ライフサイエンスコーパス: gene

1 ither direction limited by the bounds of the gene.

2 600 bp region in the promoter of the Ifitm3 gene.

3 er receptor B1 (SCARB1; also known as SR-B1) gene.

4 muscle and may also be a schizophrenia risk gene.

5 start sites in the promoters of co-expressed genes.

6 ught-after nephrin and tumor necrosis factor genes.

7 n supporting evolution of new protein-coding genes.

8 ificant overlap in the most upregulated host genes.

9 ethyltransferase 3B to methylate a subset of genes.

10 and B cell receptor (BCR)/pre-BCR-signaling genes.

11 in most cases, expression of immediate early genes.

12 intrinsic factors for the majority of immune genes.

13 GR-mediated transrepression of inflammatory genes.

14 osynthesis, plants require a large cohort of genes.

15 -chromosomes mostly conserve their ancestral genes.

16 agenic CpG-methylation of highly-transcribed genes.

17 s, concomitant with downregulation of target genes.

18 ate mechanism that is directly controlled by genes.

19 7me3, at the promoters of affected endocrine genes.

20 sertional mutagenesis or the use of nonhuman genes.

21 ng mutations have been discovered in several genes.

22 functions associated with root colonization genes.

23 the expression pattern of key immune system genes.

24 for a class of downregulated, H3K36me3-rich genes.

25 of synaptic and schizophrenia-susceptibility genes.

26 Brahma-related gene 1 (Brg1), a catalytic subunit of the mammalian SWI/

27 l costimulator (ICOS), lymphocyte activation gene 3 protein (LAG-3), and CD49b, and exert strongly su

28 histone H2AX and that ectopic expression of Gene 33 promotes the interaction between ATM and histone

29 Moreover, we observed a clear association of Gene 33 with histone H2AX and that ectopic expression of

30 nts predicted to be deleterious in each of 3 genes ( ACACB, PTPRS, MIB1) in individuals from independ

31 es is a central player in epigenetics and in gene activation and repression.

32 ific super-enhancer, resulting in high-level gene activation.

33 entarity to the mRNA for the important viral gene activator ICP0, inhibition of ICP0 expression by mi

34 ltiple regulatory factors in modulating Fshb gene activity.

35 nce of positive selection on the ND2 and ND5 genes against a background of purifying selection across

36 Female-biased genes already in an active chromatin state in male liver

37 methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylati

38 on chromosome 13, which encompassed the Bhmt gene and defined a potentially sensitive region with mos

39 etome in Chagas heart disease by integrating gene and microRNA expression profiling data from hearts

40 Moreover, IL-33 increases NK-1 gene and surface protein expression, as well as IKbeta-a

41 ntify associations between several candidate genes and agronomically important traits.

42 pathways, with associations between mutated genes and pathways, and stage or subtype of T-ALL.

43 nteractions between regulators on downstream genes and proteins.

44 unction disrupts a core set of OL maturation genes and reduces the DNA occupancy of YY1, a transcript

45 on rely on a limited set of host-dispensable genes and suggest that these pathways can be studied for

46 alysis between each TF and all other genomic genes and then constructing collaborative networks of TF

47 gene expression was observed in leaves (3605 genes) and tubers (6156 genes) that contrasted the prefe

48 iates uniformly at any position within a tuf gene, and proceeds with an effectively uniform conversio

49 Gene structure was improved in over 13% of genes, and 651 novel genes were predicted by the GC-spec

50 versity, copy number variation of paralogous genes, and long repetitive sequences.

51 rigin, highlighting oligodendroglial lineage genes, and reveals unexpected mechanisms mediating tumor

52 phage that specifically transcribes its late genes, and thus represents a novel type of bacteriophage

53 rized the diversity of the nitrite reductase gene (aniA), the factor H-binding protein gene (fHbp), a

54 R-RTs is critical for achieving high-quality gene annotation.

55 tion predicts that at least 66 potential PME genes are contained in Arabidopsis (Arabidopsis thaliana

56 e their resistant counterparts if resistance genes are costly.

