ライフサイエンスコーパス: geminal

1 rrelates with a conformational dependence of geminal 119Sn-15N couplings and a possible correlation w

2 SiMe3)2, are active for the hydrogenation of geminal and 1,2-disubstituted alkenes.

3 effect on acyclic conformation, inducing the geminal and vicinal hydrogens on the adjacent sp3-sp3 C-

4 In vacuo and solvated DFT calculations of geminal and vicinal J(CH) and J(CC) values are similar a

5 ired electrons of Bt being stabilized by the geminal anionic oxygen.

6 istic experiments with chiral (10)B-enriched geminal bis(boronates) suggest that the reaction occurs

7 c-group-selective cross-couplings of achiral geminal bis(pinacolboronates) provide a route for the co

8 between the structures of a wide variety of geminal bisphosphonates and their activity in inhibiting

9 selective substrates are those containing a geminal bulky substituent on the enoxysilane.

10 ersible steps ii and iii, and interchange of geminal C H bonds of the methane and cyclohexane C H sig

11 demonstrate the first example of a directed, geminal C-H bisoxidation, a new fragmentation cascade to

12 The lack of a hydroxyl group on the geminal carbon also reduced K(isom).

13 central bond, whereas bisubstitution on the geminal carbon leads to a shortening of this bond due to

14 logue show intrinsic isotope shifts from the geminal CD(3) and from only one distant CD(3), an unusua

15 f the catalytic mechanism, followed by their geminal coupling with O atoms coordinated by the same Co

16 These geminal couplings depend highly on the orientation of C-

17 2-Amino-4H-pyrans undergo geminal dialkoxylation with the migration of an amino gr

18 The rates for the formation of the geminal diamine and external aldimine in this pathway we

19 he PLP group that accompany formation of the geminal diamine complex, the first intermediate in the r

20 phosphates appear to be primarily present as geminal diamine complexes, with bonds to both glycine an

21 e excitation and emission wavelengths of the geminal diamine intermediate, we were able to monitor th

22 tor the formation and decay of two different geminal diamine species.

23 Finally, the formation of the geminal diamine was determined to be Mg2+-dependent.

24 The electron density reveals that the geminal diamine, a tetrahedral intermediate in the forma

25 rapid equilibrium of isomeric aldimines and geminal diamines.

26 Geminal diazides constitute a rare class of compounds wh

27 The degradation of geminal diazides is described.

28 A broad range of geminal diazides with various structural motifs includin

29 n aqueous DMSO providing a general access to geminal diazides.

30 amonolayer coverages (CO*/Ru > 1) by forming geminal dicarbonyls at low-coordination corner/edge atom

31 The requisite allylic geminal dicarboxylates are prepared in good yields and h

32 Asymmetric alkylations of allylic geminal dicarboxylates with dialkyl malonates have been

33 The solvation properties of the geminal dicationic ILs tend to be similar to those of th

34 Thirty-nine geminal dicationic ILs were synthesized and characterize

35 more highly cross-linked stationary phase of geminal dicationic ILs, exclusively, an increase in effi

36 rmination of water due to the new PEG-linked geminal dicationic ionic-liquid-coated GC capillary colu

37 degrees C for one of the pyrrolidinium-based geminal dicationic liquids.

38 The various geminal dications were paired with up to four different

39 was used to investigate the role of the 3,3-geminal diester groups and the origin of torquoselectivi

40 hod for the catalytic, asymmetric, migratory geminal difluorination of beta-substituted styrenes to a

41 [GEM] was also computed to determine how the geminal difluoro group of dFdC perturbs DNA electrostati

42 ased electron density in the vicinity of the geminal difluoro group.

43 lytic asymmetric cross-coupling that employs geminal dihalides as electrophiles.

44 The reaction of geminal dihalocyclopropanes with metals or alkyllithiums

45 A chemoselective, tandem geminal dihalogenation of an unactivated methyl group, a

46 ilyldiperoxyketals and -acetals derived from geminal dihydroperoxides and from a new method employing

47 substituted hexofuranoses 7a-c with required geminal dihydroxymethyl group.

48 of DMDO is largely a consequence of combined geminal dimethyl and dioxa substitution effects and its

49 ds to a dihydrodipyrrin-acetal (1) bearing a geminal dimethyl group and a p-tolyl substituent.

50 )N atoms yet lacks substituents other than a geminal dimethyl group in each pyrroline ring.

51 hydrogenation by virtue of the presence of a geminal dimethyl group in each pyrroline ring.

52 ded 3,13-substituted chlorins that contain a geminal dimethyl group in the pyrroline ring (for stabil

53 ation of a dihydrodipyrrin-acetal (bearing a geminal dimethyl group in the pyrroline ring) typically

54 se route to synthetic chlorins, which bear a geminal dimethyl group in the pyrroline ring, has been e

55 ns are sterically uncongested and bear (1) a geminal dimethyl group in the reduced pyrroline ring, (2

56 e been prepared wherein each chlorin bears a geminal dimethyl group in the reduced ring and a water-s

57 Chlorin building blocks incorporating a geminal dimethyl group in the reduced ring and synthetic

58 in is sterically uncongested and bears (1) a geminal dimethyl group in the reduced, pyrroline ring, (

59 o beta substituents, one meso substituent, a geminal dimethyl group to lock in the chlorin hydrogenat

60 chlorins that bear two meso substituents, a geminal dimethyl group to lock in the chlorin hydrogenat

61 The presence of the geminal dimethyl groups in 6SS increased the stability o

62 Each bacteriochlorin contains two geminal dimethyl groups to lock-in the bacteriochlorin h

63 d corrole, is enantiomeric, and contains two geminal dimethyl groups, 2,12-di-p-tolyl substituents, a

64 ring 4 position and additional substitution (geminal dimethyl or aryl) at the 5 position are crucial

65 MDO is largely a consequence of the combined geminal dimethyl- and dioxa-substitution effects and unu

66 dialdehydes yield on reaction with OH- ions geminal diol anion, which is electro-oxidized to a carbo

67 linked N2-(3-oxo-propyl)-dG aldehyde and its geminal diol hydrate.

