ライフサイエンスコーパス: gene ablation

1 t been previously explored in the context of gene ablation.

2 rgone excision to assess the consequences of gene ablation.

3 or gene recapitulates the phenotype of PTHrP gene ablation.

4 o specifically target dermal condensates for gene ablation.

5 tely eliminated in isogenic cells with CASP3 gene ablation.

6 diac BNIP3 and NIX/BNIP3L overexpression and gene ablation.

7 smooth muscle cells (VSMC) using conditional gene ablation.

8 ACAT1 gene ablation (A1-) in triple transgenic (i.e., 3XTg-AD)

9 STING gene ablation abolished IFN-alphabeta and IDO induction

10 This study addresses whether RBP gene ablation affects heart development.

11 Thus, Ctip2 gene ablation alters sphingolipid levels and expression

12 erive mice deficient for Klf4 by conditional gene ablation and analyze their vascular phenotype follo

13 We investigated this possibility through gene ablation and biochemical studies.

14 Studies using conditional gene ablation and chemical genetic approaches demonstrat

15 Analysis of brain mRNA confirmed gene ablation and demonstrated no compensatory changes i

16 ntal phenotype depends on the degree of Igf2 gene ablation and the interplay between placental and fe

17 Here we show, using conditional gene ablation and three-dimensional tissue culture, that

18 n mouse line for corneal epithelium-specific gene ablation and to analyze the allelic selection of th

19 Here, we combine conditional gene ablation and transgenic RNA interference to uncover

20 dy used bioinformatics, expression analysis, gene ablation, and specific pharmacologic inhibitors to

21 Here we used a tissue-specific gene ablation approach to assess roles of Noggin (Nog) i

22 ze and contrast data obtained using integrin gene ablation approaches in mice with other experimental

23 n total phospholipid mass was reduced 17% by gene ablation, ascribed to a 27% and 32% reduction in th

24 ild-type genes, and Cre recombinase-mediated gene ablations at the single-cell level in the context o

25 models, we demonstrate that beta-arrestin-2 gene ablation augments beta-agonist-mediated airway smoo

26 HSC development ends before Tie2Cre-mediated gene ablation becomes effective.

27 The first group is heterozygous for betaARK1 gene ablation, betaARK1(+/-), and the second is not only

28 second is not only heterozygous for betaARK1 gene ablation but is also transgenic for cardiac-specifi

29 re, implementing spatiotemporally restricted gene ablation by way of the Cre recombinase/loxP system,

30 (Fra-1) is activated in multiple cancers and gene ablation can suppress the invasive phenotypes of ma

31 Interestingly, ROCK1 gene ablation caused a significant increase in glucose-i

32 Although mouse Por gene ablation causes embryonic lethality, POR missense m

33 floxed Alpl allele, allowing for conditional gene ablation (conditional knockout [cKO]) when crossed

34 e Genetics Project, where the treatment is a gene ablation, demonstrates the benefits of the new pipe

35 ylation by conventional or conditional cMLCK gene ablation did not affect troponin-I or myosin-bindin

36 While L-FABP gene ablation did not alter liver LCFA-CoA pool size, LC

37 Using conditional gene ablation during a later phase of liver development,

38 These studies demonstrated that GPBAR1 gene ablation enhanced the recruitment of classically ac

39 dothelial-specific MAP4K4 gene silencing and gene ablation experiments in Apoe(-/-) mice, we show tha

40 Gene ablation experiments show AtSfh1p nullizygosity com

41 Gene ablation experiments using small interfering RNA de

42 Lineage-specific gene-ablation further indicated that Dvl1/2 function is

43 Constitutive neuroplastin deficiency or Nptn gene ablation in adult mice causes substantial electroph

44 is finding, we conditionally targeted Dicer1 gene ablation in embryonic skin progenitors.