57 The causative genes are known for fewer than 40% of PCLD index cases.

58 MMB target genes are overexpressed in several different cancer type

59 tardigrade desiccation tolerance, and these genes are sufficient to increase desiccation tolerance w

60 ontrolling the expression of Longus-encoding genes are unknown.

61 shown to possess both MAT1-1-1 and MAT1-2-1 genes as observed in homothallic filamentous Ascomycetes

62 In contrast, genes associated with abdominal adiposity function in ad

63 rease in LPC proliferation and expression of genes associated with cholangiocyte differentiation (cyt

64 Genes associated with neutrophil activation, ROS product

65 We previously developed eight gene association methods for genome-wide coexpression an

66 es positional information to activate target genes at different positions along the anterior-posterio

67 vated pathways associated with pro-oncogenic genes at network analysis.

68 Conditional and gene-based testing was undertaken, and variants were inv

69 resided within the Tubb4a (beta-tubulin 4A) gene, because mutations in the TUBB4A gene have been des

70 Our prior work uncovered 16S rRNA genes belonging to a novel, as-yet-uncultivated mycoplas

71 y combining Brassica napus cysteine-protease gene (BnCysP1) with anther-specific P12 promoter of rice

72 ght-responsive genes, levels of H2A.Z in the gene body correlate with transcript levels.

73 vitamin D, the VDREs are present in primate genes, but neither the VDREs nor the regulation by 1,25D

74 n the levels of expression of relatively few genes, but this is sufficient to adjust the configuratio

75 demonstrate targeted deletions in up to six genes by expressing 12 gRNAs from a single transcript.

76 e evolutionary analyses of phototransduction genes by using a variety of approaches (restricted branc

77 a stabilized attenuating mutation in the P/C gene (C(Delta170)).

78 udy demonstrates that functional analyses of genes carrying DNMs are warranted to delineate the full

79 subpopulations that express the neuropeptide gene Cck.

80 Here, we report that the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negati

81 multitask approach, which explicitly models gene-centric dependencies across multiple and distinct g

82 Synthetic gene circuits that combine DNA, protein, and RNA compone

83 investigations into the interactions between genes, circuits, and computation.

84 We observed variation in 40 of 41 genes comprising the NOD signaling pathway.

85 d to have X and Y Chromosomes with different gene content.

86 The analysis suggests that gene conversion effectively initiates uniformly at any p

87 likely evolutionary precursors, the antibody gene deaminase AID and the RNA/DNA editing enzyme APOBEC

88 lysis revealed 1062 differentially expressed genes (DEGs) in G. arboreum.

89 psoriasis-increased differentially expressed genes (DEGs), but analysis of KC cultures identified mor

90 dy-resistant strains arising through further gene deletion could compromise such a strategy.

91 s the efficacy of non-viral TUS-based hSef-b gene delivery approach for the treatment of prostate can

92 g of the voltage gated sodium channel (VGSC) gene did not detect the common L1014F mutation in field

93 rgeted sHsps that have emerged from a recent gene duplication event resulting from the ongoing divers

94 Here the authors employ CRISPR/Cas9 gene editing technology to silence VEGFR2, a major regul

95 ges and plasmids, as well as a revolutionary gene editing tool.

96 Here we combine CRISPR/Cas9 gene editing with an innovative high-throughput genotypi

97 PDA in mice, whereas deletion of Clec7a-the gene encoding dectin 1-or blockade of dectin 1 downstrea

98 three stage 4 tumors contained mutations in genes encoding protein products that regulate immune fun

99 ferences, this work sheds light on ways that genes, environment and sex interact to affect the transc

100 of these approaches has uncovered effects of gene-environment interactions relevant to drug response

101 re living in Costa Rica to examine potential gene-environment interactions.

