ライフサイエンスコーパス: gene cluster

1 pes that apparently regulate the entire rRNA gene cluster.

2 y region of the Escherichia coli kps capsule gene cluster.

3 n A2 by tailoring enzymes encoded in the btm gene cluster.

4 function due to defects in the OPN1LW/OPN1MW gene cluster.

5 tide sequence for each operationally defined gene cluster.

6 ransporter Gpy2 is encoded by the gibepyrone gene cluster.

7 genes regulated by members of the human RHOX gene cluster.

8 mX is a transcriptional activator of the adm gene cluster.

9 rin, confirming the identity of the putative gene cluster.

10 tance gene was identified in the cladosporin gene cluster.

11 m a mutant of S Montevideo, each lacking the gene cluster.

12 Gfi1b, which in turn downregulates the HOXA gene cluster.

13 fied this signal in the CHRNA5-CHRNA3-CHRNB4 gene cluster.

14 ukemogenicity including Meis1, Mn1, and Hoxa gene cluster.

15 ed by a reductive, iterative polyketide-like gene cluster.

16 ChRs) formed by the subunits encoded by this gene cluster.

17 the expression of the PKS PfmaE and the Pfma gene cluster.

18 ed transcripts identified many p53-regulated gene clusters.

19 putative specialized metabolite biosynthetic gene clusters.

20 om the primary sequences of the biosynthetic gene clusters.

21 ility to heterologously express biosynthetic gene clusters.

22 vation, conserved gene order or monophyletic gene clusters.

23 b repression such as the Hox and NK homeobox gene clusters.

24 tion defects and transcription into adjacent gene clusters.

25 rstanding of the evolution of the underlying gene clusters.

26 cording to their genomic position within Hox gene clusters.

27 fferentiated and aberrantly express homeobox gene clusters.

28 atic chromatin domains that sequester the OR gene clusters.

29 ylated regions on chromosome 6 harboring MHC gene clusters.

30 ing, which consequently created co-regulated gene clusters.

31 ll molecule elicitors of silent biosynthetic gene clusters.

32 s reveal that mcrA regulates at least ten SM gene clusters.

33 ed roles in the evolution of plant metabolic gene clusters.

34 es to identify thousands of plant-associated gene clusters.

35 e nuclear pore complex are prerequisites for gene clustering.

36 collinearity might contribute to keeping Hox genes clustered.

37 m Rhodobacter sphaeroides that comprises 120 gene clusters, 1211 genes (including 93 TFs), 1858 predi

38 rgeted identification of custom biosynthetic gene clusters across 40 000 isolate microbial genomes, a

39 ted products; a distinct aniline dioxygenase gene cluster adoQTA1A2BR, which has a broad substrate ra

40 an inducible catechol meta-cleavage pathway gene cluster adoXEGKLIJC.

41 t mutations in either the znuABC or zrgABCDE gene cluster affect bacterial growth, with znuABC mutant

42 Our operationally defined gene clusters aim to address a major challenge in studyi

43 The gene encoding HELLP is part of a three-gene cluster also encoding a lipase (SBP) and a Nod-like

44 beta-diketone biosynthesis, demonstrating a gene cluster also in the beta-diketone biosynthesis Cer-

45 he analytical tool relies on a bioinformatic gene cluster analysis and utilizes a predictive enoylred

46 into the widely used antiSMASH biosynthetic gene cluster analysis pipeline and is also available as

47 Gene cluster analysis showed differences in temporal exp

48 k provides detailed characterization of a TF gene cluster and advances our understanding of the trans

49 natural products that are encoded by the clb gene cluster and are produced by certain commensal, extr

50 The ORCA gene cluster and CrMYC2 act downstream of a MAP kinase c

51 scherichia coli expressing a heterologous GV gene cluster and purified using buoyancy-assisted techni

52 Both the expression of the adm gene cluster and regulation of andrimid synthesis were i

53 s with coding variation in 4 genes and PCDHG gene cluster and several candidate recessive alleles.