45 The consequence of pikfyve gene ablation in mammals is unknown.

46 Adipose Phd2 gene ablation in mice enhanced adiposity, with a paralle

47 Dok1 and Dok2 gene ablation in mice induces an NK-cell maturation defe

48 od pressure and sodium balance, in that Drd3 gene ablation in mice results in hypertension and failur

49 ments using dominant negative constructs and gene ablation in mice suggested that two phosphoinositid

50 drives lymphatic morphogenesis through Mmp2-gene ablation in mice, mmp2 knockdown in zebrafish and i

51 s achieved by complete or epithelia-specific gene ablation in mice, results in defective mammary morp

52 Using conditional gene ablation in mice, we demonstrate here that the home

53 RNAi should be more pertinent than gene ablation in modeling disease pathogenesis linked to

54 Conditional gene ablation in NCCs results in neonatal lethality beca

55 8 mice provide an improved tool for studying gene ablation in rod photoreceptor cells.

56 estin-CreER(T2)/R26R-YFP mouse for inducible gene ablation in stem cells and their progeny in vivo in

57 We show that mice with Tgfbr2 conditional gene ablation in the CNC have complete cleft secondary p

58 INSM1 gene ablation in the mouse results in the impairment of

59 This notion was tested by conditional gene ablation in transgenic mice.

60 -type-specific and developmentally regulated gene ablation in vivo.

61 CXCR4 gene ablation increased the number of colony-forming uni

62 Second, L-FABP gene ablation inhibited phytanic acid peroxisomal oxidat

63 Myocd gene ablation is accompanied by dissolution of sarcomeri

64 genetic manipulations, such as transgenesis, gene ablation (knockouts) and targeted mutagenesis (knoc

65 in many cases, the phenotype resulting from gene ablation might not provide a complete picture of th

66 This study uses a conditional gene ablation model to further explore the role of AP-2

67 Using an in vivo hematopoietic-specific gene ablation model, we demonstrate that loss of Klf5 fu

68 We used constitutive and neuron-specific gene ablation models targeting an integral subunit of ne

69 spase 1 into inflammasomes, and consistently gene ablation of ASC abolishes caspase 1 activation and

70 ensation on N-cadherin deletion, SC-specific gene ablation of beta-catenin was generated and characte

71 is required in APC/C function; specifically, gene ablation of CBP by RNA-mediated interference marked

72 First, gene ablation of CD99L2 impairs neutrophil recruitment i

73 tified all intestinal miRNAs and shown using gene ablation of Dicer1 that miRNAs play a vital role in

74 ta-cell differentiation, we used conditional gene ablation of Foxa2 in mice.

75 Furthermore, gene ablation of G(ialpha1) or antisense oligonucleotide

76 In these cells, gene ablation of Lyn leads to defective B cell receptor

77 e of N-cadherin, mice displaying SC-specific gene ablation of N-cadherin were generated and character

78 T cell-specific gene ablation of Notch1 and Notch2 impaired differentiat

79 n in engulfment of apoptotic cells, although gene ablation of PSR has resulted in a variety of phenot

80 Gene ablation of smpd3 causes a generalized prolongation

81 Paradoxically, gene ablation of the alpha 1A and alpha 1B subtypes in m

82 e we show that pharmacological inhibition or gene ablation of the Ep3 receptor in mice suppresses acc

83 Using conditional gene ablation of the maintenance methyltransferase Dnmt1

84 We show that selective gene ablation of the mouse gimap5 gene impairs the final

85 Antibody blocking or gene ablation of the newly identified complement recepto

86 By using T cell-specific gene ablation of the Notch effector RBP-J or the Notch1

87 We employed gene ablation of the obligatory miRNA-processing enzyme

88 Furthermore, gene ablation of TRAF2 or combined down-regulation of TR

89 We examined the effect of H-FABP gene ablation on brain incorporation of arachidonic ([1-

90 estigated the consequences of PDE4B or PDE4D gene ablation on cAMP signaling at a subcellular level u

91 The effect of folate transporter gene ablation on colon carcinogenesis was evaluated 8 an

92 disease model, we evaluated the effect of C3 gene ablation on disease development in MRL/lpr-Daf-1(-/

93 on of CD99L2 on peripheral neutrophils, only gene ablation on endothelial cells but not on myeloid ce

94 To address this issue, the effect of L-FABP gene ablation on liver cytosolic LCFA-CoA binding, LCFA-

95 -arrestin-1 or beta-arrestin-2 inhibition or gene ablation on signaling and function of multiple GPCR

96 In contrast, calpain 1 gene ablation or inhibition with calpastatin prevented i

97 abilization with beta-escin was unaltered by gene ablation or overexpression.

