ライフサイエンスコーパス: gene activation

1 well as increased H3-K4me3 signal (marker of gene activation).

2 ific super-enhancer, resulting in high-level gene activation.

3 genetic modification that is associated with gene activation.

4 ion between topological domains and aberrant gene activation.

5 amily members has little effect on early Hox gene activation.

6 complex (SC), thereby enabling TLR3-mediated gene activation.

7 ilencing, whereas H3K4me3 is associated with gene activation.

8 nery contribute to the selectivity of immune gene activation.

9 sease susceptibility and EWSR1-FLI1-mediated gene activation.

10 either BRD2 or BRD4 alone blunted erythroid gene activation.

11 n PTIP, thus inhibiting H3K4 methylation and gene activation.

12 ate regulation of gene repression as well as gene activation.

13 , such as PDX1, leads to enhancer and target gene activation.

14 r:promoter looping, and the resultant coding gene activation.

15 he level of signal-dependent TF binding, and gene activation.

16 d regions of closed chromatin independent of gene activation.

17 responsible for the variability in galactose gene activation.

18 ines the timing and variability of galactose gene activation.

19 methyltransferases strongly associated with gene activation.

20 the role of chromatin regulators during Hox gene activation.

21 exes, is needed for efficient stress-induced gene activation.

22 ac factors, such as Gata4 and Hand1, use for gene activation.

23 ion of IRF5-targeted M1 macrophage signature gene activation.

24 maintenance of cellular identity but not for gene activation.

25 N-beta or ISGs promoters and sharply reduced gene activation.

26 long-range chromatin interactions and target gene activation.

27 l properties and can antagonize TBX5a target gene activation.

28 ct as an inhibitor of development-associated gene activation.

29 ansferase complexes normally associated with gene activation.

30 d acinar morphogenesis is essential in EcSOD-gene activation.

31 g both enhancer RNA transcription and target gene activation.

32 n remodeling are required for functional EDC gene activation.

33 ependent on and obligatorily linked to Bnip3 gene activation.

34 h the BCR and do not show evidence of target gene activation.

35 ocking Pit1-dependent enhancer/coding target gene activation.

36 n, a single binding site suffices for target gene activation.

37 phosphorylation (H3T11P) promotes AR target gene activation.

38 itment of Mediator and RNA polymerase II for gene activation.

39 on or recruitment of activating complexes in gene activation.

40 the presence of histone marks permissive of gene activation.

41 AUTS2-mediated recruitment of P300 leads to gene activation.

42 e set of pathways as are involved in initial gene activation.

43 at releasing the P nucleosome contributes to gene activation.

44 tone modifications required for inflammatory gene activation.

45 of histone H3 modifications associated with gene activation.

46 to enhanced NF-kappaB activity and cytokine gene activation.

47 ngle-cell model of steroid-receptor mediated gene activation.

48 comb complexes to PAX5 and leads to aberrant gene activation.

49 l RNA complexes to the promoter RNA triggers gene activation.

50 circulating DSAs and immune-response-related gene activation.

51 ion with transcription factors to facilitate gene activation.

52 e rates of transcription by Pol II following gene activation.

53 RelA to inhibit RelA DNA binding and target gene activation.

54 ts in abnormal development and defective hox gene activation.

55 ubsequent steps required for proinflammatory gene activation.

56 ave been found to play a major role in MMP-9 gene activation.

57 ent acetylation in insulin-induced lipogenic gene activation.

58 of other nucleosomes and are associated with gene activation.

59 eering of designer TAL effectors (dTALE) for gene activation.

60 tive or TNF-alpha-induced NF-kappaB reporter gene activation.

61 simple and versatile approach for RNA-guided gene activation.

62 ons in embryonic stem cells (ESCs), prior to gene activation.

63 cription factors, via direct transcriptional gene activation.

64 such as IRF4 and IRF8 to mediate cooperative gene activation.

65 rr), which is required for hormone-dependent gene activation.

66 signaling molecules accumulation and defense gene activation.

67 uced strong TLR4- and TLR7-mediated reporter gene activation.

68 UV39H1, to promoters to limit KLF11-mediated gene activation.

69 plex, which has no deacetylase activity, for gene activation.

70 compounds examined failed to induce reporter gene activation.

71 NuRD complex is involved in GATA-1-mediated gene activation.

72 actors of the AP-1 family to stimulate bfl-1 gene activation.

73 ed histone H3 Lys 4 (H3K4me3), a hallmark of gene activation.

74 s application based on a generative model of gene activation.