54 ssociations between the CHRNA5-CHRNA3-CHRNB4 gene cluster and smoking heaviness and nicotine dependen

55 the matrices (species) to identify the same gene cluster and the row vector specifies for each speci

56 ecific nitrogenase encoded by the large nif1 gene cluster and the similar nif2 gene cluster that func

57 entification of the seven-gene pleuromutilin gene cluster and verify that using various targeted appr

58 Gene clustering and gene trees support the idea that the

59 ing a computational approach that integrates gene clustering and network reconstruction with genetic

60 sulted in transcriptional changes in several gene clusters and a significant deregulation of 10 micro

61 ce an algorithm to catalog RiPP biosynthetic gene clusters and chart genetically encoded RiPP chemica

62 r previously characterized terpene metabolic gene clusters and demonstrate new functional pairing of

63 mechanisms that underlie the organization of gene clusters and networks, despite much effort made to

64 nome-wide synteny conservation (e.g., mobile gene clusters and nonhomologous cluster alleles), our ap

65 bases, which encompasses the sizes of genes, gene clusters and regulatory domains, the three-dimensio

66 disassembly of CBs disrupts the CB-targeting gene clusters and suppresses the expression of U sn/snoR

67 idulans for negative regulators of fungal SM gene clusters and we have used this screen to isolate mu

68 tion polymorphism in the cytidine deaminases gene cluster APOBEC3 resulting in increased expression o

69 knowledge of the features of plant metabolic gene clusters - architecture, regulation and assembly -

70 Variants in the SERPINB gene cluster are associated with SERPINB10 expression in

71 These acquired gene clusters are concentrated in specific genomic islan

72 Identified genes and gene clusters are enriched with immune pathways previous

73 ilamentous fungal species have shown that SM gene clusters are often either highly divergent or uniqu

74 Gene clusters are regions of co-localized genes on genom

75 These so-called silent or cryptic gene clusters are sources of new natural products, but h

76 ate that signaling results in the control of genes clustered around prosurvival and proapoptotic func

77 omes of several photoarsenotrophs revealed a gene cluster, arxB2AB1CD, where arxA is predicted to enc

78 Here, using the alpha-globin gene cluster as an illustrative model, we provide an ove

79 The metabolites are encoded by the clb gene cluster as prodrugs termed precolibactins.

80 here may be from 10(5) to 10(6) biosynthetic gene clusters as yet uncharacterized for potential new t

81 s (SNPs) on chromosome 17 within a chemokine gene cluster associated with delayed onset of mild-cogni

82 or sets from all three species and comprised gene clusters associated with cell cycle and mitosis and

83 analysis of KDM3A-depleted cells identified gene clusters associated with cell growth.

84 e significance, the clade B serpin (SERPINB) gene cluster at 18q21.3, the cytokine gene cluster at 5q

85 lation of APOBEC3A expression in the APOBEC3 gene cluster at 22q13.

86 RPINB) gene cluster at 18q21.3, the cytokine gene cluster at 5q31.1, the filaggrin gene, the C11orf30

87 mulates transcription of an EPS biosynthesis gene cluster at elevated c-di-GMP levels.

88 in durum wheat is controlled by a metabolic gene cluster at the WAX1 (W1) locus and a dominant suppr

89 ters of co-located genes called biosynthetic gene clusters (BCs).

90 nes often found within the same biosynthetic gene cluster (BGC) responsible for manufacturing the ant

91 ity in the form of 176 distinct biosynthetic gene clusters (BGCs) of which only 24 have been linked t

92 es are synthesized by dedicated biosynthetic gene clusters (BGCs), which assemble architecturally com

93 tered in specific genomic loci: biosynthetic gene clusters (BGCs).

94 istributions of natural-product biosynthetic gene clusters (BGCs).

95 including all six known to form biosynthetic gene clusters (BGCs).

96 Arcadin-2, also encoded by the arcade gene cluster, binds tightly with its C-terminus to the h

97 eral novel features, including prediction of gene cluster boundaries using the ClusterFinder method o

98 The third protein in the btub gene cluster, BtubC, previously known as "bacterial kine

99 scription of genes in the ddhD-wzz O-antigen gene cluster, but not core oligosaccharide genes, was re

100 entify the secondary metabolite biosynthetic gene clusters by genome mining, to clone them, and to ex

101 uggested that micro-deletion of the Snord116 gene cluster can lead to PWS, however, the extent of the

102 re detailed resolution on the copy number of gene clusters can be obtained from read coverage depth u

103 bitaceae, indicates, on the other hand, that gene clustering cannot account for this novel secondary