102 on of structurally distinct antigen receptor genes evolved independently in jawless and jawed vertebr

103 Thus, the ASCC3 gene expresses both coding and non-coding transcript iso

104 ypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a uni

105 le in developmentally regulated gamma-globin gene expression and the ability to control oxidative str

106 Cell aggregation, gtfP gene expression and water-insoluble glucan production we

107 eurons, but found no striking differences in gene expression between male and female mice, neither be

108 in the 3'UTR composition of mRNAs can alter gene expression by regulating transcript localization, s

109 esis to help explain the repression of lytic gene expression during latency.

110 velopment by integrating in vivo analysis of gene expression dynamics with a reverse engineering appr

111 the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of spong

112 Heterologous gene expression in E. coli confirmed its functions for h

113 ability to both attract and induce virulence gene expression in EHEC, we propose that DHMA acts as a

114 rared laser, for reproducible heat-dependent gene expression in small sublineages (one to four cells)

115 Ralpha that can be targeted to block ERalpha gene expression is a critical topic of endocrine therapy

116 ity is differentially recruited to fine-tune gene expression levels in each cardiac chamber.

117 Lastly, we trained a classifier based on the gene expression levels in the non-infected cells, and de

118 wth by inducing an early myogenesis -related gene expression pattern which includes myogenin and Myf5

119 actions between HNF4A and microbiota promote gene expression patterns associated with human inflammat

120 onfronted an automatically generated RN with gene expression profiles (GEP) from a cohort of multiple

121 Hierarchical clustering based on gene expression profiles delineated brain regions into s

122 l clustering of participants based on global gene expression profiles revealed that participants with

123 ts, together with a new dataset of 265 ccRCC gene expression profiles.

124 ulated when p16 is inactivated by looking at gene expression profiling studies.

125 rotein interactions are essential for proper gene expression regulation, particularly in neurons with

126 ion factors (TFs) is crucial to the study of gene expression regulation.

127 toma metastasis in vivo Overall, we identify gene expression signatures and candidate therapeutics th

128 binding, triggering a major reprogramming of gene expression that includes components of the virulenc

129 Computational analysis of gene expression to determine both the sequence of lineag

130 Additive gene expression was observed in leaves (3605 genes) and

131 Early perturbations in tissue-wide gene expression, as observed here, may underpin a profou

132 tions mediated the effects of age and sex on gene expression, including CD8(+) T cells for age and CD

133 ifically upregulate additional regulators of gene expression, including other AP2 transcription facto

134 are associated with activated and repressed gene expression, respectively.

135 nd repressive functions in the regulation of gene expression.

136 nitiation is a key step in the regulation of gene expression.

137 ting oxidative promoter lesions may modulate gene expression.

138 s both as a repressor and as an activator of gene expression.

139 Differential gene-expression analysis has allowed us to confirm the r

140 bility Complex (MHC) region contains several gene families characterized by highly polymorphic loci w

141 arkable expansions of protease and cell wall gene families, while divergent infection strategies are

142 are linked to radiations of lineage-specific gene families.

143 se gene (aniA), the factor H-binding protein gene (fHbp), and the capsule biosynthetic locus, all of

144 All sediments contain abundant genes for autotrophic carbon fixation used in the Calvin

145 ively reduced CSLC only were found to target genes for cholesterol and unsaturated fatty acid synthes

146 antioxidation, and leukocyte migration plus genes for proinflammatory cytokines and various toll-lik

147 By contrast, activation of the Eomes target genes Foxa2 and Lhx1 is associated with higher order chr

148 Within specific mutated genes, frequency, mutation hotspot residues, in silico p

149 for Pxr function, we deleted the entire pxr gene from a developmentally defective strain that fails

150 as designated as aidP (autoinducer degrading gene from Planococcus sp.).

151 Phylogenetic analysis of SNAP genes from 22 diverse plant species showed that SNAPs we

152 Identifying differentially expressed (DE) genes from RNA sequencing (RNAseq) studies is among the

153 ion is necessary to make strong claims about gene function.