75 ) in gene promoters is a signaling agent for gene activation.

76 r a novel mechanism of TFIID recruitment and gene activation.

77 a critical mechanism for specifying precise gene activation.

78 platforms which both trigger cell death and gene activation.

79 hogonal STARs that achieve up to 9000-fold gene activation.

80 age specification-requires HDAC activity for gene activation.

81 r-protein complexes with an impact on timely gene activation.

82 e potential to modulate the pattern of viral gene activation.

83 Enhancer activation is a critical step for gene activation.

84 ated H3K14 (H3K14ac), is generally linked to gene activation.

85 chromatin, where it mediated transcriptional gene activation.

86 specific enhancers and contributes to target gene activation.

87 amic response and NF-kappaB-dependent target gene activation.

88 H3 lysine 27 (H3K27), an epigenetic mark of gene activation.

89 pression of proinflammatory and inflammasome gene activation.

90 e in regulating transcription elongation and gene activation.

91 her variant chromatin plays a direct role in gene activation.

92 preventing transcription factor binding and gene activation.

93 studies on these genes indicate that during gene activation a local increase of phospho-S2 CTD nearb

94 ded ERalpha induces many genes within 1-4 h, gene activation after 6 h is thought to be indirect.

95 to a higher level of endogenous beta-globin gene activation after differentiation.

96 rsal of polycomb repression as a key step in gene activation after injury.

97 ted plastid-to-nucleus signaling and nuclear gene activation after mutagenizing a flu line expressing

98 as recently been repurposed to enable target gene activation, allowing regulation of endogenous gene

99 LE transcription factors induced substantial gene activation and allowed tuning of gene expression le

100 en-dependent manner leading to TOT-dependent gene activation and cell proliferation of the TOT-resist

101 chromatin-bound BRD4, instigating autophagy gene activation and cell survival.

102 s a new paradigm of DNA methylation-mediated gene activation and chromatin remodeling, and provides a

103 Furthermore, transynaptic gene activation and conventional double retrograde label

104 , it also has an uncharacterized function in gene activation and DNA damage responses.

105 on and butyrylation, while sustaining direct gene activation and dynamic bromodomain binding, could i

106 gs is involved in their suppression of viral gene activation and expression.

107 ription factors and cofactors in thermogenic gene activation and identified zinc finger and BTB domai

108 study epigenetic regulation often focuses on gene activation and ignores repression elicited by 5aza-

109 nflammatory and rescued M2 anti-inflammatory gene activation and improved the cholesterol efflux defi

110 LUBAC deficiency results in attenuated gene activation and increased cell death, causing pathol

111 ond solely repression and also includes both gene activation and iron-independent regulation.

112 rstanding of the molecular mechanism of Pdr1 gene activation and multidrug resistance inhibition by i

113 se lncRNAs play a key role in regulating var gene activation and mutually exclusive expression.

114 GFAP gene activation and protein induction appear to play a c

115 tablish a function of Nup98 in hematopoietic gene activation and provide mechanistic insight into whi

116 controlling the threshold for NRF2-dependent gene activation and provides a framework for elucidating

117 ead compound (iKIX1) inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glab

118 at disrupt FOG1 cofactor binding impair both gene activation and repression and are associated with p

119 y by a wide variety of mechanisms, including gene activation and repression by regulation of chromati

120 rstood at an atomic level, new mechanisms of gene activation and repression by this protein are still

121 ent chemical inducers that mediate efficient gene activation and repression in mammalian cells.

122 including Rowley et al. (2017), suggest that gene activation and repression play fundamentally import

123 riptional effects, including tissue-specific gene activation and repression, are mediated by the gluc

124 interactions, are essential for both normal gene activation and repression, form a chromosome scaffo

125 es is a central player in epigenetics and in gene activation and repression.

126 ulates 5-HT neuron maturation through direct gene activation and repression.

127 mics uncovers ordered sequences of events in gene activation and repression.

128 ranscriptional responses, which include both gene activation and repression.

129 f histone modifications associated with both gene activation and repression.

130 o gene regulatory regions can result in both gene activation and repression.

131 nterfering with R-loop formation can trigger gene activation and reveal a new strategy for upregulati

132 ween nuclear-WASp- and hSWI/SNF-complexes in gene activation and reveals molecular distinctions in TH

133 histone modifications often associated with gene activation and showed an increased level of ubiquit

134 YRK1A inhibitors, along with CRISPR-mediated gene activation and shRNA knockdown of DYRK1A, we show h

135 velopment is governed by complex programs of gene activation and silencing, including microRNA-depend

136 plays a key role in epigenetic regulation of gene activation and silencing.