104 Phylogenetically these bat Mx1 genes cluster closely with their human ortholog MxA.

105 By gene cluster comparison and a combination of precursor f

106 , which grouped into biologically meaningful gene clusters consistent with known functional annotatio

107 While several gene clusters consistent with this molecule's newly repo

108 treptococcus parasanguinis, is mediated by a gene cluster consisting of six genes, gtf1, gtf2, gly, g

109 treptococcus parasanguinis, is mediated by a gene cluster consisting of six genes: gtf1, gtf2, gly, g

110 The OAP gene cluster consists of a PG O-acetyltransferase A (pat

111 econcilibacillus cellulovorans', possessed a gene cluster containing multidomain glycoside hydrolases

112 The discovery of approximately 20-kb gene clusters containing a family of paralogs of tRNA gu

113 ght differences in the transfer of favorable gene clusters controlling key traits during selection br

114 B. longum SC596 contains a novel gene cluster devoted to the utilization of fucosylated H

115 genetic basis and evolutionary drivers of SM gene cluster divergence.

116 previously hypothesized to contribute to SM gene cluster diversity across entire fungal classes and

117 ranscription into the opposing polycistronic gene cluster does not lead to downregulation of sense mR

118 and its genomic locus in regulating the HOXA gene cluster during ESC differentiation.

119 Several Peptostreptococcus species contain a gene cluster enabling production of the tryptophan metab

120 Typically, lasso peptide biosynthetic gene clusters encode enzymes for biosynthesis and export

121 The X-linked reproductive homeobox (RHOX) gene cluster encodes transcription factors preferentiall

122 The extended FUB gene cluster encodes two Zn(II)2 Cys6 transcription fact

123 As a result, a gene cluster encoding for transporters, an integrase and

124 accharide Utilization Loci (PULs) consist of gene clusters encoding different proteins with a vast ar

125 is rare enzyme family and identifies further gene clusters encoding L-threonine transaldolases.

126 dates common microbiome-derived biosynthetic gene clusters encoding peptide aldehydes that inhibit hu

127 o identify and characterize the biosynthetic gene clusters encoding the production of such compounds.

128 rmatics, synthetic biology, and heterologous gene cluster expression can rapidly expand our knowledge

129 We show that rRNA gene cluster expression is controlled via complex epista

130 Further, we developed a novel gene cluster expression summary score (GCESS) to quantif

131 Identification of the gene cluster for herbicidin A biosynthesis in Streptomyc

132 The biosynthetic gene cluster for the antiplasmodial natural product siph

133 Here we report cloning of the biosynthetic gene cluster for the beta-lactone antibiotic obafluorin

134 iles revealed temporally distinct functional gene clusters for apoptosis, chemotaxis, and morphogenes

135 little help in prioritizing and identifying gene clusters for compounds active against specific and

136 This approach first identifies gene clusters for each species by a cluster analysis of

137 Gene clusters for gas vesicle biosynthesis are partially

138 s analysis of genome databases suggests that gene clusters for Pel biosynthesis are present in >125 b

139 le or multiple mutations in the biosynthetic gene clusters for seven natural products and two exoenzy

140 hich are often positioned adjacent or within gene clusters for specialized metabolites.

141 ht to be synthesized in this way via the mft gene cluster found in many strains of mycobacteria.

142 Related gene clusters found in sequenced genomes appear to encod

143 This is the first gene cluster from a basidiomycete to be successfully exp

144 ately determine the presence or absence of a gene cluster from reads as short as 70 bp.

145 have previously cloned and sequenced the lnm gene cluster from Streptomyces atroolivaceus S-140.

146 For example, expression of a 17-kb O-PS gene cluster from the highly virulent Francisella tulare

147 Herein the oxa gene cluster from the marine-derived fungus Penicillium

148 ases for 22 species and identified metabolic gene clusters from 18 species.

149 to identify metabolic enzymes, pathways, and gene clusters from a sequenced genome.

150 logenetic analysis based on 2148 orthologous gene clusters from all isolates is consistent with patie

151 evolutionary relationships among alginolytic gene clusters from Bacteroidetes and Proteobacteria.

152 e environment and then guide the recovery of gene clusters from metagenomic libraries.