154 gly, most of these differentially methylated genes function in cell adhesion and communication pathwa

155 These tumors also frequently displayed ERG gene fusions involving alternative 5'-partners to TMPRSS

156 The ST18 gene has been proposed to act either as a tumor suppress

157 in 4A) gene, because mutations in the TUBB4A gene have been described in patients with central nervou

158 otide polymorphisms within the prion protein gene have been linked to differential susceptibility to

159 Mutations in a small number of genes have been reported to cause PCH, and the vast majo

160 To further characterize genes identified by our screen, we compared the function

161 In 16S rRNA gene Illumina libraries, four Pseudomonas sp. operationa

162 ESCd display a high level of expression of genes implicated in migration and invasion compared to c

163 ase-causing retrocopies of the same parental gene in a mammalian species.

164 We sequenced exons of this gene in DNA from a total of 134 nonsyndromic cases.

165 elium ( Irf6 cKO), bypassing the role of the gene in lip and palate morphogenesis and thus ensuring s

166 Results showed that deficiency of the Tgr5 gene in mice alleviated fasting-induced hepatic lipid ac

167 liver generally showed early cGH responses; genes in an inactive chromatin state often responded lat

168 53 to induce the expression of pro-apoptotic genes in breast cancer with mutant p53.

169 is associated with transcriptionally active genes in early-diverging fungal lineages.

170 studies and understanding the roles of these genes in keratoconus are warranted.

171 s the transactivation of the AR/AR-V7 target genes in ligand dependent and independent manners respec

172 RS-1 phosphorylation, stronger regulation of genes in metabolic pathways and more dramatic glycolytic

173 elp reduce the load of antibiotic-resistance genes in the environment.

174 n of between 2180 and 3502 and 3367 and 5270 genes in the leaf and tuber transcriptome, respectively.

175 ng the ectopic expression of tissue-specific genes in the thymic medullary epithelium.

176 vity suppressed the expression of interferon genes in uhrf1 mutants.

177 Following gene inactivation and replacement in human cells, we dem

178 Mutations were also found in rarely reported genes including CRYBA4, CRYBA2, BFSP1, VIM, HSF4, and EZ

179 ing increases expression of EC morphogenesis genes, including Sox17, shifts the genomic targeting of

180 ade by multipotent cells and to identify the genes influencing these decisions is challenging.

181 connected network of pluripotency-associated genes, integrates external signals and exerts control ov

182 volved in genome stability and expression of genes involved in oxidative stress responses, tumor prog

183 m/phosphorus levels and affect expression of genes involved in phosphate homeostasis.

184 targeting approach, we ablated the major CLP gene Irf6 only in the late embryonic oral epithelium ( I

185 The MED25 gene is expressed in trichomes.

186 e loss of one or both functional copies of a gene is related to the gene's causal role in disease.

187 e of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq(-/-) ) and wild-type (WT) mice wer

188 letions in the PBX homeobox 1 gene (PBX1), a gene known to have a crucial role in kidney development.

189 more, we observed that in drought-responsive genes, levels of H2A.Z in the gene body correlate with t

190 WebGIVI can accept a gene list that is used to retrieve the gene symbols and

191 nscriptomes using Gene Ontology, adult-brain gene lists generated by Translating Ribosome Affinity Pu

192 iant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblasto

193 with a substantially increased resolution of gene models will not only further our understanding of t

194 Toxin-antitoxin (TA) systems are gene modules that are ubiquitous in free-living prokaryo

195 ces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive

196 Our study shows that different gene mutations induce DCM via diverse cellular pathways.

197 transcriptomic variation; a small number of genes (n = 263) were differentially regulated according

198 ng the N gene (pre-N) or between the N and P genes (N-P) of rHPIV1 bearing a stabilized attenuating m

199 ability, as many mutations in protein-coding genes occurred during the outbreak.

200 Target genes of a cis-regulatory motif were identified from the

201 ations, with a relevant proportion affecting genes of the lysine demethylase (KDM) family.

202 iad of genomic sites and switch the targeted genes on or off with precision.