137 hydrogen peroxide (H2O2) correlated with bim gene activation and subsequent neuronal death, whereas e

138 y to structurally divergent AICEs to promote gene activation and T(H)17 differentiation.

139 Lat deletion impaired TCR-dependent cytokine gene activation and the ability of DETCs to undergo prol

140 ranscription cycle that are regulated during gene activation and the importance of the underlying enh

141 the involvement and role of MDA5 in cytokine gene activation and the pathogenesis of TMEV-induced dem

142 p65 axis mediated the TNF-alpha-induced MLCK gene activation and the subsequent MLCK increase in inte

143 pecification is tightly coupled with zygotic gene activation and, in most metazoans, is dependent upo

144 e proliferation to PDGF, pericyte migration, gene activation, and cytoskeletal reorganization to TGF-

145 ponses, protein-protein interactions, target gene activation, and function were investigated.

146 hormone treatment in juveniles enhanced NR1 gene activation, and GnRHa treatment in adults improved

147 y mitochondrial dysfunction, proinflammatory gene activation, and mTORC1 signaling, whereas IMs at da

148 link promoters and enhancers, correlate with gene activation, and show conservation across cell types

149 : One enhancer is responsible for sequential gene activation, and the other is responsible for freezi

150 script turnover and failure in early zygotic gene activation appeared to associate with the aberrant

151 ts, a chromatin-dependent mechanism of clock gene activation appears to be common to both plant and m

152 Thus, oxidative demethylation to promote gene activation appears to be functionally required for

153 ghly expressed genes but that other steps in gene activation are more rate-limiting for most other ye

154 To determine whether synchronous patterns of gene activation are significant in development, we manip

155 This correlated with a pattern of gene activation, as revealed by microarray analysis, inc

156 he temporal order of histone acetylation and gene activation, as well as the stability of the install

157 ophoretic mobility shift assays and reporter gene activation assays.

158 ression of housekeeping genes and a delay in gene activation at inducible loci.

159 ) T-cell infiltration, and attenuated global gene activation at the site of cutaneous VZV antigen cha

160 loidy, but does not appear to affect zygotic gene activation at the two-cell stage or lineage gene tr

161 ment, apparently contributes to E2-dependent gene activation, at least in part by stabilizing E2/ER-a

162 fluorescent reporter system able to document gene activation both in vitro and in vivo.

163 domains does not lead to widespread ectopic gene activation but does affect a significant minority o

164 RR phosphorylation is typically required for gene activation, but few studies have addressed how and

165 y networks provide a tissue-specific mode of gene activation, but it also determines the spatial expr

166 mmune differentiation and stimulus-dependent gene activation, but only 10-20% directly alter recogniz

167 ey early genes at 6 h and transition to late gene activation by 12 h by both viruses.

168 Compounds 2-75 and 1005 antagonized gene activation by androgen without inducing chromatin a

169 led molecular knowledge of the mechanisms of gene activation by disease-associated transcription acti

170 nts a novel mechanism for tamoxifen-specific gene activation by ER, secondary to its TOT preferential

171 Liver X receptors antagonize TLR4-dependent gene activation by maintaining NCoR/SMYD5-mediated repre

172 Whereas much is known about gene activation by MYC, there is no established mechanis

173 aments, inhibits Nrf2 translocation and Mrp2 gene activation by pB(25)R infection.

174 es, OCT4 is required for proper enhancer and gene activation by recruiting co-regulators and RAR:RXR

175 onential growth phase and thus enables rapid gene activation by sigma(S) as soon as the cells enter e

176 provide a promising alternative strategy for gene activation by tethering an autonomous transcription

177 The relationship between gene activation by the AHR and TCDD toxicities is not we

178 Gene activation by the targeted acetyltransferase was hi

179 l evidence in vivo for a cofactor, Dot1L, in gene activation by TR during vertebrate development.

180 ion system, overexpression of Dot1L enhances gene activation by TR in the presence of T3.

181 s cellular proliferation and immediate early gene activation, CaMKII-mediated signaling to H3 is asso

182 demonstrate that CRISPR/Cas9-mediated target gene activation can be achieved in vivo, leading to meas

183 orting Reactive Oxygen Species (ROS) induced gene activation, Cdk12 suppresses genes that support met

184 f H3NT proteolysis impaired osteoclastogenic gene activation concomitant with defective osteoclast di

185 Gata6 is expressed in SMCs and its target genes activation control SMC differentiation.

186 elongating RNA polymerase II (Pol II) during gene activation, Danko et al., in this issue of Molecula

187 n factor that can have two distinct roles in gene activation, depending on its location within a prom

188 Consistent with the role of KMT2B in gene-activation DNA microarray analysis revealed that 15

189 revealing an unexpected function of Mel18 in gene activation during cardiac differentiation.