153 Here, we show that all three gene clusters functionally cooperate to provide individu

154 While the cercosporin biosynthetic gene cluster has been described in the tobacco pathogen

155 This gene cluster has important roles in male fertility based

156 rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFA

157 ription initiation of specialized metabolite gene clusters have been identified, those affecting tran

158 o the sequential nature of the approach, the gene clusters identified in the first step may have litt

159 fied two polymorphisms belonging to the IL-1 gene cluster (IL-1beta and IL-1ra) in strong association

160 ated Microbial Genomes Atlas of Biosynthetic gene Clusters (IMG-ABC).

161 s through heterologous expression of the kgp gene cluster in Escherichia coli.

162 Sequencing of the dynemicin biosynthetic gene cluster in Micromonospora chersina previously ident

163 ory receptors in vivo, we deleted the entire gene cluster in mouse germline through homologous recomb

164 -like-pteridine synthase hybrid biosynthetic gene cluster in Photorhabdus luminescens using genome sy

165 Here, we reconstitute the noscapine gene cluster in Saccharomyces cerevisiae to achieve the

166 of the mouse protocadherin alpha (Pcdhalpha) gene cluster in serotonergic neurons disrupts local axon

167 The host selective ACT gene cluster in strain Z7 was identified, which included

168 successfully used HiTES to activate a silent gene cluster in Streptomyces albus J1074.

169 ue, aprD4 and aprD3 genes from the apramycin gene cluster in Streptomyces tenebrarius were expressed

170 Previous studies have identified a gene cluster in the virus genome, encoding enzymes invol

171 al exploration of the nature and dynamics of gene clustering in plant metabolism.

172 3 and to exemplify our method, we search for gene clusters in a dataset of 678 bacterial genomes usin

173 ten considered the main force preserving Hox gene clusters in animal genomes.

174 st, FL induced the expression of alternative gene clusters in B. infantis.

175 f eQTLs on the structure and organization of gene clusters in Caenorhabditis elegans.

176 we show that the majority of the putative SM gene clusters in F. fujikuroi are located within faculta

177 ays that produce SMs are found in contiguous gene clusters in fungal genomes, an atypical arrangement

178 ed family of nonribosomal peptide synthetase gene clusters in gut bacteria.

179 Gecko 3, an open-source software for finding gene clusters in hundreds of bacterial genomes, that com

180 ecessitates bioinformatics tools for finding gene clusters in hundreds of genomes.

181 ase J at specific sites within polycistronic gene clusters in L. major leads to read through transcri

182 pulation-level patterns of variation in IGHV gene clusters in larger diverse datasets and for quantit

183 covered a widespread occurrence of metabolic gene clusters in plants: 11,969 clusters from 18 species

184 and chemical output of the countless silent gene clusters in Streptomyces spp.

185 ered owing to our inability to express these gene clusters in the laboratory.

186 and expression of genes within polycistronic gene clusters in trypanosomatids.

187 Upregulated genes clustered in immunologic, cell adhesion, and kerat

188 with a MeCP2 reporter on the Xi and found 30 genes clustered in seven functional groups.

189 in ADHD converge on biologically meaningful gene clusters, including ones now established as conferr

190 d by a halogenase encoded in the pyoluteorin gene cluster into mono- and di-chlorinated phloroglucino

191 recombineered the S. sonnei form I O-antigen gene cluster into the Ty21a chromosome to create Ty21a-S

192 We find that cell cycle genes cluster into two major waves of expression, which

193 These genes clustered into groups involved in cell wall and ce

194 l analysis of the module genes revealed four gene clusters involved in innate and adaptive immunity,

195 Two gene clusters involved in the biosynthesis of an alleloc

196 The allelochemical DIMBOA gene cluster is activated in response to co-cultivation

197 Here, we report that (1) the ORCA gene cluster is differentially regulated; (2) ORCA4, whi

198 thetase and polyketide synthase biosynthetic gene cluster is encoded in the genomes of three anabaeno

199 in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917.

200 The Snord116 gene cluster is important for developmental processes in

201 ed gladiolin production, confirming that the gene cluster is responsible for biosynthesis of the anti

202 We verified that this gene cluster is responsible for the production of the ka

203 ing syntenic relationships among orthologous gene clusters is a frequent undertaking of biologists st

204 st propensity for heterologous expression of gene clusters, led to the identification of the novel na

205 One such gene cluster, located on the smaller of the two chromoso

206 alysis, we demonstrate how the X-linked RHOX gene cluster may function in normal human spermatogenesi

207 that the wheat W1 locus contains a metabolic gene cluster mediating beta-diketone biosynthesis.