203 Due to the sequence similarity of several genes on the megaplasmid, BTA121 can serve as a model fo

204 candidates from two sets of plant-associated genes: one involved in plant colonization, and the other

205 were extracted from the transcriptomes using Gene Ontology, adult-brain gene lists generated by Trans

206 ell gene signatures and substantiate several genes/pathways.

207 driven by expression of the oncogenic fusion gene PAX3-FOXO1A.

208 on mutations/deletions in the PBX homeobox 1 gene (PBX1), a gene known to have a crucial role in kidn

209 ges known as Pf EMP1 encoded by up to 60 var genes per genome.

210 fically tailored to analyze high-dimensional gene perturbation data, to incorporate logical functions

211 Many ALS/FTD linked genes play a direct role in autophagy/lysosomal degradat

212 GP was inserted either preceding the N gene (pre-N) or between the N and P genes (N-P) of rHPIV

213 logy in mouse models and that the HTT exon 1 gene product can self-assemble into amyloid structures.

214 isrupted the interaction of PU.1 with target gene promoters and led to downregulation of canonical PU

215 The SMYD2 transcriptional target gene Ptpn13 also linked SMYD2 to other PKD-associated si

216 dom mutagenesis is highly inefficient due to gene redundancy.

217 UG codons plays an important role in various gene regulation programs.

218 age, and as a result, they have relevance in gene regulation.

219 mportance of metastable states for RNA-based gene regulation.

220 uggesting interplay between these factors in gene regulation.

221 driven dynamic network models of multi-organ gene regulatory influences.

222 ation of these four TFs and PHO1;H3 in a new gene regulatory network controlling phosphate accumulati

223 changes that have restructured developmental gene regulatory networks (GRNs).

224 help us relate the structure and function of gene regulatory networks.

225 phases, and for the underlying expression of genes related to morphological feature formation.

226 , correlating with significant expression of genes related to skin barrier repair.

227 d with a labeled antibody against calcitonin gene-related peptide (CGRP), a marker of nociceptive sen

228 urons that respond to CO2 express calcitonin gene-related peptide (CGRP), we hypothesized that CGRP m

229 analysis so far of variation in specific EBV genes relevant to these diseases and proposed EBV vaccin

230 Affinity Purification (TRAP) and CREB-target gene repositories.

231 s suggest that DISARM is a new type of multi-gene restriction-modification module, expanding the arse

232 unctional copies of a gene is related to the gene's causal role in disease.

233 r characterised for resistance and virulence genes, SCCmec and spa typing.

234 Unsupervised clustering of 16S rRNA gene sequences revealed three clusters (subtypes), one o

235 utations in the CTLA-4 pathway identified by gene-sequencing approaches.

236 Gene Set Enrichment Analysis revealed pathways including

237 Gene set enrichment and leading edge analyses identified

238 Gene set enrichment and pathway analysis of the microarr

239 co-regulators for the atrial and ventricular gene sets, and a subset of these was found to cooperate

240 pression of MYC-, E2F-, and ribosome-related gene sets, promoted excessive proliferation, and led to

241 We report on East-Asian alpha- and beta-cell gene signatures and substantiate several genes/pathways.

242 RNAi-mediated gene silencing of il17a in fibrotic mice arrested the pr

243 nal activation as well as the maintenance of gene silencing, while H2AX is important in DNA damage re

244 We show that the same as for genes SPAD follows a beta distribution, which provides a

245 Gene structure was improved in over 13% of genes, and 65

246 of a poor understanding of how mutations in genes such as GRN contribute to disease pathogenesis and

247 phorylation and the expression of downstream genes, such as Bcl-2 (B-cell lymphoma 2), c-Myc, MMP7 (m

248 ept a gene list that is used to retrieve the gene symbols and corresponding iTerm list.

249 These genes, termed late-life cyclers, were also rhythmically

250 Single gene tests to predict whether cancers respond to specifi

251 ter mRNA levels of select restriction factor genes than CSF-1-Mphis.