68 reactions of the C-7 methyl group to form a geminal diol intermediate, which spontaneously dehydrate

69 und I (Cmpd I) mediated deformylation of the geminal diol was considered in the context of the protei

70 designed to contain cleavable bonds such as geminal diol, disulfide, and acetal.

71 to initiate a concerted deformylation of the geminal diol.

72 to a lesser extent ketones, hydrate to form geminal diols.

73 e prepared a new polymer which uses a pseudo-geminal disubstituted [2.2]paracyclophane scaffold to ho

74 for the catalytic hydroboration of terminal, geminal, disubstituted internal, tri- and tetrasubstitut

75 ts for the enantioselective hydrogenation of geminal-disubstituted olefins.

76 lene protons interfere with the reaction, so geminal disubstitution alpha to the amide carbonyl was n

77 and cellular antiviral data for a series of geminal disulfones.

78 derivatives to form hydrazido complexes and geminal double cleavage to form unusual late transition

79 ference compound is especially important for geminal electronegative substitutents.

80 ons between the geminal hydroxyl groups, the geminal fluorine atoms, and the active-site aspartate re

81 and octanitrocubane, and (8) the effects of geminal fluorine substitution at C-2 of 1,3-diradicals.

82 iplet states of diradical 6, which lacks the geminal fluorines at C-2 that are present in 4.

83 w that a cooperative interaction between the geminal fluorines at C2 and the fluorines at C1 and C3 i

84 the reason that addition of a second pair of geminal fluorines to methylenecyclopropane lowers the ba

85 hate; because of unusual interactions of the geminal fluorines, the ribose and base of GemdP shift su

86 thy synthesis (along with its monofluoro and geminal fluoro analogues).

87 Geminal frustrated Lewis pairs (FLPs) are expected to ex

88 mpounds 1b-d were compared with those of the geminal (gem) selectivity model ethyl tiglate (1a).

89 (2)H(1)]glucose have been used to assign the geminal H-6'a, H-6'b methylene bridge of the 11-carbon d

90 s and up to -109 Hz for (1)H-(1)H vectors of geminal hydrogen atoms (magnetic field of 14.09 T, tempe

91 magnetic environment in the capsule and the geminal hydrogen atoms of encapsulated alkanes show dias

92 nd bound in an unprecedented fashion via two geminal hydrogen atoms.

93 Charge analysis reveals that the geminal hydrogens are in fact more acidic than the agost

94 e shielding environment experienced by these geminal hydrogens differs by 1.26 ppm, indicative of pro

95 ymmetric pyrrolidine carbons and unsymmetric geminal hydrogens on the pyrrolidine ring, as confirmed

96 t symmetric, set of interactions between the geminal hydroxyl groups, the geminal fluorine atoms, and

97 udy, phlorins with different combinations of geminal methyl and phenyl substituents were prepared in

98 Changing the geminal methyl groups on 1alpha,25-dihydroxyvitamin D3 a

99 stereospecifically deuterated in one of the geminal methyl groups on C1 of the cyclohexene ring.

100 of a 23-yne function and replacement of the geminal methyl groups with trifluoromethyl groups, the o

101 sine, indicating that a positive charge on a geminal N does not inhibit the (1)H/(2)H exchange.

102 hydrogen whose bond is being cleaved but its geminal neighbor.

103 he presence of a 2-methyl substituent at the geminal or distal alpha-carbon, and (e) branching in the

104 Reaction of the geminal PAl ligand [Mes2PC( horizontal lineCHPh)AltBu2]

105 Results indicate that the geminal protons of the A-ring, the H5 and H8 protons of

106 t topoisomerase II demonstrated that the H15 geminal protons of the etoposide A-ring, the H5 and H8 p

107 nsymmetric pyrrolidine carbons and symmetric geminal protons.

108 ine substituents are especially strain-rich: geminal, proximate, and W-related.

109 radical annulation using sulfur dioxide as a geminal radical acceptor/donor is presented.

110 in a variety of organic solvents, require a geminal relationship between a peroxyanion and a peroxid

111 The results suggest that geminal repulsion can provide a simple, unified explanat

112 In contrast, an explanation based on geminal repulsion provides a general conceptual framewor

113 based on 1,3 repulsive steric interactions (geminal repulsion) is proposed for explaining the variat

114 ne is a good lone pair electron donor toward geminal sigma bonds.

115 Geminal sites ( identical withFe(OH2)2(+)) at this plane

116 The design relies on the incorporation of geminal substituents at C5 in combination with a substit

117 to the sterics of cis substituents, but not geminal substituents.

118 high, although in substrates not blocked by geminal substitution aromatization to a dipyrromethane i

119 yl-1,3-di-tert-butylbicyclo[1.1.0]butane and geminal substitution in 2,2'-di-tert-butylbicyclo[1.1.0]

120 lective, and the selectivity is increased by geminal substitution on carbon 3.

121 While beta-amino acids containing geminal substitution patterns have enormous potential fo

122 nhibitors, we have introduced a CF(2) moiety geminal to an amino group in the long tail of one of the

123 eprotonation of one of the C-H bonds that is geminal to the agostic interaction, rather than the agos

124 y the placement of various functional groups geminal to the H-C bond.

125 requiring only four general types of SSCCs: geminal, vicinal, 1,3-, and long-range constants.