208 genomic contexts illustrate the biosynthetic gene cluster mobility that underlies the diversity and d

209 The underlying gene cluster model is intuitive, can cope with low degre

210 e most highly expressed secondary metabolite gene clusters (more than 244,000 base pairs deleted in t

211 One of the four putative SM gene clusters, named STC5, was analysed in more detail t

212 Gene cluster networking highlights that this genus is di

213 revealed 5 general types of variation in SM gene clusters: nonfunctional gene polymorphisms; gene ga

214 Furthermore, we find that coregulated genes cluster nonrandomly in spatial interaction network

215 produced by the fungus Cladosporium fulvum A gene cluster of 10 genes controls cladofulvin biosynthes

216 Cupriavidus pinatubonensis JMP134 contains a gene cluster of sqr and pdo, and their functions were an

217 tion coded for in the jadomycin biosynthetic gene cluster of Streptomyces venezuelae ISP5230, affects

218 We also discovered a syntenic gene cluster of transcription factors that regulates the

219 Snord116 is a snoRNA gene cluster of unknown function that can localize to th

220 The HoxA and HoxD gene clusters of jawed vertebrates are organized into bi

221 The prevalence of metabolic gene clusters offers an intriguing possibility of an unt

222 dentified and characterized the biosynthetic gene cluster (oka) of 1 and 2, then elucidated the pathw

223 ns in the complement factor H-related (CFHR) gene cluster on chromosome 1q32 and CFHR5 mutant protein

224 protocadherin (PCDH)-alpha, -beta and -gamma gene cluster on chromosome 5 that were associated with n

225 opsins due to mutations in the OPN1LW/OPN1MW gene cluster on the X chromosome.

226 eins encoded in experimentally characterized gene clusters on a per-protein basis and a domain-level

227 nd are found within evolutionarily-conserved gene clusters on different chromosomes.

228 es with ROHs >3 Mb vs 19% of controls) and a gene-cluster on Chr3p21.31 (empirical P value 2 = .006-.

229 As exemplified by the CXC chemokine genes clustered on chromosome 4, we demonstrate that NF-

230 encoded by a large family of highly related genes clustered on chromosome 4.

231 rmed from compounds produced by two separate gene clusters, one of which makes the well-known product

232 levels, all located within the CHRNA5-A3-B4 gene cluster or adjacent genes, consistent with previous

233 6 families with either a structurally intact gene cluster or at least one intact single (hybrid) gene

234 Further we tested, whether paralogs of Hox gene clusters originated from this paddlefish specific g

235 of five genes found in the ptm, but not ptn, gene cluster, partitions the biosynthesis of the PTM and

236 proteins are encoded by three closely linked gene clusters (Pcdhalpha, Pcdhbeta, and Pcdhgamma).

237 increased abundance of the diol dehydratase gene cluster (pduCDE) in Firmicutes metagenomes predicte

238 cdh) adhesion molecules encoded by the Pcdhg gene cluster play critical roles in nervous system devel

239 gene family expansions, including resistance gene clusters, predate the split of the Mesoamerican and

240 t directed genome mining methods, antibiotic gene cluster predictions and 'essential gene screening'

241 genome analysis identified 10,110 homologous gene clusters present only in a subset of strains, inclu

242 lling the expression of secondary metabolite gene clusters, ranging from epigenetic control and signa

243 The ribosomal gene cluster (rDNA) on synXII was left intact during the

244 ZIC2 localized at immediate early and early gene cluster regions of the KSHV genome and contributed

245 e conclude that PCDH-alpha, -beta and -gamma gene cluster regulatory variation influences the severit

246 We identified 35 gene clusters representing genetically derived biologica

247 sual cyclization steps, the phn biosynthetic gene cluster responsible for herqueinone biosynthesis wa

248 Streptomyces chromofuscus ATCC49982, and the gene cluster responsible for its biosynthesis was identi

249 cing revealed the putative type I polyketide gene cluster responsible for selvamicin's biosynthesis i

250 We confirm detected gene clusters reviewing the literature and comparing the

251 Analysis of their biosynthetic gene cluster shows that it constitutes a distinct evolut

252 ightly regulated, leaving the majority of SM gene clusters silent under laboratory conditions.