252 Through RNA-Seq analyses, we identified 137 genes that are missing in chicken, including the long-so

253 cilitate the expression and/or repression of genes that are necessary for the initiation of gametocyt

254 we find multiple clusters within individual genes that have differential functional associations: th

255 uid mechanosensor that functions to regulate genes that promote metastasis.

256 rved in leaves (3605 genes) and tubers (6156 genes) that contrasted the preferential allele expressio

257 s and their vectors have shown potential for gene therapy in preclinical studies.

258 cytes and thus the outcome of liver-directed gene therapy using AAV vectors and showed in a proof-of-

259 rs have made great progress in their use for gene therapy; however, fundamental aspects of AAV's caps

260 eys a general chromatin modifier to specific genes, thereby allowing the execution of hepatocyte tran

261 ing for risk-causative variants in candidate genes; therefore, more complex genetic and epigenetic me

262 , and plant TF families tend to contain more genes; these expansions are linked to adaptation to envi

263 ptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor

264 uite of stress response and nutrient cycling genes to fix carbon under the fluctuating conditions tha

265 These data show the versatility of NB-LRR genes to generate resistance to unrelated pathogens with

266 ed the functional contributions of P. simiae genes to growth in 90 distinct in vitro conditions by RB

267 ic information from the nuclear residence of genes to the disparate, cytoplasmic sites of protein syn

268 rtant insights into the relationship between gene transcript levels and HLA ligand presentation.

269 ignificantly with those bound by the S-phase gene transcription factor E2F1.

270 n a deeper understanding of the evolution of gene transcription in and between plant species, we perf

271 es chromatin accessibility, enhances histone gene transcription, and promotes HLB formation.

272 1 contains an AD required for Rap1-dependent gene transcription.

273 Ex vivo gene transfer method, while efficient, requires addition

274 Horizontal gene transfer permits rapid dissemination of genetic ele

275 Through simulation we demonstrate that the gene tree probabilities computed by STELLS2 and STELLS h

276 ors for AD, including coding variants in the gene TREM2 (triggering receptor expressed on myeloid cel

277 The TTK protein kinase gene (TTK) on chromosome 6q14.1 was the most significant

278 KOS is autosomal recessive mutations in the gene UBE3B However, to date, there are no studies that h

279 g site motifs of differentially dysregulated genes uncovered distinct MEF2A co-regulators for the atr

280 In humans, mutations in the NMD factor gene, UPF3B, cause intellectual disability (ID) and are

281 omatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine

282 equencing to identify potentially pathogenic gene variants in families in which a person had multiple

283 e-exome sequencing was performed to identify gene variants.

284 ts functions for hydrolysis of AHLs, and the gene was designated as aidP (autoinducer degrading gene

285 Expression of both genes was elevated in obese mice, and induction of Cadm1

286 pe; furthermore, H3K27me3 coverage at target genes was strongly reduced in eol1 clf double mutants co

287 in the promoters of differentially expressed genes was used to reconstruct regulatory networks involv

288 Using these genes, we constructed a classifier for bacterial LRTI wi

289 ific amplification systems based on the trnL gene were designed (A-, B-, C- and D-trnL systems).

290 markers for AML subtypes and c-MYC regulated genes were considered potential predictors of response t

291 NA sequencing analysis was performed and 263 genes were differentially regulated by RpoE, and surpris

292 Both TmELO genes were expressed at various levels in eggs, 1(st) an

293 Three genes were identified, two possibly involved in biogenes

294 improved in over 13% of genes, and 651 novel genes were predicted by the GC-specific MAKER protocol.

295 nherited inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regu

296 Loss-of-function mutations in the MCOLN1 gene, which encodes TRPML1, cause the neurodegenerative

297 cally SLC45A3 and NDRG1 and other ETS family genes, which retained interstitial TMPRSS2/ERG sequences

298 Identification of genes whose basal mRNA expression predicts the sensitivi

299 We found that CNOT3 was bound primarily to genes whose expression was affected by CNOT3 loss, and a

300 ayesian network analysis revealed key driver genes within these modules.