98 sm via the analysis of their phenotype after gene ablation or overexpression.

99 hanced by Runx2 deficiency that results from gene ablation or RNA interference, whereas induction of

100 alpha inhibition (with etanercept), TNFalpha gene ablation, or p38 inhibition, prevents atrial struct

101 rotein expression using short hairpin RNA or gene ablation prevented the sensitizing effects of ethan

102 er by spontaneous mutation or by conditional gene ablation, prevented the induction of p21(CIP1) and

103 n sensory neurons is a direct effect of Klf7 gene ablation, rather than a secondary effect of cell de

104 s provided three new insights: First, L-FABP gene ablation reduced maximal, but not initial, uptake o

105 Importantly, Sirt3 gene ablation reduced the brain injury after IR.

106 scence photobleaching recovery, where L-FABP gene ablation reduced the cytoplasmic, but not membrane,

107 Finally, beta1 gene ablation reduced the EC(50) of the U46619 agonist i

108 H-FABP gene ablation reduced total heart fatty acid uptake 40 a

109 L-FABP gene ablation resulted not only in loss of L-FABP but al

110 Finally, L-FABP gene ablation selectively increased the amount of LCFAs

111 H-FABP gene ablation significantly increased PtdIns mass 1.4-fo

112 Here, using temporally controlled gene ablation specifically in beta cells in mice, we ide

113 ically or via complete or conditional NFATc1 gene ablation, stem cells are activated prematurely, res

114 e transcription factors STAT1 and STAT2, and gene ablation studies have demonstrated that both STAT1

115 Gene ablation studies have shown severe dental defects i

116 Gene ablation studies in mice have revealed roles for ga

117 Recent gene ablation studies in mice have shown that matriptase

118 Here we used gene ablation studies in mice to demonstrate a central r

119 nsation in the animal kingdom, identified by gene ablation studies, has raised questions about whethe

120 Gene-ablation studies have indicated important developme

121 Gene-ablation studies showed that MTP function and chylo

122 ysis ('ChIP-on-chip') and cell type-specific gene ablation that the winged helix transcription factor

123 c DP precursors for labeling, isolation, and gene ablation that will greatly enhance investigations i

124 insulin promoter, has been shown by targeted gene ablation to be required for pancreatic development.

125 We used tissue-specific gene ablation to generate mice lacking Klf4 in their gas

126 rphic Fgf8 allele (Fgf8neo) and Cre-mediated gene ablation to show that Fgf8 is essential for the sur

127 del in vivo, we utilized hepatocyte-specific gene ablation to study the binding of HNF6 to its target

128 We have used conditional gene ablation to uncover a dramatic and unpredicted role

129 is an acidic noncollagenous protein shown by gene ablations to be critical for the proper mineralizat

130 ncluding a model derived using Car6 and CHOP gene ablations, to delineate a role for CAVI-b in ischem

131 se (SOD1), reduction of MMP-9 function using gene ablation, viral gene therapy, or pharmacological in

132 Bmp2 gene ablation was confirmed by real-time PCR analysis in

133 Gene ablation was used to study the function of Ubc13 in

134 Using mice with conditional gene ablation, we analyzed the tissue-specific function

135 in C3H mice carrying the type I IFN receptor gene ablation, which effectively blocks all autocrine/pa

136 em, enabling tamoxifen inducible conditional gene ablation while controlling for genetic background a

137 Using conditional gene ablation with the Cre-LoxP system in mice, we demon