253 th rice, while the phytoalexin momilactone A gene cluster specifically to infection by pathogenic Pyr

254 e function of representative A. fumigatus SM gene clusters, such as those involved in the production

255 t locations or were exchanged with unrelated gene clusters suggesting a plug and play type model of e

256 Genes within the co-regulated gene clusters tend to have relevant functions and shared

257 Ten highly coexpressed gene clusters, termed metagenes, were identified, valida

258 hen derive GRFs for target genes in the CLB2 gene cluster that are expressed during G2/M phase.

259 scherichia coli contain the clb biosynthetic gene cluster that codes for small molecule prodrugs know

260 inked to a plasmid-borne Bacillus megaterium gene cluster that contains four genes: oxsA, oxsB, oxrA

261 large nif1 gene cluster and the similar nif2 gene cluster that functions under anaerobic conditions i

262 I contains the toxin-coregulated pilus (TCP) gene cluster that is necessary for colonization of the h

263 etoplastids are organized into polycistronic gene clusters that are flanked by the modified DNA base

264 production is the abundance of biosynthetic gene clusters that are not expressed under typical labor

265 xpression analysis indicated the presence of gene clusters that co-vary over different genetic backgr

266 We also identified two large gene clusters that jointly encompass many key phenotypic

267 ptome analyses identified markedly different gene clusters that reflected the tumorigenic and angioge

268 s the infarcted heart enabled us to identify gene clusters that share a comparable expression profile

269 natural products are organized as metabolic gene clusters, thereby unveiling a highly unusual form o

270 otentially distinct from all other bacterial gene clusters to date.

271 lation of expression of secondary metabolite gene clusters to increase the diversity of metabolites t

272 for rapidly recombining polyketide synthase gene clusters to replace, add or remove modules that, wi

273 variation in terms of codon-usage within the gene cluster, together with the dislocated domain organi

274 transcriptional repressor that silences the gene cluster under standard growth conditions.

275 of CTL responses revealed uniquely expressed gene clusters upon encountering hepatoma target cells pr

276 s sequenced and the responsible biosynthetic gene cluster was identified by bioinformatic analysis an

277 The 9 kb kawaguchipeptin (kgp) gene cluster was identified in a 5.26 Mb draft genome of

278 the cloned Salmonella Choleraesuis O-antigen gene cluster was introduced into three constructed Salmo

279 that a defective repression of the miR-17-92 gene cluster was responsible for evolution of a selectio

280 far cryptic and otherwise silent putative SM gene clusters was induced in the KMT6(kd) strain, in whi

281 only a 400-kb deletion, including the whole-gene cluster, was eventually able to merge the neighbori

282 sms and copy number variation of the FCGR2/3 gene cluster were studied in a FCGR-specific multiplex l

283 Similar gene clusters were analyzed in approximately 150 phyloge

284 A total of 331 homologous gene clusters were essential for fitness during in vitro

285 is exemplified in the rapamycin biosynthetic gene cluster where, in a single experiment, multiple str

286 ignaling pathways and formation of embryonic gene clusters, whereas the NS5A TCR activation induced e

287 mensal Escherichia coli harbor the 54-kb clb gene cluster which codes for small molecules named preco

288 common functional polymorphisms in the IL-1 gene cluster, which are associated with the inflammatory

289 mentation mutants, a new fungal pigmentation gene cluster, which contains Mr-Pks1, Mr-EthD and Mlac1

290 The human C-type lectin 18 (clec18) gene cluster, which contains three clec18a, clec18b, and

291 ired to form BMCs are typically organized in gene clusters, which promoted their distribution across

292 plification of the plasmepsin 2-plasmepsin 3 gene cluster with in-vitro piperaquine resistance.

293 de polymorphisms (SNPs) in the CHRNB3-CHRNA6 gene cluster with ND in a Chinese Han population (N = 5,

294 s to exchange all native promoters in silent gene clusters with constitutively active promoters.

295 d to encode vast collections of biosynthetic gene clusters with diverse chemical potential, almost no

296 Gene clusters with functional roles in melanoma metastas

297 Gene clusters, with variable organization and distributi

298 found to be grouped together in biosynthetic gene clusters within plant genomes.

299 ave given rise to 12 copies of alpha-gliadin genes clustered within a 550-kb region.

300 s and Relevance: In this analysis, candidate genes clustered within gene networks that were associate