190 this stable epigenetic mark works to prevent gene activation during development.

191 Such activity was crucial for gene activation during mammalian neurogenesis.

192 locus body (HLB) assembles prior to zygotic gene activation early during development and concentrate

193 on partners that are required for HIF target gene activation, exhibit specific binding to the promote

194 The sequence of gene activation/expression and receptor editing of these

195 its coactivators to select promoters during gene activation, followed by promoting Myc's release ass

196 dent epigenetic programming regulates escape gene activation from inactive sex chromosomes in post-me

197 pounds uncouples flavonoid repression and PR gene activation from the activation of reactive oxygen s

198 However, modest levels of gene activation have limited potential applications.

199 ion of CRTC2, LSD1-mediated demethylation of gene-activation histone marks H3K4-me2/3, and subsequent

200 The largest proportion of gene activation [i.e., (i) 59%, (ii) 42%, and (iii) 58%]

201 ollaborative mechanisms of mSWI/SNF-mediated gene activation, identifying functions that are co-opted

202 control chromatin structural alterations and gene activation in a cell context dependent manner.

203 during respiratory infection, Bvg-regulated gene activation in B. bronchiseptica has not been invest

204 n, is a key chromatin organizer that directs gene activation in chromatin through transcription facto

205 s and emphasizes the importance of timing of gene activation in development.

206 ing factor that also has a necessary role in gene activation in development.

207 s to ensure appropriate target selection and gene activation in each context.

208 Gene activation in eukaryotes frequently involves intera

209 p gain insights into the mechanism of silent gene activation in fungal defense.

210 ic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to d

211 onic stem cell reporter cell line to monitor gene activation in individual cells and to show that act

212 postnatal 3' CGI methylation and associated gene activation in intestinal epithelial cells are signi

213 regulatory factors that affect LXR-dependent gene activation in macrophages remain to be elucidated.

214 Gene activation in metazoans is accompanied by the prese

215 -chip) for histone modifications implicating gene activation in normal cells.

216 the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how th

217 ammalian evolution distinct from its role in gene activation in other organisms.

218 PCa, can inhibit AR-mediated cell growth and gene activation in PCa cells via distinct mechanisms.

219 ppaB that drives alterations in enhancer and gene activation in response to chronic TNF-alpha signali

220 d may therefore play a major role in driving gene activation in response to GCs.

221 expression, but rather delayed the timing of gene activation in response to specific extracellular si

222 YAP/TAZ target gene activation in response to USP9X knockdown was suppr

223 udy reveals that stress-induced pathological gene activation in the heart requires a previously uncha

224 al hair cell-specific gene deletion/reporter gene activation in the inner ear.

225 method by monitoring the mRNA dynamics upon gene activation in the presence of a splicing inhibitor.

226 gene expression and potentiates stronger GAL gene activation in the presence of Gal1.

227 ation confers tissue- and cell-type-specific gene activation in vivo.

228 also called Oct4) and SoxB1 regulate zygotic gene activation in zebrafish.

229 In contrast, Sp7 gene activation involves changes in histone modification

230 Gene activation is associated with chromatin disruption:

231 MEF2 target gene activation is directly linked to VEGFA-induced rele

232 y, the coupling between inducer identity and gene activation is flexible: the ligand specificity of Z

233 regulation and function of ERF6 in defensin gene activation is independent of ethylene.

234 average than non-responsive genes, and rapid gene activation is linked to conditional pause-release.

235 Thus, either partial gene activation is sufficient to induce resistance, or t

236 e B cell subpopulations, an order of L chain gene activation is suggested as: sigma-2 followed by kap

237 Although RA-mediated gene activation is well understood, less is known about

238 ation of two distinct domains of coordinated gene activation located at different places in the genom

239 Upon signal-induced gene activation, long-range enhancer contacts at the dom

240 accumulate on chromatin, and is defective in gene activation, maintenance of histone H3 lysine 4 trim

241 uptake transporter gene Ntcp, and removes a gene-activation marker, trimethylated histone H3 lysine-

242 odeling complexes in repressor depletion and gene activation necessary for lymphoblastoid cell line g

