2+-sensitive actin filament re

186 Both RPGR and Gelsolin knockout mice show abnormalities of actin polym

187 YopO-mediated phosphorylation activates host gelsolin, leading to severed actin filaments and disturb

188 Repletion of plasma gelsolin leads to solubilization of circulating actin ag

189 Plasma gelsolin levels lower than 61 mg/L predicted longer ICU

190 Low plasma gelsolin levels were associated with increased risk of d

191 elated proteins have three or six repeats of gelsolin-like (G) domain, and each domain plays a distin

192 ventional gelsolin-related protein with four gelsolin-like (G) domains (G1-G4), unlike typical gelsol

193 n F-actin regulating, modular protein with a gelsolin-like core and a distinct C-terminal "headpiece"

194 f villin, D6-HP, which consists of the sixth gelsolin-like domain of villin (D6) and the headpiece (H

195 ) and c.2933A>C (p.Gln978Pro, located in the gelsolin-like domain).

196 lsolin-like protein-1 (GSNL-1) has only four gelsolin-like domains (G1-G4) and still exhibits Ca(2+)-

197 Gelsolin has six homologous gelsolin-like domains (G1-G6), and Ca(2+)-dependent conf

198 Purified FliI containing gelsolin-like domains (GLDs) 1-6 capped actin filaments

199 gher calcium concentrations, is capable of a gelsolin-like F-actin severing.

200 We have previously identified a gelsolin-like protein (C/L-gelsolin) as a corneal crysta

201 e observed up-regulation of an actin-binding gelsolin-like protein in hypertrophic chondrocytes.

202 The Caenorhabditis elegans gelsolin-like protein-1 (gsnl-1) gene encodes an unconve

203 Caenorhabditis elegans gelsolin-like protein-1 (GSNL-1) has only four gelsolin-

204 Caenorhabditis elegans gelsolin-like protein-1 (GSNL-1) is a new member of the

205 s that there are at least six genes encoding gelsolin-like proteins based on their gelsolin domains i

206 lymerization, is indirectly regulated by the gelsolin-like sequence of g2-g3 linker.

207 One result of gelsolin-LPS binding is inhibition of the actin binding

208 h Ras mutations and/or reduced expression of gelsolin may show enhanced apoptosis in response to 5-FU

209 Conversely, when gelsolin-mediated actin filament elongation was inhibite

210 strength was progressive in homozygous D187N gelsolin mice.

211 solin, but the functional importance of this gelsolin modification has not been clear.

212 Gelsolin modulation of cell death using this fragment in

213 g of the gradual Ca2+-induced opening of the gelsolin molecule and highlighted the critical role play

214 d the maximum linear dimension (Dmax) of the gelsolin molecule increased 55 A, from 100 to 155A.

215 of gyration and maximum linear dimension of gelsolin molecules increased from 30.3 to 34.1 A and fro

216 Using phosphomimetic and phosphodeletion gelsolin mutants, we found that YopO-mediated phosphoryl

217 vasopressin action, including Mal2, Akap12, gelsolin, myosin light chain kinase, annexin-2, and Hsp7

218 ein (WASP) was observed in the actin ring of gelsolin null osteoclast.

219 Although gelsolin null osteoclasts failed to exhibit podosomes, a

220 a tail length is also calcium-insensitive in gelsolin-null mouse embryo fibroblasts.

221 not inhibit the capping activities of either gelsolin or CapG and does not uncap gelsolin-capped fila

222 eak and allowed filament elongation, whereas gelsolin or gelsolin-actin complex strongly capped and i

223 ure (CLP) were treated with exogenous plasma gelsolin or placebo.

224 In vivo analyses revealed that Gelsolin overexpression increased the metastasis of orth

225 When D187N/Y gelsolin passes through the Golgi, furin endoproteolysis

226 egulator of gelsolin, revealing a novel PYK2-gelsolin pathway in regulating actin cytoskeletal organi

227 The use of N-terminal gelsolin peptide1-70 alone or in combination with TRAIL,

228 Plasma gelsolin (pGSN) binds actin and bioactive mediators to l

229 ctivated actin-capping and -severing protein gelsolin plays a key role in regulating vacuolar H(+)-AT

230 ially mimics calcium-dependent activation of gelsolin, potentially contributing to a reduction in fil

231 furin consensus sequence in D187N and E209Q gelsolin prevents cleavage during secretion, indicating

232 These data therefore demonstrate that gelsolin protects cells from butyrate-induced apoptosis

233 NMMIIA knockdown retards gelsolin recruitment to adhesions and blocks collagen ph

234 lation of SV and the closely related protein gelsolin reduces invasion through ECM.

235 he actin-severing protein gelsolin, and that gelsolin regulates actin disassembly in the connecting c

236 is postulated that the secretory isoform of gelsolin regulates several biological processes through

237 Gelsolin regulates the dynamic assembly and disassembly

238 tcome of serine/threonine phosphorylation in gelsolin regulation and provides critical insight into h

239 in-1 (gsnl-1) gene encodes an unconventional gelsolin-related protein with four G domains.

240 It is an unconventional gelsolin-related protein with four gelsolin-like (G) dom

241 Typically, gelsolin-related proteins have three or six repeats of g

242 lin-like (G) domains (G1-G4), unlike typical gelsolin-related proteins with three or six G domains.

243 t into functional diversity and evolution of gelsolin-related proteins.

244 Plasma gelsolin replacement may have therapeutic application.

245 crucial protective role in sepsis, and that gelsolin replacement represents a potential therapy for

246 Plasma gelsolin repletion also shifted the cytokine profile of

247 -actin by the homologous proteins villin and gelsolin requires unphysiologically high calcium concent

248 that the F-actin depolymerizing property of gelsolin resides in its N terminus, we made several trun

249 alized by gelsolin and by a peptide based on gelsolin residues 160-169 (GSN160-169) which comprise pa

250 tation (D187N/Y) in domain 2 of human plasma gelsolin, resulting in domain 2 misfolding within the se

251 segment) simultaneously to the sequences of gelsolin results in a mutant, CapG-sev, capable of sever

252 results suggest that PYK2 is a regulator of gelsolin, revealing a novel PYK2-gelsolin pathway in reg

253 such as lipoteichoic acid (LTA) and whether gelsolin's interaction with bacterial lipids from Gram-n

254 160-169 (GSN160-169) which comprise part of gelsolin's phosphoinositide binding site.

255 actin-capping and -severing proteins such as gelsolin, scinderin, and severin, are calcium-regulated

256 at the mutation induces a destabilization of gelsolin second domain, without compromising its calcium

257 tightly packed architecture of calcium-free gelsolin, seen from both SAXS and x-ray crystallographic

258 and unphosphorylated actin in complexes with gelsolin segment 1 and profilin.

259 ies based on the similarities of cofilin and gelsolin segment 1 proposed the cleft between subdomains

260 One end of the particles was capped by a gelsolin (segment 1-3)-TnT fusion protein (substituting

261 region encompassing amino acids 1-70 in the gelsolin sequence; antibody directed to an epitope withi

262 extracted (using the actin severing protein gelsolin) showed that the difference in hysteresis betwe

263 essibility and local structural contacts for gelsolin shows a statistically significant agreement bet

264 The structure of an inactive form of gelsolin shows that the equivalent acidic residues are i

265 ation and maturation through the cytoplasmic gelsolin signaling pathway, providing new drug targets f

266 egion (phosphoinositide-binding domain 2) of gelsolin, significant V-ATPase apical membrane mobilizat

267 filin that shares actin-binding domains with gelsolin, significantly increased PC2(iv) channel functi

268 changes that accompany calcium activation of gelsolin, small-angle x-ray scattering (SAXS) data were

269 Gelsolin stimulated PC2(iv) channel function in the pres

270 severin is a member of the calcium-regulated gelsolin superfamily of actin-binding proteins.

271 we found that Flightless-I, a member of the gelsolin superfamily of actin-remodeling proteins, inter

272 an actin binding protein that belongs to the gelsolin superfamily, is expressed almost exclusively in

273 ng a muscle-specific promoter to drive D187N gelsolin synthesis.

274 including SYWC, kallistatin, complement C9, gelsolin, testican-2, and aldolase C, performed well in

275 cal interaction between endogenous N-RAS and gelsolin that correlates with survival.Oncogene advance

276 is uncovered the actin-depolymerizing factor gelsolin, the membrane glycoprotein dysadherin, the cent

277 thin filament was selectively removed using gelsolin (thin filament severing protein), and the actin

278 tivated the actin-depolymerizing function of Gelsolin to inhibit cell motility.

279 addition of purified LTA, and the binding of gelsolin to LTA inhibits F-actin depolymerization by gel

280 increase of alpha-actin and the decrease of gelsolin to promote MSC differentiation.

281 oteins, including the actin-severing protein gelsolin, to disrupt actin filaments and thus impair pha

282 In Gelsolin-transfected cells, coexpression of Nm23-H1 abro

283 Average actin, tropomyosin, and gelsolin-troponin composition indicated one troponin-tro

284 n dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of

285 amyloidogenic fragments from the full-length gelsolin variants and demonstrated that heparin is capab

286 Unlike human plasma gelsolin, VLN1 does not nucleate the assembly of filamen

287 Gelsolin was able to partially inhibit LPS- or LTA-induc

288 Conversely, actin severing by Gelsolin was abrogated by RNA interference-mediated sile

289 Glomerular labeling of ezrin, moesin, and gelsolin was altered at 3 wk, but expression of nestin a

290 The OD of recombinant human plasma gelsolin was found to decrease following the addition of

291 uld induce a shape where the g3-g4 linker of gelsolin was open when we truncated the C-tail latch fro

292 Gelsolin was recently reported to bind endotoxin (LPS) f

293 ase in the molecular mobility of recombinant gelsolin when buffer pH was lowered from 9 to 5.

294 cross-linked actin filaments assembled with gelsolin, whereas soluble macromolecules of the same siz

295 Gelsolin, which maintains an organized actin cytoskeleto

296 fully activate the F-actin-severing shape of gelsolin with micromolar levels of Ca(2+) available.

297 entration ([Ca(2+)]i, and the association of gelsolin with nonmuscle myosin IIA (NMMIIA) at collagen

298 re loosely folded inactive conformation than gelsolin, with a shorter S1-S2 latch.

299 gnificant role for RPGR in the activation of gelsolin, without which abnormalities in actin polymeris

300 ull-length (wt) Jak3 using Jak3-wt or villin/gelsolin-wt as substrate showed that Jak3 autophosphoryl