243 rm during cleavage, a sequence of regulatory gene activations occur within this territory which depen

244 When gene activation occurred before DNA circularization, coh

245 roductive elongation is a major mechanism of gene activation of virtually all VEGF-regulated genes, w

246 binding site in the promoter of the TGF-beta gene, activation of STAT6 in splenocytes by NaB, recruit

247 For the rat gene, activation of the Slick promoter was found to be a

248 upregulation of a cohort of cardiac-specific genes, activation of pathways associated with muscle con

249 inactivation with upregulation of CIC target genes, activation of proliferative pathways, inhibition

250 re recombinase-mediated fluorescent reporter gene activation only in Stra8-expressing cells, newly-fo

251 o the estrogen response elements, modulating gene activation or repression.

252 itute a regulatory context leading to either gene activation or repression.

253 iption factors (TFs) to target promoters for gene activation or repression.

254 anges the properties of chromatin to mediate gene activation or silencing is not fully understood.

255 f histone methylation associated with either gene activation or silencing.

256 A gene-activation or gene-specific ramp-up strategy would

257 ed to) the dynamical characterization of the gene activation patterns ruling cell types and different

258 of Bisphenol A inducible genes showed a weak gene activation peak at a very low concentration range (

259 (ca. 0.1 nM) in addition to the main, strong gene activation peak at and above 100 nM.

260 same hierarchy, indicating that it reflects gene activation per se.

261 (ROS) generation, stomatal closure, defense gene activation, phytoalexin biosynthesis, cell wall str

262 Our results suggest a multistep gene activation process during the formation and retriev

263 igand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate c

264 sed microbes to trigger host-defense-related gene activation remains to be fully resolved.

265 Gene activation requires cooperative assembly of multipr

266 In most cases, Zap1-dependent gene activation results in increased levels of mRNAs and

267 nected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where reg

268 sed this approach for a high-coverage pooled gene-activation screen in vivo and discovered previously

269 g enhancers and genes, thereby resisting the gene activation signals during embryonic stem cell diffe

270 However, PIP5K does not interact with the gene activation signature protein H3K4me3.

271 The effects of each mutated FXR on target gene activation, subcellular localization, protein-prote

272 arks and regulators associated with myogenic gene activation, such as myogenin and the SWI/SNF chroma

273 ted with STAT3, deregulate cytokine-mediated gene activation, suppress an interferon response, and in

274 imuli trigger highly coordinated cascades of gene activation that are precisely calibrated to the nat

275 lation of chromosomal HIF-1alpha turnover in gene activation that bears important implication in canc

276 -independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic r

277 eeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in

278 elicited oxidative stress and innate immune gene activation that were exacerbated by p38 GOF and Bsk

279 e) mice, both for gene deletion and reporter gene activation, these data are significant and necessar

280 that FACT is involved in the early steps of gene activation through its histone chaperone activities

281 ching between transcriptional repression and gene activation through the auxin-dependent degradation

282 that polymerase pausing allows plasticity in gene activation throughout embryogenesis, as transiently

283 oth act to regulate nucleosome depletion and gene activation, thus promoting ES cell differentiation,

284 istence of lineage-to-lineage variability in gene activation times and mean RNA production rates, and

285 is not required for either transcription or gene activation to occur.

286 uitment of ERalpha to prevent ERalpha target gene activation under an estrogen-depleted condition.

287 In addition, we explored tissue-specific gene activation using positive feedback loops.

288 ription factor able to support either target gene activation via direct binding to DNA or gene repres

289 sor for bacterial cdNs, shaping inflammatory gene activation via its effects on STING and NF-kappaB.

290 In contrast, a broader effect on MafA/MafB gene activation was observed in mice lacking NCoA6 in is

291 erm memory (LTAM) and identified three major gene activation waves.

292 light on the mechanism for lncRNA-dependent gene activation, we show that rapid induction of the pro

293 For one of these regions of coordinate gene activation, we show that regional epigenetic regula

294 in instances where new phenotypes arise via gene activation, we suggest a set of principles: evoluti

295 Transcriptional response and target gene activation were also investigated in PBMCs.

296 ylation without Pol II recruitment or robust gene activation, whereas MyoD induces histone acetylatio

297 : one enhances matrix deposition by fibrotic gene activation, whereas the other slows down matrix deg

298 and persistent Ag expression with low innate gene activation, while less potent rAds induced less Ag

299 ptimized by rational design to confer robust gene activation with no background expression in plants.

300 erapeutic inhibitor that targets AR-mediated gene activation with potential to arrest the growth of p